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Macule

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141. Warts - anogenital

in secondary syphillis and are highly contagious. Carcinoma in situ — multifocal erythematous macules, lichenoid, or pigmented papules which may form plaques on the external anogenital region. The surface is usually smooth and velvety. For more information, see the CKS topic . Other common, benign differential diagnoses skin tags, seborrhoeic keratoses, epidermoid cysts, and sebaceous glands of the foreskin and vulva. Basis for recommendation Basis for recommendation This information is based on the Royal

2017 NICE Clinical Knowledge Summaries

142. Parvovirus B19 infection

or in the interpretation of results, is extrapolated from expert opinion in a review article on pregnant women exposed to childhood rash [ ]. Differential diagnosis What else might it be? Other conditions that may present similarly to parvovirus B19 infection include: Rubella In children, there may be a rash of coalescing pink macules starting on the head and neck, although it does not usually cause the 'slapped cheek' appearance with accompanying perioral pallor of parvovirus B19 infection. The rash spreads (...) , fine macules and sandpaper-like papules. There may be associated petechiae on the palate and erythematous, swollen papillae on the tongue ('strawberry tongue'). See the CKS topic on for more information. Roseola infantum This is caused by herpesvirus type 6 and typically affects children younger than three years of age. There may be mild rhinorrhoea, sore throat, and sudden onset of high fever. As the fever subsides, the typical rash consists of tiny pink papules or is maculopapular

2017 NICE Clinical Knowledge Summaries

143. Boils, carbuncles, and staphylococcal carriage

of discharging pus and fluctuance. Boils initially appear as firm, tender, erythematous nodules, which after several days enlarge and become painful and fluctuant (a wave-like feeling on palpating skin overlying a fluid-filled cavity with non-rigid walls). A fluctuant lesion feels 'boggy', and the overlying skin has a shiny appearance. Boils may rupture spontaneously, draining pus or necrotic material. They heal (over several days to several weeks) to leave a violaceous macule, and possibly a permanent scar

2017 NICE Clinical Knowledge Summaries

144. Scabies

aetiology. Impetigo — suggested by macules which develop into vesicles and form golden yellow crusts. Most often affects exposed areas on the face, hands, and extremities, and is more common in young children. For more information, see the CKS topic on . Langerhans cell histiocytosis — this may present with the following: greasy scales on the scalp; discrete, yellow-brown, scaly papules on the trunk often with areas of purpura which may become nodular, crusted, or eroded; ulceration of the flexures

2017 NICE Clinical Knowledge Summaries

145. A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma. (Abstract)

A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma. Melasma is a condition in which patients develop symmetric, reticulated, hyperpigmented macules and patches on the face which is thought to be the result of ultraviolet (UV) exposure and hormonal influences, although the pathogenesis is not completely understood. The topical application of epidermal growth factor has been used as a whitening agent

2018 Journal of drugs in dermatology : JDD Controlled trial quality: uncertain

146. Activation of melanoblasts and melanocytes after treatment with monochromatic excimer light and narrowband-ultraviolet B of skin of vitiligo patients. (Abstract)

Activation of melanoblasts and melanocytes after treatment with monochromatic excimer light and narrowband-ultraviolet B of skin of vitiligo patients. Vitiligo is a hypopigmentation disease characterized by achromatic or hypochromatic macules in several sites of human skin. Although monochromatic excimer light (MEL) and narrowband-ultraviolet B (NB-UVB) have recently been used for efficacious treatment of vitiligo, the repigmentation process and role of melanocytes/melanoblasts are not well (...) known.White macules of 28 vitiligo patients were repeatedly exposed with MEL/NB-UVB. After the exposures, punch biopsies of the center and edge of the lesional skin in addition to normal skin were fixed and processed to dopa and combined dopa-premelanin reactions. Melanocytes positive to the dopa reaction and melanoblasts/melanocytes positive to the combined dopa-premelanin reaction were surveyed.Two repigmentation patterns were observed; one was "marginal" and the other was "perifollicular." Although

2018 International Journal of Dermatology

147. A novel approach to the classification of epidermodysplasia verruciformis. (Abstract)

A novel approach to the classification of epidermodysplasia verruciformis. Epidermodysplasia verruciformis (EV) is a rare genodermatosis that causes disseminated eruptions of hypo- or hyperpigmented macules and wart-like papules that can coalesce and scale. It is uniquely characterized by an increased susceptibility to specific human papillomavirus (HPV) genotypes. Classically, EV is associated with mutations of the EVER1/TMC6 and EVER2/TMC8 genes. The term "acquired" epidermodysplasia

2018 International Journal of Dermatology

148. Microneedle and Trichloroaceticacid in Treatment of Melasma

Information provided by (Responsible Party): Safaa Hamed, Assiut University Study Details Study Description Go to Brief Summary: Melasma is an acquired disorder of hyperpigmentation characterised by blotchy, light-to-dark brown macules distributed symmetrically on the sun-exposed parts of the body. Although many factors have been proposed to have a role in pathogenesis, the exact ethology is yet to be understood. The most commonly identifiable risk factors include ultraviolet radiation, genetic

2018 Clinical Trials

149. Dermoscopy in Diagnosis of Pigmentary Skin Lesions

, psoriasis, atopic and contact dermatitis, lichen planus, trauma, drugs, and fixed-drug eruptions) Melasma Solar lentigines Ephelides (freckles) Café-au-lait macules Nevi Melanoma and precursors Acquired (common) Vitiligo Pityriasis alba Tinea versicolor Postinflammatory hypopigmentation Congenital (uncommon) Albinism Piebaldism Tuberous sclerosis Hypomelanosis of Ito Several studies have shown that dermoscopy may come in very handy for assisting the noninvasive diagnosis of various general

2018 Clinical Trials

150. The Effect of UVB Phototherapy With Microneedling and Circled Needing in Vitiligo Patients

: October 25, 2018 Last Update Posted : October 26, 2018 See Sponsor: Shin Kong Wu Ho-Su Memorial Hospital Information provided by (Responsible Party): Shin Kong Wu Ho-Su Memorial Hospital Study Details Study Description Go to Brief Summary: Vitiligo is a relatively common acquired disorder of pigmentation characterized by the development of well-defined white macules on the skin. Biopsies of lesional skin reveal a loss of epidermal melanocytes. Lesions may occur in a localized or generalized

2018 Clinical Trials

151. Acquired disorders with depigmentation: A systematic approach to vitiliginoid conditions. (Abstract)

Acquired disorders with depigmentation: A systematic approach to vitiliginoid conditions. Acquired disorders with depigmentation are commonly encountered by dermatologists and present with a wide differential diagnosis. Vitiligo, the most common disorder of acquired depigmentation, is characterized by well-defined depigmented macules and patches. Other conditions, such as chemical leukoderma, can present with similar findings, and are often easily mistaken for vitiligo. Key clinical features

2018 Journal of American Academy of Dermatology

152. Clinical and Radiographic Gastrointestinal Abnormalities in McCune-Albright Syndrome. Full Text available with Trip Pro

Clinical and Radiographic Gastrointestinal Abnormalities in McCune-Albright Syndrome. McCune-Albright syndrome (MAS) is a rare disorder characterized by fibrous dysplasia of bone, café-au-lait macules, and hyperfunctioning endocrinopathies. It arises from somatic gain-of-function mutations in GNAS, which encodes the cAMP-regulating protein Gαs. Somatic GNAS mutations have been reported in intraductal papillary mucinous neoplasms (IPMNs) and various gastrointestinal (GI) tumors. The clinical

2018 Journal of Clinical Endocrinology and Metabolism

153. Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study Full Text available with Trip Pro

Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study Melasma is an acquired pigmentary disorder characterized by hyperpigmented macules and/or patches affecting sun-exposed skin. Tranexamic acid (TA) can reduce melanin content of epidermis. Thus, we conducted this study to evaluate the efficacy and safety of tranexamic acid

2018 Dermatology research and practice Controlled trial quality: uncertain

154. Prurigo Pigmentosa: A Clinicopathological Report of Three Middle Eastern Patients Full Text available with Trip Pro

Prurigo Pigmentosa: A Clinicopathological Report of Three Middle Eastern Patients Prurigo pigmentosa is a unique cutaneous inflammatory disorder characterized by a sudden onset of pruritic and erythematous macules, urticarial papules, and plaques that may coalesce to form a reticulated pattern. Lesions typically heal within weeks leaving a reticulated and mottled postinflammatory hyperpigmentation. The majority of reported cases originate from Japan with much fewer cases described worldwide

2018 Case reports in dermatological medicine

155. P-Phenylenediamine Hair Dye Allergy and Its Clinical Characteristics Full Text available with Trip Pro

between July 2009 and March 2015. Clinical symptoms, signs, associated skin diseases, involved ACD area, and patterns of hair dye use were obtained by reviewing medical records and by interview.HDCA was more common in women and in individuals aged more than 50 years. Pruritus was the most common symptom; erythematous macules and patches were the most frequently observed clinical signs. The most common site of HDCA was the face and non-specific eczema and urticaria were frequently observed with HDCA

2018 Annals of dermatology

156. Acquired Brachial Cutaneous Dyschromatosis in a Middle Aged Male Full Text available with Trip Pro

Acquired Brachial Cutaneous Dyschromatosis in a Middle Aged Male Acquired brachial cutaneous dyschromatosis (ABCD) is an acquired disorder of pigmentary change that presents as chronic, asymptomatic, geographic-shaped, gray-brown patches, consisting of mixed hyper and hypopigmented macules on the dorsal aspect of the forearms. We report a case of a 40-year-old male who presented with asymptomatic, multiple brown-colored macules on the outer aspects of both arms. He had no history (...) of hypertension and had never taken angiotensin converting enzyme inhibitors. He also denied chronic sun exposure history. Histologic examination demonstrated epidermal atrophy, increased basal layer pigmentation, and several telangiectatic vessels in the upper dermis. Solar elastosis was not remarkable. The patient's clinical and histopathologic features were consistent with a diagnosis of ABCD. Poikiloderma of Civatte, melasma, acquired bilateral telangiectatic macules and other pigmentary disorders should

2018 Annals of dermatology

157. Laugier–Hunziker syndrome in endocrine clinical practice Full Text available with Trip Pro

is a rare, acquired cause of asymptomatic, benign mucocutaneous hyperpigmentation.Prior to making a final diagnosis, certain medical entities with overlapping clinical features must be excluded.Endocrine conditions that usually present with the hyperpigmentation of the skin and mucous membranes (e.g. Addison's disease, McCune-Albright syndrome) can be easily ruled out based on clinical and laboratory findings.Its major differential diagnosis, Peutz-Jeghers syndrome is characterized by melanotic macules

2018 Endocrinology, diabetes & metabolism case reports

158. Incidence of tuberous sclerosis and age at first diagnosis: new data and emerging trends from a national, prospective surveillance study Full Text available with Trip Pro

macules in 92%) and cardiac rhabdomyoma in half of the patients. Cardiac rhabdomyoma were detected by prenatal ultrasonography in 22.1% of patients. The presence of cardiac rhabdomyoma was associated with cardiac arrhythmias in 25.6% (about 13% of all diagnosed patients) in our cohort. The overall prevalence of seizure disorders was 69.8%. The annual incidence rate of TSC is estimated at a minimum of 1:17.785 live births. However correcting for underreporting, the estimated incidence rate of definite

2018 Orphanet journal of rare diseases

159. Lichen planus-like keratosis: clinical applicability of in vivo reflectance confocal microscopy for an indeterminate cutaneous lesion Full Text available with Trip Pro

Lichen planus-like keratosis: clinical applicability of in vivo reflectance confocal microscopy for an indeterminate cutaneous lesion Lichen planus-like keratosis (LPLK) is an involuting cutaneous lesion often presenting between the fifth and seventh decades of life. These lesions typically appear abruptly as a solitary macule, papule, or plaque that continuously evolves as it undergoes regression. Clinical and dermoscopic features of LPLK can mimic both benign and malignant lesions, often

2018 Dermatology practical & conceptual

160. Red nodular melanoma of the penile foreskin: A case report and literature review Full Text available with Trip Pro

Red nodular melanoma of the penile foreskin: A case report and literature review The penis is an extremely rare primary site for malignant melanomas, and the clinical presentation may vary greatly. We herein present the case of a 71-year-old male patient who presented with a 6-year history of two slow growing, asymptomatic red macules on the penile foreskin. On physical examination, the mobility of the foreskin was good, and there was no metastasis on computed tomography and magnetic resonance

2018 Molecular and clinical oncology

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