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Lymphoid Hyperplasia

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941. An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. (Abstract)

lymphomagenesis, resulting in highly disseminated disease. To determine whether RNAi suppression of Trp53 could produce a similar phenotype, we introduced several Trp53 short hairpin RNAs (shRNAs) into hematopoietic stem cells derived from E(mu)-Myc transgenic mice, and monitored tumor onset and overall pathology in lethally irradiated recipients. Different Trp53 shRNAs produced distinct phenotypes in vivo, ranging from benign lymphoid hyperplasias to highly disseminated lymphomas that paralleled Trp53

2003 Nature Genetics

942. TCF and Groucho-related genes influence pituitary growth and development. Full Text available with Trip Pro

of split (Aes), causes pituitary anomalies and growth insufficiency. TLE3 and AES have been shown to interact with TCF/LEF (transcripiton factors of the T cell-specific and lymphoid enhancer specific group) family members in cell culture systems. In the absence of TCF4 (Tcf7L2), Prop1 levels are elevated, pituitary hyperplasia ensues and palate closure is abnormal. Thus, we demonstrate that Tcf4 and Aes influence pituitary growth and development, and place Tcf4 and Tle3 in the genetic hierarchy

2003 Molecular Endocrinology

943. Pathogenesis of human and bovine Cryptosporidium parvum in gnotobiotic pigs. Full Text available with Trip Pro

parasites were seen microscopically throughout the intestines during the prepatent and patent periods. HuG1 parasites were only detected during the patent period in the ileum and colon but colonized the mucosal surface in significantly larger numbers than did BoG2. Moderate-to-severe villus/mucosal attenuation with lymphoid hyperplasia was seen throughout the intestines of BoG2-infected pigs, whereas lesions in HuG1-infected pigs were mild to moderate and restricted to the ileum and colon

2002 Journal of Infectious Diseases

944. The impact of human immunodeficency virus 1 on largyngeal airway obstruction in children. Full Text available with Trip Pro

ventilation, and ICU and hospitalisation stay were similar in the HIV infected group compared to the HIV uninfected group. Episodes of laryngotracheobronchitis were equally distributed between both groups (31.6% v 31.3%), while oropharyngeal/laryngeal candidiasis (26.3%), tuberculosis (15.8%), and benign lymphoid hyperplasia (15.8%) were commonly seen in the HIV infected group.

2002 Archives of Disease in Childhood

945. Duodenal pathology and clinical-immunological implications in common variable immunodeficiency patients. (Abstract)

underwent upper endoscopy, and biopsy specimens were taken in the descending duodenum for histological assessment. A blood sample was obtained to determine immunoglobulin and Hb levels and to evaluate the CD4+ T-lymphocyte count. Body mass index was calculated for all patients.Histological assessment of duodenal specimens revealed the presence of villous atrophy in 10 (31.2%) patients, a feature of nodular lymphoid hyperplasia in five (15.6%), and mild duodenitis in two (6.3%), whereas normal histology

2003 American Journal of Gastroenterology

946. Retrograde ileoscopy in chronic nonbloody diarrhea: a prospective, case-control study. (Abstract)

with biopsy was attempted in all cases. Endoscopic and histological features of Crohn's disease, nonspecific ileitis, and nodular lymphoid hyperplasia were recorded for each patient. Exclusion criteria were presence of any colonic alterations at either endoscopy or histology as well as failure of ileal intubation.Overall, 156 patients were recruited. Ileal intubation was successful in 149 (95.5%), but 11 (7%) patients were excluded because colonic diseases were detected at histology. At endoscopy (...) , alterations of the terminal ileum were significantly more frequent in patients than in controls (47/138 vs 15/138; p < 0.0001). Crohn's disease (9/138 vs 0/138; p = 0.007) and nonpecific ileitis (18/138 vs 2/138; p = 0.0009) were significantly more frequent in patients than in controls as well as nodular lymphoid hyperplasia (33/138 vs 16/138; p = 0.008). A final diagnosis of Crohn's disease was achieved on the basis of both endoscopic and histological findings in eight (5.8%) patients.Retrograde

2003 American Journal of Gastroenterology

947. Progressive transformation of germinal centers: review of histopathologic and clinical features. (Abstract)

Progressive transformation of germinal centers: review of histopathologic and clinical features. Although progressive transformation of germinal centers (PTGC) in lymph nodes was defined as an entity almost three decade ago, it is not well known to surgical and head and neck pathologists. PTGC may be mistaken for focal nodular lymphocyte predominant Hodgkin's Disease (NLPHD).To review the histopathologic and clinical features of PTGC, and PTGC's relationship with lymphoid neoplasia in pediatric (...) and adult populations. HISTOPATHOLOGIC FEATURES: PTGC occurs in 10-15% of enlarged lymph nodes with reactive follicular hyperplasia. PTGC is characterized as a nodule, which is three to five times the size of a typical reactive follicle, with mantle zone small B-cells infiltrating the residual germinal center. Epithelioid histiocytic clusters, immunoblasts, mononuclear cells, and eosinophils may also be present. Solitary or multiple nodules may be found. The immunophenotypes of both PTGC and NLPHD may

2002 International Journal of Pediatric Otorhinolaryngology

948. Risk factors for adenotonsillar hypertrophy in children following solid organ transplantation. (Abstract)

Risk factors for adenotonsillar hypertrophy in children following solid organ transplantation. Post-transplantation lymphoproliferative disorder (PTLD), or its precursor, Epstein-Barr virus (EBV)-related lymphoid hyperplasia, may first present in the tonsils and adenoids in the pediatric solid organ transplant population. We sought to identify signs and symptoms of and risk factors for adenotonsillar hypertrophy (ATH), a potential precursor to PTLD in children following solid organ

2003 International Journal of Pediatric Otorhinolaryngology

949. Unusual complication of tonsillectomy: taste disturbance and the lingual branch of the glossopharyngeal nerve. (Abstract)

tonsillectomy that was performed for chronic tonsillitis and unilateral (left) tonsillar hypertrophy. During surgery, hypertrophic tonsils were found to be sited deeply into the tonsillar bed, especially at the lower pole of the left tonsil. Pathologic examination following tonsillectomy revealed a keratinous cyst and chronic infection at the left tonsil, and lymphoid hyperplasia and chronic infection at the right tonsil. Although his complaint had been getting better, qualitative examination of his taste

2003 Journal of Laryngology & Otology

950. Diagnosis of conjunctival B-cell lymphoma by polymerase chain reaction heteroduplex analysis. (Abstract)

to an extensive palpebral conjunctival follicular-like process. Excisional biopsy showed a dense small lymphocyte infiltrate consistent with benign lymphoid hyperplasia by histology and immunohistologic marker studies. Polymerase chain reaction heteroduplex analysis revealed low-grade B-cell lymphoma, however. Systemic examination was negative. Focal radiation therapy was performed, and preliminary results show no signs of lymphoma.Polymerase chain reaction heteroduplex analysis established a diagnosis (...) of conjunctival B-cell lymphoma in the absence of supporting histology and immunohistochemistry studies. This technique may provide independent, diagnostic distinction between benign lymphoid hyperplasia and low-grade B-cell lymphoma of the ocular adnexa.

2003 American Journal of Ophthalmology

951. Evaluation of interphase fluorescence in situ hybridization for the t(14;18)(q32;q21) translocation in the diagnosis of follicular lymphoma on fine-needle aspirates: a comparison with flow cytometry immunophenotyping. (Abstract)

) on FNAs.Concurrent testing by FISH for t(14;18)(q32;q21) and FCM was performed on 84 FNAs, including 40 FLs and 44 non-FLs (de novo DLBCLs, mantle cell lymphomas, small lymphocytic lymphomas/chronic lymphocytic leukemias [SLLs/CLLs], small B-cell lymphomas, and reactive lymphoid hyperplasias). The final diagnosis was rendered based on the combined information from cytomorphology, FCM, FISH, immunocytochemical staining for Ki-67, monoclonality for kappa and lambda light chains, and, if available, corresponding

2003 Cancer

952. Factor-XIIIa-positive dendrocytes in drug-induced toxic epidermal necrolysis (Lyell's syndrome): paradoxical activation in skin and rarefaction in lymph nodes. (Abstract)

Factor-XIIIa-positive dendrocytes in drug-induced toxic epidermal necrolysis (Lyell's syndrome): paradoxical activation in skin and rarefaction in lymph nodes. Drug-induced toxic epidermal necrolysis (TEN) is a rare life-threatening disease characterized by the extensive destruction of the epidermis contrasting with the discreteness of lymphoid cell infiltration. The precise pathomechanism of the disease remains unclear.Skin specimens and peripheral and thoracic lymph nodes (LNs) were collected (...) and negative controls.TEN LNs showed absence of germinal centers but a moderate hyperplasia of the paracortical T cell zone. Immunohistochemistry did not reveal any distinctive aspect in LN cellular densities between TEN and other control conditions except for the factor-XIIIa+ dendritic cells which were dramatically reduced in numbers in TEN LNs. This rarefaction in LNs contrasted with the great number of these cells in the skin of the same patients.The structure of TEN LNs rules out the involvement

2003 Dermatology

953. Secondary syphilis presenting as pseudolymphoma of the skin. (Abstract)

Secondary syphilis presenting as pseudolymphoma of the skin. Secondary syphilis most commonly presents with a papulosquamous eruption that involves the palms, soles, and mucous membranes. The papulonodular variant has only been described 11 times in the literature. We describe a case of papulonodular secondary syphilis presenting as an atypical lymphoid hyperplasia suggestive of cutaneous lymphoma.

2003 Journal of American Academy of Dermatology

954. Surgical resection of a solitary plasmacytoma originating in a rib of a patient with Castleman's disease. (Abstract)

Surgical resection of a solitary plasmacytoma originating in a rib of a patient with Castleman's disease. Castleman's disease is a rare disorder characterized by lymphoid hyperplasia. It may present as asymptomatic involvement of one lymph node group or as a multicentric disease with systemic features. We report a patient with Castleman's disease who presented with axillary lymphadenopathy associated with a solitary plasmacytoma originating from a rib. The affected rib was surgically resected

2003 Annals of Thoracic Surgery

955. Familial adenomatous polyposis and duodenal lymphoma: report of a case. (Abstract)

Familial adenomatous polyposis and duodenal lymphoma: report of a case. The occurrence of duodenal polyposis is well recognized in familial adenomatous polyposis. Lymphoid hyperplasia in association with familial adenomatous polyposis usually occurs in the terminal ileum, but it can occur in the duodenum and may be endoscopically difficult to distinguish from an adenoma. A case report is presented in which a 54-year-old male with familial adenomatous polyposis, who 20 years earlier had (...) a subtotal colectomy and ileorectal anastomosis, presented with a large rectal villous tumor and was found to have a duodenal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. The role of lymphoid hyperplasia in the development of mucosa-associated lymphoid tissue lymphoma is discussed, as well as the issue of mucosa-associated lymphoid tissue lymphoma in familial adenomatous polyposis. In cases in which biopsies of polypoid lesions in patients with familial adenomatous polyposis

2003 Diseases of the Colon & Rectum

956. Detection of Epstein-Barr virus-derived latent membrane protein-1 gene in various head and neck cancers: is it specific for nasopharyngeal carcinoma? (Abstract)

and neck cancers from different locations and histopathological types, noncancerous nasopharyngeal biopsy samples, and tonsillectomy specimens from patients with chronic hypertrophic tonsillitis.Of 202 patients enrolled in the study, 53 were diagnosed by pathological study with oropharyngeal carcinoma, 45 with nasopharyngeal carcinoma, 26 with oral cavity carcinoma, 26 with laryngohypopharyngeal carcinoma, 31 with nasopharyngeal lymphoid hyperplasia, and 21 with tonsils with lymphoid hyperplasia. After (...) the application of polymerase chain reaction, the LMP-1 gene was not detected in any sample from oral cavity carcinoma, laryngohypopharyngeal carcinoma, or nasopharyngeal lymphoid hyperplasia or from tonsillectomy specimens but was detected in only one case of tonsillar carcinoma. On the contrary, the LMP-1 gene was detected in 43 (95.6%) of 45 samples from patients with nasopharyngeal carcinoma. The statistical analysis shows a significant association (P <.001) between the presence of LMP-1 gene and tumor

2003 Laryngoscope

957. Ileal lymphonodular hyperplasia is not associated with NOD2/CARD15 mutations. (Abstract)

Ileal lymphonodular hyperplasia is not associated with NOD2/CARD15 mutations. Lymphonodular hyperplasia (LNH) is a mass of lymphoid tissue that has been described in the terminal ileum, colon and duodenum mainly in children. Controversy exists regarding the benign nature of LNH. The combination of chronic abdominal pain and hematochezia leads many of these patients to undergo investigations for inflammatory bowel diseases. NOD2/CARD15 on chromosome 16 has been identified as a susceptibility

2006 Journal of Pediatric Gastroenterology and Nutrition

958. Role of polymerase chain reaction and immunocytochemistry in the cytological assessment of lymphoid proliferations. Full Text available with Trip Pro

lymphoid proliferation and 13 had reactive hyperplasia. A World Health Organization (WHO) subtype was suggested in 8 patients. Incorporating the results of immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) gene rearrangements enabled diagnosis of lymphoma in 17 patients, including 5 of the 6 patients suspected to have NHL or an atypical lymphoid proliferation. Identification of the translocations t (14;18) and t (2;5) helped WHO categorisation in 3 of the patients. The cytological findings (...) Role of polymerase chain reaction and immunocytochemistry in the cytological assessment of lymphoid proliferations. Fine-needle aspiration cytology (FNAC) is used as a screening test to evaluate lymphadenopathy. The combined use of genetic analysis and flow cytometry for immunophenotyping has increased the accuracy of diagnosis and correct categorisation of lymphomas on cytological preparations.To show the utility of immunocytochemistry and polymerase chain reaction (PCR) in the evaluation

2006 Journal of Clinical Pathology

959. Augmented expression of secondary lymphoid tissue chemokine and EBI1 ligand chemokine in Crohn's disease. Full Text available with Trip Pro

Augmented expression of secondary lymphoid tissue chemokine and EBI1 ligand chemokine in Crohn's disease. A dominant T helper type 1 (Th1) immune response is thought to be involved in Crohn's disease (CD). SLC/CCL21 and ELC/CCL19, chemokines that regulate T cell homing and promote recirculating T and dendritic cell (DC) interactions, help control antigen specific T cell responses.To investigate the Th1 response and SLC and ELC in CD pathogenesis.Surgically resected intestine and mesenteric (...) lymph nodes (MLNs) from controls and patients with CD and ulcerative colitis (UC) were investigated. CD3, CD83, HECA452, VEGFR3, SLC, ELC, and CCR7 expression was studied immunohistochemically. CCR7 mRNA was quantified using real time RT-PCR.ELC was almost undetectable in intestinal samples. SLC was found sporadically in lymphoid follicles, lymphoid aggregate venules, and lymphatic vessels. In MLNs, SLC was highly expressed in high endothelial venules (HEVs), lymphatic vessels, and stromal DCs

2005 Journal of Clinical Pathology

960. Role of Helicobacter pylori in conjunctival mucosa-associated lymphoid tissue lymphoma. (Abstract)

lymphoma were investigated. Five samples of conjunctival lymphoid hyperplasia and 20 biopsies of normal conjunctiva served as controls.The specimens were investigated for the presence of H. pylori with immunohistochemistry (IHC) and nested polymerase chain reaction (PCR) techniques. For each case of conjunctival MALT lymphoma, information regarding gender, age at presentation, conjunctival localization, and information of generalized MALT lymphoma were collected.Detection of H. pylori and patient (...) characteristics.The 13 conjunctival MALT lymphomas originated from 8 women and 5 men with an average age of 62 years (range, 25-87). Only 1 patient had evidence of systemic MALT lymphoma. H. pylori could not be identified in any of the conjunctival MALT lymphomas, in conjunctival lymphoid hyperplasia, or in normal conjunctival biopsies using IHC and PCR techniques.An association between H. pylori and localized conjunctival MALT lymphoma could not be verified. Antigens other than H. pylori may take part

2007 Ophthalmology

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