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141. A case report of lupus erythematosus tumidus converted from discoid lupus erythematosus. (PubMed)

, including prominent swelling of the eyelids, a few erythematous, edematous plaques on the left forehead, face, and neck, and 2 hairless macules. The histopathologic findings reveal liquefaction degeneration of the basal cells, perivascular, and periadnexal infiltration of lymphocytes, and interstitial mucin deposition in the superficial, and deep dermis.A diagnosis of LET was made on clinical and histological features.The patient started treatment with prednisolone (1 mg/kg. d), combined

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2018 Medicine

142. Epidemiology of Kaposi sarcoma: review and description of the nonepidemic variant. (PubMed)

Epidemiology of Kaposi sarcoma: review and description of the nonepidemic variant. Kaposi sarcoma (KS) is a rare angioproliferative tumor whose etiology is associated with human herpesvirus 8 (HHV 8). KS lesions typically involve the skin or mucosal surfaces and are characterized by purplish, red-blue, or brown-black macules, papules, and nodules which are prone to bleeding and ulceration. Definitive diagnosis requires biopsy revealing characteristic angioproliferative features. There are four

2018 International Journal of Dermatology

143. Decreased choroidal thickness in vitiligo patients. (PubMed)

Decreased choroidal thickness in vitiligo patients. Vitiligo is a disease characterized by depigmented macules and patches that occur as a result of the loss of functional melanocytes from the affected skin through a mechanism which has not been elucidated yet. Destruction of pigment cells in vitiligo may not remain limited to the skin; the eyelashes, iris, ciliary body, choroid, retinal pigment epithelium and meninges may also be affected. This study aims to compare the choroidal thickness

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2018 BMC Ophthalmology

144. Dyskeratosis congenita with a novel genetic variant in the DKC1 gene: a case report. (PubMed)

with hypopigmented macules involving the face, neck and extremities, hyperkeratosis of palms and soles, nail dystrophy, leukoplakia of the tongue, premature graying of hair, watery eyes and dental caries. Several of his male relatives, including two maternal uncles and three maternal cousins were affected with a similar type of disease condition. Pedigree analysis suggested a possible X-linked pattern of inheritance. Genetic testing in the proband showed a novel hemizygous, non-synonymous likely pathogenic

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2018 BMC Medical Genetics

145. A novel TSC2 missense variant associated with a variable phenotype of tuberous sclerosis complex: case report of a Chinese family. (PubMed)

TSC family with two siblings presenting with multiple hypomelanotic macules, cardiac rhabdomyomas and cortical tubers associated with a small subependymal nodule. The older child had seizures. A novel heterozygous missense variant in the TSC2 gene (c.899G > T, p.G300 V) was identified and shown to be inherited from their father as well as paternal grandfather, both of whom presented with variable TSC-associated signs and symptoms.We identified a novel heterozygous TSC2 variant c.899G > T

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2018 BMC Medical Genetics

146. A cross-sectional study of sweat-induced dermatitis during a South Indian summer: a glimpse of sweat gland-mediated cutaneous inflammation. (PubMed)

dermatitis" presenting with dry, hyperpigmented, fissured "parchment"-like skin, shiny "crinkled cellophane paper"-like skin, or asymptomatic hyperpigmented macules was seen. Other atypical presentations included miliaria pustulosa with "hypopyon sign" and "linear and parallel ridge pattern" of dermatitis in patients with miliaria rubra affecting the lower neck and upper chest.A wide spectrum of sweat-induced dermatitis was seen during the summer months in a tropical region. It reflects the role

2018 International Journal of Dermatology

147. Diagnostic challenges in a child with early onset desmoplastic medulloblastoma and homozygous variants in MSH2 and MSH6. (PubMed)

macules and other pigmentation alterations. We report on a 13-month-old girl suspected of having CMMRD due to a desmoplastic medulloblastoma and a striking skin pigmentation that included multiple café-au-lait macules, hypopigmented areas and Mongolian spots. Whole-exome sequencing revealed homozygosity for MSH2 variant p.(Leu92Val) and MSH6 variant p.(Val809del), both variants of uncertain significance (VUS). Immunohistochemical analysis of the tumour tissue showed expression of all four MMR proteins

2018 European Journal of Human Genetics

148. The endovascular management of neurofibromatosis-associated aneurysms: A systematic review.

The endovascular management of neurofibromatosis-associated aneurysms: A systematic review. Neurofibroblastoma (NF) or Von Recklinghausen disease, is an autosomal dominant disorder affecting one in 3000 individuals. Cardinal features of NF include multiple café-au-lait macules, benign neurofibromas, and iris hamartomas. Albeit less common, vascular lesions of medium and large-sized arteries and veins are a well-recognized complication, which can lead to fatal consequences such as rupture.A

2018 European journal of radiology

149. Blaschko-linear “Congenital Mixed Hemato-lymphangio-keratoma Serpiginosum” Naeviforme: A New Hybrid Entity or Various Morphological Reflections of the Two Different Vascular Abnormalities? (PubMed)

-yellowish papules; 3) bright-red grouped papules; 4) keratotic-surfaced grouped dark-red papules; and 5) patchy, punctate, and erythematous red macules. All of the lesions were intertwined along the lines of Blaschko and were in the form of irregular serpiginous plaques. Histopathological examinations of the lesions showed three main histological features, and diagnoses of the lesions were made as lymphangioma circumscriptum, lymphangiokeratoma, and verrucous hemangioma. To the best of our knowledge

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2018 The Journal of clinical and aesthetic dermatology

150. P-Phenylenediamine Hair Dye Allergy and Its Clinical Characteristics (PubMed)

between July 2009 and March 2015. Clinical symptoms, signs, associated skin diseases, involved ACD area, and patterns of hair dye use were obtained by reviewing medical records and by interview.HDCA was more common in women and in individuals aged more than 50 years. Pruritus was the most common symptom; erythematous macules and patches were the most frequently observed clinical signs. The most common site of HDCA was the face and non-specific eczema and urticaria were frequently observed with HDCA

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2018 Annals of dermatology

151. Acquired Brachial Cutaneous Dyschromatosis in a Middle Aged Male (PubMed)

Acquired Brachial Cutaneous Dyschromatosis in a Middle Aged Male Acquired brachial cutaneous dyschromatosis (ABCD) is an acquired disorder of pigmentary change that presents as chronic, asymptomatic, geographic-shaped, gray-brown patches, consisting of mixed hyper and hypopigmented macules on the dorsal aspect of the forearms. We report a case of a 40-year-old male who presented with asymptomatic, multiple brown-colored macules on the outer aspects of both arms. He had no history (...) of hypertension and had never taken angiotensin converting enzyme inhibitors. He also denied chronic sun exposure history. Histologic examination demonstrated epidermal atrophy, increased basal layer pigmentation, and several telangiectatic vessels in the upper dermis. Solar elastosis was not remarkable. The patient's clinical and histopathologic features were consistent with a diagnosis of ABCD. Poikiloderma of Civatte, melasma, acquired bilateral telangiectatic macules and other pigmentary disorders should

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2018 Annals of dermatology

152. Which egg features predict egg rejection responses in American robins? Replicating Rothstein's (1982) study (PubMed)

evaluated with replication. Here, we partially replicated Rothstein's (1982) experiments using parallel artificial model egg treatments to simulate cowbird (Molothrus ater) parasitism in American robin (Turdus migratorius) nests. We compared our data with those of Rothstein (1982) and confirmed most of its original findings: (1) robins reject model eggs that differ from the appearance of a natural robin egg toward that of a natural cowbird egg in background color, size, and maculation; (2) rejection (...) of cowbird eggs. Future work on egg recognition will benefit from utilizing a range of model eggs varying continuously in background color, maculation patterning, and size in combination with avian visual modeling, rather than using model eggs which vary only discretely.

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2018 Ecology and evolution

153. Eruptive lentiginosis in resolving psoriatic plaques (PubMed)

Reports Retracted Publication 2018 03 31 United States JAAD Case Rep 101665210 2352-5126 JAAD Case Rep. 2018 Sep 18;4(8):841 30238053 ELRP, eruptive lentiginosis in resolving psoriatic plaques IL, interleukin TNF, tumor necrosis factor hyperpigmentation lentigines macules plaque psoriasis 2018 4 26 6 0 2018 4 26 6 0 2018 4 26 6 1 epublish 29693059 10.1016/j.jdcr.2017.10.009 S2352-5126(17)30261-8 PMC5911780 Pigment Cell Melanoma Res. 2012 Mar;25(2):219-30 22136309 Clin Exp Dermatol. 2006 Mar;31(2):298

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2018 JAAD Case Reports

154. Nevus anemicus and RASopathies (PubMed)

, University Hospital Leuven, Leuven, Belgium. Department of Human Genetics, KU Leuven, Leuven, Belgium. eng Case Reports 2018 04 06 United States JAAD Case Rep 101665210 2352-5126 CALMs, café au lait macules Legius syndrome MAPK, mitogen-activated protein kinase NF1, neurofibromatosis type 1 Noonan syndrome PTPN11, protein tyrosine phosphatase nonreceptor type 11 RAF1, rapidly accelerated fibrosarcoma-1 RAS, rat sarcoma family of protooncogenes RASopathy SPRED1, sprouty-related, EVH1 domain containing

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2018 JAAD Case Reports

155. Peutz-Jeghers Syndrome Presenting as Colonic Intussusception: A Rare Entity (PubMed)

Peutz-Jeghers Syndrome Presenting as Colonic Intussusception: A Rare Entity Peutz-Jeghers syndrome is an autosomal dominant inherited medical condition characterized by hyperpigmented mucocutaneous macules, hamartomatous polyps in the digestive tract, and with a greater risk of gastrointestinal and non-gastrointestinal cancers. In fact, without appropriate medical surveillance, the lifetime risk for all cancers combined may be as high as 93%. The syndrome is rare, with estimates of incidence

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2018 Gastroenterology research

156. Early diagnosis of tuberous sclerosis complex: a race against time. How to make the diagnosis before seizures? (PubMed)

for early diagnosis.82/100 children were diagnosed with TSC within the first 4 months of life. Apart from cardiac tumors, the most frequently observed early TSC signs were subependymal nodules (71/100, 71%), cortical dysplasia (66/100, 66%), and hypomelanotic macules (35/100, 35%). The most useful clinical studies for early TSC diagnosis were brain magnetic resonance imaging (MRI), skin examination and echocardiography. Genetic testing was performed in 49/100 of the patients, but the results were

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2018 Orphanet journal of rare diseases

157. An unusual lesion on the nose: microvenular hemangioma (PubMed)

cases revealed that 15% of MVH patients were over 40 years of age and only 3% of the cases showed macules or patches. A literature survey showed only two cases of MVH located on the facial region, one on the chin and the other on the cheek. Our case was unique for its location and interesting for other rarely encountered features. MVH should be considered in the differential diagnoses of vascular lesions on nasal skin.

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2018 Dermatology practical & conceptual

158. A secondary syphilis rash with scaly target lesions (PubMed)

virus positive. The characteristic rash of secondary syphilis may appear as maculopapular, evolving initially from macules to small reddish-brown papules with minor scaling later. When the scaling is prominent, lesions can be difficult to differentiate from guttate psoriasis. Typical target lesions are most often associated with erythema multiforme, but they can rarely occur in secondary and congenital syphilis. Syphilis should be suspected in high-risk patients presenting a variety of atypical

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2018 Oxford Medical Case Reports

159. Vestibular Injury After Low-Intensity Blast Exposure (PubMed)

damage to both the peripheral and central vestibular system; similar to previous findings that blast exposure results in damage to auditory receptors. In this study, mice were exposed to a 63 kPa peak blast-wave over pressure and were examined for vestibular receptor damage as well as behavioral assays to identify vestibular dysfunction. We observed perforations to the tympanic membrane in all blast animals. We also observed significant loss of stereocilia on hair cells in the cristae and macule up

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2018 Frontiers in neurology

160. Unilateral Focal Dermal Hypoplasia (Goltz Syndrome): Case Report and Literature Review (PubMed)

-reticulated atrophic macules and patches in a linear pattern distributed along the lines of Blaschko over the right side of the face and the right arm. Also she is having hypoplasia of the right breast with dental enamel abnormality and partial anodontia in the lower jaw. Sparse hair and partial alopecia on the right side (scalp, eyebrows, and eyelashes) were also observed.

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2018 Case reports in dermatology

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