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Lymphoid Hyperplasia

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241. Mast Cells Exhibiting Strong Cytoplasmic Staining for IgE and High Affinity IgE Receptor are Increased in IgG4-Related Disease Full Text available with Trip Pro

by using immunohistochemistry and dual immunofluorescence. We analyzed 23 cases of IgG4-related lymphadenopathy and compared them with 23 cases of non-specific lymphoid hyperplasia. The majority of patients with IgG4-related lymphadenopathy had cervical lesions with involvement of other organs. Immunohistologically, mast cells with strong cytoplasmic staining for immunoglobulin E and high affinity immunoglobulin E receptor were significantly increased in IgG4-related lymphadenopathy as compared (...) to those in non-specific lymphoid hyperplasia (mean: 3.83 ± 3.99 cells per high power field and 7.14 ± 8.21 cells per high power field, respectively; P = 0.007 and P = 0.011). In addition, dual immunofluorescence assay showed that immunoglobulin E and high affinity immunoglobulin E receptor staining exhibited a cytoplasmic granular pattern in IgG4-related lymphadenopathy, suggesting internalization of the antibodies and receptors. Our findings showed that mast cell activation might be involved

2018 Scientific reports

242. SSTR2a is a Useful Diagnostic Marker for Follicular Dendritic Cells and Their Related Tumors. (Abstract)

from 182 cases including 83 lymphoid reactive follicular hyperplasias, 17 follicular lymphomas, 18 follicular dendritic cell sarcomas (FDCSs), 6 inflammatory pseudotumor-like FDCSs, and 58 other histologic mimics. Immunohistochemistry for SSTR2a and other FDC markers (CD21, CD23, CD35, clusterin, and podoplanin) were performed in all 182 cases. Diffuse membrane immunoreactivity for SSTR2a in FDCs was observed in 100% of follicular lymphoma and FDCS cases and in 96.4% of the reactive follicular (...) hyperplasias cases. Notably, the positive rate of SSTR2a in FDCSs was higher than that of CD21 (88.9%), CD23 (77.8%), CD35 (94.4%), clusterin (55.6%), and podoplanin (94.4%). All inflammatory pseudotumor-like FDCSs were negative for SSTR2a. The histologic mimics were negative for SSTR2a, except for 1 leiomyosarcoma case that showed focal (~10%) positive expression for SSTR2a. Overall, our findings indicate that SSTR2a is a highly sensitive and diagnostically useful marker for FDCs and FDCSs. Furthermore

2018 American Journal of Surgical Pathology

243. Comparison of Routine Histopathological Examination Results in Children and Adults After Tonsillectomy and/or Adenoidectomy Full Text available with Trip Pro

underwent adenoidectomy were diagnosed with reactive lymphoid hyperplasia. Of the 1356 patients who underwent tonsillectomy, only two were detected with malignancies. These two patients were adults.While routine histopathologic examination is necessary for every case in adult population, risk factors should be considered in pediatric patients after tonsillectomy and/or adenoidectomy.

2018 Turkish Archives of Otorhinolaryngology

244. The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses Full Text available with Trip Pro

The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses Infection with Citrobacter rodentium triggers robust tissue damage repair responses, manifested by secretion of IL-22, in the absence of which mice succumbed to the infection. Of the main hallmarks of C. rodentium infection are colonic crypt hyperplasia (CCH) and dysbiosis. In order to colonize the host and compete with the gut microbiota, C. rodentium employs a type III (...) of IL-22 from colonic explants. While we observed no differences in the recruitment of group 3 innate lymphoid cells (ILC3s) and T cells, which are the main sources of IL-22 at the early and late stages of C. rodentium infection respectively, infection with ΔespO was characterized by diminished recruitment of sub-mucosal neutrophils, which coincided with lower abundance of Mmp9 and chemokines (e.g. S100a8/9) in IECs. Moreover, mice infected with ΔespO triggered significantly lesser nutritional

2018 PLoS pathogens

245. RB inactivation in keratin 18 positive thymic epithelial cells promotes non-cell autonomous T cell hyperproliferation in genetically engineered mice. Full Text available with Trip Pro

resulted in donor T lymphocyte hyperplasia confirming the non-cell autonomous requirement for Rb proteins in K18+ TEC in regulating T cell proliferation. Our data suggests that thymic epithelial cells play an important role in regulating lymphoid proliferation and thymus size. (...) RB inactivation in keratin 18 positive thymic epithelial cells promotes non-cell autonomous T cell hyperproliferation in genetically engineered mice. Thymic epithelial cells (TEC), as part of thymic stroma, provide essential growth factors/cytokines and self-antigens to support T cell development and selection. Deletion of Rb family proteins in adult thymic stroma leads to T cell hyperplasia in vivo. To determine whether deletion of Rb specifically in keratin (K) 18 positive TEC was sufficient

2017 PLoS ONE

246. A novel recombinant variant of latent membrane protein 1 from Epstein Barr virus in Argentina denotes phylogeographical association. Full Text available with Trip Pro

A novel recombinant variant of latent membrane protein 1 from Epstein Barr virus in Argentina denotes phylogeographical association. To study LMP1 variants distribution among children with EBV+ malignant and benign conditions as well as in healthy carriers.Oral secretions and blood cells from 31 children with IM, and biopsies from 14 EBV+ reactive lymphoid hyperplasia and 33 EBV+ lymphomas were included. LMP1 was amplified by nested PCR and sequenced. Phylogenetic reconstructions were made

2017 PLoS ONE

247. Establishment of a combination scoring method for diagnosis of ocular adnexal lymphoproliferative disease. Full Text available with Trip Pro

Establishment of a combination scoring method for diagnosis of ocular adnexal lymphoproliferative disease. Lymphoproliferative diseases (LPDs) of the ocular adnexa encompass the majority of orbital diseases and include reactive follicular hyperplasia (RFH), atypical lymphoid hyperplasia (ALH), and mucosa-associated lymphoid tissue lymphoma (MALToma). Lymphoid follicles (LFs) are usually observed during the histological examination of LPDs. Currently, because there is a lack of specific clinical

2017 PLoS ONE

248. Daxx plays a novel role in T cell survival but is dispensable in Fas-induced apoptosis. Full Text available with Trip Pro

Daxx plays a novel role in T cell survival but is dispensable in Fas-induced apoptosis. Daxx was originally isolated as a Fas-binding protein. However, the in vivo function of Daxx in Fas-induced apoptosis has remained enigmatic. Fas plays an important role in homeostasis in the immune system. Fas gene mutations lead to autoimmune-lymphoproliferation (lpr) diseases characterized by hyperplasia of secondary lymphoid organs. It is well established that the FADD adaptor binds to Fas, and recruits

2017 PLoS ONE

250. Use of Multicolour Flow Cytometry in the diagnosis of Haematological Neoplasms

from the referring institution: Name, address, telephone and fax numbers of the referring doctor. Referring centre should also provide a freshly made film for PB and BM specimens and relevant clinical details. The final report should mention if this was not the case (1A). Flow cytometry ( FC ) data: PB reports for general lymphocytosis queries should include a breakdown of lymphoid populations: T cells, B cells, natural killer (NK) cells, and large granular lymphocytes (LGL), as percentage (...) antigens for the investigation of suspected haematological neoplasms (Wood et al , ; Craig & Foon, ; Borowitz et al , ; Béné et al , ). In addition, the World Health Organization (WHO) Classification of Tumours of Haematopoietic and Lymphoid Tissue lists major clinically important entities together with their phenotypic profile and other clinical and pathological features (Swerdlow et al , ). Appendix lists further useful references that describe panels for particular specimens, disorders and MRD

2014 British Committee for Standards in Haematology

251. Management of Thyroid Cancer

, Grade of tumour, Extent, Size of primary tumour AMES Age at presentation, Metastases, Extent, Size of pri- mary tumour ARSAC Administration of Radioactive Substances Advisory Committee (part of Health Protection Agency) ATA American Thyroid Association ATC Anaplastic thyroid cancer BAETS British Association of Endocrine and Thyroid Sur- geons BAO- HNS British Association of Otolaryngologists, Head & Neck Surgeons CCH C-Cell hyperplasia CEA Carcinoembryonic antigen CT Computed tomography DTC (...) variant papillary thyroid cancer GP General practitioner IJV Internal jugular vein LNM Lymph node metastasis IMRT Intensity modulated radiotherapy MACIS Metastases, Age at presentation, Completeness of surgical resection, Invasion (extra-thyroidal), Size MALT Mucosa associated lymphoid tissue MDL Minimum detection level MDT Multidisciplinary team MEN Multiple endocrine neoplasia MIBG Metaiodobenzylguanidine Micro PTC micro-papillary thyroid carcinoma MRI Magnetic resonance imaging MRND Modi? ed

2014 British Thyroid Association

252. Peripheral T-Cell Lymphomas

markers: CD10, Bcl6, CXCL13,PD1,SAP,ICOS,andCCR5aresuggestiveofafollicular T-helper (FTH) cell origin [9, 11, 12]. Although FTH cells are considered to be the cell of origin in AITL, this diagnosis should also be based on morphological parameters such as hyperplasia of follicular dendritic cells (FDCs), arborising high endothelial † ApprovedbytheESMOGuidelinesCommittee:June2015. *Correspondence to: ESMO Guidelines Committee, ESMO Head Of?ce, via L. Taddei 4, CH-6962Viganello-Lugano,Switzerland. E (...) +/-,subsetFTHfeatures,cytotoxicgranules+/- aß,rarely?d Variable,mostlyT-helpercell AITL CD4+, CD10+/-,BCL+/-,CXCL13+,PD1+,ICOS+/-, SAP+/, CCR5+/-, hyperplasia of FDC, EBV+ B blasts aß FTH ALCLALK+ ALK+,CD30+,EMA+,CD25+,cytotoxicgranules+,CD4+/-, CD3+/- aß CytotoxicT-cell ALCLALK- ALK-,CD30+,EMA+,CD25+,cytotoxicgranules+,CD4+/-, CD3+/- aß CytotoxicT-cell Extranodal EATL,type1 CD8(+)/-,CD56-,HLA-DQ2/-DQ8 aß Intra-epithelialTcells(aß) , pre- existingenteropathy EATL,type2 CD8+,CD56+,HLA-DQ2/-DQ8 ?doraß Intra

2015 European Society for Medical Oncology

253. Thymic Epithelial Tumours

to play a role in the pathogenesis of thymic epithelial tumours. Reports on development of thymoma after radiation, solid-organ transplantation and immunosuppression, including the context of human immunode?ciency virus infection, are rare; differential diagnosis with thymic rebound hyperplasia maybediscussedinthissetting(seebelow). Genetic risk factors, such as multiple endocrine neoplasia 1 (MEN1), may in?uence the development of thymomas, as well as thymic carcinoids, given their reported familial (...) or elevated lactate dehydrogenase. Teratoma usually shows a het- erogeneous morphology on imaging, with fat and cystic pattern [18].Seminomasandnon-seminomatousgerm-celltumoursmay be large and have a fulminant onset. Elevated serum ß-human chorionic gonadotropin may be observed in seminomas, along with elevated alphafetoprotein in non-seminomatous germ-cells tumours. Differentiating thymic malignancy from hyperplasia or non-involuted thymus may be challenging. Thymic rebound hyperplasia should

2015 European Society for Medical Oncology

254. PD-1 Expression in T-cell Lymphomas and Reactive Lymphoid Entities: Potential Overlap in Staining Patterns Between Lymphoma and Viral Lymphadenitis. Full Text available with Trip Pro

PD-1 Expression in T-cell Lymphomas and Reactive Lymphoid Entities: Potential Overlap in Staining Patterns Between Lymphoma and Viral Lymphadenitis. Peripheral T-cell lymphomas are a heterogeneous group that often requires the use of ancillary testing for accurate diagnosis. This is particularly applicable to the diagnosis of angiommunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma, unclassified (PTCLU), because of their histologic and immunophenotypic overlap with reactive (...) lymphoid proliferations. Recently, immunohistochemistry for programmed death-1 (PD-1), a marker of follicular helper T cells, was shown to be sensitive in the detection of AITL and PTCLU. The sensitivity of this marker in reactive entities, however, has not been adequately evaluated. We confirm that PD-1 staining is a highly sensitive marker in the diagnosis of peripheral T-cell lymphomas: increased extrafollicular PD-1-positive cells were seen in 93% (76/82) of AITL, 62% (16/26) of PTCLU, and 11% (2

2010 American Journal of Surgical Pathology

255. Classification, Evaluation, and Management of Childhood Interstitial Lung Disease in Infancy: An Official ATS Clinical Practice Guideline

. Structural pulmonary changes with chromosomal abnormalities A. Trisomy 21 B. Others 4. Associated with congenital heart disease in chromosomally normal children C. Speci?c conditions of unde?ned etiology 1. Pulmonary interstitial glycogenosis 2. Neuroendocrine cell hyperplasia of infancy D. Surfactant dysfunction mutations and related disorders 1. SPFTB genetic mutations—PAP and variant dominant histologic pattern 2. SPFTC genetic mutations—CPI dominant histologic pattern; also DIP and NSIP 3. ABCA3 (...) as the preferred method of CT im- aging. However, see text for discussion of CVHRCT versus HRCT. BAL¼ bronchoalveolar lavage; CF¼ cystic ?brosis; CHD ¼ congenital heart disease; EKG ¼ electrocardio- gram; EM¼ electron microscopy; iPFT¼ infant pulmonary function test; NEHI ¼ neuroendocrine cell hyperplasia of infancy. Figure 4. Geneticapproachtochildhoodinterstitiallungdisease(chILD) diagnosis. Possible genetic mechanisms are listed at right,ordered depending upon age of the patient at presentation (top

2013 American Thoracic Society

256. Photopheresis, extracorporeal

, alteration of the cytokine profile, and induction of particular T-cell subpopulations (10, 11). ECP, like psoralen plus UVA (PUVA), induces psoralen-mediated DNA crosslinks, which cause apoptosis of lymphoid cells, particularly natural killer (NK) and T-cells (12). The therapeutic effect of ECP in Sézary syndrome (SS), however, cannot be explained by depletion of malignant cells, as only a minority of the entire lymphocyte pool is included in a photopheresis cycle. Monocytes treated in the same way

2013 European Dermatology Forum

257. Clinical Features Differentiating Benign From Malignant Conjunctival Tumors in Children. (Abstract)

included 262 children who were part of a published review.Features of benign and malignant tumors were compared. Data were collected on patient demographics, tumor features, and specific diagnoses to determine findings related to each tumor.Among the 806 patients with conjunctival tumor, the top 5 diagnoses included nevus (492 [61%]), benign reactive lymphoid hyperplasia (BRLH) (38 [5%]), nodular conjunctivitis (31 [4%]), dermoid (30 [4%]), and primary acquired melanosis (27 [3%]). Overall

2017 JAMA ophthalmology

258. Acute Liver Failure/Injury Related to Drug Reaction With Eosinophilia and Systemic Symptoms: Outcomes and Prognostic Factors. (Abstract)

=7) revealed atypical lymphoid infiltrates, Kupffer cell hyperplasia with erythrophagocytosis, and an inconstant presence of eosinophils.The spontaneous prognosis of patients with sALI/ALF due to DRESS is poor and was not improved by corticosteroid therapy. Histology is helpful to establish diagnosis. Dynamic variables regarding factor V values are predictive of a poor outcome.

2017 Transplantation

259. Noncanonical NF-κB signaling and the essential kinase NIK modulate crucial features associated with eosinophilic esophagitis pathogenesis Full Text available with Trip Pro

signaling molecule of the noncanonical NF-κB (NFKB1) pathway, an alternative signaling cascade producing chemokines involved in lymphoid stroma development and leukocyte trafficking. Nik-/- mice have been shown to develop a hypereosinophilic syndrome in peripheral blood and major filtering organs; however, the gastrointestinal mucosa of these mice has not been well characterized. We show that Nik-/- mice develop significant, localized eosinophilic esophagitis that mimics human EoE, including features (...) such as severe eosinophil accumulation, degranulation, mucosal thickening, fibrosis and basal cell hyperplasia. The remainder of the GI tract, including the caudal stomach, small intestine and colon, in mice with active EoE are unaffected, also similar to human patients. Gene expression patterns in esophageal tissue of Nik-/- mice mimics human EoE, with thymic stromal lymphopoetin (TSLP) in particular also elevated at the protein level. In gene expression data sets from human biopsy specimens, we further

2017 Disease models & mechanisms

260. Histopathology, microbiology and the inflammatory process associated with Sarcoptes scabiei infection in the Iberian ibex, Capra pyrenaica Full Text available with Trip Pro

hyperplasia. The cellular response in the dermis was consistent with type I and type IV hypersensitivity responses. The most prominent histological findings in non-dermal tissues were lymphoid hyperplasia, leukocytosis, congestion and the presence of amyloid deposits. The increase in serum concentrations of acetylcholinesterase and amyloid A protein correlated positively with the establishment of the inflammatory response in mangy skin and the presence of systemic amyloidosis. A wide variety of bacterial

2017 Parasites & vectors

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