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Lymphoid Hyperplasia

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124. Odefsey (emtricitabine / rilpivirine / tenofovir alafenamide) - HIV-1

Page 25/120 Figure 1. Intracellular Activation of TAF in Lymphoid Cells and Tissues Cat A = cathepsin A; NDP = nucleoside diphosphate; RT = reverse transcriptase; TAF = tenofovir alafenamide; TFV = tenofovir Figure 2. Intracellular TAF Metabolites in CD4+ T cells and Monocyte-derived Macrophages from Different Donors D= Donor; TAF = tenofovir alafenamide; TFV = tenofovir; TFV-MP = tenofovir monophosphate; TFV-DP = tenofovir diphosphate Following incubation for 4 hours with 1µM TAF, the formation

2016 European Medicines Agency - EPARs

125. Lonsurf (trifluridine / tipiracil) - adult patients with metastatic colorectal cancer (CRC)

lymphoid atrophy 1000: dark areas of stomach, gastritis, gastric mucosal hemorrhage, mixed cell infiltration in gall bladder, lymphoid hyperplasia of mesenteric lymph node and infiltration of foamy macrophages with lymphoid atrophy of spleen cells Genotoxicity TAS-102 and FTD scored positive in all three pivotal genotoxicity assays, with and without metabolic activation and are therefore considered genotoxic. TPI scored negative in all three pivotal genotoxicity assays, with or without metabolic (...) in the gastrointestinal tract, hypocellularity of bone marrow, lymphoid atrophy of the thymus, spleen, lymph nodes and intestines ? =50: Mortality (50: 1M, 150: 1M), activity ?, cold to touch, tremors, weakness, red blood cell count, haemoglobin and haematocrit ?, raised, dark, firm areas and hemorrhagic pneumonia in lungs ? 87936 GLP Monkey M+F/3 0, 1.9, 7.5, 30, 120 Oral gavage 2 weeks 1.9 =7.5: white blood cell and lymphocyte count ?, =30: Liquid/soft feces ? (F), salivation ?, Typhlitis, colitis, villous atrophy

2016 European Medicines Agency - EPARs

126. Common Variable Immunodeficiency-Associated Inflammatory Enteropathy: The New Era of Biological Therapy Full Text available with Trip Pro

, with multiple visits to the emergency department due to abdominal pain in the lower quadrants and diarrhea. Her biochemical analysis showed elevated inflammatory parameters. Stool cultures and parasitological examination of feces were negative. Ileocolonoscopy revealed lymphoid nodular hyperplasia of the terminal ileum, and the small bowel capsule endoscopy demonstrated edema and multiple pleomorphic ulcers (Lewis score = 1,104). CVID-associated inflammatory enteropathy was suspected. Budesonide 9 mg/day

2018 GE Portuguese journal of gastroenterology

128. Entresto - sacubitril / valsartan

. Thymus lymphoid depletion / involution was observed in rats and monkeys treated with LCZ696 and in one rat study with sacubitril. Otherwise, no effects affecting the immune system were observed. Known effects of valsartan in the repeated dose studies were juxtaglomerular cell hypertrophy / hyperplasia in the kidney, increased BUN and reductions in red blood cell parameters. Genotoxicity No evidence of genotoxicity was found in an extensive package of tests in which both LCZ696 and sacubitril were (...) dilatation in stomach and duodenum was observed in marmosets, hyperplasia and/or hyperkeratosis in the stomach were observed in marmosets and rats and stomach ulceration at high dose in one rat study. Both LCZ696 and sacubitril induced diarrhoea and emesis in monkeys and abdominal distention in rats and mice. In several rodents, labored respiration was observed which seemed to correlate with abdominal distention. Gastro-intestinal irritation may be an effect of NEP inhibition, but it is likely that also

2015 European Medicines Agency - EPARs

129. Lenvima - lenvatinib

hyperplasia, submucosal edema and decreased goblet cells), submaxillary glands (acinar hypertrophy), thymus (atrophy), heart (adventitial thickening of arterioles), liver (Kupffer cell hypertrophy or hyperplasia and pigmentation of periportal hepatocytes), common bile duct (cholangitis), pancreas (pancreatitis, fatty necrosis and decreased zymogen granules), and spleen (trabecular mineralization and lymphoid depletion) were considered to be secondary effects of the pharmacology-related changes (...) ( ? thickness of epiphysial growth plate and cartilage), kidney (glomerulopathy), ovary (follicular atresia), liver (sinusoidal dilatation), brain (changes in blood vessels of choroid plexus), incisor (dysplasia), testes (hypocellularity of seminiferous epithelium), adrenal gland (sinusoidal dilatation and cortical necrosis), stomach (mucosal hyperplasia), small intestine (duodenal gland inflammation) 2 mg/kg: less severe changes in incisors, ovaries and submaxillary glands EMA/250082/2015 Page 34/169 SD

2015 European Medicines Agency - EPARs

130. Farydak - panobinostat

adipocytes (1f, 1m), mild haemodilution (2f), lymphoid atrophy and depletion spleen mand. LN & PP, granulocytic aplasia & hyperplasia, haematopoiesis spleen, hyperostosis, ? # females in oestrus part of cycle @ 5 wks of treatment : ? of Hb, RBC, Hct, MCH, MCV, WBC, L, N, M, Eos, B, LUC and Plat, ? CKMB (m also @ 5days )@ 14 wks : ? MCHC, ? Hb. ? Lymp, ? Neut,, ? EOS (m), ? plat (f), ? K (m), ? Phos., ? T. Bi (m), ?AST, ? Urea, @11 wks : ? rT3 (dose rel. not sign.) ? rT4 (m, sign. & f ), @ 13 wks ? U-vol (...) + 6/sex for control and high dose for recovery 0, 3, 10, 30 Oral gavage (Mon. Wed. Fri.) 4 wks + 4 wks rec. NOAEL could not be determined =3 ? thyroid w =10 ? platelets (m), ? spleen (f), cyt. vacuolation in the follicular epithelium (3m) =30 ? BW gain (f) d22-d29, ? WBC, lymphocytes and platelets, ? reticulocytes (f), ? RBC and RBC corpus Hgb (f), ? P (m), ? total protein ? thymus, ? pituary gland (m), small thymus (2f, 2m), ? min. to slight extramedullary hematopoiesis (f) + lymphoid content

2015 European Medicines Agency - EPARs

133. Zontivity - vorapaxar

and with the exception of phospholipodosis (all species), seem to be species specific (rat retinal vacuolation) and reversible. The main histopathology findings include urinary bladder and ureter hyperplasia in mice, hepatic vascular thrombi, lymphoid necrosis and retinal vacuolation in rats and phospholipidosis in all species. The phospholipidosis was observed in mice and monkeys at exposures up to 398-times and 214-times the human steady-state exposure at 2.5 mg/day. The NOAEL for this finding in rats, a species

2015 European Medicines Agency - EPARs

138. Vascular diseases of the liver

(INCPH) can be made if all these disorders have been excluded and consequently no clear liver disease has been identi?ed (Table 3). The nomenclature of this condition is ambiguous and it has been referred to as hepatoportal sclerosis, non-cirrhotic portal ?brosis, idiopathic portal hypertension, incomplete septal cirrhosis and nodular regenerative hyperplasia Clinical Practice Guidelines Please cite this article in press as: EASL Clinical Practice Guidelines: Vascular diseases of the liver. J Hepatol

2015 European Association for the Study of the Liver

139. ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation. Full Text available with Trip Pro

ILC2 activation by keratinocyte-derived IL-25 drives IL-13 production at sites of allergic skin inflammation. Atopic dermatitis skin lesions demonstrate increased expression of IL-25 by keratinocytes and increased numbers of type 2 innate lymphoid cells (ILC2s) that express high levels of IL-25 receptor (IL-25R). IL-13 is expressed in atopic dermatitis skin lesions and plays an important role in pathogenesis of the disease.Our aim was to determine the role of IL-25 and ILC2s in a mouse model (...) expression was quantitated by RT quantitative PCR.In both acute and chronic antigen-driven allergic skin inflammation, signaling by keratinocyte-derived IL-25 in ILC2s is important for epidermal hyperplasia, dermal infiltration by CD4+ T cells, and cutaneous expression of Il13 and the IL-13-dependent TH2-cell-attracting chemokines Cc17 and Ccl22. ILCs are the major source of IL-13 in acutely sensitized mouse skin, whereas T cells are its major source in chronically sensitized mouse skin.ILC2 activation

2020 Journal of Allergy and Clinical Immunology

140. Clinical analysis of Kimura's disease in 24 cases from China. Full Text available with Trip Pro

to 65 years. Lesion diameter ranged from 0.6 cm to 7 cm with unilateral involvement being more popular (79%). Imaging examination had a high detection rate for KD involving the parotid gland and subcutaneous but had low specificity. Microscopic analysis indicated that KD mainly involved subcutaneous soft tissue and lymph nodes. The prominent feature of lymphoid tissue was germinal center hyperplasia surrounded by several lobules associated with hyperplastic vascular structures. Out of the 24

2020 BMC Surgery

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