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Lymphadenopathy in HIV

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1. Dolutegravir rilpivirine (Juluca) - For the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults who are virologically suppressed (HIV-1 RNA copies <50 copies/mL) on a stable antiretroviral regimen

Dolutegravir rilpivirine (Juluca) - For the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults who are virologically suppressed (HIV-1 RNA copies <50 copies/mL) on a stable antiretroviral regimen Published 10 September 2018 1 dolutegravir 50mg / rilpivirine 25mg film-coated tablets (Juluca ® ) SMC2091 ViiV Healthcare Ltd. 10 August 2018 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug (...) and Therapeutic Committees (ADTCs) on its use in NHS Scotland. The advice is summarised as follows: ADVICE: following a full submission dolutegravir / rilpivirine film-coated tablet (Juluca ® ) is accepted for use within NHSScotland. Indication under review: The treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults who are virologically-suppressed (HIV-1 RNA 50 copies/mL in the 6-month period before screening and no more than one instance of viral load >50 copies/mL but <200 copies/mL

2018 Scottish Medicines Consortium

2. Prenatal and Perinatal Human Immunodeficiency Virus Testing - Expanded Recommendations

Prenatal and Perinatal Human Immunodeficiency Virus Testing - Expanded Recommendations Prenatal and Perinatal Human Immunodeficiency Virus Testing - Expanded Recommendations - ACOG Menu ▼ Prenatal and Perinatal Human Immunodeficiency Virus Testing - Expanded Recommendations Page Navigation ▼ INTERIM UPDATE Number 752 (Replaces Committee Opinion No. 635, June 2015) Committee on Obstetric Practice HIV Expert Work Group This Committee Opinion was developed by the American College of Obstetricians (...) advances in the prevention of perinatal transmission of human immunodeficiency virus (HIV), it is clear that early identification and treatment of all pregnant women with HIV is the best way to prevent neonatal infection and also improve women’s health. Furthermore, new evidence suggests that early initiation of antiretroviral therapy in the course of infection is beneficial for individuals infected with HIV and reduces the rate of sexual transmission to partners who are not infected. Screening should

2018 American College of Obstetricians and Gynecologists

3. Follicular Dendritic Cells of Lymph Nodes as Human Immunodeficiency Virus/Simian Immunodeficiency Virus Reservoirs and Insights on Cervical Lymph Node Full Text available with Trip Pro

Follicular Dendritic Cells of Lymph Nodes as Human Immunodeficiency Virus/Simian Immunodeficiency Virus Reservoirs and Insights on Cervical Lymph Node A hallmark feature of follicular dendritic cells (FDCs) within the lymph nodes (LNs) is their ability to retain antigens and virions for a prolonged duration. FDCs in the cervical lymph nodes (CLNs) are particularly relevant in elucidating human immunodeficiency virus (HIV)-1 infection within the cerebrospinal fluid (CSF) draining LNs (...) only recently garnered attention. This interest in CLN FDCs has been driven by detailed characterization of the meningeal lymphatic system. As the CSF drains through the meningeal lymphatics and nasal lymphatics via the cribriform plate, CLN FDCs may acquire HIV after capturing them from T cells, antigen-presenting cells, or cell-free virions. In addition, CD4+ T follicular helper cells within the CLNs are productively infected as a result of acquiring the virus from the FDCs. In this review, we

2018 Frontiers in immunology

4. Kaposi Sarcoma Herpesvirus Inflammatory Cytokine Syndrome-like Clinical Presentation in Human Immunodeficiency Virus-infected Children in Malawi. (Abstract)

Kaposi Sarcoma Herpesvirus Inflammatory Cytokine Syndrome-like Clinical Presentation in Human Immunodeficiency Virus-infected Children in Malawi. We describe 7 human immunodeficiency virus-infected Malawian children with Kaposi sarcoma who met criteria for Kaposi sarcoma herpesvirus (KSHV) inflammatory cytokine syndrome. Each presented with persistent fevers, bulky lymphadenopathy, massive hepatosplenomegaly, and severe cytopenias. Plasma analyses were performed in 2 patients, both

2019 Clinical Infectious Diseases

5. ACOG Committee Opinion No. 752 Summary: Prenatal and Perinatal Human Immunodeficiency Virus Testing. (Abstract)

ACOG Committee Opinion No. 752 Summary: Prenatal and Perinatal Human Immunodeficiency Virus Testing. Given the enormous advances in the prevention of perinatal transmission of human immunodeficiency virus (HIV), it is clear that early identification and treatment of all pregnant women with HIV is the best way to prevent neonatal infection and also improve women's health. Furthermore, new evidence suggests that early initiation of antiretroviral therapy in the course of infection is beneficial (...) for individuals infected with HIV and reduces the rate of sexual transmission to partners who are not infected. Screening should be performed after women have been notified that HIV screening is recommended for all pregnant patients and that they will receive an HIV test as part of the routine panel of prenatal tests unless they decline (opt-out screening). Human immunodeficiency virus testing using the opt-out approach, which is currently permitted in every jurisdiction in the United States, should

2018 Obstetrics and Gynecology

6. ACOG Committee Opinion No. 752: Prenatal and Perinatal Human Immunodeficiency Virus Testing. (Abstract)

ACOG Committee Opinion No. 752: Prenatal and Perinatal Human Immunodeficiency Virus Testing. Given the enormous advances in the prevention of perinatal transmission of human immunodeficiency virus (HIV), it is clear that early identification and treatment of all pregnant women with HIV is the best way to prevent neonatal infection and also improve women's health. Furthermore, new evidence suggests that early initiation of antiretroviral therapy in the course of infection is beneficial (...) for individuals infected with HIV and reduces the rate of sexual transmission to partners who are not infected. Screening should be performed after women have been notified that HIV screening is recommended for all pregnant patients and that they will receive an HIV test as part of the routine panel of prenatal tests unless they decline (opt-out screening). Human immunodeficiency virus testing using the opt-out approach, which is currently permitted in every jurisdiction in the United States, should

2018 Obstetrics and Gynecology

7. Bilateral central retinal artery occlusion as presenting manifestation of human immunodeficiency virus infection Full Text available with Trip Pro

Bilateral central retinal artery occlusion as presenting manifestation of human immunodeficiency virus infection A 30-year-old male with bilateral acute visual loss presented with retinal edema in the posterior pole and peripapillary region with extensive retinal hemorrhages. Fluorescein angiography revealed delayed arterial filling in the right eye and absent arterial filling in the left eye, suggesting bilateral central retinal artery occlusion. Systemic evaluation revealed a history (...) of chronic low-grade fever and generalized lymphadenopathy. HIV (ELISA) was positive, and other systemic comorbidities were ruled out. Cervical lymph node biopsy stained positive for acid-fast bacilli, with large areas of necrosis, palisaded by epithelioid cell granulomas, macrophages, and multinucleated giant cells, suggesting lymph node tuberculosis. Despite antiretroviral and antitubercular therapy, he developed optic atrophy at 4 weeks.

2018 Indian journal of ophthalmology

8. An unexpected diagnosis of human immunodeficiency virus-2 infection in an overseas visitor: a case report Full Text available with Trip Pro

progression to acquired immunodeficiency syndrome. Human immunodeficiency virus 2 is also associated with diagnostic challenges given the lack of commercially available diagnostic tests, and management challenges given intrinsic resistance to many anti-retroviral therapies.We describe a case of a 65 year old South Indian female, visiting her family in Australia, who presented with weight loss, pancytopaenia and generalised lymphadenopathy on a background of newly diagnosed congestive cardiac failure (...) to non-nucleoside reverse transcriptase inhibitors. Human immunodeficiency virus 2 infection should be considered in patients who present with symptoms and signs that do not point towards a clear diagnosis, such as unexplained pancytopaenia or lymphadenopathy, and who have risk factors such as being from an endemic area or having had blood transfusions, especially prior to the commencement of blood-borne virus screening of blood donors.

2017 BMC research notes

9. Human Immunodeficiency Virus

immunodeficiency virus (HIV) infection (diagnosis) , human T-lymphotropic virus 3 (HTLV-III) infection (diagnosis) , lymphadenopathy-associated virus (diagnosis) , lymphadenopathy-associated virus , human T-lymphotropic virus 3 (HTLV-III) infection , HIV infection NOS , Human immunodeficiency virus infection, unspecified , Human immunodeficiency virus syndrome , Human immuno virus dis , Human immunodeficiency virus [HIV] disease , HIV Infections [Disease/Finding] , Infection;HIV , Human immunodeficiency virus (...) Human Immunodeficiency Virus Aka: Human Immunodeficiency Virus , HIV Infection , Acquired Immunodeficiency Syndrome , AIDS From Related Chapters II. Epidemiology: Global Statistics: WHO HIV : 36.7 M people worldwide (2015) Africa alone accounts for 25.5 M cases Women account for 50% of cases worldwide Children (age<15) account for 1.8 Million cases worldwide HIV : 2.1 M people worldwide (2015) Children (age <15) account for 150,000 new cases per year AIDS AIDS Deaths 1.1 M, of which 110,000 were

2018 FP Notebook

10. Gut Associated Lymphatic Tissue (GALT) in HIV (Human Immunodeficiency Virus)- Infected Patients

Gut Associated Lymphatic Tissue (GALT) in HIV (Human Immunodeficiency Virus)- Infected Patients Gut Associated Lymphatic Tissue (GALT) in HIV (Human Immunodeficiency Virus)- Infected Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one (...) or more studies before adding more. Gut Associated Lymphatic Tissue (GALT) in HIV (Human Immunodeficiency Virus)- Infected Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01679067 Recruitment Status : Completed First Posted : September 5, 2012 Last Update Posted : January 13, 2016 Sponsor

2012 Clinical Trials

11. Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant

Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Gene Therapy in Treating Patients With Human Immunodeficiency Virus-Related Lymphoma Receiving Stem Cell Transplant The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details

2016 Clinical Trials

12. A Retrospective Analysis of 7 Human Immunodeficiency Virus-Negative Infants Infected by Penicillium marneffei. Full Text available with Trip Pro

A Retrospective Analysis of 7 Human Immunodeficiency Virus-Negative Infants Infected by Penicillium marneffei. Infection with Penicillium marneffei has rarely been reported in human immunodeficiency virus (HIV)-negative infants. We aimed to determine the epidemiological, clinical, pathological, and immunological characteristics of 7 HIV-negative infants infected by P. marneffei, and to provide insights into its diagnosis and treatment.We retrospectively reviewed the cases of 7 HIV-negative (...) with immunodeficiencies or immune disorders. In endemic areas, clinicians should aware of disseminated P. marneffei infections when infants present with serious or recurrent infections, even if they are HIV negative. P. marneffei is highly susceptible to amphotericin B and voriconazole. Timely diagnosis and treatment can improve patients' prognoses. Intravenous voriconazole could be recommended as the initial antifungal agent for HIV-negative infants infected by P. marneffei, because of its low nephrotoxicity, high

2015 Medicine

13. Assessment of lymphadenopathy

=bestpractice.com Brown JR, Skarin AT. Clinical mimics of lymphoma. Oncologist. 2004;9(4):406-16. http://theoncologist.alphamedpress.org/cgi/reprint/9/4/406.pdf http://www.ncbi.nlm.nih.gov/pubmed/15266094?tool=bestpractice.com Differentials Infectious mononucleosis (Epstein-Barr virus) HIV Adenovirus Cytomegalovirus (CMV) Herpes zoster (shingles) Streptococcal pharyngitis Non-Hodgkin's lymphoma Hodgkin's lymphoma Chronic lymphocytic leukaemia (CLL) Metastatic solid tumour Drug-associated lymphadenopathy Serum (...) sickness Graft-versus-host disease (GVHD) Human T-lymphotropic virus 1 (HTLV-1) Mumps Measles Hepatitis B Hepatitis C Cat scratch disease Tuberculosis Leprosy Mycobacterium avium-intracellulare (MAI) Syphilis Tularaemia Brucellosis Rocky Mountain spotted fever Histoplasmosis Coccidioidomycosis Cryptococcosis Lymphogranuloma venereum (LGV) Toxoplasmosis Leishmaniasis Systemic lupus erythematosus (SLE) Rheumatoid arthritis Dermatomyositis Sjogren's syndrome Sarcoidosis Crohn's disease Kawasaki disease

2018 BMJ Best Practice

14. Human Immunodeficiency Virus Infection (Follow-up)

Human Immunodeficiency Virus Infection (Follow-up) Pediatric HIV Infection Treatment & Management: Approach Considerations, Overview of Antiretroviral Therapy, Prophylaxis and Treatment of Opportunistic Infections Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTY1MDg2LXRyZWF0bWVudA== processing > Pediatric HIV Infection Treatment & Management Updated: Nov 16, 2018 Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD Share Email Print Feedback Close Sections Sections Pediatric HIV Infection Treatment Approach Considerations ART is the mainstay in human immunodeficiency virus (HIV) treatment. Appropriate antiretroviral therapy (ART) and treatment of specific infections and malignancies are critical in treating patients who are HIV positive. Intervening early may

2014 eMedicine Pediatrics

15. Human Immunodeficiency Virus Infection (Diagnosis)

Human Immunodeficiency Virus Infection (Diagnosis) Pediatric HIV Infection: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTY1MDg2LW92ZXJ2aWV3 processing (...) > Pediatric HIV Infection Updated: Nov 16, 2018 Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD Share Email Print Feedback Close Sections Sections Pediatric HIV Infection Overview Practice Essentials Since the first cases of human immunodeficiency virus (HIV) infection were identified, the number of children infected with HIV has risen dramatically in developing countries, the result of an increased number of HIV-infected women of childbearing age in these areas. HIV is a retrovirus and can

2014 eMedicine Pediatrics

16. Human Immunodeficiency Virus Infection (Treatment)

Human Immunodeficiency Virus Infection (Treatment) Pediatric HIV Infection Treatment & Management: Approach Considerations, Overview of Antiretroviral Therapy, Prophylaxis and Treatment of Opportunistic Infections Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTY1MDg2LXRyZWF0bWVudA== processing > Pediatric HIV Infection Treatment & Management Updated: Nov 16, 2018 Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD Share Email Print Feedback Close Sections Sections Pediatric HIV Infection Treatment Approach Considerations ART is the mainstay in human immunodeficiency virus (HIV) treatment. Appropriate antiretroviral therapy (ART) and treatment of specific infections and malignancies are critical in treating patients who are HIV positive. Intervening early may

2014 eMedicine Pediatrics

17. Human Immunodeficiency Virus Infection (Overview)

Human Immunodeficiency Virus Infection (Overview) Pediatric HIV Infection: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvOTY1MDg2LW92ZXJ2aWV3 processing (...) > Pediatric HIV Infection Updated: Nov 16, 2018 Author: Delia M Rivera, MD; Chief Editor: Russell W Steele, MD Share Email Print Feedback Close Sections Sections Pediatric HIV Infection Overview Practice Essentials Since the first cases of human immunodeficiency virus (HIV) infection were identified, the number of children infected with HIV has risen dramatically in developing countries, the result of an increased number of HIV-infected women of childbearing age in these areas. HIV is a retrovirus and can

2014 eMedicine Pediatrics

18. Lymphatic endothelial cells promote productive and latent HIV infection in resting CD4+ T cells Full Text available with Trip Pro

productive and latent HIV infection of resting CD4+ T cells. However, the EC used in previous studies were from human umbilical cords (HUVEC), which are macrovascular; whereas EC residing in the lymphoid tissues are microvascular.In this study, we investigated the effects of microvascular EC stimulation of resting CD4+ T cells in establishing viral infection and latency. Human resting and activated CD4+ T cells were cultured alone or with endothelial cells and infected with a pseudotyped virus. Infection (...) Lymphatic endothelial cells promote productive and latent HIV infection in resting CD4+ T cells An HIV cure has not yet been achieved because latent viral reservoirs persist, particularly in resting CD4+ T lymphocytes. In vitro, it is difficult to infect resting CD4+ T cells with HIV-1, but infections readily occur in vivo. Endothelial cells (EC) line the lymphatic vessels in the lymphoid tissues and regularly interact with resting CD4+ T cells in vivo. Others and we have shown that EC promoted

2018 Virology journal

19. A 32-Year-Old Man With HIV Infection, Pleural Effusions, and Lymphadenopathy. Full Text available with Trip Pro

A 32-Year-Old Man With HIV Infection, Pleural Effusions, and Lymphadenopathy. A 32-year-old man presented with fever, nonproductive cough, diffuse lymphadenopathy, and polyarticular pain for 2 weeks. His medical history included HIV diagnosed 10 years ago, anal intraepithelial neoplasia, Kaposi sarcoma, and herpes simplex virus-2 infection. The patient was not receiving antiretroviral therapy or antibiotic prophylaxis, and his last known CD4 count a month before was 45 cells/mm3. He

2018 Chest

20. Lymphatic Dissemination of Simian Immunodeficiency Virus after Penile Inoculation Full Text available with Trip Pro

Lymphatic Dissemination of Simian Immunodeficiency Virus after Penile Inoculation The human immunodeficiency virus (HIV) is primarily transmitted by heterosexual contact, and approximately equal numbers of men and women worldwide are infected with the virus. Understanding the biology of HIV acquisition and dissemination in men exposed to the virus by insertive penile intercourse is likely to help with the rational design of vaccines that can limit or prevent HIV transmission. To characterize (...) the target cells and dissemination pathways involved in establishing systemic simian immunodeficiency virus (SIV) infection, we necropsied male rhesus macaques at 1, 3, 7, and 14 days after penile SIV inoculation and quantified the levels of unspliced SIV RNA and spliced SIV RNA in tissue lysates and the number of SIV RNA-positive cells in tissue sections. We found that penile (glans, foreskin, coronal sulcus) T cells and, to a lesser extent, macrophages and dendritic cells are primary targets

2016 Journal of virology

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