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MRI with MRA in abdominal aortic aneurysm

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101. Portal Hypertension

-recalled echo MRI, but these techniques cannot demonstrate the direction of portal flow. Time-of-flight MRI with bolus tracking has been found to be successful in imaging portal hypertension and its sequelae. Phase-contrast sequences may be used to evaluate the portal vein, and phase-contrast cine MRA may show the direction of portal venous flow and the presence of portal vein thrombus. MRI evaluation of the portal venous system is accurate in demonstrating thrombosis and collateral circulation (...) dimeglumine [Magnevist], gadobenate dimeglumine [MultiHance], gadodiamide [Omniscan], gadoversetamide [OptiMARK], gadoteridol [ProHance]) have been linked to the development of nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy (NFD). The disease has occurred in patients with moderate to end-stage renal disease after being given a gadolinium-based contrast agent to enhance MRI or MRA scans. NSF/NFD is a debilitating and sometimes fatal disease. Characteristics include red or dark

2014 eMedicine Radiology

102. Renal Artery Stenosis/Renovascular Hypertension

is fast becoming a clinical standard for the safe and noninvasive detection of RAS, aneurysms, and occlusions. [ ] A comprehensive examination includes 3D dynamic gadolinium-enhanced and 3D phase-contrast MRA techniques, which allow an evaluation of the renal arteries and other visceral arteries. The 3D phase-contrast technique is flow based and subject to dephasing in the presence of significant arterial stenosis. The 3D gadolinium-enhanced MRA method produces excellent contrast angiograms without (...) . [ , , ] Gadolinium-based contrast agents (gadopentetate dimeglumine [Magnevist], gadobenate dimeglumine [MultiHance], gadodiamide [Omniscan], gadoversetamide [OptiMARK], gadoteridol [ProHance]) have recently been linked to the development of nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy (NFD). The disease has occurred in patients with moderate to end-stage renal disease after being given a gadolinium-based contrast agent to enhance MRI or MRA scans. As of late December 2006, the FDA had

2014 eMedicine Radiology

103. Pulmonary Angiography

airway disease ( , , ), congenital pulmonary disease (absent lung), vasculitis, vascular compression (pulmonary fibrosis, benign and malignant neoplasms, aortic aneurysm/dissection), and altered pulmonary circulation (absence or hypoplasia of the pulmonary artery, bronchopulmonary sequestration, , mitral valvular disease). Previous Next: Digital Subtraction Pulmonary Angiography Digital subtraction pulmonary angiography (DSPA) is the criterion standard or definitive test in evaluating diseases (...) to the development of nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy (NFD). The disease has occurred in patients with moderate to end-stage renal disease after being given a gadolinium-based contrast agent to enhance MRI or MRA scans. NSF/NFD is a debilitating and sometimes fatal disease. Characteristics include red or dark patches on the skin; burning, itching, swelling, hardening, and tightening of the skin; yellow spots on the whites of the eyes; joint stiffness with trouble moving

2014 eMedicine Radiology

104. Non-Hodgkin Lymphoma, Thoracic

and its multiplanar capability make MRI an excellent modality in the initial diagnosis of a mediastinal mass and in its follow-up after treatment. The vascular images provided are superior to CT scans and can better delineate the relationship of an identified mediastinal mass to adjacent intrathoracic vascular structures. MRI can be used to differentiate a suspected mediastinal mass and a vascular abnormality, such as an aortic aneurysm. MRI contrast agents can be used when iodinated contrast (...) and major blood vessels. However, angiography is being challenged by magnetic resonance angiography (MRA) and CTA. Lymphomatous deposits may be hypovascular. In rare cases, false-negative results may also occur in the differentiation of aneurysms associated with laminar intraluminal thrombus from other mediastinal masses. The sensitivity and specificity of angiography in the diagnosis of aortic aneurysms are 85% and 95%, respectively. Previous Next: Questions & Answers Overview Previous References Bligh

2014 eMedicine Radiology

105. Takayasu Arteritis (Overview)

or aneurysm formation are found on angiography or magnetic resonance angiography (MRA). Vascular insufficiency related to stenosis and thrombosis of affected vessels may cause renovascular hypertension, neurologic symptoms, or lower extremity claudications. (See Workup.) Cardiac involvement may include aortic regurgitation and resulting from myocarditis or increased afterload. Aortic root dilatation contributes to the aortic regurgitation. Often, the diagnosis of Takayasu arteritis is made when a widened (...) of the disease. Although 5-year survival rates exceed 90%, the disease has a high incidence of residual morbidity. (See Prognosis, Presentation, and Workup.) Complications Complications of Takayasu arteritis include the following: Congestive heart failure due to aortic insufficiency, myocarditis, and/or hypertension Aortic aneurysms, thrombus formation, and rupture Ischemic stroke Myocardial infarction Hypertension Clinically silent progressive disease (despite normal acute phase reactants) Morbidity

2014 eMedicine Pediatrics

106. Syncope (Overview)

mass, effusion, or widened mediastinum Computed tomography (CT) of the head (noncontrast) - Has a low diagnostic yield in syncope but may be clinically indicated in patients with new neurologic deficits or in patients with head trauma secondary to syncope CT of the chest and abdomen - Indicated only in select cases (eg, suspected aortic dissection, ruptured abdominal aortic aneurysm, or pulmonary embolism [PE]) Magnetic resonance imaging (MRI) of the brain and magnetic resonance arteriography (MRA (...) a history of cardiac problems and are symptomatic. Chest pain, dyspnea, decreased exercise tolerance, and fatigue may all be present. Consider cardiac ischemia and medication side effects as additional causes. Cardiac outflow obstruction may also result in sudden-onset syncope with little or no prodrome. One critical clue is the exertional nature, and the other is the presence of a cardiac murmur. Young athletes may present with this etiology for syncope. Specific pathology includes aortic stenosis

2014 eMedicine Pediatrics

107. Syncope (Overview)

mass, effusion, or widened mediastinum Computed tomography (CT) of the head (noncontrast) - Has a low diagnostic yield in syncope but may be clinically indicated in patients with new neurologic deficits or in patients with head trauma secondary to syncope CT of the chest and abdomen - Indicated only in select cases (eg, suspected aortic dissection, ruptured abdominal aortic aneurysm, or pulmonary embolism [PE]) Magnetic resonance imaging (MRI) of the brain and magnetic resonance arteriography (MRA (...) a history of cardiac problems and are symptomatic. Chest pain, dyspnea, decreased exercise tolerance, and fatigue may all be present. Consider cardiac ischemia and medication side effects as additional causes. Cardiac outflow obstruction may also result in sudden-onset syncope with little or no prodrome. One critical clue is the exertional nature, and the other is the presence of a cardiac murmur. Young athletes may present with this etiology for syncope. Specific pathology includes aortic stenosis

2014 eMedicine Emergency Medicine

108. Teriflunomide

component assessing a different function Medical Outcome Study SF-36-a self-administered quality of life scaleEuroQoL EQ-5D-another patient-rated quality of life scale Other secondary imaging measures MRI variables: Burden of Disease (BOD), defined as the total volume of abnormal brain tissue, further defined as the sum of the T2 lesion load and the T1 hypointense lesion component. Volume of post-gadolinium T 1 hypointense black holes Total number of gadolinium enhanced T1 lesions Total volume (...) at alpha 0.025, only if the proceeding contrast was significant at 0.025 (presumably independent of dose): 1) Change from baseline in total FIS at week 108 2) Total number of gadolinium enhancing T1 lesions/scan over the treatment period 3) Change from baseline in MRI BOD at Week 108 Reference ID: 3185084 4 Results The trial was conducted at 126 sites in 21 countries. For some analyses, countries were grouped into regions; Americas (23%), Eastern Europe (31%), and Western Europe (46%). The greatest

2012 FDA - Drug Approval Package

109. Glybera - alipogene tiparvovec

results in chylomicronemia and hence in extremely high levels of circulating triglyceride-rich lipoproteins. LPLD patients usually present with fasting plasma triglyceride values >11 mmol/l (1000 mg/dL) and those levels may exceed 113 mmol/l (10,000 mg/dL). Fasting triglyceride values of normal individuals range between 1 and 2.3 mmol/l. The disease may present in infancy or childhood with severe abdominal pain, repetitive colicky pains, repeated episodes of pancreatitis, and often failure to thrive (...) and packaging of the finished product were provided. Certain quality control tests are contracted out to appropriate third party contract laboratories to perform. All relevant sites underwent GMP inspections by EEA/MRA authorities with a satisfactory outcome within the last 3 years. Hence, no GMP inspections deem necessary within the scope of this MAA evaluation procedure. Manufacturing licenses and/or GMP certifications are provided. Manufacture, process control and validation The process is relatively

2012 European Medicines Agency - EPARs

110. Reporting Standards for Carotid Artery Angioplasty and Stent Placement

prospective study ex- amining 17 patients with diffusion- weighted MRI showed new (clinically silent) lesions in 3 cases (141,142). The problem of distal embolization during balloon angioplasty and ca- rotid stenting has increased interest in providing methods of cerebral protec- tion. A triple-coaxial catheter system, designed to provide cerebral protec- tion, has been described by Theron et al (143). Theron et al reported distal embolic complications in 3 of 38 pa- tients (8%) undergoing internal ca

2009 Society of Interventional Radiology

111. Autosomal Dominant Polycystic Kidney Disease

of regional structures symptoms VI. Signs With advanced renal or hepatic disease, cyst-related mass effect may be palpable VII. Labs test monitoring tic screening indications Not routinely indicated Young, at risk asymptomatic patients with normal screening Large s with s and no known of ADPKD transplant potential donor who is at risk of ADPKD VIII. Imaging First-Line Renal (effective, lower cost, no radiation) Alternative screening (if non-diagnostic or large body habitus) Abdominal MRI IX. Diagnosis (...) criteria for those at risk of ADPKD Type 1 Age <30 years: 2 or more cysts in one or both s Age 30 to 59 years: 2 or more cysts in each s Age >60 years: 4 or more cysts in each s criteria for those at risk of ADPKD with unknown Age 15 to 39 years: 2 or more cysts in one or both s Age 40 to 59 years: 2 or more cysts in each s Age >60 years: 4 or more cysts in each s MRI criteria for those at risk of ADPKD Age <30 years: 5 or more cysts in each s Age 30 to 44 years: 6 or more cysts in each s Age 45 to 59

2015 FP Notebook

112. New Heart Imaging Techniques to Evaluate Possible Heart Disease

and blood vessels. Participants may also have a computed tomography scan to confirm the findings of an MRI scan. No treatment will be provided as part of this protocol. Condition or disease Healthy Obesity Diabetes Arteriosclerosis Healthy Volunteers Detailed Description: Specialized imaging techniques now available allow a unique opportunity to characterize the micro-environment of the human body. Magnetic Resonance (MR) vascular wall imaging and angiography (MRA) are developing techniques that permit (...) of arterial structural, distensibility, and endothelial functional disorders associated with atherosclerosis in a cohort of patients with known or suspected coronary atherosclerosis. Results from accelerated high-resolution MRA will be correlated with corresponding Computerized Tomography Coronary Angiogram (CTA) results. The third aim of this protocol is to develop, implement, and optimize new non-invasive methods for characterization of the micro-environment in the thoracic and abdominal area utilizing

2011 Clinical Trials

113. The Effect of Renal Denervation on Biological Variables

and/or effectiveness of the participant or the study (i.e., patients with clinically significant peripheral vascular disease, abdominal aortic aneurysm, bleeding disorders such as thrombocytopenia, haemophilia, or significant anaemia, or arrhythmias such as atrial fibrillation). Individual is pregnant, nursing or planning to be pregnant. Individual has a known, unresolved history of drug use or alcohol dependency, lacks the ability to comprehend or follow instructions, or would be unlikely or unable to comply (...) : The objectives of this study are: the investigation of changes in left ventricular mass (LV mass) after RD using MRI, renal perfusion and renal oxygenation after RD using dynamic contrast enhanced MRI (DCE MRI)and blood oxygenation level dependent MRI (BOLD MRI), the evaluation of safety of RD, in terms of structural changes in the renal arteries and kidney using Magnetic resonance angiography (MRA). Secondly the evaluation of changes in various biological functions assessed by analysis of blood and/or urine

2011 Clinical Trials

114. Ischemic Stroke

Video How to do the Motor Examination SOCIAL MEDIA Add to Any Platform Loading Topic Resources Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). Common causes are (from most to least common) atherothrombotic occlusion of large arteries; cerebral embolism (embolic infarction); nonthrombotic occlusion of small, deep cerebral arteries (lacunar infarction); and proximal (...) arterial stenosis with hypotension that decreases cerebral blood flow in arterial watershed zones (hemodynamic stroke). Diagnosis is clinical, but CT or MRI is done to exclude hemorrhage and confirm the presence and extent of stroke. Thrombolytic therapy may be useful acutely in certain patients. Depending on the cause of stroke, carotid endarterectomy or stenting, antiplatelet drugs, or warfarin may help reduce risk of subsequent strokes. Etiology The following are the modifiable risk factors

2013 Merck Manual (19th Edition)

115. Endurant Bifurcated and Aorto-Uni-Iliac (AUI) Stent Graft System

requirements. Subject is a suitable candidate for elective surgical repair of AAA by as evaluated by American Society of Anesthesiologists (ASA) Physical Status Classification System I, II, III, or IV Subject has an abdominal aortic or aortoiliac aneurysm characteristics that meet protocol parameter Subject meets all the protocol anatomical criteria* as demonstrated on contrast-enhanced CT or MRA Subject has vascular dimensions in the range of sizes available for the Endurant Stent Graft Subject has (...) Party): Medtronic Endovascular Study Details Study Description Go to Brief Summary: To demonstrate safety and effectiveness of the Endurant Stent Graft in the treatment of Abdominal Aortic or Aorto-Uni-Iliac Aneurysms. Condition or disease Intervention/treatment Phase Abdominal Aortic Aneurysms Device: Endurant Stent Graft System Not Applicable Detailed Description: Prospective, two-arm, non-randomized, multicenter clinical study enrolling subjects treated with the bifurcated stent graft in one arm

2008 Clinical Trials

116. A Study to Evaluate the Effects of the Neuroflo Device in People Who Have Had a Stroke

, or diastolic (BP) >140 mm Hg that cannot be lowered with medical management Any use of intravenous or intra-arterial thrombolytic medication Known secured or unsecured cerebral aneurysm or vascular malformation on CTA or MRA or history thereof Imaging evidence of current intracranial bleeding History of intracerebral hemorrhage Any aortic or femoral endovascular graft Aortic surgery within 6 weeks prior to the time of enrollment Known heparin sensitivity or allergy Participation in another therapeutic (...) count < 100,000 Creatinine > 1.5 times local laboratory standard Patients with cerebral arterial perforation or dissection due to attempted thrombectomy Patients with complications of femoral artery cannulation Patients with aortic diameter greater than 28 mm or smaller than 11 mm in diameter measured within 6 cm above and below the midpoint of the renal ostia (for 7Fr NeuroFlo Device) Evidence of aortic aneurysm High-grade iliac stenosis or vascular tortuosity that could prevent safe delivery

2008 Clinical Trials

117. Autosomal Dominant Polycystic Kidney Disease

renal function or blood pressure. Aneurysms can also occur elsewhere in the vascular tree (eg, thoracic aorta, cervicocephalic artery, coronary artery) and may cause dissections. Cardiac abnormalities are also reasonably common: mitral valve prolapse is found in up to 25% and aortic insufficiency can occur with aortic root dilatation. Screening [ ] ADPKD commences in utero but there may be several decades before symptoms or signs of disease emerge. Screening offers a means of detecting asymptomatic (...) will depend on the distribution and size of cysts (eg, percutaneous cyst aspiration, laparoscopic cyst fenestration, liver resection or liver transplant). Intracranial aneurysms [ ] Magnetic resonance angiography (MRA) is used to detect aneurysms in patients with ADPKD where there is: A family history of aneurysm or stroke. Previous aneurysm rupture. New-onset headache or other relevant CNS sign or symptom. Preparation for major surgery. High-risk occupation (eg, airline pilot). Routine screening

2008 Mentor

118. Follow-up of Endovascular Aneurysm Treatment

Division, UMC Utrecht Study Details Study Description Go to Brief Summary: After endovascular abdominal aortic aneurysm repair, life-long follow-up is needed to monitor the effectiveness of exclusion of the aneurysm sac from blood flow. For this reason, aneurysm diameter and the presence of endoleaks is evaluated with CT angiography yearly after Endovascular Aneurysm Repair (EVAR). The aim of this study is to investigate the value of MRA examinations for the follow-up of these patients. The advantages (...) of MRA with respect to CTA are no use of ionizing radiation, use of less nephrotoxic contrast agents. Condition or disease Intervention/treatment Aortic Aneurysm, Abdominal Procedure: Computed Tomography Angiography Procedure: Magnetic Resonance Angiography Detailed Description: The FEAT trial (Follow-up of Endovascular Aneurysm Treatment) is designed as a prospective, single-center, follow-up study. 100 Patients will be enrolled in this study. These patients will undergo additional MRA-examinations

2006 Clinical Trials

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