How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

1,317 results for

Macule

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

1. Noninvasive RCM for Differentiation of Melanotic Macules From Melanocytic Lesions-Blinded Evaluation of a Series of 42 Pigmented Macules. (PubMed)

Noninvasive RCM for Differentiation of Melanotic Macules From Melanocytic Lesions-Blinded Evaluation of a Series of 42 Pigmented Macules. Differentiation of melanotic macules from melanocytic lesions, most importantly of melanoma, is a common problem on clinical-dermoscopic examination.To assess the value of noninvasive reflectance confocal microscopy (RCM) in the differential diagnosis of melanotic macules and melanocytic lesions.Reflectance confocal microscopy images of 42 pigmented macules (...) on mucocutaneous junctions of genitalia and lips, including 31 melanotic macules, 6 nevi, and 5 melanomas, were retrospectively and independently assessed in a blinded manner by one expert observer and 2 less experienced observers together.The authors differentiated 3 subtypes of melanotic macules; 2 subtypes ("solar lentigo type" and regular subtype of "dendritic type" melanotic macules) could be classified with confidence as benign by all RCM investigators, comprising 64% of melanotic macules. The third

2017 Dermatologic Surgery

2. Dermoscopy of venous lake on the lips: A comparative study with labial melanotic macule. (Full text)

Dermoscopy of venous lake on the lips: A comparative study with labial melanotic macule. Venous lake (VL) is a common vascular tumor occurring on the lips in the elderly. VL is sometimes difficult to distinguish from melanotic lesions such as labial melanotic macule (LMM) or oral malignant melanoma. However, the dermoscopic features of VL have not been sufficiently established in the literature.This study was aimed at investigating the dermoscopic features of VL on the lips, and to compare

2018 PLoS ONE PubMed

3. Independent NF1 mutations underlie café-au-lait macule development in a woman with segmental NF1 (Full text)

Independent NF1 mutations underlie café-au-lait macule development in a woman with segmental NF1 30065955 2018 11 14 2376-7839 4 4 2018 Aug Neurology. Genetics Neurol Genet Independent NF1 mutations underlie café-au-lait macule development in a woman with segmental NF1. e261 10.1212/NXG.0000000000000261 Freret Morgan E ME Department of Neurology (M.E.F., C.A., D.H.G.), Washington University School of Medicine, Saint Louis, MO; and Harvard Medical School (M.E.F.), Boston, MA. Anastasaki Corina

2018 Neurology: Genetics PubMed

4. Dermoscopic “Landscape Painting Patterns” as a Clue for Labial Melanotic Macules: An Analysis of 80 Cases (Full text)

Dermoscopic “Landscape Painting Patterns” as a Clue for Labial Melanotic Macules: An Analysis of 80 Cases Labial melanotic macules (LMMs) are benign pigmented lesions that usually take the shape of flat asymmetrical macules with tan-brown to black color and variable size. Whereas the dermoscopic features of other pigmented skin lesions have been relatively well described, little is known about LMMs.To describe the dermoscopic features and find typical and schematic dermoscopic patterns

2018 Annals of dermatology PubMed

5. Piebaldism with multiple café-au-lait–like hyperpigmented macules and inguinal freckling caused by a novel KIT mutation (Full text)

Piebaldism with multiple café-au-lait–like hyperpigmented macules and inguinal freckling caused by a novel KIT mutation 29693058 2019 02 26 2352-5126 4 4 2018 May JAAD case reports JAAD Case Rep Piebaldism with multiple café-au-lait-like hyperpigmented macules and inguinal freckling caused by a novel KIT mutation. 318-321 10.1016/j.jdcr.2017.10.005 Nagaputra Jerry C JC Dermatology Service, KK Women's & Children's Hospital, Singapore. Koh Mark J A MJA Dermatology Service, KK Women's (...) & Children's Hospital, Singapore. eng Case Reports 2018 03 31 United States JAAD Case Rep 101665210 2352-5126 CALM, café-au-lait macules NF1, neurofibromatosis type 1 TK, tyrosine kinase 2018 4 26 6 0 2018 4 26 6 0 2018 4 26 6 1 epublish 29693058 10.1016/j.jdcr.2017.10.005 S2352-5126(17)30253-9 PMC5911795 Am J Med Genet A. 2012 May;158A(5):1195-9 22438235 Am J Med Genet A. 2003 Oct 1;122A(2):125-32 12955764 J Invest Dermatol. 1993 Jul;101(1):22-5 7687267 Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8696-9

2018 JAAD Case Reports PubMed

6. Reflectance confocal microscopy features of labial melanotic macule: Report of three cases (Full text)

Reflectance confocal microscopy features of labial melanotic macule: Report of three cases 30417063 2019 02 26 2352-5126 4 10 2018 Nov JAAD case reports JAAD Case Rep Reflectance confocal microscopy features of labial melanotic macule: Report of three cases. 1000-1003 10.1016/j.jdcr.2018.07.019 Porto Ana Carolina AC Cutaneous Oncology Department, AC Camargo Cancer Center, Sao Paulo. Fraga-Braghiroli Naiara N Skin and Cancer Associates, Plantation, Florida. Blumetti Tatiana Pinto TP Cutaneous (...) junction LCs, Langerhans cells MML, melanotic macule of the lips RCM, reflectance confocal microscopy dermoscopy labial melanotic macule reflectance confocal microscopy 2018 11 13 6 0 2018 11 13 6 0 2018 11 13 6 1 epublish 30417063 10.1016/j.jdcr.2018.07.019 S2352-5126(18)30200-5 PMC6216092 Br J Dermatol. 2014 Jun;170(6):1276-84 24359328 JAMA Dermatol. 2017 Sep 1;153(9):882-891 28467525 J Am Acad Dermatol. 1993 Jan;28(1):33-9 8425968 Dermatol Surg. 2017 Jul;43(7):911-919 28430732 Anat Cell Biol. 2015

2018 JAAD Case Reports PubMed

7. Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier-Hunziker syndrome (Full text)

Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier-Hunziker syndrome Labial and oral melanotic macules are commonly encountered in a broad range of conditions ranging from physiologic pigmentation to a sign of an underlying life-threatening disease. Although Laugier-Hunziker syndrome (LHS) shares some features of labial and oral pigmentation with a variety of conditions, it is a benign and acquired condition, frequently associated

2018 World journal of clinical cases PubMed

8. A tiny facial pigmented macule: overcoming the diagnostic challenge (Full text)

A tiny facial pigmented macule: overcoming the diagnostic challenge 30479865 2018 12 07 2160-9381 8 4 2018 Oct Dermatology practical & conceptual Dermatol Pract Concept A tiny facial pigmented macule: overcoming the diagnostic challenge. 322-323 10.5826/dpc.0804a15 Stefanis Athanasios J AJ Department of Dermatology, Third Faculty of Medicine, Charles University, Prague, Czech Republic. Apalla Zoe Z First Department of Dermatology, Aristotle University, Thessaloniki, Greece. Papageorgiou

2018 Dermatology practical & conceptual PubMed

9. Antihelix/helix violaceous macules in Japanese patients with anti-melanoma differentiation-associated protein 5 (MDA5) antibody-associated dermatomyositis. (PubMed)

Antihelix/helix violaceous macules in Japanese patients with anti-melanoma differentiation-associated protein 5 (MDA5) antibody-associated dermatomyositis. 30431155 2019 01 01 1365-2133 2018 Nov 15 The British journal of dermatology Br. J. Dermatol. Antihelix/helix violaceous macules in Japanese patients with anti-melanoma differentiation-associated protein 5 (MDA5) antibody-associated dermatomyositis. 10.1111/bjd.17431 Okiyama N N http://orcid.org/0000-0002-5398-0773 University of Tsukuba, 1-1

2018 British Journal of Dermatology

10. Preliminary experience of the Q-switched 1064-nm neodymium:yttrium aluminum garnet laser in the treatment of Café-au-lait macules. (PubMed)

Preliminary experience of the Q-switched 1064-nm neodymium:yttrium aluminum garnet laser in the treatment of Café-au-lait macules. Solitary CALMs are a common finding and they occur in 10-20% of the normal polulation. Although benign, CALMs in exposed parts of the body(face, forearms, neck et al) are cosmetically distressing to patients. Various types of laser devices have been utilized to remove CALMs over the years with high rates of recurrence and adverse events. Based on the theory

2018 Journal of the European Academy of Dermatology and Venereology

11. A Split-Face, Single-Blinded, Randomized Controlled Comparison of Alexandrite 755 nm Picosecond Laser vs. Alexandrite 755 nm Nanosecond Laser in the Treatment of Acquired Bilateral Nevus of Ota-like Macules (ABNOM). (PubMed)

A Split-Face, Single-Blinded, Randomized Controlled Comparison of Alexandrite 755 nm Picosecond Laser vs. Alexandrite 755 nm Nanosecond Laser in the Treatment of Acquired Bilateral Nevus of Ota-like Macules (ABNOM). Q-switched alexandrite lasers (QSALs) have been used for the treatment of acquired bilateral nevus of Ota-like macules (ABNOMs). Currently, picosecond alexandrite laser (PSAL) pulses have become available for pigmentary disorders. However, no studies have compared PSAL and QSAL

2017 Journal of American Academy of Dermatology

12. Folliculotropism in pigmented facial macules: Differential diagnosis with Reflectance confocal microscopy. (PubMed)

Folliculotropism in pigmented facial macules: Differential diagnosis with Reflectance confocal microscopy. Pigmented facial macules are common on sun damage skin. The diagnosis of early stage lentigo maligna (LM) and lentigo maligna melanoma (LMM) is challenging. Reflectance confocal microscopy (RCM) has been proven to increase diagnostic accuracy of facial lesions. A total of 154 pigmented facial macules, retrospectively collected, were evaluated for the presence of already-described RCM

2017 Experimental Dermatology

13. Dysregulation of autophagy in melanocytes contributes to hypopigmented macules in tuberous sclerosis complex. (PubMed)

Dysregulation of autophagy in melanocytes contributes to hypopigmented macules in tuberous sclerosis complex. Tuberous sclerosis complex (TSC) gene mutations lead to constitutive activation of the mammalian target of rapamycin (mTOR) pathway, resulting in a broad range of symptoms. Hypopigmented macules are the earliest sign. Although we have already confirmed that topical rapamycin treatment (an mTOR inhibitor) protects patients with TSC against macular hypopigmentation, the pathogenesis (...) of such lesions remains poorly understood.Recently emerging evidence supports a role for autophagy in skin pigmentation. Herein, we investigated the impact of autophagic dysregulation on TSC-associated hypopigmentation.Skin samples from 10 patients with TSC, each bearing characteristic hypopigmented macules, and 6 healthy donors were subjected to immunohistochemical and electron microscopic analyses. In addition, TSC2-knockdown (KD) was investigated in human epidermal melanocytes by melanin content

2017 Journal of dermatological science

14. The importance of dermoscopy for the diagnosis of acquired bilateral telangiectatic macules: the angioid streak pattern reveals underlying chronic liver disease. (PubMed)

The importance of dermoscopy for the diagnosis of acquired bilateral telangiectatic macules: the angioid streak pattern reveals underlying chronic liver disease. Acquired bilateral telangiectatic macules (ABTM) are a newly recognized disease entity, which manifest as multiple telangiectatic pigmented macules confined mostly to the upper arms.To evaluate clinical and dermoscopic features in a group of 50 patients with ABTM and to determine the diagnostic usefulness of dermoscopy in ABTM.Patients

2017 Journal of the European Academy of Dermatology and Venereology

15. Response to Laser Treatment of Café au Lait Macules Based on Morphologic Features. (Full text)

Response to Laser Treatment of Café au Lait Macules Based on Morphologic Features. Response to laser treatment for café au lait macules (CALMs) is inconsistent and difficult to predict.To test the hypothesis that irregularly bordered CALMs of the "coast of Maine" subtype respond better to treatment than those of the smooth-bordered "coast of California" subtype.This retrospective case series included patients from 2 multiple-clinician US practices treated from 2005 through 2016. All patients

2017 JAMA dermatology (Chicago, Ill.) PubMed

16. Histopathologic and Immunohistochemical Correlates of Confocal Descriptors in Pigmented Facial Macules on Photodamaged Skin. (Full text)

Histopathologic and Immunohistochemical Correlates of Confocal Descriptors in Pigmented Facial Macules on Photodamaged Skin. Pigmented facial macules on photodamaged skin are a clinical, dermoscopic, and histopathologic challenge.To clinically and dermoscopically characterize, by means of reflectance confocal microscopy (RCM), ambiguous pigmented facial macules and establish a correlation between RCM, histopathologic, and immunohistochemical findings.A prospective study of ambiguous pigmented (...) facial macules on photodamaged skin was conducted in a tertiary referral center for dermatology between January 1, 2009, and December 31, 2015. Sixty-one patients with 63 ambiguous pigmented facial macules and 12 control photodamaged facial areas were included in the study. Melanocyte density in 1-mm basal layers was determined in skin biopsy specimens from all lesions stained with hematoxylin-eosin and immunohistochemical markers (melan-A, microphthalmia-associated transcription factor, and SRY

2017 JAMA dermatology (Chicago, Ill.) PubMed

17. In Vivo Reflectance Confocal Microscopy for the Diagnosis of Melanoma and Melanotic Macules of the Lip. (Full text)

In Vivo Reflectance Confocal Microscopy for the Diagnosis of Melanoma and Melanotic Macules of the Lip. Benign melanotic macules (MAC) are the most frequent cause of lip pigmentation and sometimes difficult to differentiate from lip melanoma (MEL).To report in vivo reflectance confocal microscopy (RCM) features of normal lips of different phototypes and to identify features that assist in distinguishing MEL from MAC using dermoscopy and RCM.For this retrospective observational study, 2 groups

2017 JAMA dermatology (Chicago, Ill.) PubMed

18. Intravenous immunoglobulin contributes to control anti-melanoma differentiation-associated protein 5 (MDA5) antibody-associated dermatomyositis with palmar violaceous macules/papules. (PubMed)

Intravenous immunoglobulin contributes to control anti-melanoma differentiation-associated protein 5 (MDA5) antibody-associated dermatomyositis with palmar violaceous macules/papules. Autoantibodies to melanoma differentiation-associated protein 5 (MDA5) are associated with a subset of patients with dermatomyositis (DM) who have rapidly progressive interstitial lung disease (RP-ILD) with poor prognosis. Intensive immunosuppressive therapy is initiated before irreversible lung damage can occur (...) to the control of the disease activity of anti-MDA5 antibody-positive DM. Moreover, palmar violaceous macules/papules around the interphalangeal joints, which was observed in all three cases in the incipient stage, might be a useful sign in suggesting a diagnosis of anti-MDA5 antibody-associated DM.© 2017 British Association of Dermatologists.

2017 British Journal of Dermatology

19. Predicting neurofibromatosis type 1 risk among children with isolated café-au-lait macules. (PubMed)

Predicting neurofibromatosis type 1 risk among children with isolated café-au-lait macules. Although isolated cafe-au-lait macules (CALMs) are a common skin finding, they are an early feature of neurofibromatosis type 1 (NF1).We sought to develop an algorithm determining the risk of children with CALMs to have constitutional NF1.We conducted a retrospective study of patients with isolated CALMs. Diagnosis of NF1 was based on detecting NF1 mutation in blood or fulfilling clinical criteria.In all (...) , 170 of 419 (41%) and 21 of 86 (24%) children with isolated CALMs who underwent molecular testing and clinical follow-up, respectively, were given a diagnosis of NF1. Presence of fewer than 6 CALMs at presentation or atypical CALMs was associated with not having NF1 (P < .001). An algorithm based on age, CALMs number, and presence of atypical macules predicted NF1 in both cohorts. According to the algorithm, children older than 29 months with at least 1 atypical CALM or less than 6 CALMs have a 0.9

2017 Journal of American Academy of Dermatology

20. Familial gastrointestinal stromal tumors, lentigines, and café-au-lait macules associated with germline c-kit mutation treated with imatinib. (PubMed)

Familial gastrointestinal stromal tumors, lentigines, and café-au-lait macules associated with germline c-kit mutation treated with imatinib. Familial lentiginosis syndromes are characterized by a wide array of manifestations resulting from activation of molecular pathways which control growth, proliferation, and differentiation of a broad range of tissues. Familial gastrointestinal stromal tumors (GISTs) are often accompanied by additional features like hyperpigmentation, mastocytosis (...) , and dysphagia. They have been described with mutations in c-kit (most commonly), platelet-derived growth factor receptor A, neurofibromatosis-1, and succinate dehydrogenase genes.We report on molecular characterization and tumor histopathology of two siblings in whom lentigines and café-au-lait macules were present along with multifocal GIST. Immuhistochemical analysis of CD34 and CD117 was performed on GIST biopsy samples from both siblings, while c-kit mutational analysis was done by PCR and direct

2017 International Journal of Dermatology

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>