How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

573 results for

Malaria Chemoprophylaxis

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

281. Epilepsy triggered by mefloquine in an adult traveler to Uganda Full Text available with Trip Pro

, he experienced four other similar episodes. The patient was still on full dose anticonvulsant therapy one year and a half after, as any attempt at reduced dose was unsuccessful. Currently, three agents (mefloquine, atovaquone/proguanil, and doxycycline) are recommended for malaria chemoprophylaxis, with similar efficacy but different adverse event profiles, regimens, and prices. Considering that mefloquine is associated with a higher risk of neurologic and psychiatric adverse events than (...) Epilepsy triggered by mefloquine in an adult traveler to Uganda We report a case of a traveler who visited Uganda for 8 d, and took mefloquine one tablet/week for malaria prophylaxis. After the second dose, he suffered from two episodes of loss of consciousness with seizures, therefore mefloquine was discontinued. During the flight back after full recovery, seizures reoccurred while he was on board, he was disembarked in Addis Ababa and then transferred to Nairobi. After repatriation to Italy

2014 World Journal of Clinical Cases : WJCC

282. Mefloquine safety and tolerability in pregnancy: a systematic literature review. Full Text available with Trip Pro

Mefloquine safety and tolerability in pregnancy: a systematic literature review. Control of malaria in pregnant women is still a major challenge as it constitutes an important cause of maternal and neonatal mortality. Mefloquine (MQ) has been used for malaria chemoprophylaxis in non-immune travellers for several decades and it constitutes a potential candidate for intermittent preventive treatment in pregnant women (IPTp).The safety of MQ, including its safety in pregnancy, is controversial (...) and a continuing subject of debate. Published studies which evaluated the use of MQ for malaria prevention or treatment in pregnant women and which reported data on drug tolerability and/or pregnancy outcomes have been reviewed systematically.Eighteen articles fitted the inclusion criteria, only one study was double-blind and placebo controlled. No differences were found in the risk of adverse pregnancy outcomes in women exposed to MQ compared to those exposed to other anti-malarials or to the general

2014 Malaria journal

283. Safety, Attenuation and Immunogenicity of GAP3KO Administered Via A Stephensi Mosquitoes

participants Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Basic Science Official Title: Trial to Assess the Safety, Attenuation and Immunogenicity of Genetically-attenuated p52-/p36-/sap1- Plasmodium Falciparum Parasites (GAP3KO) Administered Via Infected Anopheles Stephensi Mosquitoes to Malaria-Naïve Adults Study Start Date : December 2014 Actual Primary Completion Date : February 2015 Actual Study Completion Date : August 2015 Resource links provided (...) diagnosis Anticipated use of the following: Investigational malaria vaccine at any time Malaria chemoprophylaxis within 6 months Chronic systemic immunosuppressive medications within 6 months Blood products or immunoglobulin within 120 days Systemic antibiotics with antimalarial effects within 30 days Investigational product or vaccine within 30 days Live vaccine within 28 days; killed vaccine within 14 days of GAP3KO Medications known to significantly interact with chloroquine or Malarone History

2014 Clinical Trials

284. Preparing Children for International Travel: Need for Training and Pediatric-Focused Research. Full Text available with Trip Pro

professional and practice details, followed by a survey regarding decisions on nine patient scenarios that represent common pediatric pre-travel health challenges.Ninety-three (34%) of 273 members completed the survey. Most were physicians (80%) having a primary specialization in pediatrics (55%) and family medicine (19%). About a third (37%) had acquired the ISTM Certificate in Travel Health (CTH); 14 and 11% chose not to provide malaria chemoprophylaxis for a 2-month-old infant and a 13-year-old child

2014 Journal of Travel Medicine

285. Pre-Travel Preparation of US Travelers Going Abroad to Provide Humanitarian Service, Global TravEpiNet 2009-2011. Full Text available with Trip Pro

% of travelers did not receive malaria chemoprophylaxis. Coordinated efforts from HSWs, HSW agencies, and clinicians could reduce vaccine coverage gaps and improve use of malaria chemoprophylaxis.

2014 American Journal of Tropical Medicine & Hygiene

286. International Travel Patterns and Travel Risks for Stem Cell Transplant Recipients. Full Text available with Trip Pro

with international travel within first 2 years after SCT were history of international travel prior to SCT [hazard ratio (HR) = 5.3, 95% CI 2.3-12.0], autologous SCT (HR = 2.6, 95% CI 1.6-2.8), foreign birth (HR = 2.3, 95% CI 1.5-3.3), and high income (HR = 2.0, 95% CI 1.8-3.7). During their first trip, 64 travelers (28%) had traveled to destinations that may have required vaccination or malaria chemoprophylaxis. Only 56% reported seeking pre-travel health advice. Of those who traveled, 16 travelers (7%) became

2014 Journal of Travel Medicine

287. Travel-Related Infection in European Travelers, EuroTravNet 2011. Full Text available with Trip Pro

A (n = 16), typhoid fever (n = 11), and measles (n = 8); 6 cases (including 3 measles cases) were associated with travel within "Western" Europe. Malaria was the most commonly diagnosed infection (n = 482, 8.1% of all travel-related morbidity). Among patients with malaria, the military most commonly received pre-travel advice (95%), followed by travelers for missionary, volunteer, research, or aid work (81%) but travelers visiting friends and relatives (VFRs) were least likely to receive pre-travel (...) advice (21%). The vast majority (96%) of malaria patients were resident in "Western" Europe, but over half (56%) were born elsewhere. Other significant causes of morbidity, which could be reduced through advice and behavioral change, include Giardia (n = 221, 3.7%), dengue (n = 146, 2.4%), and schistosomiasis (n = 131, 2.2%). Of 206 (3.5%) travelers with exposure in "Western" Europe, 75% were tourists; the highest burden of disease was acute gastrointestinal infection (35% cases). Travel from

2014 Journal of Travel Medicine

288. Illness in Returned Travelers from Brazil: The GeoSentinel Experience and Implications for the 2014 FIFA World Cup and the 2016 Summer Olympics. Full Text available with Trip Pro

at a GeoSentinel Clinic from July 1997 through May 2013.The most common travel-related illnesses were dermatologic conditions (40%), diarrheal syndromes (25%), and febrile systemic illness (19%). The most common specific dermatologic diagnoses were cutaneous larva migrans, myiasis, and tungiasis. Dengue and malaria, predominantly Plasmodium vivax, were the most frequently identified specific causes of fever and the most common reasons for hospitalization after travel. Dengue fever diagnoses displayed marked (...) , and chemoprophylaxis; it can also help to focus posttravel evaluation of ill returned travelers. Travelers planning to attend mass events will encounter other risks that are not captured in our surveillance network.

2014 Clinical Infectious Diseases

289. Neutropenia (Diagnosis)

at eliminating the clonal population. Acquired neutropenia caused by infection Infections are the most common form of acquired neutropenia. Infections that may cause neutropenia include, but are not limited to, the following: Bacterial sepsis Viral infections (eg, influenza, measles, Epstein Barr virus [EBV], cytomegalovirus [CMV], , human immunodeficiency virus [HIV]-1) (see first image below) Toxoplasmosis Brucellosis Typhoid Tuberculosis (see second and third images below) Malaria Dengue fever Rickettsial (...) 18, 2018. Kern WV, Cometta A, De Bock R, Langenaeken J, Paesmans M, Gaya H. Oral versus intravenous empirical antimicrobial therapy for fever in patients with granulocytopenia who are receiving cancer chemotherapy. International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer. N Engl J Med . 1999 Jul 29. 341(5):312-8. . Bow EJ, Mandell LA, Louie TJ, Feld R, Palmer M, Zee B, et al. Quinolone-based antibacterial chemoprophylaxis

2014 eMedicine.com

290. African Trypanosomiasis (Sleeping Sickness) (Treatment)

including 394 patients with late-stage human African trypanosomiasis due to T brucei gambiense treated with fexinidazole or nifurtimox-eflornithine combination therapy (NECT), success at 18 months was noted in 91% of patients treated with fexinidazole versus 98% of patients treated with NECT. [ ] Previous Next: Prevention No vaccine is available for African trypanosomiasis. Chemoprophylaxis is unavailable. Avoidance of travel to areas heavily infested with tsetse flies is recommended. Tsetse flies (...) experience in the Democratic Republic of the Congo. Clin Infect Dis . 2013. 56(2):195–203. . . Media Gallery African trypanosomiasis (sleeping sickness). Human trypanosomes blood smear. Trypanosoma life cycle. Courtesy of the CDC Division of Parasitic Diseases and Malaria (DPDx at https://www.cdc.gov/dpdx/trypanosomiasisafrican/index.html). Trypanosoma brucei in a thin blood smear stained with Giemsa. Courtesy of the CDC Division of Parasitic Diseases and Malaria (DPDx at https://www.cdc.gov/dpdx

2014 eMedicine.com

291. Leptospirosis (Treatment)

: Consultations In severe cases of leptospirosis, several specialty consultations may aid in proper patient management. An infectious disease specialist may assist in differentiating leptospirosis from diseases with similar presentations but that may have significantly different treatments and in treating co-infections such as malaria, dengue, or others, depending on exposure history. A nephrologist should be alerted early in the course because the need for dialysis may develop rapidly. If available, critical (...) pulse therapy in pulmonary involvement in leptospirosis. J Assoc Physicians India . 2001 Sep. 49:901-3. . Martins MG, Matos KT, da Silva MV, de Abreu MT. Ocular manifestations in the acute phase of leptospirosis. Ocul Immunol Inflamm . 1998 Jun. 6(2):75-9. . Takafuji ET, Kirkpatrick JW, Miller RN, Karwacki JJ, Kelley PW, Gray MR, et al. An efficacy trial of doxycycline chemoprophylaxis against leptospirosis. N Engl J Med . 1984 Feb 23. 310(8):497-500. . [Guideline] Guidugli F, Castro AA, Atallah

2014 eMedicine.com

292. Neutropenia (Overview)

at eliminating the clonal population. Acquired neutropenia caused by infection Infections are the most common form of acquired neutropenia. Infections that may cause neutropenia include, but are not limited to, the following: Bacterial sepsis Viral infections (eg, influenza, measles, Epstein Barr virus [EBV], cytomegalovirus [CMV], , human immunodeficiency virus [HIV]-1) (see first image below) Toxoplasmosis Brucellosis Typhoid Tuberculosis (see second and third images below) Malaria Dengue fever Rickettsial (...) 18, 2018. Kern WV, Cometta A, De Bock R, Langenaeken J, Paesmans M, Gaya H. Oral versus intravenous empirical antimicrobial therapy for fever in patients with granulocytopenia who are receiving cancer chemotherapy. International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer. N Engl J Med . 1999 Jul 29. 341(5):312-8. . Bow EJ, Mandell LA, Louie TJ, Feld R, Palmer M, Zee B, et al. Quinolone-based antibacterial chemoprophylaxis

2014 eMedicine.com

293. Splenomegaly (Treatment)

splenomegaly from myeloproliferative disorders. An onset of fever several days following splenectomy can be due to a recrudescence of malaria. This should be considered as a cause of fever in patients who have lived in areas commonly associated with malaria and in persons who abuse intravenous (IV) drugs who share needles. With Plasmodium malariae infection, this may occur decades after the initial infection. Malaria from P vivax (3-7 y) and P falciparum (about 1 y) remain active for shorter intervals (...) . A major contributing factor is the frequent existence of splenic implants or accessory spleens in traumatized patients, although accessory spleens can also be seen as a developmental anomaly. Prevention Preventative strategies for OPSI fall into 3 major categories: education, immunoprophylaxis, and chemoprophylaxis. As previously mentioned, education represents a mandatory strategy in the prevention of OPSI. Asplenic patients should be encouraged to wear a Medi-Alert (Pinellas Park, Fla/Henderson, Nev

2014 eMedicine.com

294. Granulocytopenia (Overview)

at eliminating the clonal population. Acquired neutropenia caused by infection Infections are the most common form of acquired neutropenia. Infections that may cause neutropenia include, but are not limited to, the following: Bacterial sepsis Viral infections (eg, influenza, measles, Epstein Barr virus [EBV], cytomegalovirus [CMV], , human immunodeficiency virus [HIV]-1) (see first image below) Toxoplasmosis Brucellosis Typhoid Tuberculosis (see second and third images below) Malaria Dengue fever Rickettsial (...) 18, 2018. Kern WV, Cometta A, De Bock R, Langenaeken J, Paesmans M, Gaya H. Oral versus intravenous empirical antimicrobial therapy for fever in patients with granulocytopenia who are receiving cancer chemotherapy. International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer. N Engl J Med . 1999 Jul 29. 341(5):312-8. . Bow EJ, Mandell LA, Louie TJ, Feld R, Palmer M, Zee B, et al. Quinolone-based antibacterial chemoprophylaxis

2014 eMedicine.com

295. Leptospirosis (Follow-up)

: Consultations In severe cases of leptospirosis, several specialty consultations may aid in proper patient management. An infectious disease specialist may assist in differentiating leptospirosis from diseases with similar presentations but that may have significantly different treatments and in treating co-infections such as malaria, dengue, or others, depending on exposure history. A nephrologist should be alerted early in the course because the need for dialysis may develop rapidly. If available, critical (...) pulse therapy in pulmonary involvement in leptospirosis. J Assoc Physicians India . 2001 Sep. 49:901-3. . Martins MG, Matos KT, da Silva MV, de Abreu MT. Ocular manifestations in the acute phase of leptospirosis. Ocul Immunol Inflamm . 1998 Jun. 6(2):75-9. . Takafuji ET, Kirkpatrick JW, Miller RN, Karwacki JJ, Kelley PW, Gray MR, et al. An efficacy trial of doxycycline chemoprophylaxis against leptospirosis. N Engl J Med . 1984 Feb 23. 310(8):497-500. . [Guideline] Guidugli F, Castro AA, Atallah

2014 eMedicine.com

296. African Trypanosomiasis (Sleeping Sickness) (Overview)

African trypanosomiasis, stage 1 - Pentamidine isethionate or suramin West African trypanosomiasis, stage 2 - Eflornithine and nifurtimox combination therapy or melarsoprol Fexinidazole is a promising new oral drug recently recommended by the European Medicines Agency for the treatment of both stages of West African trypanosomiasis. No vaccine is available for African trypanosomiasis. Chemoprophylaxis is unavailable. In both early- and late-stage trypanosomiasis, symptoms usually resolve after (...) reservoir (West African trypanosomiasis) or an animal reservoir (East African trypanosomiasis). The trypanosomes multiply over a period of 2-3 weeks in the fly midgut; then, the trypanosomes migrate to the salivary gland. Trypanosoma life cycle. Courtesy of the CDC Division of Parasitic Diseases and Malaria (DPDx at https://www.cdc.gov/dpdx/trypanosomiasisafrican/index.html). Humans are infected with T brucei after a fly bite, which occasionally causes a painful skin chancre at the site 5-15 days later

2014 eMedicine.com

297. Agranulocytosis (Overview)

at eliminating the clonal population. Acquired neutropenia caused by infection Infections are the most common form of acquired neutropenia. Infections that may cause neutropenia include, but are not limited to, the following: Bacterial sepsis Viral infections (eg, influenza, measles, Epstein Barr virus [EBV], cytomegalovirus [CMV], , human immunodeficiency virus [HIV]-1) (see first image below) Toxoplasmosis Brucellosis Typhoid Tuberculosis (see second and third images below) Malaria Dengue fever Rickettsial (...) 18, 2018. Kern WV, Cometta A, De Bock R, Langenaeken J, Paesmans M, Gaya H. Oral versus intravenous empirical antimicrobial therapy for fever in patients with granulocytopenia who are receiving cancer chemotherapy. International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer. N Engl J Med . 1999 Jul 29. 341(5):312-8. . Bow EJ, Mandell LA, Louie TJ, Feld R, Palmer M, Zee B, et al. Quinolone-based antibacterial chemoprophylaxis

2014 eMedicine.com

298. Splenomegaly (Follow-up)

splenomegaly from myeloproliferative disorders. An onset of fever several days following splenectomy can be due to a recrudescence of malaria. This should be considered as a cause of fever in patients who have lived in areas commonly associated with malaria and in persons who abuse intravenous (IV) drugs who share needles. With Plasmodium malariae infection, this may occur decades after the initial infection. Malaria from P vivax (3-7 y) and P falciparum (about 1 y) remain active for shorter intervals (...) . A major contributing factor is the frequent existence of splenic implants or accessory spleens in traumatized patients, although accessory spleens can also be seen as a developmental anomaly. Prevention Preventative strategies for OPSI fall into 3 major categories: education, immunoprophylaxis, and chemoprophylaxis. As previously mentioned, education represents a mandatory strategy in the prevention of OPSI. Asplenic patients should be encouraged to wear a Medi-Alert (Pinellas Park, Fla/Henderson, Nev

2014 eMedicine.com

299. African Trypanosomiasis (Sleeping Sickness) (Follow-up)

including 394 patients with late-stage human African trypanosomiasis due to T brucei gambiense treated with fexinidazole or nifurtimox-eflornithine combination therapy (NECT), success at 18 months was noted in 91% of patients treated with fexinidazole versus 98% of patients treated with NECT. [ ] Previous Next: Prevention No vaccine is available for African trypanosomiasis. Chemoprophylaxis is unavailable. Avoidance of travel to areas heavily infested with tsetse flies is recommended. Tsetse flies (...) experience in the Democratic Republic of the Congo. Clin Infect Dis . 2013. 56(2):195–203. . . Media Gallery African trypanosomiasis (sleeping sickness). Human trypanosomes blood smear. Trypanosoma life cycle. Courtesy of the CDC Division of Parasitic Diseases and Malaria (DPDx at https://www.cdc.gov/dpdx/trypanosomiasisafrican/index.html). Trypanosoma brucei in a thin blood smear stained with Giemsa. Courtesy of the CDC Division of Parasitic Diseases and Malaria (DPDx at https://www.cdc.gov/dpdx

2014 eMedicine.com

300. African Trypanosomiasis (Sleeping Sickness) (Diagnosis)

African trypanosomiasis, stage 1 - Pentamidine isethionate or suramin West African trypanosomiasis, stage 2 - Eflornithine and nifurtimox combination therapy or melarsoprol Fexinidazole is a promising new oral drug recently recommended by the European Medicines Agency for the treatment of both stages of West African trypanosomiasis. No vaccine is available for African trypanosomiasis. Chemoprophylaxis is unavailable. In both early- and late-stage trypanosomiasis, symptoms usually resolve after (...) reservoir (West African trypanosomiasis) or an animal reservoir (East African trypanosomiasis). The trypanosomes multiply over a period of 2-3 weeks in the fly midgut; then, the trypanosomes migrate to the salivary gland. Trypanosoma life cycle. Courtesy of the CDC Division of Parasitic Diseases and Malaria (DPDx at https://www.cdc.gov/dpdx/trypanosomiasisafrican/index.html). Humans are infected with T brucei after a fly bite, which occasionally causes a painful skin chancre at the site 5-15 days later

2014 eMedicine.com

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>