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81. Shingles

, does not cross the body midline May involve any area of skin, but thoracic, cranial ( ), lumbar and cervical dermatomes most common Rash typically consists of macules or papules that evolve into vesicles or pustules: Begins with macule formation, quickly turns into papules Clear vesicles form within 1-2 days of rash onset; new ones appear over 3-5 days Vesicles evolve into pustules within 1 week Lesions ulcerate and crust 3-5 days later Healing occurs within 2 to 4 weeks (but may take longer (...) urticarial plaques and bullae (blisters) typically in a bilateral, symmetric formation on the trunk and/or limbs. Does not follow dermatomes Related to celiac disease Vesicles form most commonly on scalp, shoulders, buttocks, elbows and knees. Typically not as wide-spread as a shingles rash and does not follow dermatomes. Suspect if patient has celiac disease Drug eruptions - typically appears on trunk, then spreads to limbs symmetrically. Rash consists of macules and papules and is commonly wide-spread

2018 medSask

83. Diagnosis of Idiopathic Pulmonary Fibrosis

pneumonitis (e.g., bronchiolocentric distribution with lymphocyte-rich bronchiolitis, extensive peribronchiolar metaplasia, poorly formed nonnecrotizing granulomas in peribronchiolar interstitium), acute exacerbation of IPF or acute interstitial pneumonia (i.e., hyaline membranes), cicatricialvariantsofcryptogenicorganizing pneumonia with ?brosis (prominent organizing pneumonia), pneumoconiosis (e.g., asbestos bodies, prominent dust macules and/or silicotic nodules), sarcoidosis (prominent well-formed

2018 American Thoracic Society

84. Bruising

eruptions Allergic contact dermatitis. See the Prodigy topic on for more information. Phytophotodermatitis — an inflammatory and pigmentary reaction of the skin to light, following contact with phototoxic substances from certain plants, such as giant hogweed. Stretch marks (striae). Non-linear eruptions Slate-grey naevi (Mongolian blue spots) — macular blue-grey non-tender macules present at birth on the sacrum and buttocks in normal dark-skinned infants. Haemangiomas — benign congenital cutaneous

2017 Prodigy

85. Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy

presentations vary with focal to diffuse distributions, including flexural, inverse, and erythrodermic variants. Pruritus can be severe and is the most common associated symptom. Vitiligo presents as well-demarcated depigmented macules and patches, reported exclusively in patients with melanoma. Besides varying clinical presentation, the time to onset varies greatly among these rashes, as vitiligo can appear months after treatment initiation; however, the inflammatory dermatoses usually present within

2018 American Society of Clinical Oncology Guidelines

86. Guidelines on autopsy practice: Industrial/occupational-related lung disease deaths including asbestos

macules (impalpable) secondary dust nodules (palpable) diffuse interstitial fibrosis. · complicated coal workers pneumoconiosis progressive massive fibrosis (lesions >1 cm). · coal dust tattoos · diffuse interstitial fibrosis. [Level of evidence: B.] 4 Specific health and safety aspects Subjects with silicosis are at increased risk of tuberculosis. [Level of evidence: B.] No other aspects beyond standard health and safety standards. [Level of evidence: GPP.] 5 Clinical information relevant (...) post mortem confirmed to examination of the thoracic cavity is considered sub-optimal. [Level of evidence: GPP.] 7 Specific significant organ systems Organ Pathology Agent Skin Linear tattoos Coal Corns (knuckles, finger tips) Asbestos Thorax/lungs Adult respiratory distress syndrome (shock lung) Smoke, fumes Emphysema Coal Macules Coal, silicates, iron Nodular fibrosis Coal, silica Silicate (talc, mica) Progressive massive fibrosis Coal, silica, silicates Diffuse interstitial fibrosis, lower zone

2017 Royal College of Pathologists

87. Predictive value of café au lait macules at initial consultation in the diagnosis of neurofibromatosis type 1. (PubMed)

Predictive value of café au lait macules at initial consultation in the diagnosis of neurofibromatosis type 1. To evaluate the predictive utility of the number and morphologic appearance of isolated café au lait macules (CALMs) in establishing the diagnosis of neurofibromatosis type 1 (NF1) in a cohort of children referred to an NF1 subspecialty clinic.Retrospective study of patients seen between the years 2004 and 2007.Tertiary care neurofibromatosis referral clinic at St Louis Children's

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2009 Archives of Dermatology

88. Treatment of acquired bilateral nevus of Ota-like macules (Hori's nevus) using 1064-nm Q-switched Nd:YAG laser with low fluence. (PubMed)

Treatment of acquired bilateral nevus of Ota-like macules (Hori's nevus) using 1064-nm Q-switched Nd:YAG laser with low fluence. Acquired bilateral nevus of Ota-like macules (ABNOM), or Hori's nevus, is a common dermal melanocytic hyperpigmentation in Asians.To describe the effect of 1064-nm Q-switched Nd:YAG laser (QSNY) with low fluence in South Korean patients with ABNOM.Fifteen South Korean patients (13 women and two men; mean age, 33.2 years; range, 26-52 years; Fitzpatrick skin type IV

2009 International Journal of Dermatology

89. Acquired bilateral nevus of Ota-like macules (Hori nevus): etiologic and therapeutic considerations. (PubMed)

Acquired bilateral nevus of Ota-like macules (Hori nevus): etiologic and therapeutic considerations. Acquired bilateral nevus of Ota-like macules (ABNOM), also known as Hori nevus, is one of the most commonly acquired dermal facial melanocytoses among people with dark skin, especially Asian women.The goals of this article were to review published work on ABNOM; address controversies about pathogenesis and therapeutic approach; and inspire further study.Articles in the literature related

2009 Journal of American Academy of Dermatology

90. Occupation-related pigmented macules on the sole with parallel-ridge pattern on dermatoscopy. (PubMed)

Occupation-related pigmented macules on the sole with parallel-ridge pattern on dermatoscopy. 27-year-old man presented with pigmented macules on the right sole, which showed a parallel-ridge pattern on dermatoscopy. His work for a chemical company involved handling para-phenylenediamine. Histological examination of a biopsy from a lesion did not find any proliferation of atypical melanocytes. Shaving the cornified layer of the lesions with a surgical knife resulted in the disappearance (...) of macules. We speculate that para-phenylenediamine on the sole of the patient's work boot might have become blotted to the cornified layer of the cutis. This report adds a new occupation-related differential diagnosis for skin diseases showing a parallel-ridge pattern on dermatoscopy.

2009 Clinical & Experimental Dermatology

91. Herpes Zoster - Diagnosis

. Agius, T. M. Lesser, and J. Sellner. The ?nal recommendations were formally con- sented within the expert panel of the guideline. Generalconsiderations Classically, HZ is a unilateral, dermatomal 18–20 eruption, with skin lesions evolving simultaneously from erythematous macules to papules, vesicles, pustules, and ?nal crusting after about 5– 7 days. Usually not the entire dermatome is involved. Clinical signs include pruritus, paresthesia, dysesthesia or anaesthesia. Local lymphadenopathy may

2017 European Dermatology Forum

92. The UK guidelines for management and surveillance of Tuberous Sclerosis Complex

is available should be considered for treatment with an mTOR inhibitor. Those likely to benefit from an mTOR inhibitor according to current evidence are those with progressive deterioration in lung function and those with chylous complications. Skin Skin involvement is common in TSC. Lesions such as facial angiofibromatosis, hypomelanotic macules, shagreen patches, forehead fibrous plaques, skin tags and periungual fibromas are observed in individuals with TSC. Facial angiofibromas can affect approximately

2018 Tuberous Sclerosis Association

93. Gastrointestinal Stromal Tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

–Stratakis syndrome, marked by a dyad of GIST and paraganglioma [4, 5]; and • Neuro?bromatosis type 1(NF1), possibly leading to wild-type (WT), often multicentric GIST, predominantly located in the small bowel [6]. Families with germline autosomal dominant mutations ofKIT are an extremely rare ?nding, presenting with multiple GISTs at an early age, possibly along with other associated features such as pigmented skin macules, urticaria pigmentosa and diffuse hyper- plasia of the interstitial cells

2018 European Society for Medical Oncology

95. Lymphangioleiomyomatosis Diagnosis and Management Part II: An Official ATS/JRS Clinical Practice Guideline

the diagnosis of TSC. Features suggestive of TSC include the presence of any of the following: subungual ?bromas, facial angio?bromas, hypomelanotic macules, confetti lesions, Shagreen patches, positive family history of TSC, history of seizures or cognitive impairment, or presence of cortical dysplasias, subependymal nodules, and/or subependymal giant cell astrocytomas on brain imaging. Routine brain imaging is not indicated if clinical suspicion for TSC is low. Detailed diagnostic criteria for TSC

2017 American Thoracic Society

96. Atopic Dermatitis - Guidelines for Prescribing Topical Corticosteroids

in life, unlike atopic dermatitis which often first appears in childhood. Drug-induced skin lesion - Most commonly (90%) appears as pinkish-red macules and papules that start on trunk and spread symmetrically to face and limbs. May also cause very pruritic hives. Rash peaks about 2 afters after stopping the offending drug and resolves in 5 to 14 days. Antibiotics and anti-convulsants are the most common culprits. Suspect if new-onset rash preceeded by starting a new medication. Below are medications

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2017 medSask

97. CRACKCast E118 – SLE and Vasculitides

Methylprednisolone Glucocorticoid 1-2mg/kg IV once daily Prednisone Glucocorticoid 1-2mg/kg PO once daily Hydroxychloroquine Anti-malarial 200-400mg PO once daily Cyclophosphamide Alkylating agent 500-750mg/m 2 IV once Azathioprine Antimetabolite 25-50mg/day IV or PO [6] How does neonatal lupus present? Rash Erythematous annular lesions or arcuate macules with slight central atrophy and raised active margins look on scalp and face Can be confused with fungal infection, present at delivery or not until child has

2017 CandiEM

98. CRACKCast E120 – Dermatologic presentations

of the lesions Systemic illness Diagnostic tests Category of rash Infectious Immune Vascular Allergic Malignancy Treatment Core questions [1] List five broad categories of rashes Infectious Allergic Autoimmune Vascular Malignancy-related [2] Describe the primary skin lesion types (table) The primary skin lesions result directly from the disease process. Primary Lesions (For original table, see Rosen’s Table 110.1) Lesion Description Size Macule Flat circumscribed pigmented area <0.5cm in diameter Patch Flat (...) - ceous macules, papules, vesicles, or bullae. Their distribution is often symmetric , most commonly involving the soles and palms, the backs of the hands or feet, and the extensor surfaces of the extremities. The presence of lesions of the palms and soles is particularly characteristic . The target lesion with three zones of color is the hallmark of erythema multiforme commonly begins with prodromal symptoms , such as fever , malaise , rhinitis , sore throat , and myal – gias . These are followed

2017 CandiEM

99. CRACKCast E130 – Viruses

sclerosing panencephalitis (SSPE) Viral, droplet spread Should be isolated at home Can be life threatening Worry about congenital rubella* In pregnant patients, the virus spreads to the placenta with subsequent infection of fetal organs. Clinical presentation Fever and a skin eruption. Well children 6 months to 3 years old. May occur post febrile seizure The rash typically appears with defervescence. The lesions are discrete pink or rose-colored macules or maculopapules 2 or 3 mm in diameter that blanch

2017 CandiEM

100. CRACKCast E083 – Infective Endocarditis and Valvular Disease

embolization (thromboembolic) avoided by higher INR goal of 2.5-3.5 usually CNS strokes at high risk for hemorrhagic conversion hemolysis hemolytic anemia due to sheer forces fatigue, jaundice, dark urine, dyspnea, endocarditis highest during the initial months post-op early <60 days Vary based on valve type: mechanical bioprosthetic 1) Describe the following lesions Janeway lesions Non-tender erythematous macules on the palms and soles. They are micro-abscesses. Much more common than Oslers and Roths

2017 CandiEM

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