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Lymphoid Hyperplasia

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901. Treatment of murine lupus with cDNA encoding IFN-γR/Fc Full Text available with Trip Pro

and progression in MRL-Fas(lpr) mice. Therapy significantly reduced serum levels of IFN-gamma, as well as disease manifestations (autoantibodies, lymphoid hyperplasia, glomerulonephritis, mortality), when treatment was initiated at the predisease stage, particularly when IFN-gammaR/Fc expression was enhanced by electroporation at the injection site. Remarkably, disease was arrested and even ameliorated when this treatment was initiated at an advanced stage. This therapy represents a rare example of disease

2000 Journal of Clinical Investigation

902. Immunological events leading to destructive thyroiditis in the AUG rat. Full Text available with Trip Pro

one week after the initial immunization, at which stage Ia positive vascular endothelium was observed within the thyroid. This was followed by large numbers of Ia positive dendritic-like cells. With time, in almost all the animals whose titre of Tg antibody rose above a critical level, lymphocytic infiltration was observed consisting mainly of Ia positive B cell aggregates with fewer scattered T cells. This was associated with raised levels of serum TSH and concomitant focal follicular hyperplasia (...) and necrosis. Expression of Ia was mainly restricted to the outer epithelial wall of follicular thyrocytes in direct contact with invading lymphoid cells, although occasional staining on the internal apical membrane was observed as a late event in the destructive process. The Ia expression on thyroid epithelial cells was only observed in areas of thyroid lymphoid infiltration. The immune infiltration of the thyroid in the AUG rat appears to be very similar to that observed in Hashimoto's thyroiditis

1988 Clinical and experimental immunology

903. Clinicopathologic features of young and old sphha/sphha mice. Mutants with congenital hemolytic anemia. Full Text available with Trip Pro

Clinicopathologic features of young and old sphha/sphha mice. Mutants with congenital hemolytic anemia. A colony of mice with congenital hemolytic anemia, sphha/sphha, were evaluated over a 3-year period. Prominent findings included decreased survivability, reticulocytosis, increased peripheral blood leukocytes, extramedullary hematopoiesis in liver and spleen, lymphoid hyperplasia and membranoproliferative glomerulonephritis. Older (12 to 21 months) anemic animals had elevated serum levels

1988 The American journal of pathology

904. p53 expression in lymphatic malignancies. Full Text available with Trip Pro

p53 expression in lymphatic malignancies. To investigate the expression of p53 protein in malignant and benign lymphoid tissues.Tissue from 42 non-Hodgkin's lymphomas, 10 Hodgkin's lymphomas, three atypical hyperplasias and five benign reactive hyperplasias was studied immunohistochemically for the expression of p53 protein.Of the 42 non-Hodgkin's lymphomas, 13 (31%) were positive for p53 in some of the tumour cells. In two cases the proportion of positive cells was more than 10% and in four (...) of these was a mixed cellular subtype and two nodular sclerosing subtypes. p53 protein was not expressed in the three atypical hyperplasias or the five benign reactive hyperplasias of the lymph nodes.The presence of p53 positivity in non-Hodgkin's and Hodgkin's lymphomas indicates that mutations of the p53 gene may play a part in the development of these tumours. The concentration of p53 positivity in high grade lymphomas suggests that p53 is involved in the transformation of low grade lymphomas to more aggressive

1992 Journal of Clinical Pathology

905. Diversion colitis: histological features in the colon and rectum after defunctioning colostomy. Full Text available with Trip Pro

chronic inflammation with or without mild crypt architectural abnormalities, crypt abscesses, or follicular lymphoid hyperplasia. One patient had more severe changes, resembling active ulcerative colitis. These features in biopsy specimens are unlikely to be diagnostic but should provide useful information in avoiding a mistaken diagnosis of inflammatory bowel disease in these patients.

1991 Gut

906. Bone marrow depletion by 89Sr complements a preleukemic defect in a long terminal repeat variant of Moloney murine leukemia virus. Full Text available with Trip Pro

% developed lymphoid leukemia with a time course resembling that caused by wild-type Mo-MuLV. In contrast, very few animals treated with Mo + PyF101 Mo-MuLV or 89Sr alone developed disease. In approximately one-third of cases, the Mo + PyF101 Mo-MuLV proviruses were found at common sites for wild-type Mo-MuLV-induced tumors (c-myc, pvt-1, and pim-1), indicating that this virus is capable of performing insertional activation in T-lymphoid cells. These results support the proposal that splenic hyperplasia (...) Bone marrow depletion by 89Sr complements a preleukemic defect in a long terminal repeat variant of Moloney murine leukemia virus. We previously described a preleukemic state induced by Moloney murine leukemia virus (Mo-MuLV) characterized by hematopoietic hyperplasia in the spleen. Further experiments suggested that splenic hyperplasia results from inhibitory effects in the bone marrow, leading to compensatory extramedullary hematopoiesis. An enhancer variant of Mo-MuLV, Mo + PyF101 Mo-MuLV

1991 Journal of virology

907. Localisation of HHV-8 in AIDS related lymphadenopathy Full Text available with Trip Pro

Localisation of HHV-8 in AIDS related lymphadenopathy Many lymph node abnormalities have been described in AIDS. These include opportunistic infections that sometimes result in spindle cell pseudotumours, Kaposi's sarcoma (KS), malignant lymphoma (Hodgkin's and non-Hodgkin's), and florid reactive hyperplasia. Among these, reactive hyperplasia is the most common manifestation of AIDS related lymphadenopathy.To examine whether human herpesvirus 8 (HHV-8), the aetiological agent of KS, can (...) of diagnosis (n = 1). Two additional patients subsequently developed KS, but were negative for HHV-8 by solution phase PCR and TaqMan PCR. Using PCR-ISH, HHV-8 amplicons were identified in some lymphoid cells (in one patient) and in spindle cells of the KS lesion in another. The positive lymphoid cells were predominantly concentrated in B cell areas of the affected lymph nodes, confirming the B cell tropism exhibited by HHV-8.The presence of HHV-8 in AIDS related lymphadenopathy is predictive of KS

2000 Molecular Pathology

908. The distribution of dividing T cells throughout the intestinal wall in inflammatory bowel disease (IBD) Full Text available with Trip Pro

colonic), seven with ulcerative colitis (UC), and 12 normal controls was studied. The distribution of dividing T cells was investigated by double-immunohistochemistry using Ki67 to identify proliferating cells, and CD3 to identify T cells. In ileal and colonic lamina propria virtually no Ki67+, CD3+ cells were seen in control, UC or CD tissue. In contrast, there were significantly more Ki67+, CD3+ cells within the lymphoid follicles of ileal and colonic CD than in the follicles in UC and controls (...) layers of the gut wall in CD. These may contribute to the fibrosis and muscle hyperplasia characteristic of the condition.

1996 Clinical and experimental immunology

909. Study of Mast Cell Precursors

Institutes of Health Clinical Center (CC) ( National Institute of Allergy and Infectious Diseases (NIAID) ) Study Details Study Description Go to Brief Summary: This study will investigate mast cell precursors that circulate in the blood. In a group of diseases collectively known as mastocytosis, mast cells accumulate in abnormal amounts in the skin, lymphoid tissues, bone marrow, liver and spleen. Some forms of mastocytosis have a generally good prognosis; for others, the prognosis is poorer (...) access Have normal renal function (creatinine less than or equal to 1.5mg/dL; less than or equal to 1 plus proteinuria) Have normal hepatic function (bilirubin less than or equal to 1.5 mg/dL) Have normal hematologic function (WBC greater than or equal to 3000/mm(3); granulocytes greater than or equal to 1500/mm(3) ; platelets greater than or equal to 175,000; hemoglobin greater than or equal to 12.5 g/dL) Patients must: Be 18-70 years of age Have mast cell hyperplasia compatible with a diagnosis

1999 Clinical Trials

910. Immune Regulation in Patients With Common Variable Immunodeficiency and Related Syndromes

of this protocol is to carry out laboratory studies concerning the immunopathogenesis of Common Variable Immunodeficiency (CVI) and related primary humoral immunodeficiency diseases. Additionally, we aim to document and track the progression of known complications of this primary immunodeficiency. Complications associated with CVID include recurrent respiratory, and gastrointestinal bacterial infections, pulmonary insufficiency, nodular regenerative hyperplasia, lymphoid malignancy, and various autoimmune

1999 Clinical Trials

911. B-Lymphocyte Stimulator (BLyS) To Treat Selective IgA Deficiency

that BLyS increases B cell number, Ig production, antigen-specific immunoglobulin response, and induces production of secretory IgA. B-cells collected from patients with Common Variable Immune Deficiency show evidence for BLyS binding to B cells and enhanced immunoglobulin secretion. In 28-day toxicology studies in mice, pharmacological effects were restricted to B lymphoid tissues including B lymphocyte hyperplasia, increased splenic weight without significant increase in spleen size, and increased

2001 Clinical Trials

912. A Pilot Study of the Combination of Retinoic Acid and Interferon-Alpha2a for the Treatment of Lymphoproliferative Disorders in Children With Immunodeficiency Syndromes

with hypergammaglobulinemia. Diffuse infiltrative lymphocytosis syndrome. Clinically symptomatic pulmonary lymphoid hyperplasia/lymphocytic interstitial pneumonitis. Polyclonal B-cell LPD. No patients with malignant lymphoma. No active opportunistic infection requiring acute intervention at entry. THERAPY: Biologic Therapy: At least 30 days since immunomodulating agents or biological response modifiers, e.g.: Interleukin-2, Interferons, Growth hormone, Insulin-like growth factor 1. Requirement waived for intravenous (...) evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00001438 Recruitment Status : Completed First Posted : December 10, 2002 Last Update Posted : March 4, 2008 Sponsor: National Cancer Institute (NCI) Information provided by: National Institutes of Health Clinical Center (CC) Study Details Study Description Go to Brief Summary: Patients with congenital or acquired immunodeficiencies are at an increased risk to develop polyclonal or oligoclonal lymphoid

1999 Clinical Trials

913. Pathology of the defunctioned rectum in ulcerative colitis. Full Text available with Trip Pro

pelvic ileal reservoir construction. All rectal stumps showed predominantly mucosal disease but there were additional features such as florid lymphoid follicular hyperplasia (12 cases), transmural inflammation (nine cases), granulomas (four cases), fissures (eight cases), and changes akin to ischaemia or to pseudomembraneous colitis (four cases). These changes may result from a combination of defunctioning and of active ulcerative proctitis. Some induce a histological appearance that may mimic

1993 Gut

914. Comparison of the Bacterial and Fungal Flora in the Pharynx of Normal Horses and Horses Affected with Pharyngitis Full Text available with Trip Pro

isolated from any of the 43 horses. None of the microorganisms were found in 100% of the animals and the majority of the isolates were opportunistic bacteria. These results demonstrate that the isolation of Moraxella spp and S. zooepidemicus in large numbers is frequent in horses with lymphoid follicular hyperplasia grades III and IV. Fungi were isolated in small numbers from two or three horses in each group.

1985 The Canadian Veterinary Journal

915. Use of Leu M1 and antiepithelial membrane antigen monoclonal antibodies for diagnosing Hodgkin's disease. Full Text available with Trip Pro

Use of Leu M1 and antiepithelial membrane antigen monoclonal antibodies for diagnosing Hodgkin's disease. Biopsies of 82 patients diagnosed as having Hodgkin's disease were reviewed. Seventeen were reclassified histologically as non-Hodgkin's lymphoma or reactive lymphoid hyperplasia. A substantial number of cases of Hodgkin's disease were negative when stained with Leu M1. Staining for Leu M1 was not found in the cases of non-Hodgkin's lymphoma or reactive lymphoid hyperplasia

1986 Journal of Clinical Pathology

916. Experimental Salmonella-associated conjunctivitis in cats. Full Text available with Trip Pro

intermittently from the inoculated conjunctivae and rectal swabs through day 7. At necropsy, mesenteric and cervical lymph nodes were enlarged. Histopathological findings included chronic conjunctivitis and lymphoid hyperplasia in cervical and mesenteric lymph nodes. This study confirms that S. typhimurium can cause a primary conjunctivitis and that the ocular route of infection can lead to fecal excretion of Salmonella, in the absence of other clinical manifestations.

1984 Canadian Journal of Comparative Medicine

917. Thin (less than or equal to 1 mm) melanomas of the extremities are biologically favorable lesions not influenced by regression. Full Text available with Trip Pro

spreading (90%), nodular (6%), and not classified (4%); thickness: less than 0.76 mm (61%) and 0.76 to 1 mm (39%); and Clark's level: II (33%), III (63%), and IV (4%). A moderate or marked lymphoid infiltrate occurred in 75%, and histologic tumor regression was found in 50%. The median margin of excision, as stated by the surgeon, was 4 cm. The median margin measured by the pathologist in unfixed specimens was 3.5 cm. Although 13% had atypical melanocytic hyperplasia in the initial excisional biopsy

1985 Annals of Surgery

918. Clonality of angioimmunoblastic lymphadenopathy and implications for its evolution to malignant lymphoma. Full Text available with Trip Pro

Clonality of angioimmunoblastic lymphadenopathy and implications for its evolution to malignant lymphoma. To investigate the relationship of the lymphoid hyperplasia of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) to supervening malignant lymphoma, we subjected DNA from lymph nodes and peripheral blood mononuclear cells from five AILD patients to Southern blot analysis to detect clonal rearrangements of immunoglobulin and T-cell receptor genes. Lymph nodes and peripheral blood (...) hyperplasia showed no gene rearrangements. As a disorder of cellular immunoregulation in which lymphoid cells may escape normal growth controls, AILD provides a natural model to dissect stages of lymphomagenesis in man.

1987 Journal of Clinical Investigation

919. Histopathology of the synovial membrane of peripheral joints in ankylosing spondylitis. Full Text available with Trip Pro

Histopathology of the synovial membrane of peripheral joints in ankylosing spondylitis. The histological features of the synovial membrane of peripheral joints in ankylosing spondylitis are similar to those seen in rheumatoid arthritis. There is intimal cell hyperplasia, a diffuse lymphocyte and plasma cell infiltrate, and formation of lymphoid follicles. Peroxidase-antiperoxidase staining shows the presence of IgG-, IgA-, and IgM-containing plasma cells in ankylosing spondylitis

1982 Annals of the Rheumatic Diseases

920. Studies of the function of natural killer-interferon system in patients with Sjögren syndrome. Full Text available with Trip Pro

with the systemic manifestations of the disease, such as hypergammaglobulinemia and lymphoid hyperplasia. The possible involvement of dysfunction of NK-IFN system in the systemic manifestations of SS is discussed.

1982 Journal of Clinical Investigation

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