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Lymphoid Hyperplasia

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122. Lymphangioleiomyomatosis Diagnosis and Management Part II: An Official ATS/JRS Clinical Practice Guideline

were blinded to clinical and histopathological information. Clinicians included thoracic radiologists (7–9),pulmonologists(9),and pulmonary fellows (9). Diseases included LAM (7–9), pulmonary Langerhans cell histiocytosis (7–9), emphysema (7–9), usual interstitial pneumonia (8), lymphoid interstitial pneumonia (8, 9), desquamative interstitial pneumonia (8), Birt-Hogg-Dub´ e syndrome (9), amyloidosis (9), hypersensitivity pneumonitis (9), nonspeci?c Table 3. Interpretation of Strong and Conditional (...) , relatively uniform, thin-walled cysts in a diffuse distribution. The intervening lung parenchyma often appears normal on HRCT. Other associated features that can be seen on HRCT in some patients with LAM include the presence of: chylous pleural effusion, pneumothorax,ground-glassopacitysuggestiveofchylouscongestion,or multipletinynodulescharacteristicofmultifocalmicronodularpneumocyte hyperplasia (in patients with TSC-LAM). 3 Referral to a TSC center should be considered if there is uncertainty regarding

2017 American Thoracic Society

123. Review of Prader-Willi syndrome: the endocrine approach Full Text available with Trip Pro

therapy until a sleep study can urgently be performed. Lymphoid hyperplasia may theoretically develop due to GH treatment and supra-physiologic IGF-1 levels ( ). Expert opinion recommends maintaining IGF-1 in the upper range of normal for appropriate reference ranges, and titrating GH dose based on IGF-1 levels ( ). Algorithm for growth hormone treatment in PWS. PSG, polysomnography; SDB, sleep disordered breathing; ENT, otolaryngology; T&A, tonsillectomy and adenoidectomy; SCFE, slipped capital

2017 Pediatric Endocrine Society

124. Lymphoma

Lymphomas associated with primary immune disorders Post-transplant lymphoproliferative disorders (PTLD) o Plasmacytic hyperplasia and infectious mononucleosis-like PTLD o Polymorphic PTLD o Monomorphic PTLD o Classical Hodgkin-type PTLD Other iatrogenic immunodeficiency-associated lymphomas T lymphoblastic leukemia/lymphoma Adult T-cell leukemia/lymphoma (ATLL) T prolymphocytic leukemia CLINICAL PRACTICE GUIDELINE LYHE-002 Version 11 I. Diagnosis and Pathologic Classification Page 3 of 5 Required (...) Immunohistochemical and Ancillary Testing for Lymphoma In general, guidelines for using the various ancillary methods, includingimmunohistochemical and fluorescence in situ hybridization (FISH) testing as outlined in the most recent version of the World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues should be followed so as to confirm a specific diagnosis and provide necessary prognostic and/or predictive information. 6 In addition, the following are recommended

2016 CPG Infobase

128. Odefsey (emtricitabine / rilpivirine / tenofovir alafenamide) - HIV-1

Page 25/120 Figure 1. Intracellular Activation of TAF in Lymphoid Cells and Tissues Cat A = cathepsin A; NDP = nucleoside diphosphate; RT = reverse transcriptase; TAF = tenofovir alafenamide; TFV = tenofovir Figure 2. Intracellular TAF Metabolites in CD4+ T cells and Monocyte-derived Macrophages from Different Donors D= Donor; TAF = tenofovir alafenamide; TFV = tenofovir; TFV-MP = tenofovir monophosphate; TFV-DP = tenofovir diphosphate Following incubation for 4 hours with 1µM TAF, the formation

2016 European Medicines Agency - EPARs

129. Lonsurf (trifluridine / tipiracil) - adult patients with metastatic colorectal cancer (CRC)

lymphoid atrophy 1000: dark areas of stomach, gastritis, gastric mucosal hemorrhage, mixed cell infiltration in gall bladder, lymphoid hyperplasia of mesenteric lymph node and infiltration of foamy macrophages with lymphoid atrophy of spleen cells Genotoxicity TAS-102 and FTD scored positive in all three pivotal genotoxicity assays, with and without metabolic activation and are therefore considered genotoxic. TPI scored negative in all three pivotal genotoxicity assays, with or without metabolic (...) in the gastrointestinal tract, hypocellularity of bone marrow, lymphoid atrophy of the thymus, spleen, lymph nodes and intestines ? =50: Mortality (50: 1M, 150: 1M), activity ?, cold to touch, tremors, weakness, red blood cell count, haemoglobin and haematocrit ?, raised, dark, firm areas and hemorrhagic pneumonia in lungs ? 87936 GLP Monkey M+F/3 0, 1.9, 7.5, 30, 120 Oral gavage 2 weeks 1.9 =7.5: white blood cell and lymphocyte count ?, =30: Liquid/soft feces ? (F), salivation ?, Typhlitis, colitis, villous atrophy

2016 European Medicines Agency - EPARs

130. Common Variable Immunodeficiency-Associated Inflammatory Enteropathy: The New Era of Biological Therapy Full Text available with Trip Pro

, with multiple visits to the emergency department due to abdominal pain in the lower quadrants and diarrhea. Her biochemical analysis showed elevated inflammatory parameters. Stool cultures and parasitological examination of feces were negative. Ileocolonoscopy revealed lymphoid nodular hyperplasia of the terminal ileum, and the small bowel capsule endoscopy demonstrated edema and multiple pleomorphic ulcers (Lewis score = 1,104). CVID-associated inflammatory enteropathy was suspected. Budesonide 9 mg/day

2018 GE Portuguese journal of gastroenterology

132. Entresto - sacubitril / valsartan

. Thymus lymphoid depletion / involution was observed in rats and monkeys treated with LCZ696 and in one rat study with sacubitril. Otherwise, no effects affecting the immune system were observed. Known effects of valsartan in the repeated dose studies were juxtaglomerular cell hypertrophy / hyperplasia in the kidney, increased BUN and reductions in red blood cell parameters. Genotoxicity No evidence of genotoxicity was found in an extensive package of tests in which both LCZ696 and sacubitril were (...) dilatation in stomach and duodenum was observed in marmosets, hyperplasia and/or hyperkeratosis in the stomach were observed in marmosets and rats and stomach ulceration at high dose in one rat study. Both LCZ696 and sacubitril induced diarrhoea and emesis in monkeys and abdominal distention in rats and mice. In several rodents, labored respiration was observed which seemed to correlate with abdominal distention. Gastro-intestinal irritation may be an effect of NEP inhibition, but it is likely that also

2015 European Medicines Agency - EPARs

133. Lenvima - lenvatinib

hyperplasia, submucosal edema and decreased goblet cells), submaxillary glands (acinar hypertrophy), thymus (atrophy), heart (adventitial thickening of arterioles), liver (Kupffer cell hypertrophy or hyperplasia and pigmentation of periportal hepatocytes), common bile duct (cholangitis), pancreas (pancreatitis, fatty necrosis and decreased zymogen granules), and spleen (trabecular mineralization and lymphoid depletion) were considered to be secondary effects of the pharmacology-related changes (...) ( ? thickness of epiphysial growth plate and cartilage), kidney (glomerulopathy), ovary (follicular atresia), liver (sinusoidal dilatation), brain (changes in blood vessels of choroid plexus), incisor (dysplasia), testes (hypocellularity of seminiferous epithelium), adrenal gland (sinusoidal dilatation and cortical necrosis), stomach (mucosal hyperplasia), small intestine (duodenal gland inflammation) 2 mg/kg: less severe changes in incisors, ovaries and submaxillary glands EMA/250082/2015 Page 34/169 SD

2015 European Medicines Agency - EPARs

134. Farydak - panobinostat

adipocytes (1f, 1m), mild haemodilution (2f), lymphoid atrophy and depletion spleen mand. LN & PP, granulocytic aplasia & hyperplasia, haematopoiesis spleen, hyperostosis, ? # females in oestrus part of cycle @ 5 wks of treatment : ? of Hb, RBC, Hct, MCH, MCV, WBC, L, N, M, Eos, B, LUC and Plat, ? CKMB (m also @ 5days )@ 14 wks : ? MCHC, ? Hb. ? Lymp, ? Neut,, ? EOS (m), ? plat (f), ? K (m), ? Phos., ? T. Bi (m), ?AST, ? Urea, @11 wks : ? rT3 (dose rel. not sign.) ? rT4 (m, sign. & f ), @ 13 wks ? U-vol (...) + 6/sex for control and high dose for recovery 0, 3, 10, 30 Oral gavage (Mon. Wed. Fri.) 4 wks + 4 wks rec. NOAEL could not be determined =3 ? thyroid w =10 ? platelets (m), ? spleen (f), cyt. vacuolation in the follicular epithelium (3m) =30 ? BW gain (f) d22-d29, ? WBC, lymphocytes and platelets, ? reticulocytes (f), ? RBC and RBC corpus Hgb (f), ? P (m), ? total protein ? thymus, ? pituary gland (m), small thymus (2f, 2m), ? min. to slight extramedullary hematopoiesis (f) + lymphoid content

2015 European Medicines Agency - EPARs

137. Zontivity - vorapaxar

and with the exception of phospholipodosis (all species), seem to be species specific (rat retinal vacuolation) and reversible. The main histopathology findings include urinary bladder and ureter hyperplasia in mice, hepatic vascular thrombi, lymphoid necrosis and retinal vacuolation in rats and phospholipidosis in all species. The phospholipidosis was observed in mice and monkeys at exposures up to 398-times and 214-times the human steady-state exposure at 2.5 mg/day. The NOAEL for this finding in rats, a species

2015 European Medicines Agency - EPARs

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