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Log Roll Test

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181. Web-based Implementation for the Science of Enhancing Resilience Study

Detailed Description: Optimizing provider well-being is critical to the delivery of safe and high quality care to the most vulnerable of patients: very preterm babies. Major innovative objectives of this proposal include testing the Web-based Implementation for the Science of Enhancing Resilience (WISER) program's effectiveness in enhancing resilience among Neonatal Intensive Care Unit (NICU) health workers, evaluating its effect on unit safety culture, and examining its effect on clinical outcomes (...) have pushed burnout among health workers to the breaking point. The few tested interventions that improve caregiver resilience lack feasibility for widespread adoption. This study is designed to achieve the following aims: Test the effectiveness of WISER in improving NICU health professional resilience; Test the effectiveness of WISER in improving patient safety and organizational outcomes; Test the sustainability of WISER; and Describe the barriers and facilitators of the WISER program

2015 Clinical Trials

182. Waitlist Hospital Admissions Predict Resource Utilization and Survival After Renal Transplantation. (PubMed)

patient and claims data for all adult renal transplant recipients between 2000 and 2010 with continuous primary Medicare coverage for 1 year before and after transplantation were examined. Outcomes included readmissions within the first-year post-transplant and 3-year graft and patient survival. Chi-square statistics, Kaplan-Meier methods (log-rank test), and goodness of fit calculations (c-statistics) were performed for models of transplant outcome.Among 37,623 patients, the percentages of patients (...) a dose-dependent effect on both death and graft loss.In summary, hospitalization in the year before transplant is an objective, readily ascertainable, and powerful predictor of excess resource utilization and inferior outcome. Incorporation of a rolling assessment of patient hospitalization has potential policy implications for maximizing value in renal transplantation.

2015 Annals of Surgery

183. More EHR thoughts

back to the physician for agreement as to what should be done to store or process the information; 2) a clinical concept processor that can process groups of clinical concepts (and demographic data, lab test results, appointment made or not made in the past…..etc against clinical practice guidelines (designable by the physician so that CPG’s can be adhered to “like rolling off a log”; 3) patient history data can also be collected using branching questionnaires and then the answers entered as data (...) . Caring for patients without accurate knowledge of their past medical history, medications and testing is both hazardous and costly. Of course interoperability could actually transform health care into one large functioning system. We would not have to repeat images as often as we currently do. We could read notes from other hospitalizations and from outpatient visits. The VA experience has shown me the value of such information. The second issue on my list is more proximate to users, improving

2015 db's Medical Rants blog

184. Med students: 10 essential tips to choose the right residency

with Uncle Sam’s name on it. Don’t expect to be rolling in cash during residency but the decade of training will eventually pay off. Regardless of what specialty you choose you will be compensated well enough and should be able to pay off these loans as long as you do not live above your means. There is a wide range in physician compensation. You can get a general idea of salaries through online sources but remember there are multiple factors that may affect these values (location, specialty demand (...) limitations that you have make sure to address them before entering a specialty that is demanding in that particular area. 7. Intellectual stimulation. I can only assume spending 30 or 40 years in a field you find boring will be very painful and it will probably show. Remember the words of Confucius. “Choose a job you love, and you will never have to work a day in your life.” A good test I found for this is while rounding as a medical student, pay attention to which cases you spent hours reading up

2015 KevinMD blog

185. Integrity of "damage control" posterior spinal fusion constructs for poly-trauma patients: A biomechanical investigation. (PubMed)

spinal stability, minimize morbidity, and accommodate ICU care needs between stages are not defined.In full-unembalmed cadavers motion-tracking sensors were placed at T11 and L1. A T12 corpectomy with PLC injury was stabilized with 1, 2, and 3 levels of PostPerc above/below the injury. Motions between T11 and L1 were measured during Log-Roll and Sit-Up on an ICU bed. After in situ testing, anatomic spinal motion ranges were determined under pure moment loads.5 cadavers were evaluated. For Log-Roll, 2 (...) with intact. During ex situ testing, 2 and 3 levels above/below were similar; 1 level above/below had significantly greater laxity in flexion, extension, and axial rotation.Posterior instrumentation 2 or 3 levels above/below a severe thoracolumbar fracture model can restore spinal stability back to its intact condition. 2 levels of fixation above/below this "worst-case scenario" is minimum fixation sufficient to provide absolute spinal stability in the ICU setting as a "Damage Control" technique

2015 Spine

186. Is it OK to K tape…?

when working in football. A sales rep came to our club for a few hours, wowed us all with stories of the Bejing Olympics and athletes performing better, stronger, longer (there’s that logo again), he got the the brightly coloured rolls out, proceeded to demonstrate the applications on us and, BOOM, we where hooked, we ordered 100 rolls right there and then. I guess we were all a little more gullible back then, or rather just fucking idiots! Anyway I did want to learn more about this K Tape stuff (...) , eg books, manual and course sales. Again don’t take this as me saying poking things doesn’t do anything or help, its just doesnt really matter too much how or where you do it. Thanks Adam, I have read your blog on palpation previously and took the time to re-read it. I do agree with some of the points made especially with relation to some of the work done on TPs and SIJ. I disagree with some however such that those tests that are able to be reliably conducted are dependent upon pain e.g

2015 The Sports Physio blog

187. High Ankle Sprains… A guest blog by Tom Whittamore

(or inability to be able to push off). It is important to consider other structures in the ankle such as the deltoid ligament, which has been shown to be injured in conjunction with the syndesmosis complex, due to its accessory role in stabilisation of the distal tibiofibula joint (Hunt, 2013). The common test I use to test for a syndesmosis injury is the external rotation test. This can be done in sitting or (if the player can weight bear) in standing (replicating the mechanism of injury). In sitting (...) the player is sat over the edge of the bed, the knee is stablised and the foot moved into dorsiflexion and eversion. Pain would point towards a suspected syndesmosis sprain (Williams and Allen, 2010). In a systematic review, Schwieterman et al (2013) looked at the diagnostic accuracy of special tests at the foot and ankle, their results (which didn’t include Pakarinen, I have just added it to the table) are below: Test Sensitivity Specificity Paper Subjects Cotton Test 0.25 0.25 N/A 0.98 Beumer et al

2015 The Sports Physio blog

188. Patient Modesty: Volume 70

just because I go to a doctor! Unless I have an rectal or genital complaint, and even then I will decide if I am going to undress. There are alternatives to a physical exam like MRI, ultrasound, and blood tests for prostate. That is the type of thinking that has put providers in the position that they are in. The thinking should be that I will NOT undress just because I am going to see a physician. Now, I good physician who has earned my trust, might be able to convince me to undress for a complete (...) calls for an anogenital examination for a (wellness) physical when a patient is requesting a "modesty wellness physical." The SOP for a modesty wellness physical" can include alternatives such as PSA testing or ultrasound to assess prostate health, urine and blood tests for genital health, self reporting for hernia, etc. I think that the ACA will help with some of these issues. Another issue is requiring pelvic exams for oral contraceptives. Under the ACA's anti-fraud provisions, this can

2015 Bioethics Discussion Blog

189. Can schools prevent eating disorders?

implementing a new programme. All the schools involved were all girls’ schools, which may limit generalizability. Misleading reporting of findings In places the authors overemphasise their findings. For example, the abstract says “significantly improved body esteem and self-esteem” : technically correct (if you look at the p values for the χ 2 tests), but the effect sizes of both were (very) small. Figure 3 makes it look as though there is an impressive difference between groups on body esteem. I switched (...) , increasing their efficacy across a range of outcomes. I agree – as attractive as the idea of universal intervention to prevent body dissatisfaction and eating disorders seems, I think we would need to have a more effective treatment programme before we start rolling it out. It’s early days for this field of research. Links Sharpe H, Schober I, Treasure J, Schmidt U. Feasibility, acceptability and efficacy of a school-based prevention programme for eating disorders: cluster randomised controlled trial. Br

2014 The Mental Elf

190. Online and social networking interventions for depression in young people

included all study design types and was not age restricted; it yielded 358 abstracts, of which 22 studies met the inclusion criteria. Results Section 1 (standard online interventions): 15 studies described 10 trials testing eight different online interventions, all of which were based on a cognitive behavioural approach Studies were categorised as: prevention (n=9); intervention (n=5); combined prevention-intervention (n=1) Two studies included moderator or clinician input With the exception of the one (...) networking sites, in order to better understand the potential role of social networking as an effective therapeutic medium. The widespread roll-out of online interventions for the prevention and treatment of depression in young people is an attractive prospect but the reviewers underline the fact that future interventions must consider features that encourage engagement and offer increased opportunity for tailored and dynamic content. The evidence suggests that real-time moderator input is likely

2014 The Mental Elf

191. PF-04449913 Single-Agent In Patients With Myelofibrosis Previously Treated With a Janus Kinase Inhibitor

*ULN.Electrolytes: sodium <0.95*LLN >1.05*ULN, potassium, chloride, calcium, magnesium <0.9* LLN >1.1*ULN,phosphate <0.8* LLN >1.2* ULN.Chemistry: glucose <0.6*LLN >1.5*ULN,creatine kinase >2.0*ULN, amylase,lipase >1.5*ULN.Urinalysis: protein, blood >1.0*ULN,red blood cells,WBC >=20,epithelial cells >=6,casts,granular casts,hyaline >1,cellular casts,crystals>=1,bacteria >20. Number of Participants With Laboratory Test Abnormalities According to National Cancer Institute (NCI) Common Terminology Criteria (...) for Adverse Events (CTCAE), Version 4.03 Grade 3 and Above Hematological Test Abnormalities: Lead-in Cohort [ Time Frame: Baseline up to Week 131 ] Anemia (grade [g]1:< LLN to 10 gram per deciliter [g/dL],g2:<10 to 8g/dL,g3:<8g/dL, g4:lifethreatening); platelet (g1:

2014 Clinical Trials

192. Somatropin Biopartners

immunglobulin positive control IPC In process control IPT In-Process tests ITT Insulin Tolerance Test IU International Units kD Kilodalton kDa Kilodalton kg Kilogramme KIGS Kabi Pharmacia International Growth Study L Litre LB03002 Biopartners human growth hormone sustained release formulation LBM Lean Body Mass LC Liquid Chromatography LDL Low-Density Lipoprotein LLOQ Lower limit of quantification LPC low dose positive control LS Least Square MAA Marketing Authorization Application mAb Monoclonal antibody (...) . Adult-onset: Patients with growth hormone deficiency in adulthood are defined as patients with known hypothalamic-pituitary pathology and at least one additional known deficiency of a pituitary hormone not being prolactin. These patients should undergo a single dynamic test in order to diagnose or exclude a growth hormone deficiency. Childhood-onset: In patients with childhood-onset isolated growth hormone deficiency (no evidence of hypothalamic-pituitary disease or cranial irradiation), two dynamic

2013 European Medicines Agency - EPARs

193. Stribild - elvitegravir / cobicistat / emtricitabine / tenofovir disoproxil

environmental risk assessment for tenofovir, including an adsorption/desorption study (OECD 106), transformation studies in aquatic sediment systems (OECD 308) and an Early-Life Stage Toxicity Test (OECD 210). Transformation products =10% will be fully characterized. These additional studies will be provided by Q2 2015. Table 1. Summary of main study results on EVG Substance (INN/Invented Name): EVG CAS-number (if available): PBT screening Result Conclusion Bioaccumulation potential- log K ow OECD117 3.39 (...) (if available): PBT screening Result Conclusion Bioaccumulation potential- log K ow OECD122 0.992-1.18 Not > 4.5; not PBT. Phase I Calculation Value Unit Conclusion PEC surfacewater , default or refined (e.g. prevalence, literature) For Fpen (1%): 1.5 For Fpen (with from data Etonie): 0.17 µg/l Then > 0.01 µg/l Phase II Physical-chemical properties and fate Study type Test protocol Results Remarks Adsorption-Desorption OECD 106 Koc soil: 18L/Kg No high adsorption with TDF. Ready Biodegradability Test OECD

2013 European Medicines Agency - EPARs

194. Kadcyla - trastuzumab emtansine

. The application submitted is composed of administrative information, complete quality data, non-clinical and clinical data based on applicants’ own tests and studies and bibliographic literature supporting certain tests or studies. Information on Paediatric requirements Pursuant to Article 7 of Regulation (EC) No 1901/2006, the application included an EMA Decision EMA/973755/2011; CW/1/2011 on the granting of a class waiver. Information relating to orphan market exclusivity Similarity Pursuant to Article 8 (...) -maleimidomethyl] cyclohexane-1-carboxylate) linker. Trastuzumab emtansine is produced from two intermediates (DM1 and trastuzumab) and a starting material (SMCC), each of which is tested and released using methods and specifications appropriate to its molecular type (small molecule or protein). The resulting antibody conjugate product exhibits a unique and specific set of product characteristics, distinct from the intermediates used in its production. Manufacture The drug substance manufacturer

2013 European Medicines Agency - EPARs

195. Enabling medication management through health information technology

, and the Technical Expert Panel. Results Our literature search retrieved 40,582 articles. After duplicates were removed, 32,785 articles were screened at title and abstract stage. From a full-text screen of 4,578 articles, we identified 789 articles that were eligible for inclusion in this report. Of these articles, 361 met only our inclusion criteria for content and did not have group comparisons, hypothesis testing, or appropriate analysis. These are listed in the bibliography of the report. Across the seven

2011 EvidenceUpdates

196. Anticholinergic drugs increase the risk of cognitive decline and dementia in older people

from Question Question: What is the relationship between anticholinergic use, cognitive decline and onset of dementia in an older, community-dwelling population? Population: 6912 adults (4128 women, mean age 73.8 years; 2784 men, mean age 73.6 years) aged ≥65 years, living in the community and recruited from electoral rolls. Setting: Three cities in France, recruitment period: 1999–2001. Prognostic factors: Cognitive performance was measured using a battery of tests: Isaacs Set Test (...) Anticholinergic drugs increase the risk of cognitive decline and dementia in older people Anticholinergic drugs increase the risk of cognitive decline and dementia in older people | Evidence-Based Mental Health We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts OR managers

2010 Evidence-Based Mental Health

197. Occupational therapy for people with Parkinson's disease

of Parkinson’s in men (NICE 2006). The average age at diagnosis of Parkinson’s is around 60 PARKINSON'S ALL TEXT.indd 8 27/4/10 11:44:34 9 College of Occupational Therapists Background years. However, one in twenty people with Parkinson’s are under 40 years old at the time of diagnosis (PDS 2008). Diagnosing Parkinson’s Currently no defi nitive scan or biochemical test is available to confi rm the presence of Parkinson’s. Diagnosis is therefore made on the basis of clinical evaluation achieved through

2010 British Association of Occupational Therapists

198. Paronychia (Overview)

Paronychia (Overview) Paronychia: Practice Essentials, Background, Epidemiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. processing > Paronychia Updated: Oct 22, 2018 Author (...) with blastomycosis. J Emerg Med . 2000 Oct. 19(3):245-8. . Turkmen A, Warner RM, Page RE. Digital pressure test for paronychia. Br J Plast Surg . 2004 Jan. 57(1):93-4. . Giacomel J, Lallas A, Zalaudek I, Argenziano G. Periungual Bowen disease mimicking chronic paronychia and diagnosed by dermoscopy. J Am Acad Dermatol . 2014 Sep. 71(3):e65-7. . Engineer L, Norton LA, Ahmed AR. Nail involvement in pemphigus vulgaris. J Am Acad Dermatol . 2000 Sep. 43(3):529-35. . Patsatsi A, Sotiriou E, Devliotou-Panagiotidou D


199. Parkinson-Plus Syndromes (Overview)

Parkinson-Plus Syndromes (Overview) Parkinson-Plus Syndromes: Clues to Diagnosis, Multiple System Atrophy, Progressive Supranuclear Palsy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. (...) ancillary findings. The early display of autonomic dysfunction is believed to anticipate a worse prognosis. [ , ] Patients with parkinsonism typically have asymmetric tremor, bradykinesia, rigidity, and postural instability. The tremor tends to be postural, irregular, and jerky, unlike the typical pill-rolling tremor of idiopathic parkinsonism. The dysarthria observed in patients with MSA tends to be hypokinetic. Those with cerebellar features present with gait and limb ataxia, ataxic dysarthria


200. Penile Prosthesis Implantation (Overview)

Penile Prosthesis Implantation (Overview) Penile Prosthesis Implantation: Background, History of the Procedure, Problem Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. processing > Penile (...) place penile prostheses after excision and grafting of the Peyronie plaque. As discussed below, many preoperative tests can be used to assess ED (see Lab Studies). However, the actual practice of evaluating ED proves to be not only quite varied but also controversial. It depends on the practice of the individual urologists. Some practitioners argue that etiology is insignificant and that ED is treated in a stepwise fashion—from least to progressively more invasive treatments. Others argue that, from


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