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Lip Cancer

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1. Surgical attitude in premalignant lesions and malignant tumors of the lower lip Full Text available with Trip Pro

Surgical attitude in premalignant lesions and malignant tumors of the lower lip Malignant tumors of the lower lip may have a variety of histopathology forms. The diagnosis and treatment of premalignant lesions are extremely important to avoid their malignant evolution. The lower lip tumor diagnosis is based on a series of correlations: anamnestic, clinical, laboratory and histopathological (the latter giving the certain diagnose).This study was carried out by selecting the cases with lower lip (...) %. In the group of patients studied, 66% were smokers.The rate of the malignant transformation of premalignant lesion was 32.6% for keratoacanthoma, 16.9% for actinic cheilitis, 10% for actinic keratoses.There were no clinical or laboratory features to plead for the pre-malignant or malignant character of the of a lower lip tumor, consequently histopathological examination was used for the diagnosis of the lesion. Due to the high percentage of malignant transformation of precancerous lesions, particularly

2015 Journal of medicine and life

2. Nomogram predicting long-term overall survival and cancer-specific survival of lip carcinoma patients based on the SEER database: A retrospective case-control study. Full Text available with Trip Pro

Nomogram predicting long-term overall survival and cancer-specific survival of lip carcinoma patients based on the SEER database: A retrospective case-control study. Our study was designed to construct nomograms to predict the overall survival (OS) and cancer-specific survival (CSS) of lip carcinoma patients.A search of the Surveillance, Epidemiology, and End Results (SEER) database provided us with detailed clinical data of the 1780 lip carcinoma patients. On the basis of the credible random

2019 Medicine

3. Dermatologist-level classification of malignant lip diseases using a deep convolutional neural network. (Abstract)

Dermatologist-level classification of malignant lip diseases using a deep convolutional neural network. Deep convolutional neural networks (DCNNs) can classify skin diseases at a level equivalent to a dermatologist, but their performance on specific areas requires further research.We aimed to evaluate the performance of a trained DCNN-based algorithm in classifying benign and malignant lip diseases.A training set of 1629 images (743 malignant, 886 benign) was used with Inception-Resnet-V2 (...) images, and 0·774 (95% CI: 0·699-0·849), 0·702 (95% CI: 0·579-0·808), and 0·759 (95% CI: 0·701-0·813), respectively for the 281 images. The DCNN was equivalent to the dermatologists and superior to the non-dermatologists when classifying malignancy. After referencing the DCNN result, the Youden's index increased significantly for the non-dermatologists, from 0·201 ± 0·156 to 0·322 ± 0·141 (p < 0·001).DCNNs can classify lip diseases at a level similar to dermatologists. This will help unskilled

2019 British Journal of Dermatology

4. Association of Nodal Metastasis and Mortality With Vermilion vs Cutaneous Lip Location in Cutaneous Squamous Cell Carcinoma of the Lip. Full Text available with Trip Pro

(fascia or beyond for vermilion lip) (subhazard ratio, 4.4; 95% CI, 1.3-14.9).The risk of nodal metastasis is 5-fold greater for cSCCs on the vermilion lip compared with those on the cutaneous lip. Squamous cell carcinomas of the cutaneous lip have a nodal metastasis risk similar to cSCCs in general (1.5%). Thus, vermilion involvement appears responsible for the increased risk associated with cSCC of lip. Vermilion involvement may merit radiologic nodal staging and inclusion in future tumor staging (...) Association of Nodal Metastasis and Mortality With Vermilion vs Cutaneous Lip Location in Cutaneous Squamous Cell Carcinoma of the Lip. Although the lip is considered a high-risk location in cutaneous squamous cell carcinoma (cSCC), it has not been established whether this risk stems from vermilion or cutaneous locations or both.To compare differences in risks of recurrence, metastasis, and death from cSCCs on the vermilion vs cutaneous lip.Retrospective cohort study of 303 patients with 310

2018 JAMA dermatology (Chicago, Ill.)

5. Diagnosis and management of patients at risk of gastric adenocarcinoma Full Text available with Trip Pro

efficacious treatments, including endoscopic resection,before cancer is established. The British Society of Gastroenterology (BSG) endoscopy committee agreed to create a guideline to provide statements and recommendations on the prevalence, risks, diagnosis, treatment, surveillance and screening of gastric premalignant and early gastric malignant lesions. The principal patient group are those found to have GA, GIM, gastric epithelial dysplasia or early gastric adenocarcinoma limited to the mucosal (...) with LGD or HGD. de Vries et al noted the annual incidence of gastric cancer was 6% in patients with HGD within 5 years. Of note, it is difficult on histopathology to distinguish between HGD and gastric adenocarcinoma from small biopsy samples. The risk of progression in individuals with LGD is less clear. There is evidence to show that LGD will regress in 38–75% of patients and persist in 19–50%. In the LGD lesions that persist, the risk of malignant progression ranges from 0% to 23% in the published

2019 British Society of Gastroenterology

6. Skin Malignancies, Merkel Cell Carcinoma and Rare Appendageal Tumors

cell carcinoma and squamous cell carcinoma (BCC) and comprise the majority of nonmelanoma malignant skin cancers. BCC is the most common malignant neoplasm. BCC is typically locally invasive, but it can metastasize on rare occasions. The most common primary site of metastatic BCC is the scrotum, where the rate of metastatic disease is 12%. Occurrence on the head and neck can also set the stage for the spread of BCC, but this is less common. SCC is a malignant neoplasm arising from transformed (...) the anogenital region in both sexes. These nonanogenital hidradenoma papilliferum have been termed ectopic hidradenoma papilliferum and occur frequently (60%) in the head and neck region. [ ] Simple surgical excision is definitive treatment. [ , ] Apocrine adenocarcinoma (extramammary Paget disease) Clinical presentation Paget disease commonly refers to the malignant infiltration of breast cancer (typically ductal carcinoma) into the apocrine glands of the areola of the nipple. Extramammary Paget disease

2014 eMedicine Surgery

7. A Prospective, Observational, Real-world Study Based on the Register System of Oral and Maxillofacial Malignant Tumors

. Condition or disease Intervention/treatment Head and Neck Neoplasms Quality of Life Postoperative Complications Procedure: resection Radiation: adjuvant radiotherapy Drug: neoadjuvant chemotherapy or adjuvant chemotherapy Detailed Description: A register system of oral and maxillofacial malignant tumors based on a prospective, observational, real-world study in north Chinese population was absent. The aim of the study is to construct a register system of oral and maxillofacial malignant tumors based (...) on a prospective, observational, real-world study in Chinese population. The variables in the study include social informatics, etiology, and psychological and quality of life, coexistence disease, baseline clinicopathological data, postoperative complications, and long-term follow-up results. By released annual analysis report, the epidemiological features and prognostic factors of oral and maxillofacial malignant tumors in north Chinese population can be identified. Study Design Go to Layout table for study

2015 Clinical Trials

8. Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma. (Abstract)

Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma. Cisplatin-based chemotherapy is moderately active in malignant pleural mesothelioma (MPM) due to intrinsic drug resistance and to low immunogenicity of MPM cells. CAAT/enhancer binding protein (C/EBP)-β LIP is a pro-apoptotic and chemosensitizing transcription factor activated in response to endoplasmic reticulum (ER) stress.We investigated if LIP levels can predict the clinical response to cisplatin and survival (...) was directly correlated with cisplatin chemosensitivity and was associated with patients' survival after chemotherapy. Overexpression of LIP restored cisplatin's pro-apoptotic effect by activating CHOP/TRB3/caspase 3 axis and up-regulating calreticulin, that triggered MPM cell phagocytosis by dendritic cells and expanded autologous anti-tumor CD8+CD107+T-cytotoxic lymphocytes. Proteasome inhibitor carfilzomib and lysosome inhibitor chloroquine prevented LIP degradation. The triple combination

2018 Lung Cancer

9. Polymorphous low grade adenocarcinoma of lip clinically mimicking squamous cell carcinoma: An unusual presentation Full Text available with Trip Pro

Polymorphous low grade adenocarcinoma of lip clinically mimicking squamous cell carcinoma: An unusual presentation Polymorphous low grade adenocarcinoma (PLGA) is a malignant neoplasm that frequently occurs in the minor salivary glands in palate and oral cavity. We present a case of upper lip swelling with ulceroproliferative growth, clinically mimicking squamous cell carcinoma (SCC). Fine-needle aspiration cytology smears suggested PLGA, which was later confirmed on histopathology. Clinical

2015 Journal of Cytology / Indian Academy of Cytologists

10. The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC) Full Text available with Trip Pro

of squamous cell carcinoma of the head and neck (HNSCC) , , , , , , , , , , , , , , , , , & volume 7 , Article number: 184 ( 2019 ) Article metrics 9607 Accesses 9 Citations 102 Altmetric Abstract Head and neck cancers, including those of the lip and oral cavity, nasal cavity, paranasal sinuses, oropharynx, larynx and nasopharynx represent nearly 700,000 new cases and 380,000 deaths worldwide per annum, and account for over 10,000 annual deaths in the United States alone. Improvement in outcomes (...) for all patients with HNSCC and pembrolizumab as a single agent for patients with HNSCC whose tumors express a PD-L1 combined positive score ≥ 1. These approvals marked the first new therapies for these patients since 2006, as well as the first immunotherapeutic approvals in this disease. In light of the introduction of these novel therapies for the treatment of patients with head and neck cancer, The Society for Immunotherapy of Cancer (SITC) formed an expert committee tasked with generating

2019 Society for Immunotherapy of Cancer

11. Synchronous Polymorphous Adenocarcinoma and Canalicular Adenoma on the Upper Lip: An Unusual Presentation and Immunohistochemical Analysis Full Text available with Trip Pro

Synchronous Polymorphous Adenocarcinoma and Canalicular Adenoma on the Upper Lip: An Unusual Presentation and Immunohistochemical Analysis Multiple salivary gland tumors (MSGTs) are most common in the major than minor salivary glands. The most MSGTs are synchronous, either benign or malignant. A 61-year-old woman was referred presenting nine submucosal nodules, firm to fluctuant, being five nodules on the right side and four nodules on the left side of the upper lip. An incisional biopsy (...) was performed. Hematoxylin and eosin staining was performed in 5-µm sections for histopathologic analysis. Immunohistochemical reactions were carried out in 3-µm sections in accordance with manufacturer's instructions. The histopathological analysis showed focal area containing low-grade polymorphous adenocarcinoma (PAC) and multiple canalicular adenomas (CAs). Immunohistochemical analysis for each lesion was carefully investigated. Here, we present an unusual case of synchronous PAC and multiple CAs

2017 Head and neck pathology

12. Lower lip squamous cell carcinoma in patients with photosensitive disorders: Analysis of cases treated at the Brazilian National Cancer Institute (INCA) from 1999 to 2012 Full Text available with Trip Pro

Lower lip squamous cell carcinoma in patients with photosensitive disorders: Analysis of cases treated at the Brazilian National Cancer Institute (INCA) from 1999 to 2012 Lower lip squamous cell carcinoma (LLSCC) is a common malignancy of the head and neck, being mainly a consequence of a chronic exposure to ultraviolet (UV) light solar radiation. Here, we evaluated the clinicopathological profile of patients with photosensitive disorders (xeroderma pigmentosum, lupus erythematosus and albinism (...) were constructed using the Kaplan-Meier method and compared by log-rank test. All statistical analyses were performed using SPSS statistics package.The mean age of patients in the photosensitive and non-photosensitive groups was 42 years and 67 years, respectively (p<0.0001). A previous history of malignant diseases was more common in the photosensitive group (p=0.001). In both groups, most tumors showed a pathological stage I/II disease. Overall and cancer-specific survival were not statistically

2017 Medicina oral, patología oral y cirugía bucal

13. The Identification of Three Cancer Stem Cell Subpopulations within Moderately Differentiated Lip Squamous Cell Carcinoma Full Text available with Trip Pro

The Identification of Three Cancer Stem Cell Subpopulations within Moderately Differentiated Lip Squamous Cell Carcinoma To identify and characterize cancer stem cells (CSCs) in moderately differentiated lip squamous cell carcinoma (MDLSCC).MDLSCC samples underwent 3,3-diaminobenzidine (DAB) immunohistochemical (IHC) staining for squamous cell carcinoma marker EMA, CSC marker CD44 and embryonic stem cell markers NANOG, octamer-binding transcription factor 4 (OCT4), spalt-like transcription (...) factor 4 (SALL4), sex-determining region Y-box 2 (SOX2), and phosphorylated signal transducer and activator of transcription 3 (pSTAT3). Immunofluorescent IHC staining was performed on two MDLSCC samples. Western blotting (WB) was used to confirm the expression of the aforementioned proteins and their transcription activation was investigated using NanoString and RT-qPCR.IHC staining demonstrated the presence of (1) an EMA+/CD44+/SALL4+/NANOG+/pSTAT3+/SOX2+/OCT4- CSC subpopulation within the tumor

2017 Frontiers in surgery

14. Cancer Stem Cells in Moderately Differentiated Lip Squamous Cell Carcinoma Express Components of the Renin–Angiotensin System Full Text available with Trip Pro

Cancer Stem Cells in Moderately Differentiated Lip Squamous Cell Carcinoma Express Components of the Renin–Angiotensin System We investigated the expression of the renin-angiotensin system (RAS) by cancer stem cell (CSC) subpopulations we have identified in moderately differentiated lip squamous cell carcinoma (MDLSCC).Ten MDLSCC samples underwent 3,3-diaminobenzidine (DAB) and immunofluorescent immunohistochemical (IHC) staining for (pro)renin receptor (PRR), angiotensin-converting enzyme (...) (ACE), angiotensin II receptor 1 (ATIIR1), and receptor 2 (ATIIR2). NanoString analysis and Western blotting (WB) were performed on six MDLSCC samples for gene and protein expression, respectively.IHC staining showed expression of PRR, ATIIR1, and ATIIR2 on cells within the tumor nests (TNs) and the stroma. ACE was localized to the microvessels within the stroma. WB detected PRR, ACE, and ATIIR2. NanoString analysis confirmed gene expression of PRR, ACE, and ATIIR1.Components of the RAS: PRR

2017 Frontiers in surgery

15. Composite Resection of Tumors of the Rostral Maxilla and Dorsolateral Muzzle Utilizing an Upper Lip-Sparing, Combined Approach in Dogs Full Text available with Trip Pro

Composite Resection of Tumors of the Rostral Maxilla and Dorsolateral Muzzle Utilizing an Upper Lip-Sparing, Combined Approach in Dogs Tumors of the rostral maxilla that involve both the oral mucosa and the dermis or subdermis of the dorsolateral muzzle provide unique challenges for the oromaxillofacial surgeon. Traditionally described approaches to such lesions may involve an intraoral incision that extends and involves the upper lip to envelope the involved dermis of the dorsolateral muzzle (...) . However, such an approach unnecessarily resects upper lip tissue resulting in a large defect that likely requires advanced skin flaps or grafts for reconstruction. Such flaps are technically challenging and introduce potential for significance postoperative complications. In this article, we provide a detailed description a combined intra- and extraoral approach that allows for composite resection of tumors of the rostral maxilla that also involve the dorsolateral muzzle. The described technique

2018 Frontiers in veterinary science

16. Recalcitrant lip verrucous carcinoma successfully treated with acitretin after carbon dioxide laser ablation Full Text available with Trip Pro

Recalcitrant lip verrucous carcinoma successfully treated with acitretin after carbon dioxide laser ablation 29998178 2019 02 26 2352-5126 4 6 2018 Jul JAAD case reports JAAD Case Rep Recalcitrant lip verrucous carcinoma successfully treated with acitretin after carbon dioxide laser ablation. 576-578 10.1016/j.jdcr.2018.02.002 Lee Chaw-Ning CN Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Huang Chun-Cheng (...) 101665210 2352-5126 CO2, carbon dioxide OVC, oral verrucous carcinoma PDT, photodynamic therapy acitretin carbon dioxide laser imiquimod photodynamic therapy verrucous carcinoma 2018 7 13 6 0 2018 7 13 6 0 2018 7 13 6 1 epublish 29998178 10.1016/j.jdcr.2018.02.002 S2352-5126(18)30039-0 PMC6038266 J Am Acad Dermatol. 2007 Feb;56(2 Suppl):S29-32 17097363 Br J Dermatol. 2007 Oct;157(4):813-5 17627786 Head Neck. 2008 May;30(5):611-7 18098309 Dermatol Surg. 2001 May;27(5):452-6 11359493 Nat Rev Cancer. 2005

2018 JAAD Case Reports

17. Lip Repair after Mohs Surgery for Squamous Cell Carcinoma by Bilateral Tissue Expanding Vermillion Myocutaneous Flap (Goldstein Technique Modified by Sawada) Full Text available with Trip Pro

Lip Repair after Mohs Surgery for Squamous Cell Carcinoma by Bilateral Tissue Expanding Vermillion Myocutaneous Flap (Goldstein Technique Modified by Sawada) Squamous cell carcinoma is the most common malignancy of the lower lip. Environmental factors such as ultraviolet light exposure, arsenic and smoking are contributing factors to the increasing incidence. Mohs surgery is the treatment of choice ensuring the lowest recurrence rates. The closure of the surgical defects, however, can (...) ) to large defects (> 2 cm) to achieve an effective and functional reconstruction of vermillion defects after Mohs surgery for lip cancer.

2018 Open access Macedonian journal of medical sciences

18. Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip Full Text available with Trip Pro

Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip An early diagnosis is of overwhelming importance for the management and prognosis of mucocutaneous cancer. Actinic cheilitis (AC), defined by the clonal expansion of genomically unstable keratinocytes, is the most common potentially malignant lesion affecting the lips. Squamous cell carcinoma (SCC) is the most frequent oral malignancy, and there is strong evidence that the majority of the SCCs of the lip originate (...) from AC. There is considerable difficulty in discerning between dysplasia and invasive carcinomas solely on a clinical basis. Although dermoscopy has become an essential tool for skin tumor evaluation, reflectance confocal microscopy (RCM) is a non-invasive imaging technology that has proved itself extremely useful in the diagnosis and monitoring of several skin diseases, including AC and SCC. The present study aimed to re-emphasize the usefulness of RCM in the early detection of malignant

2018 Molecular and clinical oncology

19. Advanced squamous-cell carcinoma of the lower lip Full Text available with Trip Pro

Beneficência, Ribeirão Preto, São Paulo, Brazil. eng Case Reports Journal Article 2018 06 20 Uganda Pan Afr Med J 101517926 IM Adult Carcinoma, Squamous Cell diagnosis pathology therapy Fatal Outcome Humans Lip Neoplasms diagnosis pathology therapy Male Prognosis Squamous Cell carcinoma neglected diseases skin neoplasms 2017 11 09 2018 05 19 2018 10 31 6 0 2018 10 31 6 0 2018 12 13 6 0 epublish 30374394 10.11604/pamj.2018.30.148.14352 PAMJ-30-148 PMC6201625 (...) Advanced squamous-cell carcinoma of the lower lip 30374394 2018 12 12 2018 12 12 1937-8688 30 2018 The Pan African medical journal Pan Afr Med J Advanced squamous-cell carcinoma of the lower lip. 148 10.11604/pamj.2018.30.148.14352 Filho Fred Bernardes FB Dermatology Division, Department of Medical Clinics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. Grupioni Priscila Vinhal PV Department of Oncology, Hospital Imaculada Conceição da Sociedade Portuguesa de

2018 The Pan African medical journal

20. The Etiology and Diagnosis of Malignant Tumors, Especially those of the Tongue and Lips Full Text available with Trip Pro

The Etiology and Diagnosis of Malignant Tumors, Especially those of the Tongue and Lips 17857409 2007 09 17 2008 11 20 0003-4932 10 4 1889 Oct Annals of surgery Ann. Surg. The Etiology and Diagnosis of Malignant Tumors, Especially those of the Tongue and Lips. 249-54 Browning W W eng Journal Article United States Ann Surg 0372354 0003-4932 1889 10 1 0 0 1889 10 1 0 1 1889 10 1 0 0 ppublish 17857409 PMC1428258

1889 Annals of Surgery

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