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Macule

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121. Association between oral lesions and disease activity in lupus erythematosus. (PubMed)

plaques, cobblestone, and red/brown-pigmented macules. In patients with CLE, red macules on jugal mucosa were statistically associated with anemia and positive antinuclear antibodies titers; additionally, the presence of gingivitis was related to systemic inflammation. In SLE patients, gingival telangiectases were statistically significantly associated with leucopenia, hypocomplementemia, and systemic inflammation. Limitations Biopsies on mucosal lesions were not performed.Some specific oral lesions

2019 Journal of the European Academy of Dermatology and Venereology

122. Shingles

, and fever. Rash — usually unilateral. Macules and papules develop into vesicular lesions in a dermatomal distribution which burst and form ulcers and crusts. Note that the rash may be atypical in certain groups of people, for example older or immunocompromised people. Pain — intense neuralgic pain over the affected area, especially in people with trigeminal nerve involvement. Healing (2–4 weeks) — the lesions usually crust over within 7–10 days. A person with shingles should be offered self-care advice (...) ) in the affected skin. The prodrome may also include headache, malaise, and occasionally fever. Rash — usually unilateral. Macules and papules develop into vesicular lesions in a dermatomal distribution. The location depends on which nerve is involved, but shingles usually occurs on the thorax, with dermatomes T1 to L2 most commonly affected. The vesicles then burst, releasing varicella-zoster virus, and form ulcers and crusts. Note that the rash may be atypical in certain groups of people, for example older

2017 NICE Clinical Knowledge Summaries

124. A Practice Guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: Referral Indications for Cancer Predisposition Assessment

or periungual fibroma • Hypomelanotic macules (=3) • Shagreen patch (connective tissue nevus) • Cortical tuber in the brain • Subependymal glial nodule • Subependymal giant cell astrocytoma • Multiple retinal nodular hamartomas • Cardiac rhabdomyomas, single or multiple • Lymphangiomyomatosis • Renal angiomyolipoma Minor criteria • Multiple, randomly distributed pits in dental enamel • Hamartomatous rectal polyps • Bone cysts • “Confetti” skin lesions • Multiple renal cysts • Nonrenal hamartoma • Cerebral

2015 American College of Medical Genetics and Genomics

126. An Australian guideline on the diagnosis of overseas acquired Lyme Disease/Borreliosis

bite and resolves spontaneously in a few weeks or months (8). The rash is present in 70 to 80 per cent of infected persons. The rash begins at the site of the tick bite as a red macule or papule, rapidly enlarges and sometimes develops central clearing but is often homogenous (1, 7). The advancing edge is typically distinct and is often intensely coloured but not markedly elevated (10). The duration of the rash is usually dependent on the infecting genospecies but will last approximately 4 to 14

2015 Clinical Practice Guidelines Portal

127. Routine newborn assessment

just above the natal cleft (less than 2.5 cm from anus and less than 5 mm wide) • Single café-au-lait spot • Single ash leaf macule • Third fontanelle • Capillary haemangioma apart from those described in table above • Accessory nipples 3.2 Consultation and follow-up Clinical judgement is required to determine the appropriate urgency of follow-up in the context of abnormal or suspicious findings arising from a newborn assessment. If there is uncertainty about the urgency of follow-up in relation

2014 Queensland Health

129. Routine newborn assessment

just above the natal cleft (less than 2.5 cm from anus and less than 5 mm wide) • Single café-au-lait spot • Single ash leaf macule • Third fontanelle • Capillary haemangioma apart from those described in table above • Accessory nipples 3.2 Consultation and follow-up Clinical judgement is required to determine the appropriate urgency of follow-up in the context of abnormal or suspicious findings arising from a newborn assessment. If there is uncertainty about the urgency of follow-up in relation

2014 Clinical Practice Guidelines Portal

131. Paediatric systemic lupus erythematosus as a manifestation of constitutional mismatch repair deficiency

Paediatric systemic lupus erythematosus as a manifestation of constitutional mismatch repair deficiency Paediatric systemic lupus erythematosus as a manifestation of constitutional mismatch repair deficiency | JMG Contact blog by Constitutional mismatch repair deficiency (CMMRD) is an autosomal recessive cancer predisposition syndrome, causing café au lait macules, brain malformations and and multiple tumors, mostly leukemia/ lymphoma, brain, and gastrointestinal cancer in the first two decades

2019 JMG Contact blog

132. Prospective Study of Pathogenesis of Atrophic Acne Scars and Role of Macular Erythema. (PubMed)

macules or hyperpigmentation (83%) and some (16%) developed directly from papules and pustules. Duration of papules was a key factor in the risk of scarring. The majority (81.7%) of the scars remaining at 6 months were still present at 2-year follow-up.

CONCLUSIONS: Atrophic acne scars continuously form, some resolve, and evolve primarily from inflammatory and post-inflammatory lesions. Clinicians should closely monitor patients with macular erythema for scarring.

J Drugs Dermatol

2018 Journal of drugs in dermatology : JDD

133. A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma. (PubMed)

A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma. Melasma is a condition in which patients develop symmetric, reticulated, hyperpigmented macules and patches on the face which is thought to be the result of ultraviolet (UV) exposure and hormonal influences, although the pathogenesis is not completely understood. The topical application of epidermal growth factor has been used as a whitening agent

2018 Journal of drugs in dermatology : JDD

134. Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study (PubMed)

Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study Melasma is an acquired pigmentary disorder characterized by hyperpigmented macules and/or patches affecting sun-exposed skin. Tranexamic acid (TA) can reduce melanin content of epidermis. Thus, we conducted this study to evaluate the efficacy and safety of tranexamic acid

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2018 Dermatology research and practice

135. Incidence of tuberous sclerosis and age at first diagnosis: new data and emerging trends from a national, prospective surveillance study (PubMed)

macules in 92%) and cardiac rhabdomyoma in half of the patients. Cardiac rhabdomyoma were detected by prenatal ultrasonography in 22.1% of patients. The presence of cardiac rhabdomyoma was associated with cardiac arrhythmias in 25.6% (about 13% of all diagnosed patients) in our cohort. The overall prevalence of seizure disorders was 69.8%. The annual incidence rate of TSC is estimated at a minimum of 1:17.785 live births. However correcting for underreporting, the estimated incidence rate of definite

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2018 Orphanet journal of rare diseases

136. Laugier–Hunziker syndrome in endocrine clinical practice (PubMed)

is a rare, acquired cause of asymptomatic, benign mucocutaneous hyperpigmentation.Prior to making a final diagnosis, certain medical entities with overlapping clinical features must be excluded.Endocrine conditions that usually present with the hyperpigmentation of the skin and mucous membranes (e.g. Addison's disease, McCune-Albright syndrome) can be easily ruled out based on clinical and laboratory findings.Its major differential diagnosis, Peutz-Jeghers syndrome is characterized by melanotic macules

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2018 Endocrinology, diabetes & metabolism case reports

137. Lichen planus-like keratosis: clinical applicability of in vivo reflectance confocal microscopy for an indeterminate cutaneous lesion (PubMed)

Lichen planus-like keratosis: clinical applicability of in vivo reflectance confocal microscopy for an indeterminate cutaneous lesion Lichen planus-like keratosis (LPLK) is an involuting cutaneous lesion often presenting between the fifth and seventh decades of life. These lesions typically appear abruptly as a solitary macule, papule, or plaque that continuously evolves as it undergoes regression. Clinical and dermoscopic features of LPLK can mimic both benign and malignant lesions, often

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2018 Dermatology practical & conceptual

138. Melanocyte abnormalities and senescence in the pathogenesis of idiopathic guttate hypomelanosis. (PubMed)

Melanocyte abnormalities and senescence in the pathogenesis of idiopathic guttate hypomelanosis. Idiopathic guttate hypomelanosis (IGH) is a pigmentary disorder of unknown pathogenesis characterized by small discrete white macules. In the skin, epidermal melanin unit between melanocytes and keratinocytes is responsible for melanin synthesis and equal distribution of melanin pigment.Therefore, this study was designed to check the role of melanocytes in the pathogenesis of IGH.For this study, six

2018 International Journal of Dermatology

139. Loss of GPNMB Causes Autosomal-Recessive Amyloidosis Cutis Dyschromica in Humans. (PubMed)

Loss of GPNMB Causes Autosomal-Recessive Amyloidosis Cutis Dyschromica in Humans. Amyloidosis cutis dyschromica (ACD) is a distinct form of primary cutaneous amyloidosis characterized by generalized hyperpigmentation mottled with small hypopigmented macules on the trunks and limbs. Affected families and sporadic case subjects have been reported predominantly in East and Southeast Asian ethnicities; however, the genetic cause has not been elucidated. We report here that the compound (...) -positive amyloid deposits in the papillary dermis and infiltrating macrophages compared with hypo- or depigmented macules. Depigmentation of the lesions was attributable to loss of melanocytes. Intracytoplasmic fibrillary aggregates were observed in keratinocytes scattered in the lesional epidermis. Thus, our analysis indicates that loss of GPNMB, which has been implicated in melanosome formation, autophagy, phagocytosis, tissue repair, and negative regulation of inflammation, underlies autosomal

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2018 American Journal of Human Genetics

140. Tuberous Sclerosis : Case Report

. Facial angiofibromas are present 75% of the time, seizures as much as 90% of the time, and mental retardation in approximately 50% of all patients. Tuberous sclerosis is usually diagnosed in infancy or early childhood because child presents with seizures, developmental delay or hypomelanotic macules. The diagnosis of tuberous sclerosis can be made earlier or later on the basis of other features that manifest themselves at other ages. Cortical tubers and cardiac rhabdomyomas can be detected prenatally (...) and in infancy, whereas renal, pulmonary, and osseous lesions are identified more commonly in adulthood. Genetic diagnostic criteria - The identification of either a TSC1 or TSC2 pathogenic mutation in DNA from normal tissue is sufficient to make a definite diagnosis of tuberous sclerosis complex (TSC). Clinical diagnostic criteria Major features Hypomelanotic macules (≥3, at least 5-mm diameter) Angiofibromas (≥3) or fibrous cephalic plaque Ungual fibromas (≥2) Shagreen patch Multiple retinal hamartomas

2018 Sumer's Radiology Blog

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