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Lymphadenopathy in HIV

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181. Study Assessing Dolutegravir in HIV-1 Infected Subjects With Virus Resistant to Raltegravir and/or Elivitegravir

7). Open label dolutegravir plus optimized background regimen (from Day 8) Other Name: GSK1349572 Drug: Dolutegravir placebo twice daily Dolutegravir placebo plus failing background regimen (Day 1 to Day 7) Other Name: GSK1349572 Placebo Outcome Measures Go to Primary Outcome Measures : Mean Change From Baseline in Plasma Human Immunodeficiency Virus Type 1 (HIV-1) Ribonucleic Acid (RNA) at Day 8 [ Time Frame: Baseline and Day 8 ] Plasma samples were collected for quantitative HIV-1 RNA analysis (...) Study Assessing Dolutegravir in HIV-1 Infected Subjects With Virus Resistant to Raltegravir and/or Elivitegravir Study Assessing Dolutegravir in HIV-1 Infected Subjects With Virus Resistant to Raltegravir and/or Elivitegravir - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved

2012 Clinical Trials

182. Collecting and Studying Tissue Samples From Patients With HIV-Associated Malignancies

high-quality, clinically annotated tissue from patients with human immunodeficiency virus (HIV)-1 malignancy. To study clinical, genetic, and immunologic parameters that have prognostic significance and/or are involved in the initiation and progression of HIV-1 malignancies, including complete genomic sequence determination of HIV-associated diffuse large B-cell lymphomas, lung cancer, anal cancer, and cervical cancer. OUTLINE: This is a multicenter study. Patients undergo tumor, lymph node, bone (...) Collecting and Studying Tissue Samples From Patients With HIV-Associated Malignancies Collecting and Studying Tissue Samples From Patients With HIV-Associated Malignancies - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before

2012 Clinical Trials

183. Short Term Intensified Chemo-immunotherapy in HIV-positive Patients With Burkitt Lymphoma

. Ferreri, IRCCS San Raffaele: HIV Burkitt's lymphoma intensive short term immuno-chemotherapy HIV-positive patients with Burkitt's lymphoma Additional relevant MeSH terms: Layout table for MeSH terms Lymphoma Burkitt Lymphoma HIV Seropositivity Neoplasms by Histologic Type Neoplasms Lymphoproliferative Disorders Lymphatic Diseases Immunoproliferative Disorders Immune System Diseases Epstein-Barr Virus Infections Herpesviridae Infections DNA Virus Infections Virus Diseases Tumor Virus Infections (...) Lymphoma, B-Cell Lymphoma, Non-Hodgkin HIV Infections Lentivirus Infections Retroviridae Infections RNA Virus Infections Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes Cytarabine Antimetabolites, Antineoplastic Antimetabolites Molecular Mechanisms of Pharmacological Action Antineoplastic Agents Antiviral Agents Anti-Infective Agents

2012 Clinical Trials

184. Long Term Immunogenicity of Quadrivalent Human Papillomavirus Vaccine (Gardasil®)in HIV-infected Adolescents and Young Adults

: Unknown Verified January 2012 by Gian Vincenzo Zuccotti, University of Milan. Recruitment status was: Recruiting First Posted : January 19, 2012 Last Update Posted : January 19, 2012 Sponsor: University of Milan Information provided by (Responsible Party): Gian Vincenzo Zuccotti, University of Milan Study Details Study Description Go to Brief Summary: Infection with human immunodeficiency virus (HIV) is an important risk factor for HPV infection and the development of HPV-associated lesions in female (...) Long Term Immunogenicity of Quadrivalent Human Papillomavirus Vaccine (Gardasil®)in HIV-infected Adolescents and Young Adults Long Term Immunogenicity of Quadrivalent Human Papillomavirus Vaccine (Gardasil®)in HIV-infected Adolescents and Young Adults - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached

2012 Clinical Trials

185. Reversing Tissue Fibrosis to Improve Immune Reconstitution in HIV

provided by University of Minnesota - Clinical and Translational Science Institute: Infection HIV 1 HIV Losartan Fibrosis Immune Activation Immune Reconstitution Additional relevant MeSH terms: Layout table for MeSH terms Infection Communicable Diseases Fibrosis HIV Infections Acquired Immunodeficiency Syndrome Pathologic Processes Lentivirus Infections Retroviridae Infections RNA Virus Infections Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency (...) the number and improve the function of peripheral and lymphatic CD4 T cells, decrease levels of systemic immune activation (IA), decrease size of the HIV reservoir, and be safe and well tolerated. Condition or disease Intervention/treatment Phase HIV Infection HIV Infections Drug: Losartan Drug: Placebo Phase 2 Detailed Description: This is a randomized, double-blind, placebo-controlled trial of 50 HIV-1 infected individuals on stable ART randomized in a 1:1 ratio to losartan (50 mg orally daily titrated

2012 Clinical Trials

186. An unusual case of Primary Effusion Lymphoma with aberrant T-cell phenotype in a HIV-negative, HBV-positive, cirrhotic patient, and review of the literature Full Text available with Trip Pro

An unusual case of Primary Effusion Lymphoma with aberrant T-cell phenotype in a HIV-negative, HBV-positive, cirrhotic patient, and review of the literature Primary effusion lymphoma (PEL) is an unusual, human herpes virus-8 (HHV-8)-associated type of lymphoma, presenting as lymphomatous effusion in body cavities, without a detectable tumor mass. It primarily affects human immunodeficiency virus (HIV)-infected patients, but has also been described in other immunocompromised individuals (...) . Although PEL is a B-cell lymphoma, the neoplastic cells are usually of the 'null' phenotype by immunocytochemistry. This report describes a case of PEL with T-cell phenotype in a HIV-negative patient and reviews all the relevant cases published until now. Our patient suffered from cirrhosis associated with Hepatitis B virus (HBV) infection and presented with a large ascitic effusion, in the absence of peripheral lymphadenopathy or solid mass within either the abdomen or the thorax. Paracentesis

2012 CytoJournal

187. Delayed HIV testing in internal medicine clinics - a missed opportunity. (Abstract)

Delayed HIV testing in internal medicine clinics - a missed opportunity. As HIV infection may be non-symptomatic for many years, many HIV-infected individuals are not aware of their infection. At a certain point in time non-specific symptoms may occur for which patients are likely be referred to internal medicine outpatient clinics. In the absence of systematic screening for HIV and in particular in patients who do not have classical risk factors for HIV, the diagnosis of HIV infection may (...) easily be overlooked. In this manuscript it is illustrated that this diagnostic and therapeutic delay can lead to increased morbidity and mortality. Moreover, undiagnosed individuals are on average more likely to transmit HIV than diagnosed individuals. It is important for public health to identify people harbouring HIV infection, as this is expected to reduce the number of new infections. HIV infection should be considered a possible cause of unexplained symptoms in an early stage of the diagnostic

2012 Netherlands Journal of Medicine

188. HIV-associated multicentric Castleman's disease Full Text available with Trip Pro

HIV-associated multicentric Castleman's disease Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder. It is found with higher frequency in patients with HIV infection, with systemic symptoms and poor prognosis. We present the case of a 32-year old man with HIV disease, Kaposi's sarcoma, lymphadenopathy, fever and hemolytic anemia. A diagnosis of Castleman's disease is confirmed through biopsy and treatment is often based only on published case reports. Systemic (...) treatments for MCD have included chemotherapy, anti-herpes virus, highly active antiretroviral therapy and, more recently, monoclonal antibodies against both IL6 and CD20.

2012 Rare tumors

189. "HHV-8 related Castleman Disease in the absence of HIV infection." Full Text available with Trip Pro

"HHV-8 related Castleman Disease in the absence of HIV infection." Castleman disease (CD) in the context of human immunodeficiency virus (HIV) infection is well described. It is almost always multicentric (MCD) and linked to human herpesvirus 8 (HHV-8). There are limited published data surrounding HHV-8-related CD among HIV-negative patients.From January 1995 through June 2012, we identified in a single center 18 HIV-seronegative patients with HHV-8-related CD. We report on their clinical (...) , pathological, and laboratory features.All cases were multicentric. Patients were aged 42-83 years and were referred with a relapsing remitting syndrome of fever (94%), constitutional symptoms (100%), peripheral lymphadenopathy (100%), splenomegaly (72%), hepatomegaly (50%), and edema (28%). Kaposi sarcoma was observed in 9 cases. Anemia and serum markers of inflammation were present in all cases. Polymerase chain reaction for HHV-8 DNA was positive on blood samples in all cases, whereas only 12 of 16

2012 Clinical Infectious Diseases

190. Site of extrapulmonary tuberculosis is associated with HIV infection. Full Text available with Trip Pro

Site of extrapulmonary tuberculosis is associated with HIV infection. In the United States, the proportion of patients with extrapulmonary tuberculosis (EPTB) has increased relative to cases of pulmonary tuberculosis. Patients with central nervous system (CNS)/meningeal and disseminated EPTB and those with human immunodeficiency virus (HIV)/AIDS have increased mortality. The purpose of our study was to determine risk factors associated with particular types of EPTB.We retrospectively reviewed (...) 320 cases of EPTB from 1995-2007 at a single urban US public hospital. Medical records were reviewed to determine site of EPTB and patient demographic and clinical characteristics. Multivariable logistic regression analyses were performed to determine independent associations between patient characteristics and site of disease.Patients were predominantly male (67%), African American (82%), and US-born (76%). Mean age was 40 years (range 18-89). The most common sites of EPTB were lymphatic (28

2012 Clinical Infectious Diseases

191. Lymphadenopathy, productive cough, eosinophilia, and a new-onset acquired immunodeficiency syndrome. (Abstract)

Lymphadenopathy, productive cough, eosinophilia, and a new-onset acquired immunodeficiency syndrome. We present a complicated case of a human immunodeficiency virus (HIV)-infected male patient with a complexity of confounding and overlapping symptoms that can masquerade as another diagnosis. This is the case of a patient with multiple secondary sexually transmitted infectious diseases, lymphadenopathy, B-cell lymphoma, a productive cough, a clinical picture suggestive of pulmonary tuberculosis (...) , eosinophilia, and a new-onset acquired immunodeficiency syndrome. Our presentation highlights those deteriorations seen in our patient as well as various underlying immunologic changes in the content of HIV infection. This case may not be unique, but less severe cases occur and can be underdiagnosed, indicating the need of timely screening, close evaluation, and monitoring of HIV-infected patients as well as those with high risk of acquiring HIV.

2011 Allergy and Asthma Proceedings

192. Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study. Full Text available with Trip Pro

with intrathoracic lymphadenopathy due to tuberculosis (TB).156 consecutive patients with isolated intrathoracic TB lymphadenitis were studied across four centres over a 2-year period. Only patients with a confirmed diagnosis or unequivocal clinical and radiological response to antituberculous treatment during follow-up for a minimum of 6 months were included. All patients underwent routine clinical assessment and a CT scan prior to EBUS-TBNA. Demographic data, HIV status, pathological findings (...) Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as an important tool for the diagnosis and staging of lung cancer but its role in the diagnosis of tuberculous intrathoracic lymphadenopathy has not been established. The aim of this study was to describe the diagnostic utility of EBUS-TBNA in patients

2011 Thorax

193. Paediatric inflammatory multisystem syndrome and SARS-CoV-2 infection in children

, but the hypothesis includes infection with common pathogens, which causes an immune-mediated response resulting in KD in genetically predisposed children [18]. It has been reported in association with a variety of infectious agents, including bacteria (mostly Group A Streptococci), fungi and viruses, including enteroviruses, adenovirus, human coronaviruses, parainfluenza virus, and Epstein–Barr virus [13]. To date, a causal association with SARS-CoV-2 has not been established. Incidence of KD Although (...) , pericarditis and carditis). A small percent of children can present with KD shock syndrome [14]. There are no diagnostic tests for KD. The diagnosis is based on prolonged fever (= 5 days) and at least four of the following criteria: bilateral conjunctivitis, changes of lips or the oral mucosa (strawberry tongue), skin rash, changes in the hands or feet (erythema, oedema, induration, desquamation), and cervical lymphadenopathy with at least one node = 1.5cm diameter [16-18]. KD aetiology remains unknown

2020 ICM Anaesthesia COVID-19

194. Non-Hodgkin's lymphoma

) jaundice pallor purpura skin lesions neurological abnormalities on examination age >50 years male sex immunocompromised host Epstein-Barr virus (EBV) human T-lymphocytotrophic virus-1 (HTLV-1) human herpesvirus-8 Helicobacter pylori coeliac disease HIV organ transplant hepatitis C virus (HCV) Borrelia burgdorferi Sjogren's syndrome rheumatoid arthritis systemic lupus erythematosus (SLE) common variable immunodeficiency Wiskott-Aldrich syndrome ataxia-telangiectasia Chediak-Higashi syndrome (...) blurred, such as in acute lymphocytic leukaemia and acute lymphoblastic lymphoma, and chronic lymphocytic leukaemia and small lymphocytic lymphoma, depending on the relative presence of a solid phase (lymphoma) versus circulating phase (leukaemia). History and exam night sweats weight loss fatigue/malaise fever lymphadenopathy splenomegaly hepatomegaly shortness of breath cough abdominal discomfort headache change in mental status dizziness, ataxia chest pain bone pain, back pain (bone involvement

2019 BMJ Best Practice

196. Cytomegalovirus infection

polymerase chain reaction-based assays. In immunocompetent people, infection is usually self-limiting; therefore, treatment is usually not indicated. In patients with compromised immune function, the treatment of choice is oral valganciclovir or intravenous ganciclovir. Intravenous foscarnet and cidofovir are less preferred agents. Definition Cytomegalovirus (CMV) is a ubiquitous beta-herpes virus that infects the majority of humans. Primary infection in individuals with normal immune function is usually (...) Cytomegalovirus infection Cytomegalovirus infection - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Cytomegalovirus infection Last reviewed: February 2019 Last updated: January 2019 Summary In people with normal immune systems, CMV infection is often asymptomatic or manifests as infectious mononucleosis-like syndrome (fever, lymphadenopathy, and atypical lymphocytosis). In immunocompromised people (patients with AIDS

2019 BMJ Best Practice

197. Immune thrombocytopenia

/pubmed/19395674?tool=bestpractice.com The focus of this topic is primary ITP. History and exam presence of risk factors bleeding absence of systemic symptoms absence of medicines that cause thrombocytopenia absent splenomegaly or hepatomegaly absent lymphadenopathy women of childbearing age age <10 or >65 years Diagnostic investigations FBC and peripheral blood smear HIV serology Helicobacter pylori breath test or stool antigen test hepatitis C serology thyroid function tests quantitative

2019 BMJ Best Practice

198. Canadian Cardiovascular Society/Canadian Cardiac Transplant Network Position Statement on Heart Transplantation: Patient Eligibility, Selection, and Post-Transplantation Care Full Text available with Trip Pro

solid organ transplantation, adult congenital heart disease, cardiac amyloidosis, high sensitization, and post-transplantation management of antibodies to human leukocyte antigen, rejection, cardiac allograft vasculopathy, and long-term noncardiac care. Attention is also given to Canadian-specific management strategies including the prioritization of highly sensitized transplant candidates (status 4S) and heart organ allocation algorithms. The focus topics in this position statement highlight (...) evidence to the contrary emerges, smoking or vaping cannabis should be actively discouraged. Cannabis and immunosuppression drug interactions has not been well studied. A systematic review of 31 studies on whether cannabinoids could affect human drug-metabolizing enzymes (including cytochrome P-450) concluded insufficient evidence to confirm any interactions in humans. Moreover, it was difficult to determine the exact effects because of variable cannabis usage. Stout S.M. Cimino N.M. Exogenous

2020 Canadian Cardiovascular Society

200. Disseminated kaposi’s sarcoma and other lymphoproliferative disorders in the era of art

and Non-Hodgkins Lymphoma Among People with HIV infection in the United States. J Clin Oncol 2016; 34: 3276 Caponetti, G, Dezube BJ, Restrepo CS, Pantanowitz L. Kaposi sarcoma of the musculoskeletal system: a review of 66 patients. Cancer 2007; 109: 1040 Pinzone MR, Berretta M, Cacopardo B, Nunnari G. Epstein-barr virus and Kaposi sarcoma associated herpesvirus-related malignancies in the setting of human immunodeficiency virus infection. Semin Oncol 2015; 42-258 T. Powles, J. Stebbing, A. Bazeos, et (...) with KS and positive for human herpes virus-8 (HHV-8). It was ultimately determined that the patient had disseminated KS as opposed to other lymphoproliferative disorders. Understand the history and pathogenesis of Kaposi’s Sarcoma: Kaposi’s Sarcoma was first described in 1872 by Moritz Kaposi. It was originally thought to be a disease of predominately older males of Eastern European, Mediterranean or Jewish descent. There are four subtypes of KS: European or western (classic) KS, African (endemic) KS

2020 Clinical Correlations

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