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141. Combination of Oral Tranexamic Acid with Topical 3% Tranexamic Acid versus Oral Tranexamic Acid with Topical 20% Azelaic Acid in the Treatment of Melasma. (PubMed)

(based upon history and the clinical findings of symmetrically distributed hyperpigmented macules and patches on the face), aged 12 to 50 years, were selected. The cases were divided into two groups by simple random sampling method. The cases in group A were treated by oral tranexamic acid (250 mg twice daily) with topical 3% tranexamic acid (twice daily). In group B, cases had oral tranexamic acid (250 mg twice daily) with topical 20% azelaic acid (daily) for six months. They were followed every

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2019 Journal of the College of Physicians and Surgeons--Pakistan : JCPSP Controlled trial quality: uncertain

142. Efficacy of Azole Antifungal in Treatment of Pityriasis Versicolor. (PubMed)

weeks (Category 3). Clinical (colour of macule, scale, pruritus) and mycological assessment were done after 4 weeks of therapy.After 4 weeks of treatment, clinical cure was observed in 62.4% (Category I), 36.3% (Category II) and 37.5% (Category III).It was reported in our study that the most effective regimen for PV patients is fluconazole 300 mg per week combined with ketoconazole 2% twice a week for 2 weeks.

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2019 Open access Macedonian journal of medical sciences Controlled trial quality: uncertain

143. NEUTROPHILIC URTICARIAL DERMATOSIS. An entity bridging monogenic and polygenic autoinflammatory disorders, and beyond. (PubMed)

NEUTROPHILIC URTICARIAL DERMATOSIS. An entity bridging monogenic and polygenic autoinflammatory disorders, and beyond. Neutrophilic urticarial dermatosis (NUD) has been described in 2009. Clinically, it is an eruption of rose or red macules or slightly elevated plaques, vanishing within 24 hours. It occurs mostly on the trunk and the limbs. Extracutaneous signs such as fever or joint pain can be associated. The histopathological findings are a dense perivascular and interstitial infiltrate

2019 Journal of the European Academy of Dermatology and Venereology

144. Association between oral lesions and disease activity in lupus erythematosus. (PubMed)

plaques, cobblestone, and red/brown-pigmented macules. In patients with CLE, red macules on jugal mucosa were statistically associated with anemia and positive antinuclear antibodies titers; additionally, the presence of gingivitis was related to systemic inflammation. In SLE patients, gingival telangiectases were statistically significantly associated with leucopenia, hypocomplementemia, and systemic inflammation. Limitations Biopsies on mucosal lesions were not performed.Some specific oral lesions

2019 Journal of the European Academy of Dermatology and Venereology

145. Café noir spots: A Feature of Familial Progressive Hyper- and Hypopigmentation. (PubMed)

Café noir spots: A Feature of Familial Progressive Hyper- and Hypopigmentation. Familial progressive hyper- and hypopigmentation (FPHH) is a rare genodermatosis characterized by multiple café au lait spots and hypopigmented ash-leaf macules intermingled with blotchy hyperpigmentation (1,2). Herein, we describe a Turkish FPHH patient with café-noir spots. A 16-year-old male presented to our Pediatric Dermatology Clinic, with extensive hyperpigmentation, irregular brown patches, and hypopigmented

2019 Journal of the European Academy of Dermatology and Venereology

148. Langerhans Cell Histiocytosis Treatment (PDQ®): Health Professional Version

of life and were necrotic papules or hypopigmented macules. Patients with nonregressing disease who required systemic therapy were more often intertriginous. Immunohistochemical studies showed no difference in interleukin (IL)-10, Ki-67, E-cadherin expression, or T-reg number between the two clinical groups. Children and adults: Children and adults may develop a red papular rash in the groin, abdomen, back, or chest that resembles a diffuse candidal rash. Seborrheic involvement of the scalp may

2016 PDQ - NCI's Comprehensive Cancer Database

149. Scabies

aetiology. Impetigo — suggested by macules which develop into vesicles and form golden yellow crusts. Most often affects exposed areas on the face, hands, and extremities, and is more common in young children. For more information, see the CKS topic on . Langerhans cell histiocytosis — this may present with the following: greasy scales on the scalp; discrete, yellow-brown, scaly papules on the trunk often with areas of purpura which may become nodular, crusted, or eroded; ulceration of the flexures

2017 NICE Clinical Knowledge Summaries

150. Melanoma and pigmented lesions

slowly over several years most common in older people on sun-exposed skin, most often found on the head and neck. Lentigo maligna melanoma develops from a pre­invasive phase lentigo maligna [ ]. It is an irregularly ­shaped brown macule which grows slowly, and over time may develop irregular colours (dark brown, black, blue). Lentigo maligna melanoma usually grows horizontally initially but can form nodules once it enters the vertical growth phase. Images of lentigo maligna and malignant melanoma (...) but is most common in darker skin types [ ]. Genital melanoma is most common on the glans penis or vulva and, as for acral lentiginous melanoma, usually starts as a flat brown macule which increases in size over time, becoming more irregularly pigmented and developing a pink nodule over time when in vertical growth. Amelanotic melanoma typically presents as a pink coloured or erythematous nodule which may completely lack pigmentation, but a small focus of pigment is usually present, often at the edge

2017 NICE Clinical Knowledge Summaries

151. Warts - anogenital

in secondary syphillis and are highly contagious. Carcinoma in situ — multifocal erythematous macules, lichenoid, or pigmented papules which may form plaques on the external anogenital region. The surface is usually smooth and velvety. For more information, see the CKS topic . Other common, benign differential diagnoses skin tags, seborrhoeic keratoses, epidermoid cysts, and sebaceous glands of the foreskin and vulva. Basis for recommendation Basis for recommendation This information is based on the Royal

2017 NICE Clinical Knowledge Summaries

152. Parvovirus B19 infection

or in the interpretation of results, is extrapolated from expert opinion in a review article on pregnant women exposed to childhood rash [ ]. Differential diagnosis What else might it be? Other conditions that may present similarly to parvovirus B19 infection include: Rubella In children, there may be a rash of coalescing pink macules starting on the head and neck, although it does not usually cause the 'slapped cheek' appearance with accompanying perioral pallor of parvovirus B19 infection. The rash spreads (...) , fine macules and sandpaper-like papules. There may be associated petechiae on the palate and erythematous, swollen papillae on the tongue ('strawberry tongue'). See the CKS topic on for more information. Roseola infantum This is caused by herpesvirus type 6 and typically affects children younger than three years of age. There may be mild rhinorrhoea, sore throat, and sudden onset of high fever. As the fever subsides, the typical rash consists of tiny pink papules or is maculopapular

2017 NICE Clinical Knowledge Summaries

153. Boils, carbuncles, and staphylococcal carriage

of discharging pus and fluctuance. Boils initially appear as firm, tender, erythematous nodules, which after several days enlarge and become painful and fluctuant (a wave-like feeling on palpating skin overlying a fluid-filled cavity with non-rigid walls). A fluctuant lesion feels 'boggy', and the overlying skin has a shiny appearance. Boils may rupture spontaneously, draining pus or necrotic material. They heal (over several days to several weeks) to leave a violaceous macule, and possibly a permanent scar

2017 NICE Clinical Knowledge Summaries

154. Gigantism in a McCune-Albright’s syndrome with calcified GH-releasing pituitary adenoma: Case report and literature review (PubMed)

Gigantism in a McCune-Albright’s syndrome with calcified GH-releasing pituitary adenoma: Case report and literature review McCune-Albright's syndrome (MAS) is a rare disorder that is characterized by café-au-lait macules, fibrous dysplasia of the skull and endocrinopathies like excessive secretion of growth hormone by a hyper-functional pituitary adenoma (PA).We describe the case of a 43-year-old male with history of Gigantism in 1990 secondary to a GH-secreting pituitary macroadenoma

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2018 International journal of surgery case reports

155. Prurigo Pigmentosa: A Clinicopathological Report of Three Middle Eastern Patients (PubMed)

Prurigo Pigmentosa: A Clinicopathological Report of Three Middle Eastern Patients Prurigo pigmentosa is a unique cutaneous inflammatory disorder characterized by a sudden onset of pruritic and erythematous macules, urticarial papules, and plaques that may coalesce to form a reticulated pattern. Lesions typically heal within weeks leaving a reticulated and mottled postinflammatory hyperpigmentation. The majority of reported cases originate from Japan with much fewer cases described worldwide

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2018 Case reports in dermatological medicine

156. Incidence of tuberous sclerosis and age at first diagnosis: new data and emerging trends from a national, prospective surveillance study (PubMed)

macules in 92%) and cardiac rhabdomyoma in half of the patients. Cardiac rhabdomyoma were detected by prenatal ultrasonography in 22.1% of patients. The presence of cardiac rhabdomyoma was associated with cardiac arrhythmias in 25.6% (about 13% of all diagnosed patients) in our cohort. The overall prevalence of seizure disorders was 69.8%. The annual incidence rate of TSC is estimated at a minimum of 1:17.785 live births. However correcting for underreporting, the estimated incidence rate of definite

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2018 Orphanet journal of rare diseases

157. Analysis of genotype/phenotype correlations in Japanese patients with dyschromatosis symmetrica hereditaria (PubMed)

Analysis of genotype/phenotype correlations in Japanese patients with dyschromatosis symmetrica hereditaria Dyschromatosis symmetrica hereditaria (DSH) is one of the genetic pigmentation disorders and shows characteristic mixture of hyper- and hypo-pigmented small macules on the extremities. Heterozygous mutations in the adenosine deaminase acting on RNA1 gene (ADAR1) cause DSH. In the present study, we report five cases of DSH and identify a distinct known mutation in each patient. Furthermore (...) , we review previously described cases with the five ADAR1 mutations found in the present study. We reviewed clinical and molecular findings in the present and previously reported cases and found an identical mutation can result in various phenotypic severities, even in one family. We found novel phenotype-genotype correlations between the presence/absence of facial lesions and the ADAR1 mutation c.3286C>T. The absence of freckle-like macules in the face was found to be more commonly associated

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2018 Nagoya Journal of Medical Science

158. Early diagnosis of tuberous sclerosis complex: a race against time. How to make the diagnosis before seizures? (PubMed)

for early diagnosis.82/100 children were diagnosed with TSC within the first 4 months of life. Apart from cardiac tumors, the most frequently observed early TSC signs were subependymal nodules (71/100, 71%), cortical dysplasia (66/100, 66%), and hypomelanotic macules (35/100, 35%). The most useful clinical studies for early TSC diagnosis were brain magnetic resonance imaging (MRI), skin examination and echocardiography. Genetic testing was performed in 49/100 of the patients, but the results were

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2018 Orphanet journal of rare diseases

159. An unusual lesion on the nose: microvenular hemangioma (PubMed)

cases revealed that 15% of MVH patients were over 40 years of age and only 3% of the cases showed macules or patches. A literature survey showed only two cases of MVH located on the facial region, one on the chin and the other on the cheek. Our case was unique for its location and interesting for other rarely encountered features. MVH should be considered in the differential diagnoses of vascular lesions on nasal skin.

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2018 Dermatology practical & conceptual

160. Unilateral Focal Dermal Hypoplasia (Goltz Syndrome): Case Report and Literature Review (PubMed)

-reticulated atrophic macules and patches in a linear pattern distributed along the lines of Blaschko over the right side of the face and the right arm. Also she is having hypoplasia of the right breast with dental enamel abnormality and partial anodontia in the lower jaw. Sparse hair and partial alopecia on the right side (scalp, eyebrows, and eyelashes) were also observed.

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2018 Case reports in dermatology

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