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Lunesta

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1. Lunesta

Lunesta Lunesta Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Lunesta Lunesta Aka: Lunesta , Eszopiclone From Related Chapters II (...) . Mechanism ( ) Acts at gamma-aminobutyric acid receptors Isomer of Zopiclone (Imovane) III. Indication IV. Dosing Starting dose: 1 mg orally at bedtime Maximum dosing of 1 mg indications Severe liver disease Concurrent use of CYP 3A4 inhibitor Maximum dosing of 2 mg indications Older patients (age over 65 years old): 1 mg Maximum of 3 mg indications Younger, healthy patients V. Precaution These agents have a duration of effect that extends past the time patients awaken Eszopiclone (Lunesta) at 3 mg dose

2018 FP Notebook

2. Efficacy of treatment of insomnia in migraineurs with eszopiclone (Lunesta(®)) and its effect on total sleep time, headache frequency, and daytime functioning: a randomized, double-blind, placebo-controlled, parallel-group, pilot study. (PubMed)

Efficacy of treatment of insomnia in migraineurs with eszopiclone (Lunesta(®)) and its effect on total sleep time, headache frequency, and daytime functioning: a randomized, double-blind, placebo-controlled, parallel-group, pilot study. A review on headache and insomnia revealed that insomnia is a risk factor for increased headache frequency and headache intensity in migraineurs. The authors designed a randomized, double blind, placebo-controlled, parallel-group, pilot study in which (...) migraineurs who also had insomnia were enrolled, to test this observation.In the study, the authors treated 79 subjects with IHS-II migraine with and/or without aura and with DSM-IV primary insomnia for 6 weeks with 3 mg eszopiclone (Lunesta(®)) or placebo at bedtime. The treatment was preceded by a 2-week baseline period and followed by a 2-week run-out period.Of the 79 subjects treated, 75 were evaluable, 35 in the eszopiclone group, and 40 in the placebo group. At baseline, the groups were comparable

2014 Cranio : the journal of craniomandibular practice Controlled trial quality: uncertain

3. Lunesta

Lunesta Lunesta Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Lunesta Lunesta Aka: Lunesta , Eszopiclone From Related Chapters II (...) . Mechanism ( ) Acts at gamma-aminobutyric acid receptors Isomer of Zopiclone (Imovane) III. Indication IV. Dosing Starting dose: 1 mg orally at bedtime Maximum dosing of 1 mg indications Severe liver disease Concurrent use of CYP 3A4 inhibitor Maximum dosing of 2 mg indications Older patients (age over 65 years old): 1 mg Maximum of 3 mg indications Younger, healthy patients V. Precaution These agents have a duration of effect that extends past the time patients awaken Eszopiclone (Lunesta) at 3 mg dose

2015 FP Notebook

8. A Neurosteroid Intervention for Menopausal and Perimenopausal Depression

modulators (SERMs), hormone replacement therapy, hormonal contraceptives (hormonal IUDs allowed), episodic sleep medications (chronic, regular, stable-dose benzodiazepines and hypnotics such as zolpiderm, Sonata (Zaleplon), and Lunesta (Eszopiclone) OR sleep-seating antihistamines such as Unisom (Doxylamine succinate) or diphenhydramine allowed), and antidepressants within 2 weeks of the baseline visit and randomization. Use of natural menopause and depression supplements, phytoestrogens, soy-based (...) in another clinical trial Exclusion of Concomitant Medications: Selective estrogen-receptor modulators (SERMs) Hormone replacement therapy Hormonal contraceptives, excluding Mirena IUD or other IUD with localized progesterone Natural menopause or antidepressant supplements Episodic sleep medications (chronic, regular, stable-dose benzodiazepines and hypnotics such as zolpidem, Sonata (Zaleplon), and Lunesta (Eszopiclone) OR sleep-sedating antihistamines such as Unisom (Doxylamine succinate

2018 Clinical Trials

9. Zaleplon in HIV Patients With Depression

disorder, or any psychotic illness History of substance abuse or dependence over the past 6 months Currently taking medication to assist with sleep (e.g., Ambien/Zolpidem,Dalmane/Flurazepam, Doral/Quazepam, Halcion/Triazolam, Lunesta/Eszopiclone, Prosom/Estazolam, Restoril/Temazepam, Rozerem/Ramelteon, Sonata/Zaleplon, Melatonin, Unisom, Benadryl). Pregnant Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact

2018 Clinical Trials

10. Sleep Disorders (PDQ®): Health Professional Version

tartrate (Ambien) 5–10 mg Useful for problems falling asleep only. Maximum suggested dose for women: 5 mg. [ ][ ] zolpidem tartrate extended-release (Ambien CR) 6.25–12.5 mg Biphasic release; useful for problems both falling asleep and staying asleep. Do not crush or split tablets. Maximum suggested dose for women: 6.25 mg. [ ][ ] eszopiclone (Lunesta) 1–3 mg Useful for problems both falling asleep and staying asleep. Do not take with or right after meal. [ ][ ] Benzodiazepine clonazepam (Klonopin

2016 PDQ - NCI's Comprehensive Cancer Database

11. The problem with prescribing sleeping pills for older patients

substances such as the benzodiazepines (e.g., Restoril, Valium, Ativan, Xanax) and their cousins (e.g., Ambien, Lunesta) are particularly problematic. And when used in combination with opioid pain medications, they increase the risk of shutting down your respiratory drive causing death. The FDA has become so concerned about this that there is now a black box warning against the co-prescription of these substances. They also cause dependence, both psychologically and physiologically. The most vexing

2017 KevinMD blog

12. A New Prescription for Sleepless Americans: Take Advice Not a Pill

pharmacologic treatments for chronic insomnia disorder. Evidence shows that CBT-I significantly improved insomnia remission, treatment response, and key sleep outcomes, including sleep quality and wakefulness after sleep onset, in the general population and in older adults. Pharmacologic treatments were not nearly as effective. Evidence also shows that commonly used sleep medications, including benzodiazepines and the “newer” non-benzodiazepine gabaminergic sleep medications such as eszopiclone (Lunesta

2016 The RAND blog

13. Neural Mechanisms Associated With Risk of Smoking Relapse

-anxiety agents; Anti-panic agents; Prescription (e.g., Provigil, Ritalin) or over-the-counter stimulants; Prescription sleep aids (e.g., Ambien, Lunesta) if used more than 2x/week. If participants report use less than twice a week, they will just be asked to refrain from use during imaging portion of the study. Any medication that could compromise participant safety as determined by the Principal Investigator and/or Study Physician; Daily use of: Opiate-containing medications for chronic pain. Medical

2016 Clinical Trials

14. Testing Doxazosin to Treat Stress Mechanisms in Alcoholism

used daily or used within past week: alpha1 agonists (e.g., midodrine, metaraminol, oxymetazoline, phenylephrine). Currently used daily or used within past week: Benzodiazepines (e.g., diazepam, chlordiazepoxide, lorazepam, clonazepam, alprazolam), zolpidem (Ambien), zaleplon (Sonata), zopiclone (Imovane), eszopiclone (Lunesta), doxepin (Silenor). Currently prescribed and used daily or used within past 2 weeks: Trazodone. Currently prescribed or used within 2 weeks: Disulfiram (Antabuse). Contacts

2016 Clinical Trials

15. Repurposing alpha1 Noradrenergic Antagonists for Alcoholism Treatment

daily or used within 72 hours: alpha1 agonists (e.g., midodrine, metaraminol, oxymetazoline, phenylephrine). Currently used daily or used within 72 hours: Benzodiazepines (e.g., diazepam, chlordiazepoxide, lorazepam, clonazepam, alprazolam), zolpidem (Ambien), zaleplon (Sonata), zopiclone (Imovane), eszopiclone (Lunesta), doxepin (Silenor). Currently prescribed and used daily or used within 72 hours: Trazodone (males only) Contacts and Locations Go to Information from the National Library

2016 Clinical Trials

16. Impact of GHRH on Sleep Promotion and Endocrine Regulation in Service Members Who Sustained a Traumatic Brain Injury and Have Current Insomnia

not be eligible for this research study if they: Have obstructive sleep apnea determined by polysomnography (insomnia group) or selfreport (no-insomnia group) Have a known hypersensitivity to tesamorelin and/or mannitol Have taken any of the following medications within the past 30 days: benzodiazepines (e.g., Valium, Ativan, etc.); benzodiazepine receptor agonists (e.g., Ambien, Lunesta, etc.); opiates (e.g., Codeine, Percocet, etc.); or sedatives (e.g., Amytal, Numbutal, etc.) Cannot abstain from using

2016 Clinical Trials

17. Benzodiazepine addiction is real. This physician shares his story.

and a single dad. The stress of the constant combat with active alcoholism led me to leave the partnership of the cardiology practice that I had started, and go off of night call. I calmed the sleepless nights with medications. Soon I could not sleep without taking a pill. I tried other medications like Lunesta, which I stopped because everything the next day tasted like tin. And then there was Ambien, which I tried after I re-married, but stopped because while “asleep” my wife said I threw my iPad at her

2016 KevinMD blog

19. Talk to Your Doctor: Direct-to-Consumer Advertising of Prescription Drugs, Part 2

with hypertension, depression, diabetes, and dyslipidemia. And yes, these newly diagnosed patients will require medications, sometimes indefinitely. PhRMA would have more credibility, though, if the DTC ads actually focused on medications used to manage chronic diseases, especially with hopes of reducing long term complications. When the top twenty advertised drugs in 2005 include Cialis ($110 million), Lamisil ($110 million), and Lunesta ($224 million), it becomes clear that drug companies are spending

2010 Clinical Correlations

20. Zolpidem and Uncontrollable Nocturnal Eating Binges

for restless leg syndrome, CPAP for sleep apnea), discontinuing zolpidem, and replacing zolpidem with another benzodiazepine agonist such as eszopiclone ( Lunesta ) or pyrazolopyrimidine ( Sonata ). 5 Najjar et al. found that despite being in the same medication class as zolpidem, eszopiclone and pyrazolopyrimidine were associated with resolution of SRED. 7 Until further studies elucidate the exact mechanisms by which zolpidem induces SRED, physicians should exercise caution when prescribing it, especially

2010 Clinical Correlations

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