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Macule

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121. Allopurinol-induced toxic epidermal necrolysis featuring almost 60% skin detachment. Full Text available with Trip Pro

. After 10 days' exposure to allopurinol, the patient manifested with an "influenza-like" prodromal phase (fever of 38°C, throat pains), which was treated with amoxicillin and nonsteroidal anti-inflammatory drugs of the oxicam type. The next day, he developed a worsening fever of 39.5°C, accompanied by a pruriginous rash all over his body.On physical examination, we observed coalescing dusky red macules over >60% of his body surface area, with blisters and detachment of large sheets of necrolytic

2019 Medicine

122. Tuberous sclerosis complex presenting as convulsive status epilepticus followed by hypoxic cerebropathy: A case report. Full Text available with Trip Pro

of the skin, brain, kidney, heart, and lungs. Although all seizure types have been observed in TSC patients, the present case is the first in the literature to present with convulsive status epilepticus followed by hypoxic cerebropathy.A 33-month-old girl presented with fever and seizure followed by unconsciousness for 6 hours. Physical examination showed 4 hypopigmented macules with diameters exceeding 5 mm. Initial magnetic resonance imaging of the brain revealed diffuse edema in the bilateral cerebral

2019 Medicine

123. Erdheim-Chester Disease: Expanding the spectrum of cutaneous manifestations. (Abstract)

common finding being subcutaneous nodules (n=5). A single patient presented with granuloma annulare-like lesions. Another patient with mixed ECD and Langerhans cell histiocytosis presented with lightly scaling, pink-red macules. In three patients, skin lesions were the first manifestation of the disease. Most patients presented with bone/extremity pain, weight loss and other constitutional symptoms at the time of diagnosis. BRAF-V600E mutation was not found in patients with panniculitis-like

2019 British Journal of Dermatology

124. Two-Week Repeated Oral Dose Toxicity Study of Mantidis Ootheca Water Extract in C57BL/6 Mice. Full Text available with Trip Pro

Two-Week Repeated Oral Dose Toxicity Study of Mantidis Ootheca Water Extract in C57BL/6 Mice. Background. Mantidis Ootheca (MO), described as the ootheca of Hierodula patellifera Serville, 1839, Tenodera angustipennis (Saussure, 1869), or Statilia maculate (Thunberg, 1784) in Korean Herbal Pharmacopoeia, is an important herbal material that has been traditionally used for treating several medical conditions including renal failure, spermatorrhea, and pediatric enuresis in Korea. Objective

2019 Evidence-based Complementary and Alternative Medicine (eCAM)

125. NEUTROPHILIC URTICARIAL DERMATOSIS. An entity bridging monogenic and polygenic autoinflammatory disorders, and beyond. (Abstract)

NEUTROPHILIC URTICARIAL DERMATOSIS. An entity bridging monogenic and polygenic autoinflammatory disorders, and beyond. Neutrophilic urticarial dermatosis (NUD) has been described in 2009. Clinically, it is an eruption of rose or red macules or slightly elevated plaques, vanishing within 24 hours. It occurs mostly on the trunk and the limbs. Extracutaneous signs such as fever or joint pain can be associated. The histopathological findings are a dense perivascular and interstitial infiltrate

2019 Journal of the European Academy of Dermatology and Venereology

126. Association between oral lesions and disease activity in lupus erythematosus. (Abstract)

plaques, cobblestone, and red/brown-pigmented macules. In patients with CLE, red macules on jugal mucosa were statistically associated with anemia and positive antinuclear antibodies titers; additionally, the presence of gingivitis was related to systemic inflammation. In SLE patients, gingival telangiectases were statistically significantly associated with leucopenia, hypocomplementemia, and systemic inflammation. Limitations Biopsies on mucosal lesions were not performed.Some specific oral lesions

2019 Journal of the European Academy of Dermatology and Venereology

127. Café noir spots: A Feature of Familial Progressive Hyper- and Hypopigmentation. (Abstract)

Café noir spots: A Feature of Familial Progressive Hyper- and Hypopigmentation. Familial progressive hyper- and hypopigmentation (FPHH) is a rare genodermatosis characterized by multiple café au lait spots and hypopigmented ash-leaf macules intermingled with blotchy hyperpigmentation (1,2). Herein, we describe a Turkish FPHH patient with café-noir spots. A 16-year-old male presented to our Pediatric Dermatology Clinic, with extensive hyperpigmentation, irregular brown patches, and hypopigmented

2019 Journal of the European Academy of Dermatology and Venereology

128. Efficacy of Azole Antifungal in Treatment of Pityriasis Versicolor. Full Text available with Trip Pro

weeks (Category 3). Clinical (colour of macule, scale, pruritus) and mycological assessment were done after 4 weeks of therapy.After 4 weeks of treatment, clinical cure was observed in 62.4% (Category I), 36.3% (Category II) and 37.5% (Category III).It was reported in our study that the most effective regimen for PV patients is fluconazole 300 mg per week combined with ketoconazole 2% twice a week for 2 weeks.

2019 Open access Macedonian journal of medical sciences Controlled trial quality: uncertain

129. Laser treatment of hyperpigmented lesions: position statement of the European Society of Laser in Dermatology. Full Text available with Trip Pro

effective for treating many hyperpigmented lesions such as lentigos, dermal hypermelanocytosis or heavy metal depositions. In the other hand, they have to be considered with great caution for other disorders, such as café au lait macules, melasma or postinflammatory hyperpigmentation. After making the correct diagnosis, if lasers or IPLS are indicated, the optimal wavelengths and parameters will be chosen taking into account the skin phototype, origin and depth of the target pigments.Although

2019 Journal of the European Academy of Dermatology and Venereology

130. Juvenile ecthyma gangrenosum caused by Pseudomonas aeruginosa revealing an underlying neutropenia: case report and review of the literature. (Abstract)

Juvenile ecthyma gangrenosum caused by Pseudomonas aeruginosa revealing an underlying neutropenia: case report and review of the literature. Ecthyma gangrenosum (EG) is characterized by the occurrence of erythematous, violaceous or haemorrhagic macules and/or vesicles, often evolving into necrotic ulcers, with a central grey-black eschar. It is a rare skin condition, usually occurring in immunocompromised patients suffering from bacterial sepsis caused by Pseudomonas aeruginosa. However

2019 Journal of the European Academy of Dermatology and Venereology

131. Hepatic Lesions Associated with McCune Albright Syndrome. (Abstract)

Hepatic Lesions Associated with McCune Albright Syndrome. McCune Albright Syndrome (MAS) results from a GNAS gene mutation. It is associated with café-au-lait macules, fibrous dysplasia, and several endocrinopathies to include gonadotropin-independent precocious puberty, growth hormone excess, Cushing syndrome, thyroid disease, and renal phosphate wasting. It is recognised to be a rare cause of neonatal cholestasis.We describe the hepatic outcome of three children with MAS referred to a single

2019 Journal of Pediatric Gastroenterology and Nutrition

132. Tinea Versicolor of the Neck As Side Effect of Topical Steroids For Alopecia Areata. (Abstract)

occlusion every other day but, after 3-4 months of treatment, they returned to our facility complaining the appearance of multiple white or red-brown round or oval macules in the neck area.Diagnosis of pityriasis versicolor was confirmed by direct microscopy examination of skin scrapings in 10% potassion hydroxide (KOH) solution. All patients received systemic antifungal therapy associated with the daily use of ketoconazole shampoo.Tinea versicolor of the neck should be included among a rare

2019 Journal of Dermatological Treatment

133. Dyschromatosis symmetrica hereditaria and reticulate acropigmentation of Kitamura: An update. Full Text available with Trip Pro

Dyschromatosis symmetrica hereditaria and reticulate acropigmentation of Kitamura: An update. Dyschromatosis symmetrica hereditaria (DSH) and reticulate acropigmentation of Kitamura (RAK) are rare, inherited pigmentary diseases. DSH shows a mixture of pigmented and depigmented macules on the extremities. RAK shows reticulated, slightly depressed pigmented macules on the extremities. The causative gene of DSH was clarified as ADAR1 by positional cloning including linkage analysis and haplotype

2019 Journal of dermatological science

134. Notalgia paresthetica: treatment review and algorithmic approach. (Abstract)

Notalgia paresthetica: treatment review and algorithmic approach. Notalgia paresthetica (NP) is a sensory neuropathy of the back characterized by a well demarcated, hyperpigmented macule or patch located medial or inferior to the scapulae. Symptoms include localized pruritus and pain, and the clinical course consists of remissions and relapses. It can be an underrecognized and difficult disease to treat since conventional treatments for pruritus in inflammatory dermatosis have variable efficacy

2019 Journal of Dermatological Treatment

135. Mucocutaneous manifestations in systemic amyloidosis A retrospective analytical study in a tertiary care center. (Abstract)

%), and purpuric macules were the most common morphology (44.1%). Mucocutaneous affectation was predominantly observed in AL (50.0%) compared to other types (20.0%) of amyloidosis (P = 0.01). Likewise, involvement of organs was also significantly different among the diverse amyloidosis types (P < 0.05). The most frequent comorbidities were hypertension (18.3%) and hypothyroidism (18.3%).The clinical spectrum of manifestations in amyloidosis is wide. Involvement of skin and mucosa in amyloidosis is common

2019 International Journal of Dermatology

136. Prurigo successfully treated with duloxetine hydrochloride. Full Text available with Trip Pro

Prurigo successfully treated with duloxetine hydrochloride. Prurigo is a common skin disease characterised by erythematous macules and papules/nodules with severe pruritus. We report here two cases with treatment-resistant prurigo that were successfully treated with duloxetine hydrochloride, a serotonin-norepinephrine reuptake inhibitor. In vivo experiments with a mouse model of prurigo-like inflammation showed that duloxetine hydrochloride ameliorated not only scratching behaviours, but also

2019 Australasian Journal of Dermatology

137. Hairy cell leukemia presenting with Ecthyma Gangrenosum- a case report. Full Text available with Trip Pro

Hairy cell leukemia presenting with Ecthyma Gangrenosum- a case report. Ecthyma gangrenosum is a cutaneous infectious usually associated with P. aeruginosa. It usually develops In patients with an underlying immunodeficiency.A 50-year old mentally disabled white male with a history of epilepsy presented with fever and a painless red macule on his right arm which rapidly progressed to a painful ulcer. Blood and lesion cultures revealed P.aeruginosa, confirming our clinical diagnosis of ecthyma

2019 BMC Infectious Diseases

138. Melanoma and pigmented lesions

slowly over several years most common in older people on sun-exposed skin, most often found on the head and neck. Lentigo maligna melanoma develops from a pre­invasive phase lentigo maligna [ ]. It is an irregularly ­shaped brown macule which grows slowly, and over time may develop irregular colours (dark brown, black, blue). Lentigo maligna melanoma usually grows horizontally initially but can form nodules once it enters the vertical growth phase. Images of lentigo maligna and malignant melanoma (...) but is most common in darker skin types [ ]. Genital melanoma is most common on the glans penis or vulva and, as for acral lentiginous melanoma, usually starts as a flat brown macule which increases in size over time, becoming more irregularly pigmented and developing a pink nodule over time when in vertical growth. Amelanotic melanoma typically presents as a pink coloured or erythematous nodule which may completely lack pigmentation, but a small focus of pigment is usually present, often at the edge

2017 NICE Clinical Knowledge Summaries

139. Warts - anogenital

in secondary syphillis and are highly contagious. Carcinoma in situ — multifocal erythematous macules, lichenoid, or pigmented papules which may form plaques on the external anogenital region. The surface is usually smooth and velvety. For more information, see the CKS topic . Other common, benign differential diagnoses skin tags, seborrhoeic keratoses, epidermoid cysts, and sebaceous glands of the foreskin and vulva. Basis for recommendation Basis for recommendation This information is based on the Royal

2017 NICE Clinical Knowledge Summaries

140. Parvovirus B19 infection

or in the interpretation of results, is extrapolated from expert opinion in a review article on pregnant women exposed to childhood rash [ ]. Differential diagnosis What else might it be? Other conditions that may present similarly to parvovirus B19 infection include: Rubella In children, there may be a rash of coalescing pink macules starting on the head and neck, although it does not usually cause the 'slapped cheek' appearance with accompanying perioral pallor of parvovirus B19 infection. The rash spreads (...) , fine macules and sandpaper-like papules. There may be associated petechiae on the palate and erythematous, swollen papillae on the tongue ('strawberry tongue'). See the CKS topic on for more information. Roseola infantum This is caused by herpesvirus type 6 and typically affects children younger than three years of age. There may be mild rhinorrhoea, sore throat, and sudden onset of high fever. As the fever subsides, the typical rash consists of tiny pink papules or is maculopapular

2017 NICE Clinical Knowledge Summaries

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