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Lower Motor Neuron Lesion

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1. Selective voluntary motor control measures of the lower extremity in children with upper motor neuron lesions: a systematic review. (PubMed)

Selective voluntary motor control measures of the lower extremity in children with upper motor neuron lesions: a systematic review. Recovery and trainability of impaired selective voluntary motor control (SVMC) of the lower extremity in children with upper motor neuron lesions has received little attention. To facilitate an evidence-based debate about this topic, this review evaluates the evidence level of the psychometric properties of SVMC measures.MEDLINE, Embase, CINAHL, PsycINFO, Scopus (...) test, modified Trost test, Gillette's Selective Motor Control test, Selective Control Assessment of the Lower Extremity (SCALE), kinematic measures, electromyography, and torque steadiness. Studies assessing the SCALE scored highest on COSMIN items. Evidence levels for SCALE's validity and reliability properties were moderate, while for the other SVMC measures these ranged from unknown to moderate. Responsiveness was not assessed.Further psychometric studies of SVMC measures are needed to provide

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2017 Developmental Medicine and Child Neurology

2. Electroacupuncture for Urinary Function of Patients With Chronic Urinary Retention (CUR) Secondary to Lower Motor Neuron Lesion

Electroacupuncture for Urinary Function of Patients With Chronic Urinary Retention (CUR) Secondary to Lower Motor Neuron Lesion Electroacupuncture for Urinary Function of Patients With Chronic Urinary Retention (CUR) Secondary to Lower Motor Neuron Lesion - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached (...) the maximum number of saved studies (100). Please remove one or more studies before adding more. Electroacupuncture for Urinary Function of Patients With Chronic Urinary Retention (CUR) Secondary to Lower Motor Neuron Lesion (CUR) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read

2018 Clinical Trials

3. Lower Motor Neuron Lesion

Lower Motor Neuron Lesion Lower Motor Neuron Lesion Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Lower Motor Neuron Lesion Lower (...) Motor Neuron Lesion Aka: Lower Motor Neuron Lesion , Lower Motor Neuron Deficit , Lower Motor Neuron II. Physiology (motor, lateral cord) transmits motor signals from the cerebral cortex s cross the midline at the and course to the contralateral muscles Motor fibers in the anterior horn (grey matter of the spinal cord) s (UMN) are from the cerebral cortex to the Lower Motor Neurons (LMN) are from the to the muscle III. Signs: Lower Motor Neuron Lesion findings Muscular atrophy Muscle fasciculations

2018 FP Notebook

4. What influences contracture formation in lower motor neuron disorders, severity of denervation or residual muscle function? An analysis of the elbow contracture in 100 children with unilateral Brachial Plexus Birth Injury (PubMed)

What influences contracture formation in lower motor neuron disorders, severity of denervation or residual muscle function? An analysis of the elbow contracture in 100 children with unilateral Brachial Plexus Birth Injury As in other neuromuscular disorders, both denervation and muscle paresis/imbalance are implicated as aetiological factors for contractures in children with a Brachial Plexus Birth Injury (BPBI). Although both factors are related, it is unclear which factor is dominant. The aim (...) severe in children with higher Narakas classifications (p = 0.001), after neurosurgery (Mann-Whitney U test, p = 0.009) and were related to age (Spearman's Rho = -0.3, p = 0.008) and to paresis of the extensors (Rho = 0.4, p = 0.000). Flexor paresis as a percentage of unaffected side (Rho = 0.06, p = 0.6) and muscle balance had no influence.In BPBI, elbow contractures are related to the severity of the neurological lesion, not to residual muscle function.Level II - prognostic study.

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2018 Journal of children's orthopaedics

5. Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study (PubMed)

Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study Many studies have examined motor impairments using voxel-based lesion symptom mapping, but few are reported regarding the corresponding relationship between cerebral cortex injury and lower limb motor impairment analyzed using this technique. This study correlated neuronal injury in the cerebral cortex of 16 patients with chronic stroke based on a voxel-based (...) lesion symptom mapping analysis. Neuronal injury in the corona radiata, caudate nucleus and putamen of patients with chronic stroke could predict walking speed. The behavioral measure scores were consistent with motor deficits expected after damage to the cortical motor system due to stroke. These findings suggest that voxel-based lesion symptom mapping may provide a more accurate prognosis of motor recovery from chronic stroke according to neuronal injury in cerebral motor cortex.

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2014 Neural Regeneration Research

6. A comparison of robotic walking therapy and conventional walking therapy in upper versus lower motor neuron lesion patients: a randomised clinical trial. (PubMed)

A comparison of robotic walking therapy and conventional walking therapy in upper versus lower motor neuron lesion patients: a randomised clinical trial. To compare a walking reeducation program with robotic locomotor training plus overground therapy (LKOGT) to conventional overground training (OGT) in individuals with incomplete upper motor neuron (UMN) or lower motor neuron (LMN) injuries having either traumatic or nontraumatic nonprogressive etiology.Randomized open controlled trial (...) of conventional OGT 5 days per week for 8 weeks. Subjects with UMN and LMN were randomized into 2 training groups.Ten-meter walk test and 6-minute walk test (6MWT). Walking Index for Spinal Cord Injury II, lower extremity motor score (LEMS), and the FIM-Locomotor were secondary outcome measures.By using the LKOGT program compared with OGT, we found significant differences in the 6MWT for groups A1 and B1. LKOGT also provided higher scores than did OGT in secondary outcomes such as the LEMS and the FIM

2014 Archives of physical medicine and rehabilitation

7. Stress exacerbates neuron loss and microglia proliferation in a rat model of excitotoxic lower motor neuron injury. (PubMed)

Stress exacerbates neuron loss and microglia proliferation in a rat model of excitotoxic lower motor neuron injury. All individuals experience stress and hormones (e.g., glucocorticoids/GCs) released during stressful events can affect the structure and function of neurons. These effects of stress are best characterized for brain neurons; however, the mechanisms controlling the expression and binding affinity of glucocorticoid receptors in the spinal cord are different than those in the brain (...) . Accordingly, whether stress exerts unique effects on spinal cord neurons, especially in the context of pathology, is unknown. Using a controlled model of focal excitotoxic lower motor neuron injury in rats, we examined the effects of acute or chronic variable stress on spinal cord motor neuron survival and glial activation. New data indicate that stress exacerbates excitotoxic spinal cord motor neuron loss and associated activation of microglia. In contrast, hypertrophy and hyperplasia of astrocytes

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2015 Brain, behavior, and immunity

8. Mirror Therapy With Cutaneous Electrical Sensory Stimulation on Lower Limb Motor Functions in Stroke

proprioceptive inputs and increase spatial attention of the paretic limb, which could improve motor function of the paretic limb, possibly through increased cortical activity in the lesioned hemisphere and mirror neurone system. The next question concerns whether MT could be combined with TENS and whether their synergetic effects could maximise the motor output of paretic limbs in people with stroke. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated (...) Mirror Therapy With Cutaneous Electrical Sensory Stimulation on Lower Limb Motor Functions in Stroke Mirror Therapy With Cutaneous Electrical Sensory Stimulation on Lower Limb Motor Functions in Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2018 Clinical Trials

9. High Dietary Iron Supplement Induces the Nigrostriatal Dopaminergic Neurons Lesion in Transgenic Mice Expressing Mutant A53T Human Alpha-Synuclein (PubMed)

, as well as WT mice with high dietary iron displayed hyperactive motor coordination and impaired colonic motility, compared with those with basal dietary iron. Only A53T mice, but not WT mice with high dietary iron exhibited nigral dopaminergic neuronal loss, lower levels of tyrosine hydroxylase (TH) in the substantia nigra (SN) and decreased dopamine contents in the striatum. Although there was no obvious elevation of iron contents in the SN in WT mice with high dietary iron, we observed iron contents (...) High Dietary Iron Supplement Induces the Nigrostriatal Dopaminergic Neurons Lesion in Transgenic Mice Expressing Mutant A53T Human Alpha-Synuclein Both alpha-synuclein aggregation and iron deposits are neuropathological hallmarks of Parkinson's disease (PD). We are particularly interested in whether iron could synergize with alpha-synuclein pathology in vivo, especially in the nigrostriatal system. In the present study, we reported transgenic mice with overexpressing human A53T alpha-synuclein

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2018 Frontiers in aging neuroscience

10. Early neonatal loss of inhibitory synaptic input to the spinal motor neurons confers spina bifida-like leg dysfunction in a chicken model (PubMed)

-limb paralysis within the first 2 weeks after hatching, coinciding with the synaptic change-induced disruption of spinal motor networks at the site of the SBA lesion in the lumbosacral region. Such synaptic changes reduced the ratio of inhibitory-to-excitatory inputs to motor neurons and were associated with a drastic loss of γ-aminobutyric acid (GABA)ergic inputs and upregulation of the cholinergic activities of motor neurons. Furthermore, most of the neurons in ventral horns, which appeared (...) Early neonatal loss of inhibitory synaptic input to the spinal motor neurons confers spina bifida-like leg dysfunction in a chicken model Spina bifida aperta (SBA), one of the most common congenital malformations, causes lifelong neurological complications, particularly in terms of motor dysfunction. Fetuses with SBA exhibit voluntary leg movements in utero and during early neonatal life, but these disappear within the first few weeks after birth. However, the pathophysiological sequence

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2017 Disease models & mechanisms

11. Diagnostic contribution of magnetic resonance imaging in an atypical presentation of motor neuron disease (PubMed)

Diagnostic contribution of magnetic resonance imaging in an atypical presentation of motor neuron disease Motor neuron disease (MND) is a neurodegenerative disease determining progressive and relentless motor deterioration involving both upper and lower motor neurons (UMN and LMN); several variants at onset are described. Here we describe a case of MND presenting as pure spastic monoparesis in which magnetic resonance imaging (MRI) gave a substantial contribution in confirming the diagnosis (...) , erythema nodosum), the increase of inflammatory indices. Conventional MRI showed no focal lesions that could explain the clinical features; therefore, we used advanced MR sequences. Diffusion tensor imaging (DTI) evaluation evidenced bilateral impairment of corticospinal tract (CST) diffusion metrics, with clear right-left asymmetry, pointing to a neurodegenerative etiology, which clinically appeared less likely at that time. Magnetic resonance spectroscopy (MRS) showed a significant reduction of NAA

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2017 Quantitative imaging in medicine and surgery

12. Dual-hemisphere Transcranial Direct Current Stimulation on Lower Limb Motor Functions After Stroke

Dual-hemisphere Transcranial Direct Current Stimulation on Lower Limb Motor Functions After Stroke Dual-hemisphere Transcranial Direct Current Stimulation on Lower Limb Motor Functions After Stroke - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove (...) one or more studies before adding more. Dual-hemisphere Transcranial Direct Current Stimulation on Lower Limb Motor Functions After Stroke The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03035162 Recruitment Status : Completed First Posted : January 27, 2017 Last Update Posted : August 17, 2018

2017 Clinical Trials

13. Acute lower motor neuron syndrome and spinal cord gray matter hyperintensities in HIV infection (PubMed)

, painful, unilateral lower motor neuron paralytic syndrome affecting the distal portion of the upper limb. These patients had segmental T2-hyperintense lesions in the central gray matter of the cervical spinal cord on MRI. One patient stabilized and the second patient improved with immunomodulatory therapy.This newly described syndrome expands the clinical spectrum of lower motor neuron diseases in HIV. (...) Acute lower motor neuron syndrome and spinal cord gray matter hyperintensities in HIV infection To describe a novel manifestation of lower motor neuron disease in patients with well-controlled HIV infection.A retrospective study was performed to identify HIV-positive individuals with acute, painful lower motor neuron diseases.Six patients were identified with HIV and lower motor neuron disease. Two patients met the inclusion criteria of well-controlled, chronic HIV infection and an acute

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2015 Neurology® neuroimmunology & neuroinflammation

14. Lower Motor Neuron Lesion

Lower Motor Neuron Lesion Lower Motor Neuron Lesion Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Lower Motor Neuron Lesion Lower (...) Motor Neuron Lesion Aka: Lower Motor Neuron Lesion , Lower Motor Neuron Deficit , Lower Motor Neuron II. Physiology (motor, lateral cord) transmits motor signals from the cerebral cortex s cross the midline at the and course to the contralateral muscles Motor fibers in the anterior horn (grey matter of the spinal cord) s (UMN) are from the cerebral cortex to the Lower Motor Neurons (LMN) are from the to the muscle III. Signs: Lower Motor Neuron Lesion findings Muscular atrophy Muscle fasciculations

2015 FP Notebook

15. Distinct Muscle Biopsy Findings in Genetically Defined Adult-Onset Motor Neuron Disorders (PubMed)

Distinct Muscle Biopsy Findings in Genetically Defined Adult-Onset Motor Neuron Disorders The objective of this study was to characterize and compare muscle histopathological findings in 3 different genetic motor neuron disorders. We retrospectively re-assessed muscle biopsy findings in 23 patients with autosomal dominant lower motor neuron disease caused by p.G66V mutation in CHCHD10 (SMAJ), 10 X-linked spinal and bulbar muscular atrophy (SBMA) and 11 autosomal dominant c9orf72-mutated (...) of upper motor neuron lesions.

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2016 PloS one

16. Canadian Urological Association guideline for the diagnosis, management, and surveillance of neurogenic lower urinary tract dysfunction

that is either induced or spontaneous. The Crede manoeu- ver (external pressure on the bladder) and Valsalva void- ing induces bladder drainage via an increase in abdominal pressure that can overcome the external urethral sphincter. It can be inefficient and risk high pressures 5 and cause hem- orrhoids, hernias, and VUR. 94 Spontaneous reflex voiding can occur with stimulation of the sacral or lumbar derma- tomes by suprapubic tapping in some patients with upper motor neuron lesions. Condom catheter (...) and surveillance of patients with NLUTD. Classification The etiology of a NLUTD is often classified based on whether the primary lesion is suprapontine, suprasacral, sacral, or infrasacral. 7 A complementary system was developed by Madersbacher et al based on the function of the detrusor muscle and of the external sphincter. 8 These systems allow a physician to have a general idea of how the lower urinary tract is likely to behave in SCI patients with more complete injuries (Fig. 1). Newer systems using

2019 Canadian Urological Association

17. The Value of Electromyography in Lesions Involving the Lower Motor Neurone (PubMed)

The Value of Electromyography in Lesions Involving the Lower Motor Neurone 19993298 2010 06 24 2018 11 13 0035-9157 39 6 1946 Apr Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. The Value of Electromyography in Lesions Involving the Lower Motor Neurone. 339-41 Bowden R E RE eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1946 4 1 0 0 1946 4 1 0 1 ppublish 19993298 PMC2181816 Proc R Soc Med. 1941 Jun;34(8):459-68 19992355 Br Med J. 1942 Aug 29;2(4260

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1946 Proceedings of the Royal Society of Medicine

18. Observations on the Value of Electromyography in Lesions Involving the Lower Motor Neurone in Man (PubMed)

Observations on the Value of Electromyography in Lesions Involving the Lower Motor Neurone in Man 19993297 2010 06 24 2010 06 24 0035-9157 39 6 1946 Apr Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Observations on the Value of Electromyography in Lesions Involving the Lower Motor Neurone in Man. 339 Weddell G G eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1946 4 1 0 0 1946 4 1 0 1 ppublish 19993297 PMC2181817

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1946 Proceedings of the Royal Society of Medicine

19. ELECTROMYOGRAPHY IN MUSCULAR DYSTROPHIES: DIFFERENTIATION BETWEEN DYSTROPHIES AND CHRONIC LOWER MOTOR NEURONE LESIONS (PubMed)

ELECTROMYOGRAPHY IN MUSCULAR DYSTROPHIES: DIFFERENTIATION BETWEEN DYSTROPHIES AND CHRONIC LOWER MOTOR NEURONE LESIONS 18127083 2007 12 27 2018 12 01 0022-3050 12 2 1949 May Journal of neurology, neurosurgery, and psychiatry J. Neurol. Neurosurg. Psychiatry Electromyography in muscular dystrophies; differentiation between dystrophies and chronic lower motor neurone lesions. 129-36 KUGELBERG E E eng Journal Article England J Neurol Neurosurg Psychiatry 2985191R 0022-3050 OM Disease (...) Electromyography Humans Muscular Dystrophies Neurons 4917:33f DYSTROPHY/muscular NEURONS/diseases 1949 5 1 0 0 2014 8 13 6 0 1949 5 1 0 0 ppublish 18127083 PMC497122

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1949 Journal of neurology, neurosurgery, and psychiatry

20. Rehabilitation of Lower Limb Amputation

to VA/DoD Clinical Practice Guideline for Rehabilitation of Individuals with Lower Limb Amputation September 2017 Page 10 of 123 sustain LLA, while those involved with motor vehicle collisions were more likely to sustain upper limb amputation.[14] C. Lower Limb Amputation in the Department of Veterans Affairs and the Department of Defense a. Department of Veterans Affairs Similar to civilian populations, the number of individuals with amputation(s) cared for in the VA and DoD medical systems has (...) Rehabilitation of Lower Limb Amputation VA/DoD CLINICAL PRACTICE GUIDELINE FOR REHABILITATION OF INDIVIDUALS WITH LOWER LIMB AMPUTATION Department of Veterans Affairs Department of Defense QUALIFYING STATEMENTS The Department of Veterans Affairs and the Department of Defense guidelines are based upon the best information available at the time of publication. They are designed to provide information and assist decision making. They are not intended to define a standard of care and should

2017 VA/DoD Clinical Practice Guidelines

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