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Lymphoid Hyperplasia

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781. Controversies in the pathogenesis of HIV-associated renal diseases Full Text available with Trip Pro

Controversies in the pathogenesis of HIV-associated renal diseases The two most common HIV-associated renal diseases, HIV-associated nephropathy and HIV immune-complex kidney disease, share the common pathologic finding of hyperplasia within the glomerulus. Podocyte injury is central to the pathogenesis of these diseases; however, the source of the proliferating glomerular epithelial cell remains a topic of debate. Parenchymal injury has been linked to direct infection of renal epithelial cells (...) by HIV-1, although the mechanism of viral entry into this non-lymphoid compartment is unclear. Although transgenic rodent models have provided insight into viral proteins responsible for inducing renal disease, such models have substantial limitations. Rodent HIV-1 models, for instance, cannot replicate all features of immune activation, a process that could have an important role in the pathogenesis of the HIV-associated renal diseases.

2009 Nature reviews. Nephrology

783. Excision of axillary lymph node recurrences in breast cancer patients with axillary ROLL (A-ROLL). (Abstract)

successfully localized by A-ROLL technique and removed surgically. Of all four patients, postoperative histopathologic examination revealed nodal cancer metastases in three patients (75%) and lymphoid hyperplasia in one patient. No complications occurred.A-ROLL technique has proved to be accurate and safe in the identification and excision of clinically occult axillary lymph node recurrence.

2009 Journal of Surgical Oncology

784. TCRgamma gene rearrangement in cutaneous T-cell lymphoma: comparative study of PCR with denaturing gradient gel electrophoresis and GeneScan analysis. (Abstract)

between both methods was 90% and the kappa coefficient was 0.79. Positivity rates did not depend on the PCR method but varied according to the type of CTCL (73-75% in mycosis fungoides, 90-100% in Sézary syndrome, 40-60% in lymphomatoid papulosis and 100% in other types). The positivity rate in BID was 14% with both methods. The most frequent BID with a monoclonal pattern were drug-induced cutaneous lymphoid hyperplasia, erythrodermic psoriasis and pityriasis lichenoides chronica.BIOMED-2-GS analysis

2009 British Journal of Dermatology

785. JAK2V617F activating mutation is associated with the myeloproliferative type of chronic myelomonocytic leukaemia. Full Text available with Trip Pro

with the mutation presented with splenomegaly and had a significantly higher haemoglobin level and neutrophil count than patients without the mutation. All bone marrow biopsies of JAK2(V617F)-mutated CMML showed increased erythropoiesis, a marked myeloid and megakaryocytic hyperplasia with occasionally clustered megakaryocytes, and a mild or moderate (grade 1 or 2) fibrosis; six cases showed an increased number of dilated sinusoids and reactive lymphoid nodules.The results indicate that JAK2(V617F) mutation

2009 Journal of Clinical Pathology

786. Cutaneous Lymphoid Hyperplasia (Pseudolymphoma) in a Tattoo After Far Infrared Light. (Abstract)

Cutaneous Lymphoid Hyperplasia (Pseudolymphoma) in a Tattoo After Far Infrared Light. 19549070 2009 09 29 2013 11 21 1524-4725 35 9 2009 Sep Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] Dermatol Surg Cutaneous lymphoid hyperplasia (pseudolymphoma) in a tattoo after far infrared light. 1434-8 10.1111/j.1524-4725.2009.01254.x Chiang Charles C Department of Dermatology, University of California San Francisco, San Francisco, California 94143

2009 Dermatologic Surgery

787. Diffuse microscopic angiodysplasia and nodular lymphoid hyperplasia in an infant with obscure massive lower gastrointestinal bleeding: a diagnostic challenge. (Abstract)

Diffuse microscopic angiodysplasia and nodular lymphoid hyperplasia in an infant with obscure massive lower gastrointestinal bleeding: a diagnostic challenge. The authors report a rare case of diffuse microscopic angiodysplasia and nodular lymphoid hyperplasia involving the distal ileum and total colon in a 13-month-old girl who had recurrent episodes of massive lower gastrointestinal bleeding of obscure origin. Colonoscopy showed multiple nodular hyperplasia and mucosal erosions, and all other

2009 Journal of Pediatric Surgery

788. Castleman disease: surgical cure in pediatric patients. (Abstract)

Castleman disease: surgical cure in pediatric patients. Castleman disease is a rare disorder characterized by lymphoid hyperplasia which rarely manifests in children. We present 2 cases which highlight both histologic variants of this disease, and provide suggestions regarding workup and treatment with the goal of making practitioners aware of Castleman disease in the differential diagnosis of a child presenting with vague symptoms.

2009 Journal of Pediatric Surgery

789. Colon in food allergy. (Abstract)

. The benign clinical course and the spontaneous resolution in most infants suggest the need for further prospective studies to validate markers that allow the identification of those children needing a dietary approach. It remains to be assessed whether lymphoid nodular hyperplasia of the colon is a manifestation of food allergy. Finally, allergic proctitis may present clinically with refractory constipation; the true prevalence of food allergy-related constipation remains to be assessed.

2009 Journal of Pediatric Gastroenterology and Nutrition

790. A case of recurrent pseudolymphomatous folliculitis: A mimic of cutaneous lymphoma. (Abstract)

folliculitis is instructive because of the resemblance to cutaneous lymphomas and cutaneous lymphoid hyperplasias, and the need for correct diagnosis to avoid overtreatment of this indolent condition.

2009 Journal of American Academy of Dermatology

791. Thiamine (Vitamin B1)

in epileptics on anticonvulsants. Lancet 4-25-1970;1:867-868. . Horwitz, S. J., Klipstein, F. A., and Lovelace, R. E. Relation of abnormal folate metabolism to neuropathy developing during anticonvulsant drug therapy. Lancet 3-16-1968;1:563-565. . Backman, N., Holm, A. K., Hanstrom, L., Blomquist, H. K., Heijbel, J., and Safstrom, G. Folate treatment of diphenylhydantoin-induced gingival hyperplasia. Scand J Dent Res 1989;97:222-232. . Zhou, K., Zhao, R., Geng, Z., Jiang, L., Cao, Y., Xu, D., Liu, Y., Huang

2009 National Centre for Complementary and Alternative Medicine

792. Ceplene - histamine dihydrochloride

in mice at a high dose (100 mg/kg), cimetidine and other H 2 receptor antagonists instead aggravate melanoma metastasis at lower doses (25 to 50 mg/kg) (10) - significantly increased the incidence of chemically induced intestinal tumours in rats (26) - long-term exposure (19 mg/mg) increases the frequency of spontaneous lymphoid neoplasms and potentiates chemical carcinogenesis in mice (27) • Secondary pharmacodynamics Histamine has proliferative effects on human and murine cells in vitro. Tilly (...) , haematology, urinalysis or clinical chemistry. Administration of both doses of IL-2 alone produced histological findings (vasculitis of lungs, liver bile duct hyperplasia and inflammation of injection site andiatic nerve). The combination of IL-2 and histamine gave similar histological effects. Female spleen-weight data suggested that the combination treatment might enhance the (high-dose) IL-2 effect of spleen total fluid volume. On the contrary, in males, by adding histamine, a significantly lower high

2008 European Medicines Agency - EPARs

793. Advagraf (tacrolimus)

of these tissues (kidney, nervous system, heart and lymphoid organs). These tissues have been associated with higher tacrolimus concentrations and/or long elimination times. When tacrolimus is administered intravenously or orally it is extensively metabolised by hydroxylation and demethylation to at least nine metabolites, with eight metabolites identified and characterised. Despite differences with respect to the rate of formation of the metabolites the metabolite profile of various species (including humans

2007 European Medicines Agency - EPARs

794. Aclasta (zoledronic acid)

. At high doses, effects possibly irritant, in organs such as GI- tract (haemorrhage, erosions, also after iv administration), liver (hepatocellular necrosis, haemorrhage, inflammation), spleen (inflammation, haemorrhage), lungs (inflammatory lesions) were reported, as well as irritation at injection sites. Effects, possibly secondary to poor physical condition, were noted in lymphoid organs and reproductive tract. Renal effects were seen in rat and dog studies and were characterised by renal tubular (...) (tubular necrosis, regeneration, hyaline casts, focal tubular basophilia) were reported in 10-day iv bolus (6 mg/kg/d), 2-week iv (3.2 mg/kg/d), 10-day sc (0.6 mg/kg/d) and 12- month sc (0.003 mg/kg/d) studies. No kidney effects were reported in the 13-week sc rat study at the high dose of 0.1 mg/kg/d. Renal effects in dogs (e.g. tubular degeneration/necrosis, inflammation, increase in connective tissue, cellular casts, tubular basophilia and urothelial hyperplasia) were noted in 3-month iv (0.2 mg/kg

2006 European Medicines Agency - EPARs

796. Crixivan - indinavir

against mammalian proteases. The IC 50 values were 0.41 nM for HIV-1 protease and > 40000 nM against several human proteases. Indinavir is considerably less active against HIV-2 than against HIV-1. Antiretroviral efficacy of indinavir in vitro was demonstrated in human T-lymphoid cell cultures, PBM (peripheral blood mononuclear) cells and primary monocytes/macrophages using the p24 assay. IC 95 values of 50 nM to 100 nM were reported for both laboratory strains of HIV-1 and clinical isolates. 4/16 (...) systems. It may be explained by the inhibition of hepatic uptake of bilirubine as well as inhibition of acylglucuronidation. Indinavir is a competitive inhibitor of uridine diphosphate glucuronyl transferases (UDPGT) in in vitro systems. However, indinavir did not inhibit the enzymes involved in glucuronidation of p-nitrophenol. An increase in thyroid weight and thyroid hyperplasia was observed in all rat toxicity studies at doses over 160 mg/kg/day. This is likely due to an increase of thyroxin

2005 European Medicines Agency - EPARs

797. Avastin (bevacizumab)

-compliant 2-week monkey studies (see also pharmacokinetic drug interactions). Administration of IFL resulted in diarrhoea, body weight loss, and decreased food consumption, in addition to a decreased white blood cell count and, in some of the animals, a small thymus with corresponding lymphoid depletion. Microscopic effects noted in the sternal bone morrow of most animals consisted mainly of erythroid and/or myeloid hyperplasia. The co-administration of bevacizumab with IFL did not alter the magnitude

2006 European Medicines Agency - EPARs

798. Breast fine needle aspiration cytology and core biopsy - a guide for practice

applicable to men with breast lesions. We are confident the successful implementation of the recommendations in the guide will foster high standards of investigation of women with breast lesions throughout Australia. v Breast fine needle aspiration cytology and core biopsy: a guide for practice 2663J NBCC FNA Guide 23/12/04 1:26 PM Page vABBREVIATIONS ACN Australian Cancer Network ADH atypical ductal hyperplasia AH atypical hyperplasia ALH atypical lobular hyperplasia ASUM Australasian Society (...) of some lesions can be difficult to make on the basis of FNA cytology.These include atypical ductal hyperplasia (ADH), low- grade DCIS, some tubular carcinomas and some invasive lobular carcinomas. • A core biopsy showing only DCIS does not exclude the possibility of invasive disease. Chapter 3. Communicating effectively with women undergoing FNA cytology and core biopsy • Adequate information should be provided to the woman about the nature of the procedure and its interpretation, benefits

2004 Cancer Australia

799. Measles, mumps, and rubella vaccine was not associated with autism in children Full Text available with Trip Pro

Campion EW. Suspicions about the safety of vaccines. N Engl J Med 2002 ; 347 : 1474 –5. Wakefield AJ, Murch SH, Anthony A, et al . Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998 ; 351 : 637 –41. Footnotes Sources of funding: Danish National Research Foundation, National Vaccine Program Office and National Immunization Program, and National Alliance for Autism Research. For correspondence: Dr K M Madsen, Danish Epidemiology

2004 Evidence-Based Nursing

800. Review: existing epidemiological evidence does not show an association between mumps, measles, and rubella vaccination and autism Full Text available with Trip Pro

-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998 ; 351 : 637 –41. Footnotes For correspondence: Dr K Wilson, Department of Medicine and Health Policy, University of Toronto, Ontario, Canada. kumanan.wilsonuhn.on.ca Source of funding: Canadian Institutes for Health Research. Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink

2005 Evidence-Based Nursing

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