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dose toxicity studies in rats (4 and 13 weeks) and dogs (4 weeks). The major target organ was the liver (particularly bile duct), and major findings included increased aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin, and brown pigmentation in the liver. Furthermore, in rats, mild anemia, hepatic necrosis, bile duct hyperplasia, peribiliary infiltration, reddish brown urine, brown pigmentation in the kidney, and proximal tubule epithelial vacuolation were also (...) -brown liver and kidney, increases in liver and kidney weights, focal hepatocellular necrosis or unicellular necrosis, bile duct hyperplasia, and proximal tubule epithelial vacuolation were noted. In the =366 mg/kg/day groups, ear or tail flushing and excoriation, which were probably due to the phototoxicity of PPIX, decreased hematocrit, increases in neutrophil proportion and white blood cell count, increases in ALP , blood urea nitrogen, total bilirubin and triglyceride, decreased creatinine
in this study. 32 lymphoproliferative disorder (PTLD) resulting from immunosuppression. It has been discussed that the T-cell lymphoma was attributed to a higher sensitivity of T-cells that regulate lymphoma development to tofacitinib in monkeys. Furthermore, lymphoid (follicular) hyperplasia in the lymph nodes and spleen were observed at all dose levels. This was B cell hyperplasia, but was negative for LCV. Thus, this lymphocyte hyperplasia was not considered a precursor of B-cell lymphoma. The NOAEL (...) conducted. In both animal species, decreases in circulating lymphocytes, NK cells, and T cells and lymphoid depletion in lymphoid tissues, which were considered attributable to JAK1/3 inhibition by tofacitinib, and decreases in red blood cell parameters and the percent reticulocytes, which were considered attributable to JAK2 inhibition by tofacitinib, were observed. In the monkey 39-week oral study, lymphomas, which were considered associated with immunosuppression, and lymphoid (follicular
of MTX-LPD. Paraffin-embedded tissue samples of 219 patients with MTX-LPD were analyzed. In total, 30,33,106, and 26 had reactive lymphoidhyperplasia (RH), polymorphic-LPD (Poly-LPD), diffuse large B-cell lymphomas (DLBCLs), and classic Hodgkin lymphoma (CHL), respectively. The clinicopathologic features of RH, Poly-LPD, DLBCLs, and CHL were as follows: extranodal involvement: 13.8% (4/29), 36.4% (12/33), 69.5% (73/105), and 15.4% (4/26); Epstein-Barr virus encoded RNA positivity: 55.2% (16/29
and response assessment of primary parotid MALT lymphoma with multiple sites involvement. As far as we know, there are no similar case reports have been published before.A 71-year-old woman, who received mass resection twice during the past 2 years due to the repeatedly relapse of facial painless masses and diagnosed as reactive lymphoidhyperplasia by pathologic tests. However, the pathological diagnosis was then changed to primary parotid MALT lymphoma after left parotidectomy operation because of a new (...) 18F-FDG PET/CT for staging and response assessment of primary parotid MALT lymphoma with multiple sites involvement: A case report. Mucosa-associated lymphoid tissue (MALT) lymphoma is an extranodal low-grade B cell lymphoma that generally exhibits an indolent clinical course. Currently, the application of F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in MALT lymphoma is still controversial. Herein, we reported a case of using F-FDG PET/CT for staging
in rats. In the fGT groups, no body weight changes or daily metabolic changes were found, and hematological and serum biochemical ranges were normal. The postmortem and histopathological examinations revealed few fGT-related abnormalities in most of the organs including the liver, although slight lymphoid cell hyperplasia in the lymph node was observed in a few rats with fGT at 2.0 g/kg. This may be secondary to increased immune response to the highest dose because there were no histopathological
cells induce, regulate and adapt to the recognized markers of airway remodeling. Mucous cell hyperplasia, epithelial dysfunction and mesenchymal transition, extracellular matrix protein synthesis and restructuration, fibroblast to myofibroblast transition, airway smooth muscle proliferation, bioactive and contractile properties, and vascular remodeling encompass complex physiopathological mechanisms that can be induced, suppressed or regulated by different cellular and molecular pathways. Growth (...) factors, cytokines, chemokines and adhesion molecules expressed or derived either from the immune network of cells infiltrating the asthmatic airways and involving T helper lymphocytes, immune lymphoid cells, dendritic cells, eosinophils, neutrophils, mast cells or by the structural components such as epithelial cells, fibroblasts, myocytes, airway smooth muscle cells concur with protein cellular matrix component and metalloproteases in modifying the airway structure in a detrimental way
groups.The percentage of AA patients with fecaliths in summer was lower than that in the non-summer months. The increase in the number of AA patients in summer may be due to the increased occurrence of lymphoidhyperplasia, which may be correlated with the yearly outbreak of enterovirus infection during this period.
. [ ] Skinnider BF, Mak TW: The role of cytokines in classical Hodgkin lymphoma. Blood 99 (12): 4283-97, 2002. [ ] Steidl C, Shah SP, Woolcock BW, et al.: MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers. Nature 471 (7338): 377-81, 2011. [ ] [ ] Green MR, Monti S, Rodig SJ, et al.: Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal (...) Defining strict CT or MRI size criteria for lymphomatous nodal involvement is complicated by several factors, such as size overlap between what proves to be benign reactive hyperplasia versus malignant lymphadenopathy, the implication of nodal clusters, and obliquity of node orientation to the scan plane. Additional difficulties more specific to children include greater variability of normal nodal size and the frequent occurrence of reactive hyperplasia. General concepts to consider in regard
, and can last over 10 years in some patients (Padmanabhan et al, 2008). However, if transition to AP-CML occurs, median survival is typically limited to under a year, while patients in BP-CML (which resembles acute leukaemia) usually live for only a few months. Most patients are diagnosed in CP-CML and may be asymptomatic or present with fatigue, anaemia, weight loss, night sweats, or splenomegaly. Acute lymphoblastic leukaemia (ALL) is a malignant proliferation of lymphoid cells. The majority of cases (...) . Three (1 male, 2 females) of 30 animals at 3 mg/kg/day in the toxicology portion of the study were found dead/sacrificed in moribund condition between Days 9 and 13. One animal (a male) of 30 animals at 1.5 mg/kg/day in the toxicology portion of the study was found dead on Day 28. 6 mg/kg: Hyperplasia of bone marrow. Minimal to marked necrosis of thymus. Sporadic necrosis of the glandular and non-glandular mucosa of the stomach. =3mg/kg: rough hair coats; inappetance; thinness; lethargy; hunched
on 27 June 2013, the CHMP, in the light of the overall data submitted and the scientific discussion within the Committee, issued a positive opinion for granting a Marketing Authorisation to Remsima. 2. Scientific discussion 2.1. Introduction Problem statement Tumour necrosis-factor-alpha (TNFa) is a multipotent cytokine that occurs in monomeric and trimeric soluble and transmembrane forms. It is mainly produced by macrophages, as well as by a broad variety of other cell types including lymphoid
as inflammatory effects. These effects were typically mild, reversible, and evident mostly in mice treated with = 44 mg/kg/week mipomersen for 13 weeks. Plasma MCP-1 was transiently increased from control levels at doses of 10 or 75 mg/kg/week on Day 1. These data demonstrated the limited scope of the inflammatory effects associated with chronic mipomersen treatment. Toxicology studies in rats showed treatment-related increased spleen weight, lymphoidhyperplasia in spleen and multiorgan lymphohistiocytic (...) /week in the 5 month study were observed. In monkeys, there was a presence of basophilic granules in Kupffer cells and hyperplasia/hypertrophy in Kupffer cells at doses = 3 mg/kg/week. In the absence of associated changes in hepatic function, Kupffer cell hyperplasia/ hypertrophy is of uncertain toxicological significance. In hyperlipidemic monkeys there were no increases in serum transaminases, indicating that there were no adverse effects of apoB inhibition on the liver. In these monkeys fed