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1. RTS,S/AS01E malaria vaccine (Mosquirix). Children living in malaria-endemic regions: little efficacy, poorly documented harms

RTS,S/AS01E malaria vaccine (Mosquirix). Children living in malaria-endemic regions: little efficacy, poorly documented harms Prescrire IN ENGLISH - Spotlight ''RTS,S/AS01E malaria vaccine (Mosquirix°). Children living in malaria-endemic regions: little efficacy, poorly documented harms'', 1 January 2017 {1} {1} {1} | | > > > RTS,S/AS01E malaria vaccine (Mosquirix°). Children living in malaria-endemic regions: little efficacy, poorly documented harms Spotlight Every month, the subjects (...) in Prescrire’s Spotlight. 100 most recent :  |   |   |   |   |   |   |   |   |  Spotlight RTS,S/AS01E malaria vaccine (Mosquirix°). Children living in malaria-endemic regions: little efficacy, poorly documented harms FEATURED REVIEW In late 2016, the harm-benefit balance of the RTS,S/AS01E malaria vaccine is highly uncertain, but its evaluation must continue where the vaccine is much needed. Full review (4 pages) available for download

2017 Prescrire

2. Regional malaria action plan 2016–2020: towards a malaria-free Region

Regional malaria action plan 2016–2020: towards a malaria-free Region Regional malaria action plan 2016–2020: towards a malaria-free Region JavaScript is disabled for your browser. Some features of this site may not work without it. Toggle navigation Toggle navigation Search Browse Statistics Related Links Regional malaria action plan 2016–2020: towards a malaria-free Region View/ Open Rights View Statistics Altmetrics Share Citation World Health Organization, Regional Office for the Eastern (...) Mediterranean . (‎2017)‎. Regional malaria action plan 2016–2020: towards a malaria-free Region. World Health Organization. Regional Office for the Eastern Mediterranean. . License: CC BY-NC-SA 3.0 IGO Description 44 p. Gov't Doc # WHO-EM/MAL/385/E Collections Language English Metadata Related items Showing items related by title and MeSH subject.  Executive Board, 83 (‎ EB83/19 , 1988 )‎  Executive Board, 85 (‎ EB85/10 , 1989 )‎  Executive Board, 73 (‎ EB73/9 , 1983 )‎ View Item

2017 WHO

3. World malaria day 2017: malaria prevention works, let's close the gap

World malaria day 2017: malaria prevention works, let's close the gap let’s close the gap For further information, please contact: Global Malaria Programme World Health Organization 20 Avenue Appia CH-1211 Geneva 27 Switzerland www.who.int/malaria Malaria prevention works World Malaria d ay 2017© World Health Organization 2017. Some rights reserved. This work is available under the CC BY-NC-SA 3.0 IGO licence. WHO/HTM/GMP/2017.6 Printed in FranceFOREWORD As World Malaria Day 2017 approaches (...) , there is much to celebrate. According to the latest estimates from WHO, many countries with ongoing malaria transmission have reduced their disease burden significantly. On a global scale, the rate of new malaria cases fell by 21% between 2010 and 2015. Malaria death rates fell by 29% in the same 5-year period (figure 1). In sub-Saharan Africa, where malaria is heavily concentrated, access to key interventions is expanding rapidly, particularly for the groups most vulnerable to infection and death. Since

2017 WHO

4. Seasonal malaria chemoprevention combined with community case management of malaria in children under 10 years of age, over 5 months, in south-east Senegal: A cluster-randomised trial

Seasonal malaria chemoprevention combined with community case management of malaria in children under 10 years of age, over 5 months, in south-east Senegal: A cluster-randomised trial Seasonal malaria chemoprevention (SMC) is recommended in the Sahel region of Africa for children under 5 years of age, for up to 4 months of the year. It may be appropriate to include older children, and to provide protection for more than 4 months. We evaluated the effectiveness of SMC using sulfadoxine (...) -pyrimethamine plus amodiaquine given over 5 months to children under 10 years of age in Saraya district in south-east Senegal in 2011.Twenty-four villages, including 2,301 children aged 3-59 months and 2,245 aged 5-9 years, were randomised to receive SMC with community case management (CCM) (SMC villages) or CCM alone (control villages). In all villages, community health workers (CHWs) were trained to treat malaria cases with artemisinin combination therapy after testing with a rapid diagnostic test (RDT

2019 EvidenceUpdates

5. Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria. (PubMed)

Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria. The World Health Organization (WHO) recommends artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium falciparum (P falciparum) malaria. Concerns about artemisinin resistance have led to global initiatives to develop new partner drugs to protect artemisinin derivatives in ACT. Pyronaridine-artesunate is a novel ACT.To evaluate the efficacy of pyronaridine-artesunate compared (...) to alternative ACTs for treating people with uncomplicated P falciparum malaria, and to evaluate the safety of pyronaridine-artesunate and other pyronaridine treatments compared to alternative treatments.We searched the Cochrane Infectious Diseases Group Specialized Register; Cochrane Central Register of Controlled Trials (CENTRAL), published in the Cochrane Library; MEDLINE; Embase; and LILACS. We also searched ClinicalTrials.gov, the WHO International Clinical Trials Registry Platform Search Portal

2019 Cochrane

6. Malaria infection

Malaria infection Malaria infection - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Malaria infection Last reviewed: February 2019 Last updated: February 2019 Summary In Western countries, almost all malaria occurs in travellers; therefore, the diagnosis may be missed if a history of travel is not elicited. Patients typically present with non-specific symptoms such as fever, chills, sweats, headache, and myalgia (...) . Examination of a Giemsa-stained blood film remains the diagnostic test of choice. Once the diagnosis of malaria is confirmed, treatment should be started urgently, as a delay may be associated with disease progression and complications. Management should be undertaken in conjunction with an infectious diseases specialist. Definition Malaria is a parasitic infection caused by protozoa of the genus Plasmodium . Five species are known to infect humans; Plasmodium falciparum is the most life-threatening. Snow

2019 BMJ Best Practice

7. Artemether for severe malaria. (PubMed)

Artemether for severe malaria. In 2011 the World Health Organization (WHO) recommended parenteral artesunate in preference to quinine as first-line treatment for people with severe malaria. Prior to this recommendation many countries, particularly in Africa, had begun to use artemether, an alternative artemisinin derivative. This Cochrane Review evaluates intramuscular artemether compared with both quinine and artesunate.To assess the efficacy and safety of intramuscular artemether versus any (...) other parenteral medication in the treatment of severe malaria in adults and children.We searched the Cochrane Infectious Diseases Group Specialized Register, CENTRAL (the Cochrane Library), MEDLINE, Embase, and LILACS, ISI Web of Science, conference proceedings, and reference lists of articles. We also searched the WHO International Clinical Trial Registry Platform, ClinicalTrials.gov, and the metaRegister of Controlled Trials (mRCT) for ongoing trials up to 7 September 2018. We checked

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2019 Cochrane

8. Indoor residual spraying for preventing malaria in communities using insecticide-treated nets. (PubMed)

Indoor residual spraying for preventing malaria in communities using insecticide-treated nets. Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) are used to control malaria vectors. Both strategies use insecticides to kill mosquitoes that bite and rest indoors. For ITNs, the World Health Organization (WHO) only recommended pyrethroids until 2018, but mosquito vectors are becoming resistant to this insecticide. For IRS, a range of insecticides are recommended. Adding IRS to ITNs (...) may improve control, simply because two interventions may be better than one; it may improve malaria control where ITNs are failing due to pyrethroid resistance; and it may slow the emergence and spread of pyrethroid resistance.To summarize the effect on malaria of additionally implementing IRS, using non-pyrethroid-like or pyrethroid-like insecticides, in communities currently using ITNs.We searched the Cochrane Infectious Diseases Group Specialized Register; the Cochrane Central Register

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2019 Cochrane

9. Primaquine at alternative dosing schedules for preventing relapse in people with Plasmodium vivax malaria. (PubMed)

Primaquine at alternative dosing schedules for preventing relapse in people with Plasmodium vivax malaria. Malaria caused by Plasmodium vivax requires treatment of the blood-stage infection and treatment of the hypnozoites that develop in the liver. This is a challenge to effective case management of P vivax malaria, as well as being a more general substantial impediment to malaria control. The World Health Organization (WHO) recommends a 14-day drug course with primaquine, an 8-aminoquinoline (...) as the standard regimen for radical cure ofP vivax malaria.To assess the efficacy and safety of alternative primaquine regimens for radical cure of P vivax malaria compared to the standard or high-standard 14 days of primaquine (0.25 or 0.5 mg/kg/day), as well as comparison of these two WHO-recommended regimens.We searched the Cochrane Infectious Diseases Group (CIDG) Specialized Register; the Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE (PubMed); Embase (Ovid); and LILACS (BIREME) up

2019 Cochrane Controlled trial quality: predicted high

10. Larviciding to prevent malaria transmission. (PubMed)

Larviciding to prevent malaria transmission. Larviciding refers to the regular application of chemical or microbial insecticides to water bodies or water containers to kill the aquatic immature forms of the mosquito (the larvae and pupae).To summarize research evidence evaluating whether larviciding with chemical or microbial insecticides prevents malaria transmission.We searched the Cochrane Infectious Diseases Group Specialized Register; the Cochrane Central Register of Controlled Trials (...) aquatic habitats were less extensive (< 1 km²), and one where habitats were more extensive (> 1 km²; a cross-over study from The Gambia).For aquatic habitats of less than 1 km², one cRCT randomized eight villages in Sri Lanka to evaluate chemical larviciding using insect growth regulator; and two CBA studies undertaken in Kenya and Tanzania evaluated microbial larvicides. In the cRCT, larviciding across all villages was associated with lower malaria incidence (rate ratio 0.24, 4649 participants, low

2019 Cochrane

11. Impact of Plasmodium falciparum malaria and intermittent preventive treatment of malaria in pregnancy on the risk of malaria in infants: a systematic review. (PubMed)

Impact of Plasmodium falciparum malaria and intermittent preventive treatment of malaria in pregnancy on the risk of malaria in infants: a systematic review. Studies of the association between malaria in pregnancy (MiP) and malaria during infancy have provided mixed results. A systematic review was conducted to evaluate available evidence on the impact of Plasmodium falciparum malaria infection during pregnancy, and intermittent preventive treatment of malaria during pregnancy (IPTp (...) ), on the risk of clinical malaria or parasitaemia during infancy.MEDLINE, EMBASE, Global Health, and Malaria in Pregnancy Library databases were searched from inception to 22 May 2018 for articles published in English that reported on associations between MiP and malaria risk in infancy. Search terms included malaria, Plasmodium falciparum, pregnancy, placenta, maternal, prenatal, foetal, newborn, infant, child or offspring or preschool. Randomized controlled trials and prospective cohort studies, which

2019 Malaria journal

12. Malaria prevention guidelines for travellers from the UK

Malaria prevention guidelines for travellers from the UK Malaria prevention guidelines for travellers from the UK - GOV.UK GOV.UK uses cookies which are essential for the site to work. We also use non-essential cookies to help us improve government digital services. Any data collected is anonymised. By continuing to use this site, you agree to our use of cookies. Accept cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Malaria prevention guidelines for travellers (...) from the UK The PHE Advisory Committee on Malaria Prevention updates and reissues these guidelines every year for UK travellers. Published 29 July 2014 Last updated 27 September 2019 — From: Documents Ref: PHE publications gateway number: GW-98 If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email . Please tell us what format you need. It will help us if you say what assistive technology you use. Details

2019 Public Health England

13. Mass media exposure and its impact on malaria prevention behaviour among adult women in sub-Saharan Africa: results from malaria indicator surveys (PubMed)

Mass media exposure and its impact on malaria prevention behaviour among adult women in sub-Saharan Africa: results from malaria indicator surveys Mass media exposure plays a pivotal role in health communication and adoption of a healthy lifestyle. In this study, we aimed to measure the prevalence of malaria prevention behaviour among adult women in eight malaria-endemic countries in sub-Saharan Africa (SSA), and assess the influence of mass media exposure in the adoption of those (...) behaviours.For this study, we collected cross-sectional data on 46,822 women aged between 15 and 49 years from the Malaria Indicator Surveys (MIS) conducted in Burkina Faso, Ghana, Mali, Malawi, Kenya, Nigeria, Sierra Leone and Uganda. As the outcome variable, malaria prevention behaviour was proxied by the use of insecticide treated nets (ITNs) and uptake of antimalarial drugs in last pregnancy.The overall prevalence of sleeping under ITN and that of taking antimalarial drug during the last pregnancy

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2018 Global health research and policy

14. Plasmodium falciparum glutamate dehydrogenase is genetically conserved across eight malaria endemic states of India: Exploring new avenues of malaria elimination. (PubMed)

Plasmodium falciparum glutamate dehydrogenase is genetically conserved across eight malaria endemic states of India: Exploring new avenues of malaria elimination. Accurate and timely diagnosis is very critical for management, control and elimination of the malaria. Malaria rapid diagnostic tests (RDTs) have improved the diagnosis and management of malaria in remote areas, community and places where microscopy is not available for diagnosis. According to WHO report 2018, Plasmodium falciparum (...) malaria constitutes more than 50% of malaria cases in India. Most of the RDTs used for diagnosis of falciparum malaria today employ HRP2 as a target antigen. However, low density parasitemia and deletion of hrp-2 gene in P. falciparum leads to false negative results and necessitates the development of alternative/ new or improved RDT for malaria diagnosis. We have analysed the genetic diversity and homology modelling of Pfgdh (glutamate dehydrogenase), ldh (lactate dehydrogenase) and aldolase genes

2019 PLoS ONE

15. The President's Malaria Initiative contributed to reducing malaria burden in sub-Saharan Africa between 2004 and 2014: Evidence from generalized estimating equation analysis. (PubMed)

The President's Malaria Initiative contributed to reducing malaria burden in sub-Saharan Africa between 2004 and 2014: Evidence from generalized estimating equation analysis. The President's Malaria Initiative (PMI) launched in 2005 as a key player in malaria prevention and treatment in sub-Saharan Africa (SSA). Several country-specific evaluations have demonstrated great progress in reducing under-five mortality associated with scaling up malaria interventions in PMI priority countries (...) the coverage of malaria control interventions and reducing under-five mortality in SSA.

2019 PLoS ONE

16. Mosquito repellents for malaria prevention. (PubMed)

Mosquito repellents for malaria prevention. Malaria is an important cause of illness and death across endemic regions. Considerable success against malaria has been achieved within the past decade mainly through long-lasting insecticide-treated nets (LLINs). However, elimination of the disease is proving difficult as current control methods do not protect against mosquitoes biting outdoors and when people are active. Repellents may provide a personal protection solution during these times.To (...) assess the impact of topical repellents, insecticide-treated clothing, and spatial repellents on malaria transmission.We searched the following databases up to 26 June 2017: the Cochrane Infectious Diseases Group Specialized Register; the Central Register of Controlled Trials (CENTRAL), published in the Cochrane Library; MEDLINE; Embase; US AFPMB; CAB Abstracts; and LILACS. We also searched trial registration platforms and conference proceedings; and contacted organizations and companies for ongoing

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2018 Cochrane

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