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61. The old Respectful Insolence is dead. Long live the new Respectful Insolence!

also want to roll the title bar clc, like the rest of the universe. This is my first time seeing on a phone. zackoz test…and Congrats to Orac on his third regeneration Denice Walter In other anti-vax news… @ kimrossi1111: claims that you can’t discuss vaccine injury ( on CNN) or gun control because “‘Merica loves its shots” ** Funny, all I seem to be hearing somehow involves control. other twits tweeting @ del bigtree and @ TMRProf ( Zoey O’Toole) ** PGP might ‘enjoy’ this twitter account and her (...) a final comment. Denice Walter What’s that poem? “We rise, we rise” No, no it’s not vampire. At any rate, I will continue to scour the crankosphere for new woo daily. As a side note, perhaps Orac’s move has inspired Jake to show up at AoA. This can be the start of something big. Heh. I feel that using RI.com, RI.org and RI.net will serve as an intelligence test, leaving many of Orac’s critics out. ( see the recent hilarious guessing game about Sceptical Raptor at AoA for a sample) If Orac and Alain

2017 Respectful Insolence

62. Why is antivaccine activist Robert F. Kennedy, Jr. meeting with government health and science officials months after meeting with President Trump?

with President Trump? By on August 21, 2017. Poor Robert F. Kennedy, Jr. He went from admired environmental activist to reviled antivaccine campaigner so quickly. It began when he outed himself in 2005 with his infamous about thimerosal in Salon.com and Rolling Stone . Basically, RFK Jr. is a member of what we used to call the mercury militia, a branch of the antivaccine movement that believes, more than anything else, that it is the mercury-containing preservative thimerosal that used to be in several (...) for pushing back against Kennedy's misinformation, though. For instance, Kennedy claims: We need to do double-blind placebo testing. Because particularly when it comes to injecting aluminum or mercury into babies, the consequences may be latent. In other words, they may not manifest or diagnosed to age 3 or 4. So the current protocols, which require testing for vaccines of sometimes as little as 48 hours, are not going to disclose the kind of dangers that the public and the regulators ought to know about

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2017 Respectful Insolence

63. Will 2018 be the year that the FDA finally regulates homeopathic remedies as drugs?

a large uptick in products labeled as homeopathic that are being marketed for a wide array of diseases and conditions, from the common cold to cancer. In many cases, people may be placing their trust and money in therapies that may bring little to no benefit in combating serious ailments, or worse – that may cause significant and even irreparable harm because the products are poorly manufactured, or contain active ingredients that aren’t adequately tested or disclosed to patients,” said FDA (...) to be worse in homeopathic sector. Gina Fredenburgh I didn’t realize that homeopathy had its own pharmacopeia but none of this magic water would pass true compendial testing. There’s some comedy gold in this aspect. jrkrideau In this case I suspect pharmacopeia = grimoire. mdfinfer I suspect that Scott Gottleib feels that the sale and use of nonsense, such as homeopathy, in some way threatens the real pharmaceutical industry. We have seen that sort of reasoning spelled out recently in the FDA’s attempt

2017 Respectful Insolence

64. 2017 year-ender: What I’ve learned from reading health news every morning

stories, and email them to the HealthNewsReview.org team. By the end of this year, I may hit 1,000 articles. As a health care reporter, I have found it’s a worthy practice. It helps me keep up with the news of the day and demonstrates how any one item—a prominent study or new screening guidelines—can be framed in different ways. I’ll admit to having favorite sites and less-than-favorite ones. And yet any of the news stories I log and share with the team has the potential to be a 5-star story or a 2 (...) . It’s clickbait. Headlines . Beware the hyped-up headline. Nothing makes me skeptical faster than a headline telling me how to . And it’s hard not do a second roll of eyes when I scan ahead to see the article describing findings from an . I also watch for any of publisher Gary Schwitzer’s you shouldn’t use. Headlines, head-spinning version . Talk about different framings to a story! In April we about seemingly opposite headlines on stories covering the same study. One news outlet’s story

2017 HealthNewsReview

65. Social Determinants of Risk and Outcomes for Cardiovascular Disease

Social Determinants of Risk and Outcomes for Cardiovascular Disease Social Determinants of Risk and Outcomes for Cardiovascular Disease | Circulation Search Hello Guest! Login to your account Email Password Keep me logged in Search March 2019 March 2019 March 2019 March 2019 March 2019 February 2019 February 2019 February 2019 February 2019 January 2019 January 2019 January 2019 January 2019 January 2019 This site uses cookies. By continuing to browse this site you are agreeing to our use

2015 American Heart Association

66. Allergic Rhinitis

: With institutional access I can: View or download all content the institution has subscribed to. Society If you have access to journal via a society or associations, read the instructions below Members of _ can log in with their society credentials below Username (required) Password (required) Society (required) Access to society journal content varies across our titles. If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view (...) , and follow the instructions in this box. Contact us if you experience any difficulty logging in. AAO-HNS Member Access AAO-HNS members have access to this journal as part of their membership. Sign in using your membership username and password. Some society journals require you to create a personal profile, then activate your society account I am signed in via: With society access I can: View or download all the content the society has access to. Need Help? Search in: Add Email Alerts You are adding

2015 American Academy of Otolaryngology - Head and Neck Surgery

67. Management of chronic Hepatitis C consensus update

Canadian Association for the Study of the Liver consensus guidelines on the management of hepatitis C was produced. The present docu- ment reviews the epidemiology of hepatitis C in Canada, preferred diagnostic testing approaches and recommendations for the treatment of chronically infected patients with the newly approved antiviral agents, including those who have previously failed peginterferon and ribavirin-based therapy. In addition, recommendations are made regarding approaches to reducing (...) of drug administration, side effects, and the requirement for careful on-treatment monitoring of symptoms and laboratory tests. The most successful model to deliver comprehensive CHC care is via a multidisciplinary approach including experienced physicians, nurses and allied health professionals (eg, psychologists, psychiatrists, addiction specialists and social workers). Currently in Canada, a relatively small number of physicians treat CHC, leading in some cases to prolonged wait times for patients

2015 Canadian Association of Gastroenterology

68. Systematic review with meta-analysis: Fruit and vegetable consumption is associated with reduced all-cause and cardiovascular mortality

Systematic review with meta-analysis: Fruit and vegetable consumption is associated with reduced all-cause and cardiovascular mortality Fruit and vegetable consumption is associated with reduced all-cause and cardiovascular mortality | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your (...) username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Fruit and vegetable consumption is associated with reduced all-cause and cardiovascular mortality Article Text Therapeutics/Prevention Systematic review

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2015 Evidence-Based Medicine (Requires free registration)

69. National Clinical Guideline for the Diagnosis, Staging and Treatment of Prostate Cancer

will require diagnostic tests (radiology, pathology) and depending on the treatment plan may require surgery, chemotherapy and radiation therapy. A proportion of patients may also require palliative care. A recent population-based cost analysis (Luengo-Fernandez et al., 2013) illustrated the economic burden of cancer on the European Union (EU). In 2009, cancer is estimated to have cost the EU €126 billion, with healthcare costs accounting for €51 billion (40%). Prostate cancer is estimated to have cost (...) of the NCCP patient information, clinical guidelines and other national projects. All NCCP booklets are submitted to the National Adult Literacy Agency (NALA) (www.nala.ie) for the Plain English Award. This is to ensure comprehension and readability are in line with health literacy best practice standards. Service user testing is a key part of the process, and includes liaising with the HSE Patient Forum, online surveys, and engaging with other relevant patient groups e.g. Irish Cancer Society, Marie

2015 Health Service Executive (Ireland) - Clinical Guidelines

70. Naloxone (Nyxoid) - Opioid-Related Disorders

information regarding proof of structure studies and physicochemical characterisation has been assessed by the EDQM before issuing the Certificate of Suitability. Manufacture, characterisation and process controls The relevant information has been assessed by the EDQM before issuing the Certificate of Suitability. Specification The active substance specification includes tests for: appearance (visual), identity (IR), identity of chlorides (Ph. Eur.), appearance of solution (Ph. Eur.), acidity (...) or alkalinity (Ph. Eur.), specific optical rotation (Ph. Eur.), related substances (HPLC), water (Ph. Eur.), sulfated ash (Ph. Eur.), assay (Ph. Eur.) and residual solvents (GC). The analytical methods used have been adequately described and non-compendial methods appropriately validated in accordance with the ICH guidelines. Satisfactory information regarding the reference standards used for assay and impurities testing has been presented. The control tests were carried out to comply

2017 European Medicines Agency - EPARs

71. Darunavir / cobicistat / emtricitabine / tenofovir alafenamide (Symtuza) - HIV Infections

is therefore to suppress the HIV-1 viral load to levels that are at least below 50 copies/mL of blood. 2.1.4. Clinical presentation and diagnosis Acute HIV-1 infection is often missed, as it usually presents with nonspecific signs and symptoms, or goes without clinical symptoms. Diagnosis therefore most often occurs during chronic infection. Diagnostic tests for HIV-1 infection include assays for HIV-1 RNA, p24 antigen, and HIV-1 and HIV-2 antibodies. 2.1.5. Management Antiretroviral therapy (ART (...) with the requirements of Ph. Eur. and European Directive 10/2011 as amended. Assessment report EMA/496527/2017 Page 13/106 Specification Darunavir specification includes tests for identification (IR, UPLC), physical description (visual), assay (HPLC), chromatographic purity (HPLC), ethanol (GC), residual solvent (GC), residue on ignition (Ph. Eur.), water content (KF), heavy metals (Ph. Eur.) and particle size (laser diffraction). Specifications, analytical procedures and validation data are in accordance

2017 European Medicines Agency - EPARs

72. Cladribine (Mavenclad) - multiple sclerosis

to be a known active substance. The application submitted is composed of administrative information, complete quality data, non-clinical and clinical data based on applicants’ own tests and studies and/or bibliographic literature substituting/supporting certain tests or studies. Information on Paediatric requirements Pursuant to Article 7 of Regulation (EC) No 1901/2006, the application included an EMA Decision(s) P/101/2009 on the granting of a product-specific waiver. Information relating to orphan market (...) 10/2011 as amended. Specification The active substance specification includes appropriate tests and limits for appearance (visual), identity (IR, Ph. Eur.), appearance of a solution (Ph. Eur.), pH of solution, specific rotation (Ph. Eur.), heavy metals, residue on ignition (Ph. Eur.), water content (Ph. Eur.), assay (Ph. Eur.), purity (HPLC, TLC, Ph. Eur.), residual solvents (GC), residual ammonia (ion chromatographic) and bacterial endotoxins (Ph. Eur.). The specification of the active substance

2017 European Medicines Agency - EPARs

73. Nusinersen sodium (Spinraza) - Spinal Muscular Atrophy

for this application refers to: Article 8.3 of Directive 2001/83/EC - complete and independent application. The applicant indicated that nusinersen was considered to be a new active substance. The application submitted is composed of administrative information, complete quality data, non- clinical and clinical data based on applicants’ own tests and studies and/or bibliographic literature substituting/supporting certain test(s) or study(ies). Information on Paediatric requirements Pursuant to Article 7 (...) toxicologically relevant exposure in the developing fetus. Nusinersen was non-genotoxic when tested in the bacterial reverse mutagenesis assay, in vitro chromosomal aberration assay in CHO cells and the in vivo mouse micronucleus assay. Therefore, nusinersen was interpreted to be neither mutagenic nor clastogenic. Carcinogenicity studies have not been conducted with nusinersen. Nusinersen is not genotoxic and does not have a direct mechanism for tumor induction. There is no reason to believe

2017 European Medicines Agency - EPARs

74. Diagnosis, Staging and Treatment of Patients with Breast Cancer

and standard of care. 1.2 Clinical and financial impact of breast cancer The diagnosis, staging and treatment of patients with breast cancer requires multidisciplinary care in an acute hospital setting. The majority of patients will require diagnostic tests (radiology, pathology) and depending on the treatment plan may require surgery, chemotherapy and radiation therapy. A proportion of patients may also require palliative care. A recent population-based cost analysis (Luengo-Fernandez et al., 2013 (...) was the largest solid tumour diagnosed annually in Ireland. The Guideline Development Group (GDG) endorses the American Society of Clinical Oncology/ College of American Pathologists (ASCO/CAP) clinical guideline (Wolff et al., 2013) for the following two pathology clinical questions: 1) What is the optimal testing algorithm for the assessment of HER2 status? 2) What strategies can help ensure optimal performance, interpretation, and reporting of established assays? 1.4.2 Target population Patients

2015 National Clinical Guidelines (Ireland)

75. Clinical Handover in Acute and Children’s Hospital Services

for the patient throughout their episode of care in the acute hospital. Rationale Staff report that the transfer of responsibility for the patient during clinical handover is often ambiguous (Bomba and Prakash 2005; Williams et al. 2007; Philibert et al. 2009; Bost et al. 2012; Chin et al. 2012; Wayne et al. 2008) and this may lead to issues in relation to the follow up of test results (Horwitz et al. 2009a) or instances where patients are handed over to a new unit without a clinician being assigned

2015 National Clinical Guidelines (Ireland)

76. Diagnosis, staging and treatment of patients with Breast Cancer

and standard of care. 1.2 Clinical and financial impact of breast cancer The diagnosis, staging and treatment of patients with breast cancer requires multidisciplinary care in an acute hospital setting. The majority of patients will require diagnostic tests (radiology, pathology) and depending on the treatment plan may require surgery, chemotherapy and radiation therapy. A proportion of patients may also require palliative care. A recent population-based cost analysis (Luengo-Fernandez et al., 2013 (...) was the largest solid tumour diagnosed annually in Ireland. The Guideline Development Group (GDG) endorses the American Society of Clinical Oncology/ College of American Pathologists (ASCO/CAP) clinical guideline (Wolff et al., 2013) for the following two pathology clinical questions: 1) What is the optimal testing algorithm for the assessment of HER2 status? 2) What strategies can help ensure optimal performance, interpretation, and reporting of established assays? 1.4.2 Target population Patients

2015 Health Service Executive (Ireland) - Clinical Guidelines

77. Specification, implementation and management of information technology (IT) systems in hospital transfusion laboratories

upgrade to the LIMS ? Electronic Issue is not permitted if test results have been manually edited ? Label attachment verification ? Remote electronic issue ? Section on electronic blood administration (tracking) systems Summary of Recommendations There are a large number of recommendations against which compliance should be assessed. This summary shows the important principles underpinning the recommendations. Adequate control and resources are required to ensure the IT project complies (...) will be archived. This may be done on the basis of time (e.g. data from the last 5 years is migrated and prior data archived) or may be specific to information types depending on the database structure (e.g. it may be more necessary to transfer patient information, blood group and antibody status than test data and component details). Where an existing database is to be split into data for migration and data for archiving careful consideration needs to be given to the boundary cases to ensure there is a clean

2014 British Committee for Standards in Haematology

78. The Non-Surgical Management of Hip & Knee Osteoarthritis (OA)

in practice will inevitably and appropriately occur when clinicians take into account the needs of individual patients, available resources, and limitations unique to an institution or type of practice. Every healthcare professional making use of these guidelines is responsible for evaluating the appropriateness of applying them in the setting of any particular clinical situation. These guidelines are not intended to represent TRICARE policy. Further, inclusion of recommendations for specific testing (...) . Therefore, as a tool for routine diagnosis for OA, MRI is not recommended. [28] Clinical Practice Guideline for the Non-Surgical Management of Osteoarthritis Page 21 of 126 A4. Routine Use of Laboratories and Synovial Fluid Analysis Background The literature review revealed little evidence of benefit from laboratory evaluation of blood, urine, or synovial fluid in the evaluation of OA. These relatively few available studies found that laboratory tests or synovial fluid analysis may be of benefit only

2014 VA/DoD Clinical Practice Guidelines

79. Stakeholder Discussion to Reduce Population-Wide Sodium Intake and Decrease Sodium in the Food Supply

Stakeholder Discussion to Reduce Population-Wide Sodium Intake and Decrease Sodium in the Food Supply Stakeholder Discussion to Reduce Population-Wide Sodium Intake and Decrease Sodium in the Food Supply | Circulation Search Hello Guest! Login to your account Email Password Keep me logged in Search March 2019 March 2019 March 2019 March 2019 March 2019 February 2019 February 2019 February 2019 February 2019 January 2019 January 2019 January 2019 January 2019 January 2019 This site uses cookies (...) to inflammation. Evidence on the adverse health effects of excess sodium intake includes results from animal studies, epidemiological studies, clinical trials, and meta-analyses of trials. To date, >50 randomized trials have tested the effects of sodium reduction on BP in adults. A meta-analysis of these trials documented that a median reduction in urinary sodium of ≈1800 mg/d lowered systolic and diastolic BP by 2.0 and 1.0 mm Hg, respectively, in nonhypertensive individuals and by 5.0 and 2.7 mm Hg

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2014 American Heart Association

80. Diagnosis and Treatment of Fetal Cardiac Disease

Diagnosis and Treatment of Fetal Cardiac Disease Diagnosis and Treatment of Fetal Cardiac Disease | Circulation Search Hello Guest! Login to your account Email Password Keep me logged in Search March 2019 March 2019 March 2019 March 2019 March 2019 February 2019 February 2019 February 2019 February 2019 January 2019 January 2019 January 2019 January 2019 January 2019 This site uses cookies. By continuing to browse this site you are agreeing to our use of cookies. Free Access article Share (...) % necessitates additional expenditure of resources and at what level (screening ultrasound or fetal echocardiogram) are topics of debate. The answers vary, depending on the healthcare system environment, skill of screening operators, and available resources. Thus, recommendations for indications for referral for fetal echocardiogram must take into account risk for CHD in individual populations. In general, risk levels of ≥2% to 3% as defined by prenatal screening tests (such as maternal serum screening

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2014 American Heart Association

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