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Liver Abscess

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1. Liver abscess

, hepatic vein, or portal vein, by extension of an adjacent infection, or as a result of trauma. One or multiple abscesses can be present. Fungal liver abscess can occur in immunocompromised hosts. Amoebic liver abscess is a complication of amoebiasis. History and exam presence of risk factors fevers and chills RUQ tenderness hepatomegaly weight loss fatigue abdominal pain nausea and vomiting cough, shortness of breath, or chest pain jaundice signs of pleural effusion in the right lower zone signs (...) Liver abscess Liver abscess - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Liver abscess Last reviewed: February 2019 Last updated: March 2018 Summary A localised infection in the liver parenchyma that may be bacterial, fungal, or parasitic in origin. Patients typically present with non-specific constitutional symptoms, RUQ abdominal pain, and tenderness. The most common underlying condition in people with pyogenic

2018 BMJ Best Practice

3. Hepatic Abscess in a Returning Traveler with Crohn's Disease: Differentiating Amebic from Pyogenic Liver Abscess Full Text available with Trip Pro

Hepatic Abscess in a Returning Traveler with Crohn's Disease: Differentiating Amebic from Pyogenic Liver Abscess Liver abscess is a rare but serious complication of Crohn's disease. Patients with Crohn's disease are at risk for pyogenic liver abscesses due to immunosuppressive therapy, fistulous disease, and intraabdominal abscesses. Inflammatory bowel disease patients are also known to have a greater prevalence of amebiasis compared to the rest of the population; however, a higher incidence (...) of amebic liver abscess has not been reported. We describe a case of a liver abscess in a patient with Crohn's disease that was initially presumed pyogenic but later determined to be amebic in origin. Epidemiology, clinical presentation, diagnosis, and treatment of amebic and pyogenic liver abscesses are discussed.

2018 Case reports in medicine

4. Case Report: Spontaneous Resolution of Intracavitary Hepatic Artery Pseudoaneurysm Caused by Amebic Liver Abscess following Percutaneous Drainage. (Abstract)

Case Report: Spontaneous Resolution of Intracavitary Hepatic Artery Pseudoaneurysm Caused by Amebic Liver Abscess following Percutaneous Drainage. Intrahepatic pseudoaneurysm (IHPA) is generally iatrogenic, and it warrants urgent management because of its reportedly significant risk of rupture leading to considerable mortality. Intrahepatic pseudoaneurysm caused by amebic liver abscess (ALA) is exceedingly rare with fewer than seven published reports. All reported symptomatic cases have been (...) treated with hepatic artery embolization; therefore, little is known about its natural course and effect of abscess drainage on its outcome. We report the first case of symptomatic intracavitary IHPA caused by ALA in which ultrasound-guided percutaneous catheter drainage of the abscess resulted in the spontaneous resolution of the IHPA.

2019 American Journal of Tropical Medicine & Hygiene

5. Prevalence of cases of amebic liver abscess in a tertiary care centre in India: A study on risk factors, associated microflora and strain variation of Entamoeba histolytica. Full Text available with Trip Pro

Prevalence of cases of amebic liver abscess in a tertiary care centre in India: A study on risk factors, associated microflora and strain variation of Entamoeba histolytica. Amebiasis, caused by Entamoeba histolytica (E. histolytica), is a significant cause of morbidity and mortality in developing countries. Mortality due to amebiasis is mostly by extra intestinal infections, amebic liver abscess being the most common one. This study was conducted to determine the current epidemiological status (...) , risk factors, associated microflora and strain variation of E. histolytica causing liver abscesses.A total of 115 liver abscess cases comprising of 107 (93%) males and 8 (6.9%) females were included in the study. Microscopic examination of pus samples from the abscesses and species discrimination using nested multiplex PCR showed the presence of E. histolytica in 101 (87.5%) cases. Data collected by face to face interviews using a pre tested questionnaire suggested intake of untreated drinking

2019 PLoS ONE

6. Correction: Prevalence of cases of amebic liver abscess in a tertiary care centre in India: A study on risk factors, associated microflora and strain variation of Entamoeba histolytica. Full Text available with Trip Pro

Correction: Prevalence of cases of amebic liver abscess in a tertiary care centre in India: A study on risk factors, associated microflora and strain variation of Entamoeba histolytica. [This corrects the article DOI: 10.1371/journal.pone.0214880.].

2019 PLoS ONE

7. Antibiotics after incision and drainage for uncomplicated skin abscesses Full Text available with Trip Pro

, such as infection with hepatitis C, hepatitis B, or HIV. The RCTs included children and adults. Almost all patients underwent incision and drainage for their skin abscess. The most common pathogen was MRSA (49-88%) followed by methicillin-sensitive Staphylococcus aureus (MSSA, 9-18%). Understanding the recommendation Absolute benefits and harms The infographic provides an overview of the recommendations and the absolute benefits and harms of different antibiotics. Estimates of the baseline risk for side effects (...) Antibiotics after incision and drainage for uncomplicated skin abscesses Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline | The BMJ Intended for healthcare professionals Username * Password * Edition: Search form Search Search Antibiotics after... Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline CC BY NC Open access (Published 06 February 2018) Cite this as: BMJ 2018;360:k243 Population

2018 BMJ Rapid Recommendations

8. Maxillary Teeth Abscesses Result in Atypical Liver Abscesses Full Text available with Trip Pro

Maxillary Teeth Abscesses Result in Atypical Liver Abscesses Hepatic liver abscesses are often misdiagnosed on initial presentation because pyogenic liver lesions are a rare occurrence in the United States. This leads to a delay in proper treatment and results in increasing morbidity and mortality. Our case report demonstrates the atypical presentation of a hepatic liver abscess in the elderly. The source of infection was found to be periapical abscesses of the teeth, which subsequently seeded

2018 Cureus

9. Society of Interventional Radiology Quality Improvement Standards for Image-Guided Percutaneous Drainage and Aspiration of Abscesses and Fluid Collections Full Text available with Trip Pro

., and Batakis, N. Potentially life-threatening neck abscesses: therapeutic management under CT-guided drainage. Cardiovasc Intervent Radiol . 2005 ; 28 : 196–199 , x 17 Wallace, M.J., Chin, K.W., Fletcher, T.B , and Society of Interventional Radiology (SIR). Quality improvement guidelines for percutaneous drainage/aspiration of abscess and fluid collections. J Vasc Interv Radiol . 2010 ; 21 : 431–435 , x 18 Yu, S.C., Ho, S.S., Lau, W.Y. et al. Treatment of pyogenic liver abscess: prospective randomized (...) –435 , x 18 Yu, S.C., Ho, S.S., Lau, W.Y. et al. Treatment of pyogenic liver abscess: prospective randomized comparison of catheter drainage and needle aspiration. Hepatology . 2004 ; 39 : 932–938 , x 20 Beland, M.D., Gervais, D.A., Levis, D.A., Hahn, P.F., Arellano, R.S., and Mueller, P.R. Complex abdominal and pelvic abscesses: efficacy of adjunctive tissue-type plasminogen activator for drainage. Radiology . 2008 ; 247 : 567–573 , x 21 Gee, M.S., Kim, J.Y., Gervais, D.A., Hahn, P.F., and Mueller

2020 Society of Interventional Radiology

10. Epidural abscess

reflexes isolated sphincter dysfunction intravenous drug use recent spinal surgery or trauma indwelling spinal catheter concomitant local infection immunosuppression diabetes mellitus male sex concomitant endocarditis alcohol abuse urinary tract infection (UTI) renal failure chronic renal disease chronic liver disease Diagnostic investigations FBC CRP erythrocyte sedimentation rate gadolinium-enhanced diffusion-weighted MRI spine blood cultures direct abscess aspiration for culture polymerase chain (...) Epidural abscess Epidural abscess - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Epidural abscess Last reviewed: February 2019 Last updated: July 2018 Summary Rare condition characterised by inflammation with pus within the epidural space. Recognised risk factors include diabetes mellitus, intravenous drug abuse, history of recent spinal surgery or trauma, indwelling spinal catheter, concomitant local infection

2018 BMJ Best Practice

11. Primary hepatic leiomyosarcoma presenting as a thick-walled cystic mass resembling a liver abscess: A case report. Full Text available with Trip Pro

Primary hepatic leiomyosarcoma presenting as a thick-walled cystic mass resembling a liver abscess: A case report. Hepatic leiomyosarcoma is a rare malignant tumor, and in rare instances, its combination with fever may lead to misdiagnosis of liver abscess. In our case, the presence of the tumor was considered by the presence of blood vessels through the observation of hepatic tumor wall.A 38-year-old woman who had been diagnosed with a liver abscess in a local hospital consulted our (...) institution by complaining left upper quadrant pain and fever. The diagnosis was questioned in our workup, since no obvious inflammatory marker was found in the circulation, and contrast-enhanced computed tomography revealed a huge thick-walled mass in the right liver with multiple tortuous vessels within the wall.Imaging revealed a neoplastic lesion rather than liver abscess. The enhancement of the solid tumor tissues was reduced during the portal phase and delayed phase, which was consistent with a wash

2018 Medicine

12. Management and Outcome of Liver Abscesses After Liver Transplantation. (Abstract)

.Fourteen patients (1.5%) developed 18 episodes of liver abscesses, and the median time from OLT to the diagnosis of liver abscess was 39.7 months. Major predisposing factors were biliary strictures in 11 patients, hepatic artery thrombosis in 8, re-OLT in 3, choledochojejunostomy in 2, living donor OLT in 2, donor after cardiac death in 1, split liver in 1, and liver biopsy in 1. All patients were managed by intravenous antibiotics; percutaneous drainage was performed in 10 patients, while 2 patients (...) Management and Outcome of Liver Abscesses After Liver Transplantation. Liver abscess after orthotopic liver transplantation (OLT) is a rare, life-threatening complication. The aim of this study is to analyze the incidence, risk factors, clinical manifestations, treatment and outcomes of liver abscesses after OLT.We perform a retrospective review of the patients who developed one or more liver abscesses among a series of 984 patients who underwent OLT between January 2000 and December 2016

2018 World Journal of Surgery

13. Culture-independent analysis of liver abscess using nanopore sequencing. Full Text available with Trip Pro

Culture-independent analysis of liver abscess using nanopore sequencing. The identification of microbial species has depended predominantly upon culture-based techniques. However, the difficulty with which types of organisms are cultured implies that the grown species may be overrepresented by both cultivation and plate counts. In recent years, culture-independent analysis using high-throughput sequencing has been advocated for use as a point-of-care diagnostic tool. Although it offers a rapid (...) and unbiased survey to characterize the pathogens in clinical specimens, its accuracy is reduced by the high level of contamination of human DNA. In this paper, we propose using a culture-independent analysis for a Klebsiella pneumoniae clinical strain within a liver abscess using nanopore sequencing. Owing to the highly-contaminated cell population within a liver abscess, we managed to reduce the confounding effects of human DNA through the use of DNase and differential centrifugation. Genomic DNA

2018 PLoS ONE

14. Management of Liver Abscess in Children: Our Experience Full Text available with Trip Pro

Management of Liver Abscess in Children: Our Experience Liver abscess is common in pediatric population in India. Children have unique set of predisposing factors and clinical features. Liver abscesses are infectious, space-occupying lesions in the liver; the two most common abscesses being pyogenic and amebic. Its severity depends on the source of the infection and the underlying condition of the patient.A total of 34 patients less than 12 years were assessed in a retrospective study from (...) patients (58.8%) underwent ultrasound-guided percutaneous catheter drainage. Two patients required catheter drainage for large abscess and needle aspiration for the smaller abscess.Antimicrobial therapy along with percutaneous drainage constitutes the mainstay of treatment, whereas open surgical drainage should be reserved for selected cases.How to cite this article: Waghmare M, Shah H, Tiwari C, Khedkar K, Gandhi S. Management of Liver Abscess in Children: Our Experience. Euroasian J Hepato

2017 Euroasian journal of hepato-gastroenterology

15. Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis

Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis Michael Gottlieb, MD*; Joshua M. DeMott, PharmD, MSc; Marilyn Hallock, MD, MS; Gary D. Peksa, PharmD *Corresponding Author. E-mail: michaelgottliebmd@gmail.com, Twitter: @MGottliebMD. Study objective: The addition of antibiotics to standard incision and drainage (...) is controversial, with earlier studies demonstrating no signi?cant bene?t. However, 2 large, multicenter trials have recently been published that have challenged the previous literature. The goal of this review was to determine whether systemic antibiotics for abscesses after incision and drainage improve cure rates. Methods: PubMed, the Cumulative Index of Nursing and Allied Health Literature, Scopus, the Cochrane Database of Systematic Reviews, the Cochrane Central Register of Controlled Trials

2018 Annals of Emergency Medicine Systematic Review Snapshots

16. A cohort study of age and sex specific risk of pyogenic liver abscess incidence in patients with type 2 diabetes mellitus. Full Text available with Trip Pro

A cohort study of age and sex specific risk of pyogenic liver abscess incidence in patients with type 2 diabetes mellitus. To investigate the age-sex-specific incidence and relative risk of pyogenic liver abscess (PLA) in patients with type 2 diabetes mellitus (T2DM), and to assess the joint effects of T2DM and other clinical risk factors for PLA on PLA incidence. We used a population-based cohort design with Taiwan's National Health Insurance claim data. Study subjects included 613,921 T2DM (...) significantly modify the relationship between T2DM and PLA, with a higher HR noted in males patients and those aged <45 years. Biliary tract diseases (HR, 8.60; 95% CI, 7.87-9.40) and liver cirrhosis (HR, 7.52; 95% CI, 6.58-8.59) may add substantially additional risk to the incidence of PLA in T2DM patients. The increased risk of PLA in T2DM was greater in male and younger patients. Careful management of biliary tract diseases and liver cirrhosis may also help reduce the incidence of PLA in T2DM patients.

2019 Medicine

17. The relation of toddy (palm wine) intake to amoebic liver abscess in a predominantly toddy-drinking population: a cross-sectional study. (Abstract)

The relation of toddy (palm wine) intake to amoebic liver abscess in a predominantly toddy-drinking population: a cross-sectional study. The role of toddy (palm wine) as an independent risk factor for amoebic liver abscess (ALA) is not clear. In a cross-sectional study, the clinico-demographic profiles of inpatients with ALA were examined. Microscopy examination of toddy (n = 43) samples was performed. A total of 198 patients with ALA were enrolled, most of whom were: admitted during the May

2019 Tropical Doctor

18. Transition to Oral versus Continued Intravenous Antibiotics for Patients with Pyogenic Liver Abscesses: A Retrospective Analysis. (Abstract)

Transition to Oral versus Continued Intravenous Antibiotics for Patients with Pyogenic Liver Abscesses: A Retrospective Analysis. The management of pyogenic liver abscesses usually requires 4 weeks of antibiotic therapy. It is unknown if oral (PO) antibiotics are as effective as intravenous (IV) antibiotics for this indication.To compare 30-, 60-, and 90-day readmission rates between patients with pyogenic liver abscesses receiving IV antibiotics for the duration of therapy and those who were (...) transitioned to PO antibiotics after discharge from the hospital.This retrospective study included patients with pyogenic liver abscesses who had undergone percutaneous drainage and received IV antibiotics while in the hospital. Patients were grouped based on receipt of either PO or IV antibiotics at discharge.The final cohort resulted in 99 patients, 48 in the PO group and 51 in the IV group. The most common organisms identified were Klebsiella sp, Escherichia coli, and Streptococcus sp. The most common

2019 Pharmacotherapy

19. Prognosis of liver abscess with no identified organism. Full Text available with Trip Pro

Prognosis of liver abscess with no identified organism. There are limited studies focusing on liver abscess with negative microbiological cultures. This study evaluated the clinical and prognostic differences of patients with culture-negative liver abscess (CNLA) compared to those with a positive culture (CPLA) and compared these factors between K. pneumoniae liver abscess (KLA) and E. coli liver abscess (ELA).A retrospective study of the patients who admitted with a liver abscess at two (...) tertiary hospitals in Korea from 2012 to 2016 was performed.Among a total of 402 patients with liver abscess, 61.2% had positive cultures. K. pneumoniae (n = 133) was the most common cause, followed by E. coli (n = 74). Patients with CPLA were significantly older (p = 0.02) and more frequently had cholelithiasis or biliary tract disease (p = 0.001) compared to patients with CNLA. In-hospital mortality (p = 0.63) and recurrence (p = 0.77) were no different between the two groups. The length of hospital

2019 BMC Infectious Diseases

20. Clinical characteristics and treatment outcomes in a cohort of patients with pyogenic and amoebic liver abscess. Full Text available with Trip Pro

Clinical characteristics and treatment outcomes in a cohort of patients with pyogenic and amoebic liver abscess. We describe the clinical features of a cohort of patients with liver abscesses and investigate relationships between clinical, radiological and microbiological findings and mortality.Retrospective review of pyogenic (PLA) or amoebic liver abscesses (ALA) diagnosed and treated at a major infectious diseases department in London over 9 years.One hundred forty-one patient records were (...) identified; 132 (93.6%) had PLA and 9 (6.4%) ALA. No organism was identified in 38.6% (51/132); a single bacterial species was isolated in 47.0% (62/132) of PLA, ≥ 2 in 14.4% (19/132). There was weak evidence of variation in abscess size by type of microorganism, with streptococcal PLA typically larger (p = 0.03 for Streptococcus milleri group, p = 0.05 for non-milleri streptococci). Patients with ALA were younger (median 41, IQR 37-51 years) than those with PLA (median 68, IQR 50.5-78 years) (p = 0.003

2019 BMC Infectious Diseases

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