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Lymphoid Hyperplasia

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81. Angiolymphoid hyperplasia with eosinophilia occurring in bilateral eyelids. Full Text available with Trip Pro

Angiolymphoid hyperplasia with eosinophilia occurring in bilateral eyelids. Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign lesion, primarily occurring in the head and neck. ALHE arising from the ocular adnexa is rare, and the bilateral presentation is especially rare in the eyelids.A 64-year-old Japanese man presented with tearing. Multiple nodules, approximately 5 mm in size, were observed in bilateral upper and lower eyelids. Surgical excisions of the both eyelids (...) masses were performed. Histopathological examination of the excised masses demonstrated proliferated blood vessels lined by plump endothelial cells together with a lymphoid and eosinopilic infiltrate, compatible with a diagnosis of ALHE. Flow cytometry studies showed that the mass consisted of mostly CD3-positive cells. During two-year follow-up, no recurrence of the mass was observed and the patient had no subjective symptom of tearingALHE may occur in the bilateral eyelids. The cause of ALHE

2013 BMC Ophthalmology

82. Hypoimmunoglobulin G, hyperimmunoglobulin M, intestinal nodular hyperplasia, and thrombocytopenia. An unusual association. Full Text available with Trip Pro

gamma-Globulins IM Agammaglobulinemia complications Biopsy Child, Preschool Female Hepatomegaly complications Humans Hyperplasia Immunoglobulin G analysis Immunoglobulin M analysis Immunologic Deficiency Syndromes Infant Intestinal Diseases complications Lymph Nodes Lymphoid Tissue growth & development Splenomegaly complications Thrombocytopenia complications gamma-Globulins biosynthesis 1969 10 1 1969 10 1 0 1 1969 10 1 0 0 ppublish 4186587 PMC2020081 Pediatrics. 1966 May;37(5):715-27 4956666 J (...) Hypoimmunoglobulin G, hyperimmunoglobulin M, intestinal nodular hyperplasia, and thrombocytopenia. An unusual association. 4186587 1969 12 03 2018 11 13 1468-2044 44 237 1969 Oct Archives of disease in childhood Arch. Dis. Child. Hypoimmunoglobulin G, hyperimmunoglobulin M, intestinal nodular hyperplasia, and thrombocytopenia. An unusual association. 621-4 Goldstein G W GW Krivit W J WJ Hong R R eng Journal Article England Arch Dis Child 0372434 0003-9888 0 Immunoglobulin G 0 Immunoglobulin M 0

1969 Archives of Disease in Childhood

83. Immunoglobulin systems of human tonsils. II. Patients with chronic tonsillitis or tonsillar hyperplasia: quantification of Ig-producing cells, tonsillar morphometry and serum Ig concentrations. Full Text available with Trip Pro

Immunoglobulin systems of human tonsils. II. Patients with chronic tonsillitis or tonsillar hyperplasia: quantification of Ig-producing cells, tonsillar morphometry and serum Ig concentrations. Patients suffering from recurrent tonsillitis (RT), hyperplastic tonsillitis (HT) or idiopathic tonsillar hyperplasia (ITH) were compared in immunological studies with subjects showing clinically normal palatine tonsils. Serum concentrations of immunoglobulins, particularly IgG, were increased (...) in association with tonsillitis. Conversely, the number of IgG-, IgA- and IgM-producing immunocytes was reduced per tonsillar tissue unit. The density of such cells was decreased in the germinal centres of the lymphoid follicles, in the extrafollicular areas and in the reticular parts of the crypt epithelium. However, only small changes in immunocyte class ratios were observed, excepting a significantly raised proportion of IgD-producing cells. The immunohistochemical results indicated a defect

1978 Clinical and experimental immunology

84. Giant lymph node hyperplasia of the mediastinum and refractory anaemia. Full Text available with Trip Pro

Giant lymph node hyperplasia of the mediastinum and refractory anaemia. An example is described of the syndrome of refractory anaemia in association with the plasma cell variant of giant lymph node hyperplasia of the mediastinum; the anaemia responded to removal of the lymphoid mass. The entity of giant lymph node hyperplasia is discussed and its relationship to the haematological syndrome is considered.

1978 Journal of Clinical Pathology

85. Biomarkers for the diagnosis of prostatic inflammation in benign prostatic hyperplasia. (Abstract)

Biomarkers for the diagnosis of prostatic inflammation in benign prostatic hyperplasia. Chronic prostatic inflammation could be a central mechanism in benign prostatic hyperplasia (BPH) progression. Currently, the histological examination of prostate biopsies remains the only way to diagnose prostatic inflammation. Our objective was to find new noninvasive biomarkers for the diagnosis of prostatic inflammation.Ninety BPH samples were investigated in two steps. First, a hypothesis was generated (...) using a profiling procedure with a panel of 96 genes on an initial set of 30 samples. Then, the candidate biomarkers were validated on a large number of samples (n = 90). Gene expression was compared with the histological prostatic inflammation score based on the density and the confluence of lymphoid nodules. Finally, protein transcripts of the candidate biomarkers were investigated in urine samples and compared with clinical data.Of the 96 genes, nine were significantly correlated

2011 Prostate

86. B cell infiltration and lymphonodular hyperplasia in bladder submucosa of patients with persistent bacteriuria and recurrent urinary tract infections. (Abstract)

B cell infiltration and lymphonodular hyperplasia in bladder submucosa of patients with persistent bacteriuria and recurrent urinary tract infections. We defined chronic inflammatory cell types in bladder submucosa and the presence of umbrella cells on the surface of bladder epithelium in patients 5 to 21 years old with persistent bacteriuria due to neurogenic bladder and recurrent urinary tract infections associated with vesicoureteral reflux.Bladder mucosa biopsies from 12 patients and 6 (...) controls were fixed in Carnoy's solution and examined for T cells (CD3, CD4, CD8), B cells (CD79) and plasma cells (CD138). The number of cells in a defined area of submucosa was determined by counting all nuclei in the area. A contiguous section was also stained for uroplakin expression with a monoclonal antibody against uroplakin III to ascertain the integrity of bladder umbrella cells.B cells, plasma cells and lymphoid nodules were found only in patient biopsies. T cell expression was evident

2011 Journal of Urology

87. Lymphoid Hyperplasia and Lymphoma in Transgenic Mice Expressing the Small Non-Coding RNA, EBER1 of Epstein-Barr Virus Full Text available with Trip Pro

Lymphoid Hyperplasia and Lymphoma in Transgenic Mice Expressing the Small Non-Coding RNA, EBER1 of Epstein-Barr Virus Non-coding RNAs have critical functions in diverse biological processes, particularly in gene regulation. Viruses, like their host cells, employ such functional RNAs and the human cancer associated Epstein-Barr virus (EBV) is no exception. Nearly all EBV associated tumours express the EBV small, non-coding RNAs (EBERs) 1 and 2, however their role in viral pathogenesis remains (...) largely obscure.To investigate the action of EBER1 in vivo, we produced ten transgenic mouse lines expressing EBER1 in the lymphoid compartment using the mouse immunoglobulin heavy chain intronic enhancer Emicro. Mice of several of these EmicroEBER1 lines developed lymphoid hyperplasia which in some cases proceeded to B cell malignancy. The hallmark of the transgenic phenotype is enlargement of the spleen and mesenteric lymph nodes and in some cases enlargement of the thymus, liver and peripheral

2010 PloS one

88. Unifocal and Multifocal Reactive Lymphoid Hyperplasia vs Follicular Lymphoma of the Ocular Adnexa. (Abstract)

Unifocal and Multifocal Reactive Lymphoid Hyperplasia vs Follicular Lymphoma of the Ocular Adnexa. To characterize the differentiating histopathologic and immunophenotypic features of reactive lymphoid hyperplasia (RLH) and follicular lymphoma of the ocular adnexa.Retrospective case study with clinical follow-up and review of the literature.Clinical records of 9 cases of RLH and 6 cases of follicular lymphoma from 2 institutions were reviewed. Light microscopic evaluation

2010 American Journal of Ophthalmology

89. Clinical significance of lymphoid hyperplasia of the lower gastrointestinal tract. (Abstract)

Clinical significance of lymphoid hyperplasia of the lower gastrointestinal tract. Lymphoid hyperplasia of the intestine has been associated with multiple diseases and symptoms. This study was undertaken to analyze the number and topographical distribution of the lymphoid follicles. A total of 302 adult consecutive patients were enrolled when they underwent elective colonoscopy. Standardized pictures from terminal ileum and colon were taken using video colonoscopes. In each picture, the number (...) , size, and mucosal elevation of lymphoid follicles were analyzed in relation to histological and immunological findings and medical history. Lymphoid hyperplasia was found to be most extensive in the terminal ileum and cecum. Patients with untreated gastrointestinally mediated allergy (GMA) showed the highest number of lymphoid follicles per visible field in the terminal ileum ( P < 0.001) and cecum ( P = 0.003) vs. the control group. Patients with infectious colitis also showed a high number

2010 Endoscopy

90. Florid Reactive Lymphoid Hyperplasia of the Lower Female Genital Tract (Lymphoma-like Lesion): A Benign Condition That Frequently Harbors Clonal Immunoglobulin Heavy Chain Gene Rearrangements. (Abstract)

Florid Reactive Lymphoid Hyperplasia of the Lower Female Genital Tract (Lymphoma-like Lesion): A Benign Condition That Frequently Harbors Clonal Immunoglobulin Heavy Chain Gene Rearrangements. Lymphoma-like lesions (LLL) of the lower female genital tract are florid reactive inflammatory processes that mainly occur in women in their reproductive years. Histologically, they are characterized by a dense lymphoid infiltrate with admixed large cells that is often suspicious for lymphoma. In contrast (...) to lymphoma, however, they are superficial lesions that typically show surface erosion and a mixed lymphoid infiltrate and do not have evidence of a mass, deep invasion, or prominent sclerosis. With the advent of widespread molecular genetic testing, it would seem that LLLs should be polyclonal helping make the correct diagnosis. However, we have found cases with morphologic and immunophenotypic features of LLLs and evidence of clonal rearrangement of the immunoglobulin heavy chain (IGH) gene, potentially

2010 American Journal of Surgical Pathology

93. The Society for Immunotherapy of Cancer perspective on regulation of interleukin-6 signaling in COVID-19-related systemic inflammatory response Full Text available with Trip Pro

in as many as 60% of patients. Other findings include patchy infiltrates, and interstitial lung disease, although some patients present with minimal imaging abnormalities. Pathological findings resemble those seen in SARS and MERS: edema, proteinaceous exudates, focal reactive pneumocyte type II hyperplasia, patchy cellular inflammation and multinucleated giant cells. Notably, neutrophil infiltration is not significant. Elevated C reactive protein (CRP) and elevated aspartate transaminase are common (...) to hydroxyurea and steroid-refractory graft versus host disease in adult and pediatric patients aged 12 years and older. Tofacitinib (Xeljanz ® , Jakvinus, Pfizer) is an oral JAK inhibitor with selectivity for JAK1 and JAK3 indicated for the treatment of rheumatoid arthritis, psoriatic arthritis and ulcerative colitis. The occurrence of serious infections and lymphoid-associated malignancies have led to a current black box warning imposed by the FDA. Baricitinib (Olumiant ® , Eli-Lilly) is an oral JAK

2020 Society for Immunotherapy of Cancer

95. AIM Clinical Appropriateness Guidelines for Molecular Testing of Solid and Hematologic Tumors and Malignancies

than 450,000/µL; megakaryocytic hyperplasia (seen in bone marrow); not meeting WHO criteria for CML, PV, PMF, MDS or other myeloid neoplasm; and the demonstration of JAK2 V617F or other clonal marker or no evidence of reactive thrombocytosis. In addition, patients can have splenomegaly and a clinical course complicated by thrombotic or hemorrhagic episodes (or both). The majority of ET patients (60%) carry a somatic JAK2 V617F variant, while a smaller percentage (5-10%) have activating MPL P/LP (...) ). Genetic Testing for Hematologic Malignancy Minimal Residual Disease (MRD) Genetic Testing Acute Lymphoblastic Leukemia (ALL) is characterized by the proliferation of immature lymphoid cells in the bone marrow, peripheral blood, and other organs. It is divided into two main immunophenotypes based on cell lineage: B-cell or T-cell. B-cell is seen in about 75% of cases and T-cell in about 25%. There are a small percentage of individuals who have a mixed cell line immunophenotype. The median age

2020 AIM Specialty Health

96. European Guidelines (S1) on the Use of Extracorporeal Photopheresis

) ECP, like psoralen plus UVA (PUVA), induces psoralen-mediated DNA crosslinks that cause apoptosis in lymphoid cells, particularly in natural killer (NK) cells and T- cells.(14) However, the therapeutic effect of ECP in Sézary syndrome (SS) cannot be explained by the depletion of malignant cells, as only a relatively low proportion of the entire lymphocyte pool is treated in a photopheresis cycle. Monocytes, which appear to be more resistant to apoptosis, undergo a differentiation process within

2020 European Dermatology Forum

97. Acute appendicitis

is required, CT scan or ultrasonography may show dilatation of the appendix outer diameter to more than 6 mm. Definitive treatment is surgical appendectomy. Definition Acute appendicitis is an acute inflammation of the vermiform appendix, Fitz RH. Perforating inflammation of the vermiform appendix with special reference to its early diagnosis and treatment. Am J Med Sci. 1886;92:321-346. most likely due to obstruction of the lumen of the appendix (by faecolith, normal stool, infective agents, or lymphoid (...) hyperplasia). Itskowitz MS, Jones SM. Appendicitis. Emerg Med. 2004;36:10-15. [Figure caption and citation for the preceding image starts]: Acute appendicitis - intraoperative specimen. Nasim Ahmed, MBBS, FACS; used with permission [Citation ends]. History and exam abdominal pain anorexia right lower quadrant tenderness adolescence or early adulthood nausea fever diminished bowel sounds tachycardia fetor vomiting Rovsing's sign psoas sign obturator sign <6 months of breastfeeding low dietary fibre

2018 BMJ Best Practice

98. Overview of leukaemia

, according to the degree of cell differentiation (not the duration of disease), and as myelogenous or lymphocytic, according to the predominant type of cell involved (myeloid or lymphoid). Several sub-types have been identified. The exact cause of leukaemia is unknown, but genetic and environmental risk factors have been identified for many sub-types. Typical signs and symptoms might include fatigue, weight loss, fever, pallor, ecchymoses, petechiae, dyspnoea, dizziness, palpitations, bleeding (...) , and recurrent infections, although each sub-type has its distinguishing features. Definitive diagnoses often require bone marrow biopsy and/or blood analysis. Related conditions Condition Description A malignant clonal disease that develops when a B/T-precursor-stage lymphoid progenitor cell becomes genetically altered through somatic changes and undergoes uncontrolled proliferation. Acute lymphocytic leukaemia (ALL) is the most common leukaemia in paediatrics, accounting for up to 80% of leukaemias

2018 BMJ Best Practice

99. Appendicitis

by a faecolith (hard mass of faecal matter), normal stool, and/or lymphoid hyperplasia secondary to viral infection. Risk (...) factors for appendicitis include age (most common between the ages of 10–20 years), male sex, frequent antibiotic use, and smoking. Appendicitis accounts for more than 40,000 hospital admissions in England every year. It is one of the most common causes of abdominal pain in young adults and children in the UK. Complications of appendicitis include appendix perforation, generalized (...) -346. most likely due to obstruction of the lumen of the appendix (by faecolith, normal stool, infective agents, or lymphoid 2018 3. Diagnosis of right lower quadrant pain and suspected acute appendicitis Diagnosis of right lower quadrant pain and suspected acute appendicitis Diagnosis of right lower quadrant pain and suspected acute appendicitis Agency for Healthcare Research and Quality (AHRQ) Record Status This is a bibliographic record of a published health technology assessment from a member

2018 Trip Latest and Greatest

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