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Macule

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21. Multiple red-brown macules and papules in a toddler (PubMed)

Multiple red-brown macules and papules in a toddler 29479170 2018 11 13 1205-7088 22 1 2017 Mar Paediatrics & child health Paediatr Child Health Multiple red-brown macules and papules in a toddler. 33-34 10.1093/pch/pxx008 Hicks Riley R Department of Medicine, University of British Columbia, Vancouver, British Columbia. Lam Joseph M JM Department of Paediatrics, University of British Columbia, Vancouver, British Columbia, Department of Dermatology, University of British Columbia, Vancouver

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2017 Paediatrics & child health

22. Urticaria Pigmentosa Mimicking Multiple Lentigine-like Brownish Macules in a 22-Month-Old Boy (PubMed)

Urticaria Pigmentosa Mimicking Multiple Lentigine-like Brownish Macules in a 22-Month-Old Boy 28480643 2019 01 30 2019 01 30 1598-6357 32 6 2017 Jun Journal of Korean medical science J. Korean Med. Sci. Urticaria Pigmentosa Mimicking Multiple Lentigine-like Brownish Macules in a 22-Month-Old Boy. 885-886 10.3346/jkms.2017.32.6.885 Suh Joon Hyuk JH http://orcid.org/0000-0002-1726-3267 Department of Dermatology, Chung-Ang University School of Medicine, Seoul, Korea. Park Kui Young KY http

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2017 Journal of Korean medical science

23. Ungual fibroma in 12-year-old boy with hypomelanotic macules, intellectual disability and attention deficit hyperactivity disorder—possible tuberous sclerosis (PubMed)

Ungual fibroma in 12-year-old boy with hypomelanotic macules, intellectual disability and attention deficit hyperactivity disorder—possible tuberous sclerosis To report a case of a 12-year-old boy with intellectual disability and attention deficit hyperactivity disorder, who came to surgery for an examination due to a minor bulge on the left thumb, which had been growing for the previous month. His mother denied any trauma.After the removal of the clinically ambiguous bulge (...) and a pathohistological confirmation that it was a periungual fibroma, complete patient analysis was performed due to the presence of hypomelanotic macules and a suspected tuberous sclerosis.Considering the presence of hypomelanotic macules, as one of the main criteria, possible TS diagnosis was set.Early detection of the symptoms of TS enables a timely provision of protocols for further patient monitoring, which affects the patient's morbidity and mortality.

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2016 SAGE Open Medical Case Reports

24. Molecular screening strategies for NF1-like syndromes with café-au-lait macules (PubMed)

Molecular screening strategies for NF1-like syndromes with café-au-lait macules Multiple café-au-lait macules (CALM) are usually associated with neurofibromatosis type 1 (NF1), one of the most common hereditary disorders. However, a group of genetic disorders presenting with CALM have mutations that are involved in human skin pigmentation regulation signaling pathways, including KIT ligand/KIT proto‑oncogene receptor tyrosine kinase and Ras/mitogen‑activated protein kinase. These disorders

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2016 Molecular medicine reports

25. Basal Cell Carcinoma or Trichoblastoma? Dermoscopic Examination of Black Macules Developing in the Same Nevus Sebaceus (PubMed)

Basal Cell Carcinoma or Trichoblastoma? Dermoscopic Examination of Black Macules Developing in the Same Nevus Sebaceus Nevus sebaceus (NS) is a common congenital birthmark, and various tumors have been reported to develop in NS. Basal cell carcinoma (BCC) seldom occurs in NS, and it is very important to be able to clinicopathologically distinguish BCC from trichoblastoma. Herein, we describe a case of BCC and trichoblastoma occurring simultaneously in the same NS, including the differential

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2016 Case reports in oncology

26. Cafe-Au-Lait Macule

Cafe-Au-Lait Macule Cafe-Au-Lait Macule Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cafe-Au-Lait Macule Cafe-Au-Lait Macule Aka (...) : Cafe-Au-Lait Macule , Cafe-Au-Lait Spot , Cafe Au Lait II. Pathophysiology Congenital or develops in early childhood from increased deposition III. Epidemiology Often present at birth Isolated lesions are common (present in up to 10-30% of the population) IV. Symptoms Asymptomatic V. Signs "Coffee with milk" (tan to brown) colored flat Usually located on trunk Size varies from <4 cm in infants to 20-30 cm in adults VI. Red Flags: Criteria to consider associated congenital conditions below Six

2018 FP Notebook

27. Labial Melanotic Macule

Labial Melanotic Macule Labial Melanotic Macule Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Labial Melanotic Macule Labial (...) Melanotic Macule Aka: Labial Melanotic Macule From Related Chapters II. Epidemiology Most common in young women III. Signs Lower lip with brown s IV. Differential Diagnosis darken with and Labial Melanotic Macules do not V. Management Benign Excise only for cosmetic reasons Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Labial Melanotic Macule." Click on the image (or right click) to open the source website in a new browser window

2018 FP Notebook

28. Macule

Macule Macule Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Macule Macule Aka: Macule , Patch II. Description Non-palpable flat (...) lesion with change Patches are Macule that are >3-4 cm in diameter III. Signs Macules are flat and not palpable If raised, then consider or Methods to determine if lesion raised Side lighting Careful palpation Color (e.g. ) (e.g. s) Hemosiderin (e.g. s) Vascular changes (e.g. ) IV. Examples Drug Eruption or Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Macule." Click on the image (or right click) to open the source website

2018 FP Notebook

29. Kaposi's sarcoma presenting as violaceous macules on the chest of a kidney transplanted patient (PubMed)

Kaposi's sarcoma presenting as violaceous macules on the chest of a kidney transplanted patient Organ transplant recipients have a high incidence of cancer associated with persistent viral infections, such as human herpes virus 8. This virus is associated with Kaposi's sarcoma, and a change in the dose or type of immunosuppression regimen should be the first step in its treatment. A multidisciplinary approach with nephrologists, dermatologists and oncologists is necessary for the management

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2016 BMJ case reports

30. Pigmented perianal macules (PubMed)

Pigmented perianal macules Primary mucosal melanoma occurs in under 2% of melanomas. Anorectal melanoma is a rare disorder, approximately accounting for 1% of all anorectal carcinomas. Primary anorectal melanoma presents predominantly in women, in the 4th-6th decade of life. Typical clinical manifestations include rectal bleeding and tenesmus. The prognosis remains poor.

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2015 Clinical Case Reports

31. A novel missense KIT mutation causing piebaldism in one Chinese family associated with café-au-lait macules and intertriginous freckling (PubMed)

A novel missense KIT mutation causing piebaldism in one Chinese family associated with café-au-lait macules and intertriginous freckling Piebaldism is a rare autosomal dominant genodermatosis, manifesting as congenital and stable depigmentation of the skin and white forelock. It has been found to be associated with mutations in the KIT or SLUG genes. We report a Chinese piebaldism family including a 28-year-old woman and her 3-year-old son with characteristics of white patches and forelock (...) associated with numerous brown macules and patches. Genomic DNA samples of the proband and her son were extracted from their peripheral blood. One hundred unrelated healthy individuals were used as controls. All coding regions of KIT, SLUG, and NF1 genes were amplified by polymerase chain reaction using exon flanking intronic primers and Sanger sequencings were performed. DNA sequencing revealed heterozygous missense c.2431T>G mutation in exon 17 of the KIT gene in the proband and the affected son

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2015 Therapeutics and clinical risk management

32. Well-defined macules on young girl's forearms. (PubMed)

Well-defined macules on young girl's forearms. Speaking to the teen without her mother in the room made the diagnosis crystal clear.

2015 Journal of Family Practice

33. Polycystic ovary syndrome (PCOS) with melanocytic mucosal macules: the role of STK11 gene polymorphisms in PCOS and Peutz-Jeghers syndrome. (PubMed)

Polycystic ovary syndrome (PCOS) with melanocytic mucosal macules: the role of STK11 gene polymorphisms in PCOS and Peutz-Jeghers syndrome. Polycystic ovary syndrome (PCOS) is a complex genetic disorder that is the most common endocrinopathy that affects women.We report two individuals with PCOS with a genetic polymorphism in serine threonine kinase 11 (STK11). Both these individuals developed mucosal pigmentation suggesting Peutz-Jeghers syndrome (PJS), which is associated with mutations

2015 International Journal of Dermatology

34. Brownish macule on the palm (PubMed)

Brownish macule on the palm 26009730 2015 05 26 2019 01 08 2229-5178 6 3 2015 May-Jun Indian dermatology online journal Indian Dermatol Online J Brownish macule on the palm. 230-1 10.4103/2229-5178.156439 Nair S Pradeep SP Department of Dermatology and Venereology, Government Medical College, Trivandrum, Kerala, India. eng Journal Article India Indian Dermatol Online J 101586880 2229-5178 2015 5 27 6 0 2015 5 27 6 0 2015 5 27 6 1 ppublish 26009730 10.4103/2229-5178.156439 IDOJ-6-230 PMC4439764

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2015 Indian dermatology online journal

35. Acquired Bilateral Telangiectatic Macules: A Distinct Clinical Entity. (PubMed)

Acquired Bilateral Telangiectatic Macules: A Distinct Clinical Entity. We evaluated 13 distinct patients with multiple telangiectatic pigmented macules confined mostly to the upper arms to determine if the clinical and histopathological features of these cases might represent a specific clinical entity.We retrospectively investigated the clinical, histopathologic, and immunohistochemical features of 13 patients with multiple telangiectatic pigmented macules on the upper arms who presented (...) in the lesional skin (P < .05). No significant difference in epidermal thickness or mast cell number was observed between the normal perilesional skin and the lesional skin.The clinical and histopathologic features of these lesions were relatively consistent in all patients. In addition, the features are quite distinct from other diseases. Based on clinical and histologic features, we suggest the name acquired bilateral telangiectatic macules for this new entity.

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2014 JAMA dermatology (Chicago, Ill.)

36. Reflectance Confocal Microscopy correlates of dermoscopic patterns of facial lesions helps to discriminate lentigo maligna from pigmented non-melanocytic macules. (PubMed)

Reflectance Confocal Microscopy correlates of dermoscopic patterns of facial lesions helps to discriminate lentigo maligna from pigmented non-melanocytic macules. The clinical recognition of lentigo maligna (LM) and LM melanoma can be very challenging due to the overlapping features it shares with other pigmented macules of the skin. Noninvasive diagnostic techniques can assist in the differential diagnosis.To identify reflectance confocal microscopy (RCM) indicators for LM through

2014 British Journal of Dermatology

37. Halo naevi and café au lait macule regression in a renal transplant patient on immunosuppression. (PubMed)

Halo naevi and café au lait macule regression in a renal transplant patient on immunosuppression. A case of halo naevi and café au lait macule regression in a renal transplant patient receiving long-term immunosuppressive therapy is described. We propose the direct transfer of an auto-reactive antibody, CD8 T-cells or tumour necrosis factor α from the transplant donor to the recipient as a possible cause. We have also considered insufficient immunosuppressive therapy as a possible mechanism. ©

2014 Australasian Journal of Dermatology

38. Hyperpigmented macules on the face of young children: A series of 25 cases. (PubMed)

Hyperpigmented macules on the face of young children: A series of 25 cases. Acquired hyperpigmented lesions in early childhood can be the presenting sign of serious diseases or benign conditions and often cause significant parental anxiety.We sought to report a series of 25 young children with hyperpigmented macules on the forehead and temples without preceding erythema, edema, or desquamation.We conducted a retrospective review of 25 children with similar clinical findings, seen from 2009 (...) to a variable degree in 19 cases in which follow-up was possible.The age of our patients precluded patch testing and/or invasive diagnostic methods.The clinical features and prolonged clinical course over years do not correspond with any known or previously described cause of acquired facial hyperpigmented macules in young children.Copyright © 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

2013 Journal of American Academy of Dermatology

39. Reflectance confocal microscopy of mucosal pigmented macules : a review of 56 cases including 10 macular melanoma. (PubMed)

Reflectance confocal microscopy of mucosal pigmented macules : a review of 56 cases including 10 macular melanoma. Although most mucosal pigmented macules are benign, it can be clinically challenging to rule out an early melanoma. Reflectance confocal microscopy (RCM) is a noninvasive imaging technique useful in discriminating between benign and malignant skin lesions.To describe the confocal aspects of benign and malignant mucosal pigmented macules with histopathological correlations.We (...) retrospectively reviewed the confocal images of 56 labial or genital pigmented macules including 10 macular melanomas. According to the retrospective nature of the study, we evaluated the recorded images chosen by the physicians that performed the RCM examination for each case.In benign macules, the most frequently observed pattern was a ringed pattern characterized by round or polycyclic papillae, with a hyper-reflective basal layer; another pattern was characterized by sparse bright dendritic cells

2013 British Journal of Dermatology

40. Labial Melanotic Macule: A Potential Pitfall on Reflectance Confocal Microscopy. (PubMed)

Labial Melanotic Macule: A Potential Pitfall on Reflectance Confocal Microscopy. 22414589 2012 12 07 2012 07 04 1421-9832 224 3 2012 Dermatology (Basel, Switzerland) Dermatology (Basel) Labial melanotic macule: a potential pitfall on reflectance confocal microscopy. 209-11 10.1159/000336775 Erfan N N Hofman V V Desruelles F F Passeron T T Ortonne J P JP Lacour J P JP Bahadoran P P eng Case Reports Letter 2012 03 09 Switzerland Dermatology 9203244 1018-8665 IM Adult Dermoscopy methods Female

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2012 Dermatology

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