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Macule

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21. Intravenous immunoglobulin contributes to control anti-melanoma differentiation-associated protein 5 (MDA5) antibody-associated dermatomyositis with palmar violaceous macules/papules. Full Text available with Trip Pro

Intravenous immunoglobulin contributes to control anti-melanoma differentiation-associated protein 5 (MDA5) antibody-associated dermatomyositis with palmar violaceous macules/papules. Autoantibodies to melanoma differentiation-associated protein 5 (MDA5) are associated with a subset of patients with dermatomyositis (DM) who have rapidly progressive interstitial lung disease (RP-ILD) with poor prognosis. Intensive immunosuppressive therapy is initiated before irreversible lung damage can occur (...) to the control of the disease activity of anti-MDA5 antibody-positive DM. Moreover, palmar violaceous macules/papules around the interphalangeal joints, which was observed in all three cases in the incipient stage, might be a useful sign in suggesting a diagnosis of anti-MDA5 antibody-associated DM.© 2017 British Association of Dermatologists.

2017 British Journal of Dermatology

22. Predicting neurofibromatosis type 1 risk among children with isolated café-au-lait macules. Full Text available with Trip Pro

Predicting neurofibromatosis type 1 risk among children with isolated café-au-lait macules. Although isolated cafe-au-lait macules (CALMs) are a common skin finding, they are an early feature of neurofibromatosis type 1 (NF1).We sought to develop an algorithm determining the risk of children with CALMs to have constitutional NF1.We conducted a retrospective study of patients with isolated CALMs. Diagnosis of NF1 was based on detecting NF1 mutation in blood or fulfilling clinical criteria.In all (...) , 170 of 419 (41%) and 21 of 86 (24%) children with isolated CALMs who underwent molecular testing and clinical follow-up, respectively, were given a diagnosis of NF1. Presence of fewer than 6 CALMs at presentation or atypical CALMs was associated with not having NF1 (P < .001). An algorithm based on age, CALMs number, and presence of atypical macules predicted NF1 in both cohorts. According to the algorithm, children older than 29 months with at least 1 atypical CALM or less than 6 CALMs have a 0.9

2017 Journal of American Academy of Dermatology

23. In Vivo Reflectance Confocal Microscopy for the Diagnosis of Melanoma and Melanotic Macules of the Lip. Full Text available with Trip Pro

In Vivo Reflectance Confocal Microscopy for the Diagnosis of Melanoma and Melanotic Macules of the Lip. Benign melanotic macules (MAC) are the most frequent cause of lip pigmentation and sometimes difficult to differentiate from lip melanoma (MEL).To report in vivo reflectance confocal microscopy (RCM) features of normal lips of different phototypes and to identify features that assist in distinguishing MEL from MAC using dermoscopy and RCM.For this retrospective observational study, 2 groups

2017 JAMA dermatology (Chicago, Ill.)

24. Labial Melanotic Macule

Labial Melanotic Macule Labial Melanotic Macule Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Labial Melanotic Macule Labial (...) Melanotic Macule Aka: Labial Melanotic Macule From Related Chapters II. Epidemiology Most common in young women III. Signs Lower lip with brown s IV. Differential Diagnosis darken with and Labial Melanotic Macules do not V. Management Benign Excise only for cosmetic reasons Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Labial Melanotic Macule." Click on the image (or right click) to open the source website in a new browser window

2018 FP Notebook

25. Macule

Macule Macule Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Macule Macule Aka: Macule , Patch II. Description Non-palpable flat (...) lesion with change Patches are Macule that are >3-4 cm in diameter III. Signs Macules are flat and not palpable If raised, then consider or Methods to determine if lesion raised Side lighting Careful palpation Color (e.g. ) (e.g. s) Hemosiderin (e.g. s) Vascular changes (e.g. ) IV. Examples Drug Eruption or Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Macule." Click on the image (or right click) to open the source website

2018 FP Notebook

26. Cafe-Au-Lait Macule

Cafe-Au-Lait Macule Cafe-Au-Lait Macule Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Cafe-Au-Lait Macule Cafe-Au-Lait Macule Aka (...) : Cafe-Au-Lait Macule , Cafe-Au-Lait Spot , Cafe Au Lait II. Pathophysiology Congenital or develops in early childhood from increased deposition III. Epidemiology Often present at birth Isolated lesions are common (present in up to 10-30% of the population) IV. Symptoms Asymptomatic V. Signs "Coffee with milk" (tan to brown) colored flat Usually located on trunk Size varies from <4 cm in infants to 20-30 cm in adults VI. Red Flags: Criteria to consider associated congenital conditions below Six

2018 FP Notebook

27. Kaposi's sarcoma presenting as violaceous macules on the chest of a kidney transplanted patient Full Text available with Trip Pro

Kaposi's sarcoma presenting as violaceous macules on the chest of a kidney transplanted patient Organ transplant recipients have a high incidence of cancer associated with persistent viral infections, such as human herpes virus 8. This virus is associated with Kaposi's sarcoma, and a change in the dose or type of immunosuppression regimen should be the first step in its treatment. A multidisciplinary approach with nephrologists, dermatologists and oncologists is necessary for the management

2016 BMJ case reports

28. Molecular screening strategies for NF1-like syndromes with café-au-lait macules Full Text available with Trip Pro

Molecular screening strategies for NF1-like syndromes with café-au-lait macules Multiple café-au-lait macules (CALM) are usually associated with neurofibromatosis type 1 (NF1), one of the most common hereditary disorders. However, a group of genetic disorders presenting with CALM have mutations that are involved in human skin pigmentation regulation signaling pathways, including KIT ligand/KIT proto‑oncogene receptor tyrosine kinase and Ras/mitogen‑activated protein kinase. These disorders

2016 Molecular medicine reports

29. Basal Cell Carcinoma or Trichoblastoma? Dermoscopic Examination of Black Macules Developing in the Same Nevus Sebaceus Full Text available with Trip Pro

Basal Cell Carcinoma or Trichoblastoma? Dermoscopic Examination of Black Macules Developing in the Same Nevus Sebaceus Nevus sebaceus (NS) is a common congenital birthmark, and various tumors have been reported to develop in NS. Basal cell carcinoma (BCC) seldom occurs in NS, and it is very important to be able to clinicopathologically distinguish BCC from trichoblastoma. Herein, we describe a case of BCC and trichoblastoma occurring simultaneously in the same NS, including the differential

2016 Case reports in oncology

30. Ungual fibroma in 12-year-old boy with hypomelanotic macules, intellectual disability and attention deficit hyperactivity disorder—possible tuberous sclerosis Full Text available with Trip Pro

Ungual fibroma in 12-year-old boy with hypomelanotic macules, intellectual disability and attention deficit hyperactivity disorder—possible tuberous sclerosis To report a case of a 12-year-old boy with intellectual disability and attention deficit hyperactivity disorder, who came to surgery for an examination due to a minor bulge on the left thumb, which had been growing for the previous month. His mother denied any trauma.After the removal of the clinically ambiguous bulge (...) and a pathohistological confirmation that it was a periungual fibroma, complete patient analysis was performed due to the presence of hypomelanotic macules and a suspected tuberous sclerosis.Considering the presence of hypomelanotic macules, as one of the main criteria, possible TS diagnosis was set.Early detection of the symptoms of TS enables a timely provision of protocols for further patient monitoring, which affects the patient's morbidity and mortality.

2016 SAGE Open Medical Case Reports

31. Pigmented perianal macules Full Text available with Trip Pro

Pigmented perianal macules Primary mucosal melanoma occurs in under 2% of melanomas. Anorectal melanoma is a rare disorder, approximately accounting for 1% of all anorectal carcinomas. Primary anorectal melanoma presents predominantly in women, in the 4th-6th decade of life. Typical clinical manifestations include rectal bleeding and tenesmus. The prognosis remains poor.

2015 Clinical Case Reports

32. Well-defined macules on young girl's forearms. (Abstract)

Well-defined macules on young girl's forearms. Speaking to the teen without her mother in the room made the diagnosis crystal clear.

2015 Journal of Family Practice

33. Polycystic ovary syndrome (PCOS) with melanocytic mucosal macules: the role of STK11 gene polymorphisms in PCOS and Peutz-Jeghers syndrome. (Abstract)

Polycystic ovary syndrome (PCOS) with melanocytic mucosal macules: the role of STK11 gene polymorphisms in PCOS and Peutz-Jeghers syndrome. Polycystic ovary syndrome (PCOS) is a complex genetic disorder that is the most common endocrinopathy that affects women.We report two individuals with PCOS with a genetic polymorphism in serine threonine kinase 11 (STK11). Both these individuals developed mucosal pigmentation suggesting Peutz-Jeghers syndrome (PJS), which is associated with mutations

2015 International Journal of Dermatology

34. A novel missense KIT mutation causing piebaldism in one Chinese family associated with café-au-lait macules and intertriginous freckling Full Text available with Trip Pro

A novel missense KIT mutation causing piebaldism in one Chinese family associated with café-au-lait macules and intertriginous freckling Piebaldism is a rare autosomal dominant genodermatosis, manifesting as congenital and stable depigmentation of the skin and white forelock. It has been found to be associated with mutations in the KIT or SLUG genes. We report a Chinese piebaldism family including a 28-year-old woman and her 3-year-old son with characteristics of white patches and forelock (...) associated with numerous brown macules and patches. Genomic DNA samples of the proband and her son were extracted from their peripheral blood. One hundred unrelated healthy individuals were used as controls. All coding regions of KIT, SLUG, and NF1 genes were amplified by polymerase chain reaction using exon flanking intronic primers and Sanger sequencings were performed. DNA sequencing revealed heterozygous missense c.2431T>G mutation in exon 17 of the KIT gene in the proband and the affected son

2015 Therapeutics and clinical risk management

35. Brownish macule on the palm Full Text available with Trip Pro

Brownish macule on the palm 26009730 2015 05 26 2019 01 08 2229-5178 6 3 2015 May-Jun Indian dermatology online journal Indian Dermatol Online J Brownish macule on the palm. 230-1 10.4103/2229-5178.156439 Nair S Pradeep SP Department of Dermatology and Venereology, Government Medical College, Trivandrum, Kerala, India. eng Journal Article India Indian Dermatol Online J 101586880 2229-5178 2015 5 27 6 0 2015 5 27 6 0 2015 5 27 6 1 ppublish 26009730 10.4103/2229-5178.156439 IDOJ-6-230 PMC4439764

2015 Indian dermatology online journal

36. Halo naevi and café au lait macule regression in a renal transplant patient on immunosuppression. (Abstract)

Halo naevi and café au lait macule regression in a renal transplant patient on immunosuppression. A case of halo naevi and café au lait macule regression in a renal transplant patient receiving long-term immunosuppressive therapy is described. We propose the direct transfer of an auto-reactive antibody, CD8 T-cells or tumour necrosis factor α from the transplant donor to the recipient as a possible cause. We have also considered insufficient immunosuppressive therapy as a possible mechanism. ©

2014 Australasian Journal of Dermatology

37. Reflectance Confocal Microscopy correlates of dermoscopic patterns of facial lesions helps to discriminate lentigo maligna from pigmented non-melanocytic macules. (Abstract)

Reflectance Confocal Microscopy correlates of dermoscopic patterns of facial lesions helps to discriminate lentigo maligna from pigmented non-melanocytic macules. The clinical recognition of lentigo maligna (LM) and LM melanoma can be very challenging due to the overlapping features it shares with other pigmented macules of the skin. Noninvasive diagnostic techniques can assist in the differential diagnosis.To identify reflectance confocal microscopy (RCM) indicators for LM through

2014 British Journal of Dermatology

38. Acquired Bilateral Telangiectatic Macules: A Distinct Clinical Entity. Full Text available with Trip Pro

Acquired Bilateral Telangiectatic Macules: A Distinct Clinical Entity. We evaluated 13 distinct patients with multiple telangiectatic pigmented macules confined mostly to the upper arms to determine if the clinical and histopathological features of these cases might represent a specific clinical entity.We retrospectively investigated the clinical, histopathologic, and immunohistochemical features of 13 patients with multiple telangiectatic pigmented macules on the upper arms who presented (...) in the lesional skin (P < .05). No significant difference in epidermal thickness or mast cell number was observed between the normal perilesional skin and the lesional skin.The clinical and histopathologic features of these lesions were relatively consistent in all patients. In addition, the features are quite distinct from other diseases. Based on clinical and histologic features, we suggest the name acquired bilateral telangiectatic macules for this new entity.

2014 JAMA dermatology (Chicago, Ill.)

39. Reflectance confocal microscopy of mucosal pigmented macules : a review of 56 cases including 10 macular melanoma. (Abstract)

Reflectance confocal microscopy of mucosal pigmented macules : a review of 56 cases including 10 macular melanoma. Although most mucosal pigmented macules are benign, it can be clinically challenging to rule out an early melanoma. Reflectance confocal microscopy (RCM) is a noninvasive imaging technique useful in discriminating between benign and malignant skin lesions.To describe the confocal aspects of benign and malignant mucosal pigmented macules with histopathological correlations.We (...) retrospectively reviewed the confocal images of 56 labial or genital pigmented macules including 10 macular melanomas. According to the retrospective nature of the study, we evaluated the recorded images chosen by the physicians that performed the RCM examination for each case.In benign macules, the most frequently observed pattern was a ringed pattern characterized by round or polycyclic papillae, with a hyper-reflective basal layer; another pattern was characterized by sparse bright dendritic cells

2013 British Journal of Dermatology

40. Hyperpigmented macules on the face of young children: A series of 25 cases. (Abstract)

Hyperpigmented macules on the face of young children: A series of 25 cases. Acquired hyperpigmented lesions in early childhood can be the presenting sign of serious diseases or benign conditions and often cause significant parental anxiety.We sought to report a series of 25 young children with hyperpigmented macules on the forehead and temples without preceding erythema, edema, or desquamation.We conducted a retrospective review of 25 children with similar clinical findings, seen from 2009 (...) to a variable degree in 19 cases in which follow-up was possible.The age of our patients precluded patch testing and/or invasive diagnostic methods.The clinical features and prolonged clinical course over years do not correspond with any known or previously described cause of acquired facial hyperpigmented macules in young children.Copyright © 2013 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

2013 Journal of American Academy of Dermatology

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