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161. Olmutinib Induced Lichen Planus Like Eruption (Full text)

Olmutinib Induced Lichen Planus Like Eruption Drug induced lichen planus like eruption is an uncommon cutaneous adverse effect of several drugs. This appears symmetric eruption of erythematous or violaceous plaques resembling lichen planus on the trunk and extremities. A 50-year-old male presented with scaly, violaceous plaques and dusky brown macules on whole body. For four months, the patient was treated with olmutinib, an oral, third-generation epidermal growth factor receptor-tyrosine

2018 Annals of dermatology PubMed abstract

162. Laugier–Hunziker syndrome in endocrine clinical practice (Full text)

is a rare, acquired cause of asymptomatic, benign mucocutaneous hyperpigmentation.Prior to making a final diagnosis, certain medical entities with overlapping clinical features must be excluded.Endocrine conditions that usually present with the hyperpigmentation of the skin and mucous membranes (e.g. Addison's disease, McCune-Albright syndrome) can be easily ruled out based on clinical and laboratory findings.Its major differential diagnosis, Peutz-Jeghers syndrome is characterized by melanotic macules

2018 Endocrinology, diabetes & metabolism case reports PubMed abstract

163. Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study (Full text)

Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study Melasma is an acquired pigmentary disorder characterized by hyperpigmented macules and/or patches affecting sun-exposed skin. Tranexamic acid (TA) can reduce melanin content of epidermis. Thus, we conducted this study to evaluate the efficacy and safety of tranexamic acid

2018 Dermatology research and practice Controlled trial quality: uncertain PubMed abstract

164. Lichen planus-like keratosis: clinical applicability of in vivo reflectance confocal microscopy for an indeterminate cutaneous lesion (Full text)

Lichen planus-like keratosis: clinical applicability of in vivo reflectance confocal microscopy for an indeterminate cutaneous lesion Lichen planus-like keratosis (LPLK) is an involuting cutaneous lesion often presenting between the fifth and seventh decades of life. These lesions typically appear abruptly as a solitary macule, papule, or plaque that continuously evolves as it undergoes regression. Clinical and dermoscopic features of LPLK can mimic both benign and malignant lesions, often

2018 Dermatology practical & conceptual PubMed abstract

165. A Cross-Sectional Assessment of Cutaneous Lumbosacral and Coccygeal Physical Examination Findings in a Healthy Newborn Population (Full text)

lumbosacral and/or coccygeal hairiness. All racial/ethnic groups had double to quadruple the risk of lumbosacral hair when compared with Caucasians. A total of 44.1% of study infants had lumbosacral/coccygeal slate-grey patches, which were least common in Caucasians. Seven infants had coccygeal skin tags, and 14 infants had lumbosacral vascular macules. Thirty-one percent had more than 1 cutaneous lumbosacral finding present, 24.8% had 2 findings, and 6.2% had 3 or more findings. Conclusion. Coccygeal

2018 Global pediatric health PubMed abstract

166. Cutaneous Neonatal Lupus Erythematosus: A Case Report (Full text)

Cutaneous Neonatal Lupus Erythematosus: A Case Report Cutaneous neonatal lupus erythematosus (NLE) is a rare condition caused by the passive transfer of autoantibodies from mother to fetus. The disease most commonly presents itself with multiple erythematosus annular lesions or arcuate macules. In 10% of the cases, a cardiac anomaly can coexist. Appropriate diagnosis and laboratory and cardiac testing should be done to rule out any complications. Treatment usually includes topical steroids

2018 Cureus PubMed abstract

167. Case Report: “Incognito” proteus syndrome (Full text)

and a series of subtle clinical signs, such as asymmetric face, scoliosis, multiple lipomas on the trunk, linear verrucous epidermal nevi, and hyperpigmented macules with a mosaic distribution. Even if the clinical presentation was elusive, she had enough criteria to be diagnosed with PS. This case describes the first evidence, to the best of our knowledge, of pauci-symptomatic PS in adulthood, reports its rare association with advanced melanoma, and illustrates the importance of even minor cutaneous

2018 F1000Research PubMed abstract

168. Clinicopathologic findings of guttate leukoderma in Darier disease: A helpful diagnostic feature (Full text)

of Medicine, Gainesville, Florida. eng Case Reports 2018 03 06 United States JAAD Case Rep 101665210 2352-5126 DD, Darier disease Darier disease GL, guttate leukoderma IGH, idiopathic guttate hypomelanosis guttate leukoderma hypopigmented macules keratosis follicularis 2018 4 25 6 0 2018 4 25 6 0 2018 4 25 6 1 epublish 29687067 10.1016/j.jdcr.2017.09.021 S2352-5126(17)30230-8 PMC5909488 J Eur Acad Dermatol Venereol. 2016 Dec;30(12 ):e205-e209 26853929 J Am Acad Dermatol. 1992 Jul;27(1):40-50 1619075 Am J

2018 JAAD Case Reports PubMed abstract

169. Sclérose tubéreuse de Bourneville: importance de l’anamnèse et de la clinique (Full text)

and learning difficulties. Epilepsy and brain and renal tumors are treated with aggressive therapeutic and surgical approaches. We report the case of a 13-year old girl, presenting with a 1-year history of acne resistant to therapy. Clinical examination showed symmetric grouped red papules with smooth surface on the central face and the chin (A). The objective clinical examination also showed frontal fibrous plaques (A), achromic macules on the upper limbs and grayish tumors in the periungual folds

2018 The Pan African medical journal PubMed abstract

170. Eruptive lentiginosis in resolving psoriatic plaques (Full text)

Reports Retracted Publication 2018 03 31 United States JAAD Case Rep 101665210 2352-5126 JAAD Case Rep. 2018 Sep 18;4(8):841 30238053 ELRP, eruptive lentiginosis in resolving psoriatic plaques IL, interleukin TNF, tumor necrosis factor hyperpigmentation lentigines macules plaque psoriasis 2018 4 26 6 0 2018 4 26 6 0 2018 4 26 6 1 epublish 29693059 10.1016/j.jdcr.2017.10.009 S2352-5126(17)30261-8 PMC5911780 Pigment Cell Melanoma Res. 2012 Mar;25(2):219-30 22136309 Clin Exp Dermatol. 2006 Mar;31(2):298

2018 JAAD Case Reports PubMed abstract

171. Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis; Extensive Review of Reports of Drug-Induced Etiologies, and Possible Therapeutic Modalities (Full text)

Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis; Extensive Review of Reports of Drug-Induced Etiologies, and Possible Therapeutic Modalities Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis are adverse hypersensitivity reactions that affect the skin and mucous membranes. They are characterised by erythematous macules and hemorrhagic erosions of the mucous membranes. Epidermal detachments of varying degrees of severity also occur in these conditions. Various aetiologies

2018 Open access Macedonian journal of medical sciences PubMed abstract

172. Which egg features predict egg rejection responses in American robins? Replicating Rothstein's (1982) study (Full text)

evaluated with replication. Here, we partially replicated Rothstein's (1982) experiments using parallel artificial model egg treatments to simulate cowbird (Molothrus ater) parasitism in American robin (Turdus migratorius) nests. We compared our data with those of Rothstein (1982) and confirmed most of its original findings: (1) robins reject model eggs that differ from the appearance of a natural robin egg toward that of a natural cowbird egg in background color, size, and maculation; (2) rejection (...) of cowbird eggs. Future work on egg recognition will benefit from utilizing a range of model eggs varying continuously in background color, maculation patterning, and size in combination with avian visual modeling, rather than using model eggs which vary only discretely.

2018 Ecology and evolution PubMed abstract

173. Nevus anemicus and RASopathies (Full text)

, University Hospital Leuven, Leuven, Belgium. Department of Human Genetics, KU Leuven, Leuven, Belgium. eng Case Reports 2018 04 06 United States JAAD Case Rep 101665210 2352-5126 CALMs, café au lait macules Legius syndrome MAPK, mitogen-activated protein kinase NF1, neurofibromatosis type 1 Noonan syndrome PTPN11, protein tyrosine phosphatase nonreceptor type 11 RAF1, rapidly accelerated fibrosarcoma-1 RAS, rat sarcoma family of protooncogenes RASopathy SPRED1, sprouty-related, EVH1 domain containing

2018 JAAD Case Reports PubMed abstract

174. Peutz-Jeghers Syndrome Presenting as Colonic Intussusception: A Rare Entity (Full text)

Peutz-Jeghers Syndrome Presenting as Colonic Intussusception: A Rare Entity Peutz-Jeghers syndrome is an autosomal dominant inherited medical condition characterized by hyperpigmented mucocutaneous macules, hamartomatous polyps in the digestive tract, and with a greater risk of gastrointestinal and non-gastrointestinal cancers. In fact, without appropriate medical surveillance, the lifetime risk for all cancers combined may be as high as 93%. The syndrome is rare, with estimates of incidence

2018 Gastroenterology research PubMed abstract

175. P-Phenylenediamine Hair Dye Allergy and Its Clinical Characteristics (Full text)

between July 2009 and March 2015. Clinical symptoms, signs, associated skin diseases, involved ACD area, and patterns of hair dye use were obtained by reviewing medical records and by interview.HDCA was more common in women and in individuals aged more than 50 years. Pruritus was the most common symptom; erythematous macules and patches were the most frequently observed clinical signs. The most common site of HDCA was the face and non-specific eczema and urticaria were frequently observed with HDCA

2018 Annals of dermatology PubMed abstract

176. Acquired Brachial Cutaneous Dyschromatosis in a Middle Aged Male (Full text)

Acquired Brachial Cutaneous Dyschromatosis in a Middle Aged Male Acquired brachial cutaneous dyschromatosis (ABCD) is an acquired disorder of pigmentary change that presents as chronic, asymptomatic, geographic-shaped, gray-brown patches, consisting of mixed hyper and hypopigmented macules on the dorsal aspect of the forearms. We report a case of a 40-year-old male who presented with asymptomatic, multiple brown-colored macules on the outer aspects of both arms. He had no history (...) of hypertension and had never taken angiotensin converting enzyme inhibitors. He also denied chronic sun exposure history. Histologic examination demonstrated epidermal atrophy, increased basal layer pigmentation, and several telangiectatic vessels in the upper dermis. Solar elastosis was not remarkable. The patient's clinical and histopathologic features were consistent with a diagnosis of ABCD. Poikiloderma of Civatte, melasma, acquired bilateral telangiectatic macules and other pigmentary disorders should

2018 Annals of dermatology PubMed abstract

177. DNA Methylation in Malar Melasma and Its Change by Sunscreen, Retinoic Acid and Niacinamide.

topics: available for: Arms and Interventions Go to Arm Intervention/treatment Control group Macules of melasma without any treatment Device: colorimetry measurement Measurement of erythema and luminosity through a colorimeter Experimental: Niacinamide group Macules of melasma treated with topical Niacinamide cream 4% for 8 weeks Device: colorimetry measurement Measurement of erythema and luminosity through a colorimeter Drug: Niacinamide topical administration in melasma lesions Experimental (...) : Retinoic acid group Macules of melasma treated with topical retinoic acid 0.05% for 8 weeks Drug: Retinoic acid topical administration in melasma lesions Other Names: Niacinamide Sunscreen Device: colorimetry measurement Measurement of erythema and luminosity through a colorimeter Placebo Comparator: Sunscreen group Macules of melasma treated with sunscreen cream with a 50 sun protection factor for 8 weeks Device: colorimetry measurement Measurement of erythema and luminosity through a colorimeter Drug

2018 Clinical Trials

178. Serum 25(OH) Vitamin D and Total Serum Immunoglobulin E Levels in Patients With Pityriasis Alba

, 2018 Sponsor: Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan Information provided by (Responsible Party): Svetlana Osipova, MD, PhD, DS, Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan Study Details Study Description Go to Brief Summary: Pityriasis alba (PA) is a common, benign skin disorder occurring predominantly in children and adolescents. It is characterized by ill-defined hypopigmented macules and patches, round (...) relative or guardian of the patients and healthy individuals of the control group. Study participants will be included about 30 children aged 5 to 12 years with pityriasis alba. The control group will be included about 20 healthy individuals. All the participants will be residents of Uzbekistan. Diagnosis of pityriasis alba Diagnosis of pityriasis alba will be based on the results of clinical examination. Inclusion criteria: revealing multiple round or oval-shaped hypopigmented macules or patches

2018 Clinical Trials

179. Microneedle and Trichloroaceticacid in Treatment of Melasma

Information provided by (Responsible Party): Safaa Hamed, Assiut University Study Details Study Description Go to Brief Summary: Melasma is an acquired disorder of hyperpigmentation characterised by blotchy, light-to-dark brown macules distributed symmetrically on the sun-exposed parts of the body. Although many factors have been proposed to have a role in pathogenesis, the exact ethology is yet to be understood. The most commonly identifiable risk factors include ultraviolet radiation, genetic

2018 Clinical Trials

180. Bimatoprost 0.03% Solution With NB-UVB Versus Their Use With Fractional Carbon Dioxide Laser in Treatment of Generalized Vitiligo

participating. Read our for details. ClinicalTrials.gov Identifier: NCT03487042 Recruitment Status : Not yet recruiting First Posted : April 3, 2018 Last Update Posted : April 3, 2018 See Sponsor: Assiut University Information provided by (Responsible Party): Aml Hassan Ali, Assiut University Study Details Study Description Go to Brief Summary: Vitiligo is a chronic disorder of pigmentation characterized by the development of white macules on the skin due to loss of epidermal melanocytes. It affects

2018 Clinical Trials

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