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Lymphadenopathy in HIV

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61. Osteonecrosis of the femoral head in people living with HIV: anatomopathological description and p24 antigen test Full Text available with Trip Pro

obtained during total hip arthroplasty was retrieved and sent for conventional and immunohistochemical analysis. Monoclonal antibodies were used to mark the p24 (HIV), CD31 (vascular endothelial cells), CD68 (macrophages), and D240 (cells of the lymphatic endothelium) antigens.Dyslipidemia was found in 48% of the patients and lipodystrophy in 31%. Histological analysis showed similar characteristics for the entire sample. Degeneration of joint cartilage was visualized with the presence of fissures (...) Osteonecrosis of the femoral head in people living with HIV: anatomopathological description and p24 antigen test To examine the presence of HIV in bone tissue of people living with HIV (PLWHIV) with osteonecrosis of femoral head and describe clinical and anatomopathological findings.This is a case series which included 44 PLWHIV with osteonecrosis of femoral head who underwent total hip arthroplasty.Clinical data were obtained through analysis of the patients' medical records. Bone tissue

2018 HIV/AIDS (Auckland, N.Z.)

62. T. marneffei infection complications in an HIV-negative patient with pre-existing pulmonary sarcoidosis: a rare case report. Full Text available with Trip Pro

T. marneffei infection complications in an HIV-negative patient with pre-existing pulmonary sarcoidosis: a rare case report. Talaromyces marneffei (T. marneffei) is a thermal dimorphic pathogenic fungus that often causes fatal opportunistic infections in human immunodeficiency virus (HIV)-infected patients. Although T. marneffei-infected cases have been increasingly reported among non-HIV-infected patients in recent years, no cases of T. marneffei infection have been reported in pulmonary (...) sarcoidosis patients. In this case, we describe a T. marneffei infection in an HIV-negative patient diagnosed with pulmonary sarcoidosis.A 41-year-old Chinese man who had pre-existing pulmonary sarcoidosis presented with daily hyperpyrexia and cough. Following a fungal culture from bronchoalveolar lavage (BAL), the patient was diagnosed with T. marneffei infection. A high-resolution computed tomography (HRCT) chest scan revealed bilateral lung diffuse miliary nodules, multiple patchy exudative shadows

2018 BMC Infectious Diseases

63. Clearance of human papillomavirus related anal condylomas after oral and endorectal multistrain probiotic supplementation in an HIV positive male: A case report. Full Text available with Trip Pro

Clearance of human papillomavirus related anal condylomas after oral and endorectal multistrain probiotic supplementation in an HIV positive male: A case report. Here we present the case of a 56-year-old human immunodeficiency virus (HIV)-infected man with multiple anal condylomas and positivity for human papilloma virus (HPV) 18 on anal brushing. Biopsies of the anal mucosa led to the diagnosis of Bowen's disease and a subsequent pelvic magnetic resonance imaging (MRI) scan evidenced multiple (...) of residual lymphadenopathies. Trials are therefore required to confirm this therapeutic possibility and for a better understanding of the mechanisms by which this specific probiotic formulation interacts with local epithelium when administered by the anal route.

2018 Medicine

64. A Study Evaluating the Safety of Cal-1 (LVsh5/C46) Drug Product in HIV-1 Infected Patient With High Risk Lymphoma

aminotransferase (ALT/AST) >10 x upper limit of normal (ULN) Total bilirubin > 2.5 x ULN Creatinine clearance <60ml/min Ex-C. Severe coagulopathy Ex-D. Prothombin time > 2x ULN Ex-E. Evidence of co-infection with hepatitis B virus (HBsAg+), hepatitis C virus, West Nile Virus, or Human T-lymphotropic virus (HTLV-1) as detected at Screening 1 Ex-F. Stay in West Nile Virus endemic area less than 6 weeks prior to CD34+ collection Ex-G. Evidence of non-treated opportunistic infection during the pre-infusion period (...) by Assistance Publique - Hôpitaux de Paris: HIV-1 Lymphoma Gene therapy Additional relevant MeSH terms: Layout table for MeSH terms Lymphoma Neoplasms by Histologic Type Neoplasms Lymphoproliferative Disorders Lymphatic Diseases Immunoproliferative Disorders Immune System Diseases

2018 Clinical Trials

65. Mannose Receptor 1 Restricts HIV Particle Release from Infected Macrophages Full Text available with Trip Pro

Mannose Receptor 1 Restricts HIV Particle Release from Infected Macrophages Human mannose receptor 1 (hMRC1) is expressed on the surface of most tissue macrophages, dendritic cells, and select lymphatic or liver endothelial cells. HMRC1 contributes to the binding of HIV-1 to monocyte-derived macrophages (MDMs) and is involved in the endocytic uptake of HIV-1 into these cells. Here, we identify hMRC1 as an antiviral factor that inhibits virus release through a bone marrow stromal antigen 2 (BST (...) -2)-like mechanism. Virions produced in the presence of hMRC1 accumulated in clusters at the cell surface but were fully infectious. HIV-1 counteracted the effect by transcriptional silencing of hMRC1. The effect of hMRC1 was not virus isolate specific. Surprisingly, deletion of the Env protein, which is known to interact with hMRC1, did not relieve the hMRC1 antiviral activity, suggesting the involvement of additional cellular factor(s) in the process. Our data reveal an antiviral mechanism

2018 Cell reports

66. Primary Effusion Lymphoma without an Effusion: A Rare Case of Solid Extracavitary Variant of Primary Effusion Lymphoma in an HIV-Positive Patient Full Text available with Trip Pro

Primary Effusion Lymphoma without an Effusion: A Rare Case of Solid Extracavitary Variant of Primary Effusion Lymphoma in an HIV-Positive Patient Primary effusion lymphoma (PEL) is a unique form of non-Hodgkin lymphoma, usually seen in severely immunocompromised, HIV-positive patients. PEL is related to human herpesvirus-8 (HHV-8) infection, and it usually presents as a lymphomatous body cavity effusion in the absence of a solid tumor mass. There have been very few case reports of HIV-positive (...) patients with HHV-8-positive solid tissue lymphomas not associated with an effusion (a solid variant of PEL). In the absence of effusion, establishing an accurate diagnosis can be challenging, and a careful review of morphology, immunophenotype, and presence of HHV-8 is necessary to differentiate from other subtypes of non-Hodgkin lymphoma. Treatment involves intensive chemotherapy, and prognosis is usually poor. We present a rare case of a PEL variant in an HIV-positive patient who presented

2018 Case reports in hematology

67. Yield of yearly routine physical examination in HIV-1 infected patients is limited: A retrospective cohort study in the Netherlands. Full Text available with Trip Pro

Yield of yearly routine physical examination in HIV-1 infected patients is limited: A retrospective cohort study in the Netherlands. Routine physical examinations might be of value in HIV-infected patients, but the yield is unknown. We determined the diagnoses that would have been missed without performing annual routine physical examinations in HIV-infected patients with stable disease.Data were collected from the medical records of 299 HIV-1-infected patients with CD4 count >350 cells/mm3 (...) if not using combination antiretroviral therapy (cART), or CD4 count >100 cells/mm3 and undetectable viral load if using cART. We defined the diagnoses that would have been missed without performing routine physical examinations on annual check-ups in 2010. Exclusion criteria were hepatitis B/C co-infection, start/ switch of cART < 24 weeks, pregnancy, and transgenderism.215 patients (72%) had positive findings: lipodystrophy (30%), lymphadenopathy (16%) and hypertension (8.4%) were the most common. Two

2017 PLoS ONE

68. Chronic and recurrent benign lymphadenopathy without constitutional symptoms associated with human herpesvirus-6B reactivation. Full Text available with Trip Pro

Chronic and recurrent benign lymphadenopathy without constitutional symptoms associated with human herpesvirus-6B reactivation. Chronic/recurrent behaviour may be encountered in some distinct atypical or malignant lymphoproliferations, while recurrences are not generally observed in reactive/benign lymphadenopathies. We retrospectively analysed a consecutive series of 486 human immunodeficiency virus-negative adults, who underwent lymphadenectomy. Neoplastic and benign/reactive (...) histopathological pictures were documented in 299 (61·5%) and 187 (38·5%) cases, respectively. Of note, seven of the 111 (6·3%) patients with benign lymphadenopathy without well-defined aetiology, showed chronic/recurrent behaviour, without constitutional symptoms. Enlarged lymph nodes were round in shape and hypoechoic, mimicking lymphoma. Reactive follicular hyperplasia and paracortical expansion were observed. Human herpesvirus (HHV)-6B positive staining in follicular dendritic cells (FDCs) was documented

2015 British journal of haematology

69. Relationship Between the Activity of Rheumatoid Arthritis and Lymph Node Morphology and Lymphatics Drainage

Relationship Between the Activity of Rheumatoid Arthritis and Lymph Node Morphology and Lymphatics Drainage Relationship Between the Activity of Rheumatoid Arthritis and Lymph Node Morphology and Lymphatics Drainage - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Relationship Between the Activity of Rheumatoid Arthritis and Lymph Node Morphology and Lymphatics Drainage The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02876874 Recruitment Status : Unknown Verified August 2016 by Shanghai University

2015 Clinical Trials

70. NIR Fluorescence Imaging of Lymphatic Transport Using ICG

(MSImager). Condition or disease Intervention/treatment Phase Rheumatoid Arthritis Drug: Indocyanine Green Device: MultiSpectral Imaging System Phase 1 Detailed Description: Lymphedema from various etiologies (i.e. infection, cancer, surgery, and rheumatoid arthritis) remains a major health concern. Efforts to develop effective treatments for this condition have been limited by the absence of quantitative outcome measures for lymphatic function. Published articles have supported the fact that human (...) NIR Fluorescence Imaging of Lymphatic Transport Using ICG NIR Fluorescence Imaging of Lymphatic Transport Using ICG - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. NIR Fluorescence Imaging of Lymphatic

2015 Clinical Trials

71. Patterns of Lymph Node Pathology; Fine Needle Aspiration Biopsy as an Evaluation Tool for Lymphadenopathy: A Retrospective Descriptive Study Conducted at the Largest Hospital in Africa Full Text available with Trip Pro

Patterns of Lymph Node Pathology; Fine Needle Aspiration Biopsy as an Evaluation Tool for Lymphadenopathy: A Retrospective Descriptive Study Conducted at the Largest Hospital in Africa Lymphadenopathy is a common clinical presentation of disease in South Africa (SA), particularly in the era of Human Immunodeficiency Virus (HIV) and tuberculosis (TB) co-infection.Data from 560 lymph node biopsy reports of specimens from patients older than 12 years at Chris Hani Baragwanath Academic Hospital (...) histopathology and cytology demonstrating definite, and suspicious for mycobacterial infection), 8% comprised HIV reactive nodes; in the remainder no specific pathology was identified (nonspecific reactive lymphoid hyperplasia). Kaposi sarcoma (KS) accounted for 2.5% of lymph node pathology in this sample. Concomitant lymph node pathology was diagnosed in four cases of nodal KS (29% of the subset). The co-existing pathologies were TB and Castleman disease. HIV positive patients constituted 49% of this study

2015 PloS one

72. The use of vaccines in HIV-positive adults

infected with human immunodeficiency virus. Clin Infect Dis 1995; 21: 1197–203. 7. Valdez H, Smith KY, Landay A et al. Response to immunization with recall and neoantigens after prolonged administration of an HIV-­-1 protease inhibitor-­-containing regimen. AIDS 2000; 14: 11–21. 8. Bonetti TC, Succi RC, Weckx LY et al. Tetanus and diphtheria antibodies and response to a booster dose in Brazilian HIV-­-1-­-infected women. Vaccine 2004; 22: 3707–12. BHIVA guidelines on the use of vaccines in HIV (...) . The influence of human immunodeficiency virus (HIV) infection on antibody responses to influenza vaccines. Ann Intern Med 1988; 109: 383–8. 26. Kroon FP, van Dissel JT, de Jong JC, van Furth R. Antibody response to influenza, tetanus and pneumococcal vaccines in HIV-­-seropositive individuals in relation to the number of CD4+ lymphocytes. AIDS 1994; 8: 469–76. 27. Iorio AM, Alatri A, Francisci D et al. Immunogenicity of influenza vaccine (1993–94 winter season) in HIV-­-seropositive and -­-seronegative ex

2015 British HIV Association

73. HIV, viral hepatitis and STIs - a guide for primary care

, Faculty of Medicine, UNSW Australia, Sydney NSW8 HIV, VIRAL HEPATITIS AND STIs – A GUIDE FOR PRIMARY HEALTH CARE Introduction The three major blood-borne viruses, human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), are members of different virus families but have one thing in common: their major mode of transmission is via blood or bodily fluids. Sexually transmitted infections (STIs) are a diverse group of infections caused by widely differing micro-organisms (...) of them. • Most STIs, in their early stages, are asymptomatic or so mildly symptomatic as to be easily overlooked, yet are infectious, screening at-risk people is essential for population management. kEY POINTS ? Human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are distinct viruses with different epidemiological profiles, modes of transmission, natural histories and treatments. ? All three viruses lead to chronic infection in many individuals with the viral

2014 Clinical Practice Guidelines Portal

74. Treatment and recommendations for homeless people/Unstably Housed Patients with HIV/AIDS

with human immunodeficiency virus (HIV) in the United States, with about 50,000 new HIV infections per year. An estimated 20% of people living with HIV infection have not been diagnosed (CDC, 2011). Among those without stable housing 1 , HIV infection rates are about three times higher than that of the general population (National Alliance to End Homelessness, 2006) and this rate increases in some specific subpopulations. In a meta-analysis of 43 studies conducted in the U.S., prevalence rates of HIV (...) cultural/religious heritage and affiliations. Ask about attitudes of family, friends, community, cultural group toward HIV risk behaviors and persons who contract the virus. Physical examination ? Comprehensive vs. serial, focused examinations – Do focused physical exams in outreach settings; reserve comprehensive exams for clinic; defer genital exam until the patient feels comfortable unless there are clinical signs or history to indicate genito- urinary infections or other issues that should

2013 National Health Care for the Homeless Council

75. Tropical Travel Trouble 009 Humongous HIV Extravaganza

and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with a low CD4 count – all bets are off) and aims to focus on the key learning points surrounding HIV. Q1. What is HIV? Answer and interpretation Human immunodeficiency virus (HIV) is caused by a lentivirus (subgroup of retrovirus) that infects and destroys immune cells expressing CD4 (T-helper cells (...) with 2 viral RNAs are released from the cell as an immature HIV. Protease splices the long amino acid strands in this immature cell to the exact proteins the HIV needs. The cell is now a mature virus ready to infect another cell. The following videos are very helpful for revision on reverse transcription and the important concepts of how HIV replicates. You will need to understand this to understand how the drugs work. If you are fairly confident then just jump to video 3 for a re-cap. Q3. How do you

2018 Life in the Fast Lane Blog

76. Molecular Characterization of Viral-associated Tumors, Tumors Occurring in the Setting of HIV or Other Immune Disorders and Castleman Disease

may collect data from participant medical records. Researchers will compare the genes in a participant s cancer tissue to their normal tissue. They may use the tissue cells to grow new cells in a lab. Participants may be contacted about the results. The samples will be stored for future research. No personal data will be kept with them. Condition or disease Human Immunodeficiency Virus Castleman's Disease Kaposi's Sarcoma Viral-Associated Cancer Detailed Description: Background: The availability (...) of HIV or other immunodeficiencies, and Castleman disease, by accrual of high quality, clinically annotated tissue from such patients as well as patients with tumors that may serve as appropriate controls. Eligibility: Age >18 years HIV or other acquired immunodeficiency and cancer or Viral-associated cancer or HIV-negative with cancer that commonly occurs in people with HIV or Kaposi sarcoma herpes virus (KSHV)-associated malignancy or related diseases, such as Multicentric Castleman Disease

2017 Clinical Trials

77. Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults. Full Text available with Trip Pro

Risk factors for early mortality on antiretroviral therapy in advanced HIV-infected adults. Many HIV-infected individuals present with advanced HIV disease. These patients are at high risk of death after antiretroviral therapy (ART) initiation, but risk factors for death in these patients are unclear.We used data from a multisite randomized trial comparing empiric vs. preventive tuberculosis therapy in HIV-infected adults initiating ART with CD4 T-cell counts less than 50 cells/μl to evaluate (...) risk factors for death within 48 weeks after ART initiation. Cox proportional hazards models were fit to evaluate characteristics present at baseline and at 4 weeks after ART initiation, including the week 4 CD4 T-cell response and new opportunistic infections.Of 850 enrolled, the median pre-ART CD4 T-cell count was 18 cells/μl and 67 (7.9%) died. Baseline risk factors for death included lymphadenopathy, lower CD4 T-cell count, lower serum albumin, high white blood cell count, elevated neutrophil

2017 AIDS

78. Evidence of inflammasome activation and formation of monocyte-derived apoptosis-associated speck-like protein containing a caspase-recruitment domain specks in HIV-1 positive patients. (Abstract)

in addition to ASC specks into the extracellular space during pyroptotic cell death. There ASC specks can propagate inflammation to other nonactivated cells or tissues. HIV-1 retroviral infection triggers inflammasome activation of abortively infected CD4⁺ T cells in secondary lymphatic tissues. However, if pyroptosis occurs in other peripheral blood mononuclear cells (PBMCs) of HIV-1-infected patients is currently unknown. We investigated if ASC speck positive cells are present in the circulation of HIV (...) Evidence of inflammasome activation and formation of monocyte-derived apoptosis-associated speck-like protein containing a caspase-recruitment domain specks in HIV-1 positive patients. The formation of large intracellular protein aggregates of the inflammasome adaptor protein ASC (apoptosis-associated speck-like protein containing a caspase-recruitment domain; also know as PYCARD) is a hallmark of inflammasome activation. ASC speck-forming cells release the highly proinflammatory cytokine IL-1β

2017 AIDS

79. Disseminated Burkitt’s Lymphoma with a Pancreatic Mass in a HIV Positive Woman Diagnosed by Axillary Lymph Node Biopsy Full Text available with Trip Pro

Disseminated Burkitt’s Lymphoma with a Pancreatic Mass in a HIV Positive Woman Diagnosed by Axillary Lymph Node Biopsy Burkitt's Lymphoma (BL) is a highly aggressive B cell lymphoma of non-Hodgkin's type usually presenting in extranodal sites for endemic and sporadic types of the disease. Like other non-Hodgkin's Lymphomas (NHL), HIV positive associated BL is associated with peripheral lymphadenopathy. We present a case of 22-year-old newly diagnosed HIV positive female patient who presented (...) with generalized peripheral lymphadenopathy and obstructive jaundice. Initial work up was suggestive of acute pancreatitis with further evaluation revealing a pancreatic head mass. BL was confirmed both by axillary lymph node biopsy and immunohistochemistry, highlighting the importance of high index of suspicion and prompt histopathological diagnosis to enable treatment of this fatal disease that is potentially curable.

2017 Journal of clinical and diagnostic research : JCDR

80. Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes Full Text available with Trip Pro

Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes In recent years it has been well established that two major constituent parts of the ubiquitin proteasome system (UPS)-the proteasome holoenzymes and a number of ubiquitin ligases-play a crucial role, not only in virus replication but also in the regulation of the immunogenicity of human immunodeficiency virus type 1 (HIV-1). However, the role in HIV-1 replication (...) of the third major component, the deubiquitinating enzymes (DUBs), has remained largely unknown. In this study, we show that the DUB-inhibitors (DIs) P22077 and PR-619, specific for the DUBs USP7 and USP47, impair Gag processing and thereby reduce the infectivity of released virions without affecting viral protease activity. Furthermore, the replication capacity of X4- and R5-tropic HIV-1NL4-3 in human lymphatic tissue is decreased upon treatment with these inhibitors without affecting cell viability. Most

2017 Viruses

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