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Malaria Chemoprophylaxis

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261. A multiplex assay for the simultaneous detection of antibodies against 15 Plasmodium falciparum and Anopheles gambiae saliva antigens. Full Text available with Trip Pro

A multiplex assay for the simultaneous detection of antibodies against 15 Plasmodium falciparum and Anopheles gambiae saliva antigens. Assessment exposure and immunity to malaria is an important step in the fight against the disease. Increased malaria infection in non-immune travellers under anti-malarial chemoprophylaxis, as well as the implementation of malaria elimination programmes in endemic countries, raises new issues that pertain to these processes. Notably, monitoring malaria immunity (...) has become more difficult in individuals showing low antibody (Ab) responses or taking medications against the Plasmodium falciparum blood stages. Commonly available techniques in malaria seroepidemiology have limited sensitivity, both against pre-erythrocytic, as against blood stages of the parasite. Thus, the aim of this study was to develop a sensitive tool to assess the exposure to malaria or to bites from the vector Anopheles gambiae, despite anti-malarial prophylactic treatment.Ab responses

2010 Malaria journal

262. Imported malaria in an area in southern Madrid, 2005-2008. Full Text available with Trip Pro

acquired in Nigeria (49.1%) and Equatorial Guinea (32.7%). 29.1% of the patients were immigrants who had arrived recently, and 61.8% acquired malaria when travelling to their countries of origin to visit friends and relatives (VFR). Majority of cases were diagnosed between June and September. Microscopy was positive in 39 cases (68.4%) immunochromatography in 42 (73.7%) and PCR in the 55 cases where performed. Plasmodium falciparum was responsible for 94.7% of the cases. The more frequent symptoms were (...) fever (77.2%), followed by headache and gastrointestinal symptoms (33.3%). Nine cases needed hospital admittance, a pregnant woman, three children, four VFR and an African tourist, but all evolved favourably. Chemoprophylaxis data was known from 55 patients. It was taken correctly in one case (1.8%), in five (9.1%) the prophylaxis was improper while the others 49 (89.1%) cases had not followed any anti-malarial prophylaxis.Children, pregnant women and the VFR have the highest risk to present severe

2010 Malaria journal

263. Statement on pregnancy and travel

interventions / Dysfonctionnement chronique d’un organe nécessitant des interventions médicales fréquentes • High altitudes / Altitude élevée • Areas endemic for or with ongoing outbreaks of life-threatening food- or insect-borne infections / Régions où on enregistre des éclosions régulières d’infec- tions potentiellement mortelles transmises par des aliments ou des insectes, ou régions où de telles infections sont endémiques • Areas where chloroquine- resistant Plasmodium falciparum malaria is endemic (...) , medical resources to deal with pregnancy-related complications may be significantly different than Canadian standards. Pregnant women may be more susceptible to and/or more severely affected by certain infectious diseases due to changes in immunity and physiology. In addition, pregnancy may increase the risk of acquiring certain infections such as malaria, toxoplasmosis, leprosy and listeriosis (1) . Similarly, certain infections such as influenza and varicella may have a more severe clinical course

2010 CPG Infobase

264. Prevention and treatment of HIV and other sexually transmitted infections among men who have sex with men and transgender people

University of New South Wales, Australia – Andrew Grulich, The Naz Foundation Trust, India – Shivananda Khan, The Global Fund to Fight AIDS, Tuberculosis and Malaria, Switzerland – Andy Seale UN Agencies UNAIDS – Michael Bartos, John Hassell, Els Klinkert, Geoffrey Manthey, Jason Sigurdson, Mariangela Simao and Susan Timberlake, UNDP – Sam Avrett, Edmund Settle and Cheikh Traore, World Bank – Robert Oelrichs9 WHO Headquarters and Regional Offices Department of HIV/AIDS – Rachel Baggaley, Andrew Ball, Kim

2011 World Health Organisation HIV Guidelines

265. Enquiries to the United Kingdom National Travel Advice Line by healthcare professionals regarding immunocompromised travellers. Full Text available with Trip Pro

Enquiries to the United Kingdom National Travel Advice Line by healthcare professionals regarding immunocompromised travellers. People who travel while immunocompromised are more at risk of serious travel-related infection. Their condition, medications or treatments can contraindicate, decrease the effectiveness of or increase the toxicity of vaccinations or malaria chemoprophylaxis. Therefore, immunocompromised travellers require careful assessment and specialized pre-travel advice. The aims (...) Sub-Saharan Africa (53%) for the purpose of tourism (43%). Sixty-seven percent of enquiries concerned vaccine use, 11% were about malaria chemoprophylaxis, 20% were about both and 2% were for other reasons. Causes of immunocompromise included inflammatory or autoimmune conditions (43%), cancer (18%), splenic dysfunction (13%), immunosuppressive drugs (12%), human immunodeficiency virus (11%), primary immunodeficiency (1%), neutropenia (0.5%) and thymus abnormalities (0.5%).There were frequent

2016 Journal of Travel Medicine

266. Sickle cell disease Full Text available with Trip Pro

of antibiotic prophylaxis in children aged under 5 years, antibiotic prophylaxis in children aged 5 years or older, hydroxyurea, malaria chemoprophylaxis, and pneumococcal vaccines.

2016 BMJ Clinical Evidence

267. Le paludisme grave d’importation chez l’adulte: étude rétrospective de treize cas admis en réanimation à Marrakech Full Text available with Trip Pro

Le paludisme grave d’importation chez l’adulte: étude rétrospective de treize cas admis en réanimation à Marrakech Imported malaria is being seen with increasing frequency in non-endemic areas. Severe forms represent 10% of cases of Plasmodium falciparum malaria. In Morocco, more than 50 cases of malaria occur each year, 83% of which with Plasmodium falciparum malaria. All patients with severe malaria admitted to the Intensive Care Unit during the period between 1 November 2009 and 31 (...) December 2015 were enrolled in our study. The main epidemiological data, the reasons for admission, the management and the outcomes of patients were studied. Thirteen patients were included in our study. The average age was 31 years. All patients had been living in sub-Saharan Africa and had no immunity to malaria. Chemoprophylaxis was adequate in 33% of cases. The mean time between symptom onset and treatment initiation was six days. Mean initial parasitemia was 12%. The main reasons for ICU admission

2016 The Pan African medical journal

268. Targeted Therapy Using Intradermal Injection of Etanercept for Remission Induction in Discoid Lupus Erythematosus

who have refractory disease to the first line agents, anti-malarials. If left untreated, uncontrolled inflammation will lead to permanent disfiguring and irreversible scar to the patient, thus pose a major cosmetic issue and significantly impair the quality of life. Targeted therapy based on immunopathogenesis is an attractive approach and tumour necrosis factor (TNF) is implicated in the pathogenesis of DLE. However, systemic administration of TNF blockers has been associated with induction (...) Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Adults aged 18-80 years old. Have at least one active DLE lesion, either diagnosed by skin biopsy or confirmation by Dermatologist/ Rheumatologist. Patients with DLE only and SLE patients with DLE are included. Have refractory disease to an anti-malarial for at least 3 months as assessed by Dermatologist/Rheumatologist. Patients receiving anti-malarials must have been receiving them for at least 3 months

2016 Clinical Trials

269. PfSPZ Challenge With Prophylaxis in Mali

: Safety, Tolerability, Immunogenicity and Protective Efficacy Against Naturally-Transmitted Malaria of Infectious, Cryopreserved Plasmodium Falciparum Sporozoites (PfSPZ Challenge) Administered by Direct Venous Inoculation Under Chloroquine Chemoprophylaxis (PfSPZ-CVac), in Malian Adults: A Randomized, Double Blind, Placebo-Controlled Trial Actual Study Start Date : April 6, 2017 Actual Primary Completion Date : June 22, 2018 Actual Study Completion Date : June 22, 2018 Resource links provided (...) by National Institute of Allergy and Infectious Diseases (NIAID): Chemoprophylaxis Chloroquine Cryopreserved Malaria Plasmodium Sporozoites Additional relevant MeSH terms: Layout table for MeSH terms Malaria Protozoan Infections Parasitic Diseases Artesunate Chloroquine Chloroquine diphosphate Antimalarials Antiprotozoal Agents Antiparasitic Agents Anti-Infective Agents Antineoplastic Agents Antiviral Agents Schistosomicides Antiplatyhelmintic Agents Anthelmintics Amebicides Antirheumatic Agents Anti

2016 Clinical Trials

270. Phase 2 Efficacy Study of Primaquine and Methylene Blue

London School of Hygiene and Tropical Medicine Heidelberg University Bill and Melinda Gates Foundation Information provided by (Responsible Party): University of California, San Francisco Study Details Study Description Go to Brief Summary: The purpose of this study is to determine the most efficacious transmission blocking drug regimen for seasonal malaria chemoprophylaxis in Mali. The primary outcome measure will be the proportion of mosquitoes infected pre and post-treatment, assessed through (...) and Methylene Blue The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02831023 Recruitment Status : Completed First Posted : July 13, 2016 Last Update Posted : January 11, 2017 Sponsor: University of California, San Francisco Collaborators: Malaria Research and Training Center, Bamako, Mali Radboud University

2016 Clinical Trials

271. Safety, Tolerability and Immunogenicity of PfSPZ Vaccine in an Age De-escalation Trial in Equatorial Guinea.

, children and infants who receive doses of 0.9x10^6, 1.8x10^6 or 2.7x10^6 PfSPZ Vaccine via direct venous inoculation (DVI) compared with control groups receiving normal saline (NS) placebo by DVI. In addition, the study will also assess a second PfSPZ-based vaccination approach known as PfSPZ-CVac- the administration of non-irradiated, infectious PfSPZ (PfSPZ Challenge) (1x10^5 PfSPZ) under anti-malarial chemoprophylaxis (chloroquine) in younger adults ages 18 to 35 years for safety, tolerability (...) Vaccine PfSPZ Challenge (NF54) CHMI Chloroquine Chemoprophylaxis PfSPZ-CVac Additional relevant MeSH terms: Layout table for MeSH terms Malaria Protozoan Infections Parasitic Diseases Vaccines Chloroquine Chloroquine diphosphate Immunologic Factors Physiological Effects of Drugs Amebicides Antiprotozoal Agents Antiparasitic Agents Anti-Infective Agents Antimalarials Antirheumatic Agents Anti-Inflammatory Agents, Non-Steroidal Analgesics, Non-Narcotic Analgesics Sensory System Agents Peripheral Nervous

2016 Clinical Trials

272. Effectiveness of twice a week prophylaxis with atovaquone-proguanil (Malarone®) in long-term travellers to West Africa. Full Text available with Trip Pro

Effectiveness of twice a week prophylaxis with atovaquone-proguanil (Malarone®) in long-term travellers to West Africa. Current guidelines recommend daily dosing of atovaquone-proguanil (AP), beginning a day before travel to endemic areas and continuing for 7 days after departure. Adherence of long-term travellers to daily malaria chemoprophylaxis tends to be poor, even when residing in highly endemic malaria regions. Evidence from a volunteer challenging study suggests that non-daily, longer (...) intervals dosing of AP provides effective protection against Plasmodium falciparum This study examines the effectiveness of twice weekly AP prophylaxis in long-term travellers to highly endemic P. falciparum areas in West Africa.An observational surveillance study aimed to detect prophylactic failures associated with twice weekly AP, during the years 2013-2014, among long-term expatriates in two sites in West Africa. The expatriates were divided according to the malaria prophylaxis regimen taken: AP

2016 Journal of Travel Medicine

273. GeoSentinel Surveillance of Illness in Returned Travelers, 2007-2011. Full Text available with Trip Pro

pretravel medical visits. The relative frequency of many diseases varied with both travel destination and reason for travel, with travelers visiting friends and relatives in their country of origin having both a disproportionately high burden of serious febrile illness and very low rates of advice before travel (18.3%). Life-threatening diseases, such as Plasmodium falciparum malaria, melioidosis, and African trypanosomiasis, were reported.Sentinel surveillance data collected by specialist clinics do (...) not reflect healthy returning travelers or those with mild or self-limited illness. Data cannot be used to infer quantitative risk for illness.Many illnesses may have been preventable with appropriate advice, chemoprophylaxis, or vaccination. Clinicians can use these 5-year GeoSentinel data to help tailor more efficient pretravel preparation strategies and evaluate possible differential diagnoses of ill returned travelers according to destination and reason for travel.Centers for Disease Control

2013 Annals of Internal Medicine

274. Effect of Antimalarial Drugs to Rabies Vaccine for Post-exposure Prophylaxis.

-exposure prophylaxis. This study will use the FDA approved post-exposure prophylaxis vaccine regimen (without rabies immune globulin) in the presence or absence of an FDA-approved malaria chemoprophylaxis regimen. Condition or disease Intervention/treatment Phase Rabies Drug: Chloroquine Drug: Atovaquone and Proguanil Drug: Doxycycline Biological: Rabies Vaccine Phase 4 Detailed Description: Rabies is present on all continents where U.S. military personnel deploy, including countries where malaria (...) is also endemic and where U.S. military personnel are required to take malaria prophylaxis. Rabies post-exposure prophylaxis in unvaccinated individuals who are not on malaria prophylaxis consists of four, 1.0-mL intramuscular (IM) injections of the purified chick embryo cell (PCECV) rabies vaccine on days 0, 3, 7, and 14. The current Advisory Committee on Immunization Practices (ACIP) guidelines recommend that exposed persons who are taking malaria prophylaxis should receive a fifth dose of rabies

2015 Clinical Trials

275. Package of Interventions After Recovering From Moderate Acute Malnutrition

/treatment No Intervention: No Intervention No specific intervention given after recovery from moderate acute malnutrition. Experimental: Package of interventions Package of interventions given after recovery from moderate acute malnutrition -- includes lipid-nutrient supplement for 2 months, malaria chemoprophylaxis for 3 months during malaria season, an insecticide-treated bed net, a one-time albendazole treatment, and 14 days of zinc. Dietary Supplement: Lipid Nutrient Supplement Drug: Sulfadoxine

2015 Clinical Trials

276. Absence of correlation between ex vivo susceptibility to doxycycline and pfteQ-pfmdt gene polymorphism in French Guiana. Full Text available with Trip Pro

Absence of correlation between ex vivo susceptibility to doxycycline and pfteQ-pfmdt gene polymorphism in French Guiana. In French Guiana, doxycycline is used for both chemoprophylaxis and the treatment of malaria. The presence of isolates with reduced ex vivo susceptibility to doxycycline in French Guiana makes it critical to identify any genetic determinants contributing to the chemosusceptibility level of Plasmodium falciparum to doxycycline, such as pfmdt and pftetQ, which were recently

2015 Malaria journal

277. How long after completing a course of Malarone should a female wait before conceiving?

chemoprophylaxis for women planning a pregnancy and states: “To avoid completely any potential adverse drug effects from preconceptual and first-trimester exposure, it is advisable to wait for complete excretion of the drug, if it was taken for prophylaxis, before becoming pregnant Nevertheless, unplanned conception while taking malaria prophylaxis is not considered a reason to recommend termination of pregnancy, owing to the low risk of teratogenicity.” On the suggested waiting times before becoming pregnant (...) including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com How long after completing a course of Malarone should a female wait before conceiving? The Royal College of Obstetricians and Gynaecologists (RCOG) published guidelines on the prevention of malaria in pregnancy (1). This discusses

2013 TRIP Answers

278. Is there any consensus as to how antimalarials should be used when patients are on warfarin.

by Tetracyclines Advice for travellers needing malaria chemoprophylaxis who are taking warfarin Travellers should start taking their malaria tablets at least 1 week (and ideally 2-3 weeks in the case of mefloquine) prior to their departure. A baseline INR should be checked prior to starting chemoprophylaxis, and re-checked after 1 week of taking chemoprophylaxis. If a traveller is away for a long period of time the INR should be checked at intervals at the destination. However, the sensitivity (...) content types including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Is there any consensus as to how antimalarials should be used when patients are on warfarin. The Health Protection Agency (HPA) has produced a guideline for malarial prevention in travellers from the United Kingdom

2012 TRIP Answers

279. WHO guidelines on drawing blood: best practices in phlebotomy

of an accidental puncture, may be more likely to transmit disease than other sharps. Bloodborne organisms that have been transmitted after needle-sticks include viruses such as hepatitis B and human immunodeficiency virus (HIV), bacteria such as syphilis and parasites such as malaria. Producing the guidelines These guidelines were produced to improve the quality of blood specimens and the safety of phlebotomy for health workers and patients, by promoting best practices in phlebotomy. In April 2008, the WHO (...) fevers (Crimean Congo haemorrhagic fever, Ebola, Lassa and Marburg) and dengue (3). For example, outbreaks of hepatitis B have been reported with the use of glucometers (devices used to determine blood glucose concentration) (4, 5). Diseases such as malaria and syphilis may also be transmitted via contaminated blood (6, 7), and poor infection- control practices may lead to bacterial infection where the needle is inserted and contamination of specimens. If a blood sample is poorly collected

2010 World Health Organisation Guidelines

280. Sporozoite immunization of human volunteers under mefloquine prophylaxis is safe, immunogenic and protective: a double-blind randomized controlled clinical trial. Full Text available with Trip Pro

Sporozoite immunization of human volunteers under mefloquine prophylaxis is safe, immunogenic and protective: a double-blind randomized controlled clinical trial. Immunization of healthy volunteers with chloroquine ChemoProphylaxis and Sporozoites (CPS-CQ) efficiently and reproducibly induces dose-dependent and long-lasting protection against homologous Plasmodium falciparum challenge. Here, we studied whether chloroquine can be replaced by mefloquine, which is the only other licensed anti (...) -malarial chemoprophylactic drug that does not affect pre-erythrocytic stages, exposure to which is considered essential for induction of protection by CPS immunization. In a double blind randomized controlled clinical trial, volunteers under either chloroquine prophylaxis (CPS-CQ, n = 5) or mefloquine prophylaxis (CPS-MQ, n = 10) received three sub-optimal CPS immunizations by bites from eight P. falciparum infected mosquitoes each, at monthly intervals. Four control volunteers received mefloquine

2014 PloS one Controlled trial quality: uncertain

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