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Liver Abscess

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41. A comparison of pyogenic liver abscess in patients with or without diabetes: a retrospective study of 246 cases. Full Text available with Trip Pro

A comparison of pyogenic liver abscess in patients with or without diabetes: a retrospective study of 246 cases. Pyogenic liver abscess(PLA) has become common in patients with diabetes mellitus (DM), but it is unclear whether differences exist between patients with and without DM. A retrospective study was performed to identify these differences, summarize the clinical experience, and improve the diagnosis and treatment of PLA.The patients were enrolled in a teaching hospital from January 2012 (...) . Patients with DM were older, had higher levels of alkaline phosphatase and γ-glutamyl transferase, hypertension, a loss of body weight, a single abscess, and combined antibiotic therapy with the use of carbapenems and Klebsiella pneumoniae in their blood cultures but a less frequent history of abdominal surgery and Escherichia coli in their pus cultures. When DM patients were compared to non-DM patients, each of these differences was significant (P < 0.05). Diabetic PLA patients with poor glycaemic

2018 BMC Gastroenterology

42. A Retrospective Case-Control Study to Evaluate the Diagnostic Accuracy of Honeycomb Sign in Melioid Liver Abscess. Full Text available with Trip Pro

A Retrospective Case-Control Study to Evaluate the Diagnostic Accuracy of Honeycomb Sign in Melioid Liver Abscess. Among pyogenic liver abscesses, melioid etiology is considered in endemic regions in the presence of known health or occupational risk factors. "Honeycomb sign," used to describe an abscess with multiple internal septations dividing the abscess cavity into multiple loculations of comparable sizes on imaging, is a sensitive sign for melioid liver abscess. This is a retrospective (...) case-control study investigating incidence, sensitivity, and specificity of "honeycomb sign" in melioid liver abscess, in a cohort of patients with culture-proven melioidosis infection. Abscesses ≥ 2 cm were analyzed for the honeycomb sign. P value < 0.05 was taken as statistically significant. Interobserver agreement was calculated between two radiologists for the presence of the sign, sensitivity, and specificity. A total of 40 abscesses were analyzed. Thirty-four abscesses (85%) manifested

2018 American Journal of Tropical Medicine & Hygiene

43. Etiology and clinical manifestations of bacterial liver abscess: A study of 102 cases. Full Text available with Trip Pro

Etiology and clinical manifestations of bacterial liver abscess: A study of 102 cases. This study aimed to analyze the clinical manifestations of patients with pyogenic liver abscess and characteristics of pathogenic that caused their infections, in order to provide guidance for the identification of the pathogens that cause liver abscess and selection of antibiotics for treatment of this disease.In the present study, the clinical characteristics, laboratory results, as well as the species (...) and drug resistance of pathogens in patients with bacterial liver abscesses admitted to our hospital from January 2013 to December 2015 were retrospectively analyzed. The patients were treated by ultrasound or CT-guided percutaneous portal vein catheterization and drainage combined with intravenous infusion of antibiotics (the third-generation cephalosporins, the coformulation of carbapenem and dehydropeptidase-I inhibitors, or the coformulation of tazobactam and piperacillin).A total of 178 patients

2018 Medicine

44. Intrahepatic Administration of Amphotericin B Liposomal (Ambisome®) for the Management of a Liver Abscess from <i>Candida albicans</i> in a preterm infant. Full Text available with Trip Pro

Intrahepatic Administration of Amphotericin B Liposomal (Ambisome®) for the Management of a Liver Abscess from Candida albicans in a preterm infant. Hepatic fungal abscesses are rare in the neonatal period and often constitute a severe complication of the catheterization of the umbilical vessels. Such life-threatening lesions are observed more frequently in preterm than in other newborn infants and the optimal treatment remains uncertain. We present the case of a preterm neonate, who (...) developed an intrahepatic lesion due to parenteral extravasation, successively contaminated by Candida albicans Despite the maximal pharmacological therapies, the treatment that led to the definitive resolution of the abscess was the placement of surgical drainage followed by the direct intralesional administration of liposomal amphotericin B (Ambisome), never described in neonates in the literature, which turned out to be a safe and effective approach.Copyright © 2018 American Society for Microbiology.

2018 Antimicrobial Agents and Chemotherapy

45. Uncommon cause of liver abscess Full Text available with Trip Pro

Uncommon cause of liver abscess Gastrointestinal perforation by fishbone causing a liver abscess is a rare entity, but should be included in the differential diagnosis to avoid delay in the treatment.

2018 Clinical Case Reports

46. Hypervirulent Klebsiella pneumoniae K1 liver abscess and endogenous endophthalmitis in a Caucasian man Full Text available with Trip Pro

Hypervirulent Klebsiella pneumoniae K1 liver abscess and endogenous endophthalmitis in a Caucasian man Invasive Liver Abscess Syndrome is the most frequent of a number of infectious syndromes caused by hypervirulent Klebsiella pneumoniae clones. While incidences peak in Southeast Asia, travels to Asia and Asian ethnicity are independent risk factors for infection in the western countries, although non-Asians are infected as well. Although challenging, a prompt diagnosis is of utmost importance

2018 Clinical Case Reports

47. Amoebic Liver Abscess and Indigenous Alcoholic Beverages in the Tropics Full Text available with Trip Pro

Amoebic Liver Abscess and Indigenous Alcoholic Beverages in the Tropics Amoebic liver abscess (ALA) seen commonly in the tropics is predominantly confined to adult males, especially those who consume locally brewed alcohol, although intestinal amoebiasis occurs in all age groups and in both genders. Whether the role of alcohol in the development of ALA is incidental and casual or whether alcohol is causally implicated has been debated. It has been argued that socioeconomic factors and poor (...) stores and lipid content is discussed. Late-stage liver disease with fibrosis seems to be protective for the development of ALA. Further research is necessary to elucidate the many possible mechanisms that predispose to hepatic amoebiasis, so that appropriate individual and population-based preventive measures can be implemented.

2018 Journal of tropical medicine

48. Clostridium tertium: An Unusual Cause of Pyogenic Liver Abscess Full Text available with Trip Pro

Clostridium tertium: An Unusual Cause of Pyogenic Liver Abscess Pyogenic liver abscess (PLA) is the result of portal vein pyemia, which usually originates from the hepatobiliary system or the gastrointestinal tract. Gram-negative organisms are the most common causative pathogens in PLA. Clostridium tertium is an anaerobic gram-positive, low-virulence organism that most commonly affects neutropenic patients with hematological malignancy and has not been reported to cause PLA. We report

2018 ACG case reports journal

49. Septic cutaneous emboli revealing a severe case of Klebsiella pneumoniae liver abscess syndrome Full Text available with Trip Pro

Septic cutaneous emboli revealing a severe case of Klebsiella pneumoniae liver abscess syndrome Klebsiella pneumoniae liver abscess syndrome (KLAS) is characterized by bacteraemia, liver abscesses and metastatic infection caused by a hypervirulent strain of Klebsiella pneumoniae, usually belonging to the capsular serotype K1 or K2. Initially, KLAS was described in Eastern Asia; recently isolated cases have been reported from different parts of the world.We describe the case of a woman with KLAS (...) including meningeal, ocular and cutaneous metastatic infection and organ dysfunctions (coagulation abnormalities, thrombocytopenia and increased creatinine level). The identification of a hypermucoviscous strain of Klebsiella pneumoniae was possible by culture from one of the cutaneous emboli and subsequently confirmed by blood cultures. The patient fully recovered after abscess drainage and prolonged antibiotic treatment.We have pointed out about the importance of sampling each septic focus in order

2018 JMM Case Reports

50. Multiple Hepatic Abscess from Parvimonas micra: An Emerging Gastrointestinal Microbe Full Text available with Trip Pro

Multiple Hepatic Abscess from Parvimonas micra: An Emerging Gastrointestinal Microbe Parvimonas micra is an obligate anaerobic bacterium and a known commensal of the human oral cavity and gastrointestinal tract. It is rarely associated with infections outside the oral cavity. Recently it has been isolated as a causative agent in a variety of systemic infections, but it has never been previously identified to cause a hepatic abscess. We report a 90-year-old woman with multiple hepatic abscesses

2018 ACG case reports journal

51. Cryptogenic and non-cryptogenic liver abscess: A retrospective analysis of 178 cases revealed distinct characteristics Full Text available with Trip Pro

Cryptogenic and non-cryptogenic liver abscess: A retrospective analysis of 178 cases revealed distinct characteristics Objective To enhance theoretical support of pyogenic liver abscess (PLA) treatment by comparing characteristics of patients with either PLA with an identified infectious origin (non-cryptogenic) or PLA with no obvious underlying cause (cryptogenic). Methods This retrospective study included all first episodes of PLA in adults admitted to a tertiary hospital between 2009

2018 The Journal of international medical research

52. Entamoeba histolytica Calreticulin Induces the Expression of Cytokines in Peripheral Blood Mononuclear Cells Isolated From Patients With Amebic Liver Abscess Full Text available with Trip Pro

Entamoeba histolytica Calreticulin Induces the Expression of Cytokines in Peripheral Blood Mononuclear Cells Isolated From Patients With Amebic Liver Abscess Calreticulin (CRT) is a highly conserved protein in the endoplasmic reticulum that plays important roles in the regulation of key cellular functions. Little is known about the participation of E. histolytica CRT (EhCRT) in the processes of pathogenicity or in the modulation of the host immune response. The aim of this study was to evaluate (...) the role of CRT in the proliferation and the cytokine profile in peripheral blood mononuclear cells (PBMCs) from patients with amebic liver abscess (ALA) during the acute phase (AP-ALA) of the disease compared to patients during the resolution phase (R-ALA). The PBMCs from each participant were cocultured with EhCRT and tested by the colorimetric method to evaluate their proliferation index (PI). The supernatants were subjected to an enzyme-linked immunosorbent assay (ELISA) to evaluate

2018 Frontiers in cellular and infection microbiology

53. Klebsiella pneumoniae Liver Abscess Full Text available with Trip Pro

Klebsiella pneumoniae Liver Abscess Since the mid 1980s, the prevalence of liver abscess caused by hypervirulent Klebsiella pneumoniae strain has increased in Asia, particularly in Taiwan and Korea. This strain is mostly K1 or K2 serotype, and has hypercapsular and hypermucoid phenotypes. Most infections are community acquired, and patients rarely have a hepatobiliary disease prior to infection. Clinical manifestations are characterized by fever and high C-reactive protein, and metastatic (...) infections, such as septic emboli in the lung and endophthalmitis and meningitis are frequently observed. Antibiotic resistance is rare. Antibiotic treatment and abscess drainage are needed, and early diagnosis and treatment of endophthalmitis is also important.Copyright © 2018 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy.

2018 Infection & chemotherapy

54. Platelet reactivity in diabetic patients with invasive Klebsiella pneumoniae liver abscess syndrome Full Text available with Trip Pro

Platelet reactivity in diabetic patients with invasive Klebsiella pneumoniae liver abscess syndrome Platelets catalyze the development of hyperinflammation and microthrombosis and contribute to increases in accumulation of circulating platelet-leukocyte complex, the key event in the development of disseminated infection.To determine the relationships of platelet activity in diabetic patients with invasive Klebsiella pneumoniae liver abscess syndrome (IKLAS), a total of 175 diabetic patients (...) with aspirin (AOR, 0.17; 95% CI, 0.04-0.79) were less likely to present with IKLAS. Among patients with IKLAS, patients with a poor glycemic control were more likely to present with hepatic venous thrombo-phlebitis than those with suboptimal or good glycemic control (P=0.03). Patients with IKLAS had a higher median fluorescence intensity of the platelet membrane expression of P-selectin than those with non-IKLAS (78.0 vs 28.0, P<0.001) and controls (78.0 vs 22.0, P< 0.001). The IKLAS group also

2018 Infection and drug resistance

55. HEPATECTOMY FOR PYOGENIC LIVER ABSCESS TREATMENT: EXCEPTION APPROACH? Full Text available with Trip Pro

HEPATECTOMY FOR PYOGENIC LIVER ABSCESS TREATMENT: EXCEPTION APPROACH? Percutaneous drainage for pyogenic liver abscess has been considered the gold-standard approach for the treatment on almost of the cases. However, when percutaneous drainage fails or even in some especial situations, as multiloculate abscess, lobe or segment surgical resection can solve infectious clinical condition.To report a series of patients who underwent hepatectomy for pyogenic liver abscess performed by a single (...) ), left lateral sectioniectomy (n=1), right posterior sectioniectomy (n=2), resection of S8 (n=1), and S1 (n=1). Postoperative morbidity rate was 30%, while mortality was null. Median hospital stay was 18 days (5-45). The median follow-up period was 49 months (13-78). There was single lesion recurrence.Hepatectomy can be done as exception approach for pyogenic hepatic abscess treatment; it is a good therapeutic option in special situations.

2018 Arquivos Brasileiros de Cirurgia Digestiva : ABCD

56. Pyogenic Liver Abscess Caused by Methicillin-Susceptible Staphylococcus aureus in a 21-Year-Old Male Full Text available with Trip Pro

Pyogenic Liver Abscess Caused by Methicillin-Susceptible Staphylococcus aureus in a 21-Year-Old Male Liver abscesses are the most common types of visceral abscesses. Pyogenic liver abscesses, a particular type of liver abscesses, are uncommonly encountered. We present a rare case of pyogenic liver abscess caused by methicillin-susceptible Staphylococcus aureus in a young man. A 21-year- old man presented from prison to the hospital with fever, nausea, vomiting, diarrhea, and abdominal pain (...) for five days. Labs were significant for leukocytosis with predominant neutrophilia and elevated liver enzymes. CT abdomen with contrast revealed an 8.4 cm multiloculated right hepatic mass extending to the kidney. Patient was started on broad spectrum antibiotics, given septic presentation. Peripheral blood cultures returned positive for methicillin-susceptible Staphylococcus aureus (MSSA). The culture from percutaneous drainage also revealed MSSA. He received a total of four weeks of IV Nafcillin

2018 Case Reports in Hepatology

57. The NFκB signaling pathway serves an important regulatory role in Klebsiella pneumoniae liver abscesses Full Text available with Trip Pro

The NFκB signaling pathway serves an important regulatory role in Klebsiella pneumoniae liver abscesses The incidence of Klebsiella pneumoniae liver abscess (KPLA) has increased in a number of Asian countries over the past 30 years. Diabetes mellitus (DM) is a risk factor for KPLA. The prevalence and clinical features of KPLA in patients with and without DM have been well described; however, the underlying molecular mechanism responsible for the increased incidence of KPLA in patients with DM (...) remains unclear. In the present study, a mouse model of DM was constructed and mice were infected with K. pneumoniae. Tissues were harvested for immunohistochemical and inflammatory factor expression analyses. The results revealed that the number of liver abscesses in mice with DM was greater than that observed in normal mice. The expression of interleukin (IL)-1β, IL-2, IL-6, macrophage inflammatory protein-1α and tumor necrosis factor-α in the liver tissues of mice with DM was significantly higher

2018 Experimental and therapeutic medicine

58. Hepatic Eosinophilic Abscess Associated with Sigmoid Colon Cancer Full Text available with Trip Pro

Hepatic Eosinophilic Abscess Associated with Sigmoid Colon Cancer The clinical course of hepatic eosinophilic abscess (HEA) induced by malignant tumors is not well-known; however, it is considered to be a benign hepatic lesion. HEA is difficult to diagnose by imaging alone and a pathological examination is generally needed, particularly in patients with malignant tumors, because the radiological findings can be similar to those of metastasis. We report a case of multiple HEAs with eosinophilia

2018 Internal Medicine

59. Photo Quiz: Isolation of a “Friendly Bacterium” from a Pyogenic Liver Abscess Full Text available with Trip Pro

Photo Quiz: Isolation of a “Friendly Bacterium” from a Pyogenic Liver Abscess 29472433 2018 12 19 1098-660X 56 3 2018 03 Journal of clinical microbiology J. Clin. Microbiol. Photo Quiz: Isolation of a "Friendly Bacterium" from a Pyogenic Liver Abscess. e00602-16 10.1128/JCM.00602-16 Recio Raúl R Servicio de Microbiología Clínica, Hospital Universitario 12 de Octubre, Madrid, Spain. Brañas Patricia P Servicio de Microbiología Clínica, Hospital Universitario 12 de Octubre, Madrid, Spain (...) . Chaves Fernando F Servicio de Microbiología Clínica, Hospital Universitario 12 de Octubre, Madrid, Spain. Orellana M Ángeles MÁ Servicio de Microbiología Clínica, Hospital Universitario 12 de Octubre, Madrid, Spain morellana.hdoc@salud.madrid.org. eng Editorial 2018 02 22 United States J Clin Microbiol 7505564 0095-1137 bacteremia liver abscess 2018 2 24 6 0 2018 2 24 6 0 2018 2 24 6 0 epublish 29472433 56/3/e00602-16 10.1128/JCM.00602-16 PMC5824042

2018 Journal of clinical microbiology

60. Gas-forming pyogenic liver abscess: A world review Full Text available with Trip Pro

Gas-forming pyogenic liver abscess: A world review Gas-forming pyogenic liver abscess (GFPLA) has an incidence of up to 30% of all pyogenic liver abscesses (PLA). GFPLA has higher mortality compared to non-GFPLA. Mere presence of gas within abscess may not determine clinical outcome. Hence it is important to study biologic characteristics that make GFPLA a distinct clinical entity. The aim of this study was to conduct a world review on GFPLA.We conducted literature searches in PubMed using (...) the following MeSH terms: "gas forming" AND "Liver abscess, pyogenic", "gas" AND "Liver abscess, pyogenic", "gas" AND "Liver abscess", "gas forming" AND "Liver abscess". Thirteen case series including 313 GFPLA patients were included. Age, gender, diabetes mellitus (DM), bacteriology, underlying etiology, symptoms, investigations, operative indications, and mortality rates were tabulated.GFPLA is often cryptogenic. There was no difference in age, gender, or symptomatology between GFPLA and non-GFPLA

2018 Annals of Hepato-Biliary-Pancreatic Surgery

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