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181. Vestibular Injury After Low-Intensity Blast Exposure Full Text available with Trip Pro

damage to both the peripheral and central vestibular system; similar to previous findings that blast exposure results in damage to auditory receptors. In this study, mice were exposed to a 63 kPa peak blast-wave over pressure and were examined for vestibular receptor damage as well as behavioral assays to identify vestibular dysfunction. We observed perforations to the tympanic membrane in all blast animals. We also observed significant loss of stereocilia on hair cells in the cristae and macule up

2018 Frontiers in neurology

182. Atypical tuberous sclerosis complex presenting as familial renal cell carcinoma with leiomyomatous stroma Full Text available with Trip Pro

Atypical tuberous sclerosis complex presenting as familial renal cell carcinoma with leiomyomatous stroma We report an atypical tuberous sclerosis complex (TSC) phenotype presenting as familial multiple renal cell carcinomas (RCCs) with (angio)leiomyomatous stroma (RCCLS) (5/7 familial RCCs) on a background of multiple angiomyolipomas, hypopigmented skin macules, and absence of neurological anomalies. In the index case and three relatives, germline genetic testing identified a heterozygous TSC2

2018 The Journal of Pathology: Clinical Research

183. Spontaneous splenic rupture complicating primary varicella zoster infection: a case report Full Text available with Trip Pro

, presented with a 2 day history of sudden onset, worsening generalised abdominal pain and a 1 day history of vomiting. The following day he developed fevers and a generalised widespread erythematous rash consisting of clusters of macules, papules and vesicles at different stages of development. There was no history of sore throat, coryza, arthralgia, myalgia, cough, shortness of breath, weight loss, or night sweats. There was no recent illness and no history of trauma. CT abdomen showed splenic rupture

2018 BMC research notes

184. Epidermodysplasie verruciforme: à propos d’un cas Full Text available with Trip Pro

Epidermodysplasie verruciforme: à propos d’un cas Epidermodysplasia verruciformis, also known as Lewandowsky-Lutz syndrome or tree man disease is a rare genetic skin disorder. It is characterized by abnormal susceptibility of the skin coating to human papillomaviruses (HPVs). It commonly affects people between the ages of 4 and 8, most often before the age of 20 years but it may exceptionally occur later. It is characterized by the appearance of scaly macules and sometimes exuberant

2018 The Pan African medical journal

185. Association rare: lichen scléroatrophique extragénital et vitiligo inflammatoire chez un enfant Full Text available with Trip Pro

Association rare: lichen scléroatrophique extragénital et vitiligo inflammatoire chez un enfant Scleroatrophic lichen (SL) and vitiligo are two depigmenting disorders which may occur separately or, rarely, in combination. Their association may seem logical because both these disorders are characterized by the suspicion of an autoimmune pathogenesis. We here report the case of a 8-year old girl, with no notable medical history, presenting with achromic macules and papular nonpruritic lesions (...) evolving over 6 months. Clinical examination showed two types of lesions (A): ovalaire achromic macules measuring 1-3 cm along their longer axis, located at the level of the front, of the neck, of the shoulders, as well as of the peri-mamelonar and of the genital region. These lesions exhibited slightly raised peripheral inflammatory border as well as a poliosis. The patient also had pearly white atrophic papular plaques at the level of the interscapular and abdominal regions as well as of the anterior

2018 The Pan African medical journal

186. Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis; Extensive Review of Reports of Drug-Induced Etiologies, and Possible Therapeutic Modalities Full Text available with Trip Pro

Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis; Extensive Review of Reports of Drug-Induced Etiologies, and Possible Therapeutic Modalities Stevens - Johnson Syndrome and Toxic Epidermal Necrolysis are adverse hypersensitivity reactions that affect the skin and mucous membranes. They are characterised by erythematous macules and hemorrhagic erosions of the mucous membranes. Epidermal detachments of varying degrees of severity also occur in these conditions. Various aetiologies

2018 Open access Macedonian journal of medical sciences

187. Eruptive lentiginosis in resolving psoriatic plaques Full Text available with Trip Pro

Reports Retracted Publication 2018 03 31 United States JAAD Case Rep 101665210 2352-5126 JAAD Case Rep. 2018 Sep 18;4(8):841 30238053 ELRP, eruptive lentiginosis in resolving psoriatic plaques IL, interleukin TNF, tumor necrosis factor hyperpigmentation lentigines macules plaque psoriasis 2018 4 26 6 0 2018 4 26 6 0 2018 4 26 6 1 epublish 29693059 10.1016/j.jdcr.2017.10.009 S2352-5126(17)30261-8 PMC5911780 Pigment Cell Melanoma Res. 2012 Mar;25(2):219-30 22136309 Clin Exp Dermatol. 2006 Mar;31(2):298

2018 JAAD Case Reports

188. Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study Full Text available with Trip Pro

Evaluation of Therapeutic Efficacy and Safety of Tranexamic Acid Local Infiltration in Combination with Topical 4% Hydroquinone Cream Compared to Topical 4% Hydroquinone Cream Alone in Patients with Melasma: A Split-Face Study Melasma is an acquired pigmentary disorder characterized by hyperpigmented macules and/or patches affecting sun-exposed skin. Tranexamic acid (TA) can reduce melanin content of epidermis. Thus, we conducted this study to evaluate the efficacy and safety of tranexamic acid

2018 Dermatology research and practice Controlled trial quality: uncertain

189. Nevus anemicus and RASopathies Full Text available with Trip Pro

, University Hospital Leuven, Leuven, Belgium. Department of Human Genetics, KU Leuven, Leuven, Belgium. eng Case Reports 2018 04 06 United States JAAD Case Rep 101665210 2352-5126 CALMs, café au lait macules Legius syndrome MAPK, mitogen-activated protein kinase NF1, neurofibromatosis type 1 Noonan syndrome PTPN11, protein tyrosine phosphatase nonreceptor type 11 RAF1, rapidly accelerated fibrosarcoma-1 RAS, rat sarcoma family of protooncogenes RASopathy SPRED1, sprouty-related, EVH1 domain containing

2018 JAAD Case Reports

190. Peutz-Jeghers Syndrome Presenting as Colonic Intussusception: A Rare Entity Full Text available with Trip Pro

Peutz-Jeghers Syndrome Presenting as Colonic Intussusception: A Rare Entity Peutz-Jeghers syndrome is an autosomal dominant inherited medical condition characterized by hyperpigmented mucocutaneous macules, hamartomatous polyps in the digestive tract, and with a greater risk of gastrointestinal and non-gastrointestinal cancers. In fact, without appropriate medical surveillance, the lifetime risk for all cancers combined may be as high as 93%. The syndrome is rare, with estimates of incidence

2018 Gastroenterology research

191. Incidence of tuberous sclerosis and age at first diagnosis: new data and emerging trends from a national, prospective surveillance study Full Text available with Trip Pro

macules in 92%) and cardiac rhabdomyoma in half of the patients. Cardiac rhabdomyoma were detected by prenatal ultrasonography in 22.1% of patients. The presence of cardiac rhabdomyoma was associated with cardiac arrhythmias in 25.6% (about 13% of all diagnosed patients) in our cohort. The overall prevalence of seizure disorders was 69.8%. The annual incidence rate of TSC is estimated at a minimum of 1:17.785 live births. However correcting for underreporting, the estimated incidence rate of definite

2018 Orphanet journal of rare diseases

192. Prurigo Pigmentosa: A Clinicopathological Report of Three Middle Eastern Patients Full Text available with Trip Pro

Prurigo Pigmentosa: A Clinicopathological Report of Three Middle Eastern Patients Prurigo pigmentosa is a unique cutaneous inflammatory disorder characterized by a sudden onset of pruritic and erythematous macules, urticarial papules, and plaques that may coalesce to form a reticulated pattern. Lesions typically heal within weeks leaving a reticulated and mottled postinflammatory hyperpigmentation. The majority of reported cases originate from Japan with much fewer cases described worldwide

2018 Case reports in dermatological medicine

193. Decreased choroidal thickness in vitiligo patients. Full Text available with Trip Pro

Decreased choroidal thickness in vitiligo patients. Vitiligo is a disease characterized by depigmented macules and patches that occur as a result of the loss of functional melanocytes from the affected skin through a mechanism which has not been elucidated yet. Destruction of pigment cells in vitiligo may not remain limited to the skin; the eyelashes, iris, ciliary body, choroid, retinal pigment epithelium and meninges may also be affected. This study aims to compare the choroidal thickness

2018 BMC Ophthalmology

194. The value of 18F-FDG PET/CT in patient with neurofibromatosis type 1: A case report and literature review. Full Text available with Trip Pro

presented with numerous lentigines and multiple café-au-lait macules on his body.These were collagen neurofibroma, which were definitively diagnosed by pathology. NF1 was eventually diagnosed.These lesions were abnormal uptake of radiotracer, when he underwent positron emission tomography (PET) with fluorine-18-fluorodeoxyglucose (FDG) scanning. Standard uptake value (SUV) and other parameters can help to distinguish benign and malignant lesions in patient with NF1. He was underwent serials F-FDG PET/CT

2018 Medicine

195. Melanocyte abnormalities and senescence in the pathogenesis of idiopathic guttate hypomelanosis. (Abstract)

Melanocyte abnormalities and senescence in the pathogenesis of idiopathic guttate hypomelanosis. Idiopathic guttate hypomelanosis (IGH) is a pigmentary disorder of unknown pathogenesis characterized by small discrete white macules. In the skin, epidermal melanin unit between melanocytes and keratinocytes is responsible for melanin synthesis and equal distribution of melanin pigment.Therefore, this study was designed to check the role of melanocytes in the pathogenesis of IGH.For this study, six

2018 International Journal of Dermatology

196. The Role of Interleukins in Vitiligo: a Systematic Review. (Abstract)

The Role of Interleukins in Vitiligo: a Systematic Review. Vitiligo is a disorder of the skin that causes depigmentation and asymptomatic macules whose exact cause is still unclear. Although its aetiology is not fully elucidated, the main theory of its pathomechanism is that it is associated with the autoimmune process. There is few summarized information about the role of inflammatory mediators, as interleukins, in vitiligo, so our aim was to present a systematic review of the role

2018 Journal of the European Academy of Dermatology and Venereology

197. Oral lichen sclerosus: an overview and report of three cases. (Abstract)

lichen sclerosus should be included in the differential diagnosis of porcelain- or ivory-white macules. Here we present three new cases of oral lichen sclerosus. A review of these cases and the previously reported cases revealed that oral lichen sclerosus is slightly more common in women and can affect individuals of any age. Oral lesions of lichen sclerosus usually do not require treatment, except when there are significant symptoms or aesthetic complaint. Almost 50% of the patients with oral lichen

2018 International Journal of Oral and Maxillofacial Surgery

198. Treatment of Seborrheic Dermatitis: A Comprehensive Review. (Abstract)

Treatment of Seborrheic Dermatitis: A Comprehensive Review. Seborrheic dermatitis (SD) is a chronic, recurring inflammatory skin disorder that manifests as erythematous macules or plaques with varying levels of scaling associated with pruritus. The condition typically occurs as an inflammatory response to Malassezia species and tends to occur on seborrheic areas, such as the scalp, face, chest, back, axilla, and groin areas. SD treatment focuses on clearing signs of the disease; ameliorating

2018 Journal of Dermatological Treatment

199. Interferon alpha as antiviral therapy in chronic active Epstein-Barr virus disease with interstitial pneumonia - case report. Full Text available with Trip Pro

blood, isolated peripheral blood lymphocytes as well as in the blood plasma. Cytokine assessment in peripheral blood revealed the lack of IFN-alpha synthesis. Disseminated maculate infiltrative areas in both lungs were observed on a computed tomography (CT) chest scan. The patient was not qualified for the allogeneic hematopoietic stem cell transplantation (allo-HSCT) due to the risk of immunosuppression-related complications of infectious IP. Inhaled (1.5 million units 3 times a day

2018 BMC Infectious Diseases

200. A case report of lupus erythematosus tumidus converted from discoid lupus erythematosus. Full Text available with Trip Pro

, including prominent swelling of the eyelids, a few erythematous, edematous plaques on the left forehead, face, and neck, and 2 hairless macules. The histopathologic findings reveal liquefaction degeneration of the basal cells, perivascular, and periadnexal infiltration of lymphocytes, and interstitial mucin deposition in the superficial, and deep dermis.A diagnosis of LET was made on clinical and histological features.The patient started treatment with prednisolone (1 mg/kg. d), combined

2018 Medicine

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