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Linear IgA Dermatosis

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1. Vancomycin mediates IgA autoreactivity in drug-induced linear IgA bullous dermatosis. (PubMed)

Vancomycin mediates IgA autoreactivity in drug-induced linear IgA bullous dermatosis. Vancomycin (VCM) is known to induce linear IgA bullous dermatosis (LAD). However, in contrast to conventional LAD, in which circulating IgA autoantibodies against basement membrane proteins are commonly detected, patient sera from VCM-induced LAD yields negative results in indirect immunofluorescence microscopy, and the targeted autoantigen remains undetermined. By using sera from a typical patient with VCM (...) -induced LAD, we identified that co-incubation of sera with VCM resulted in linear IgA deposition at the basement membrane zone by indirect immunofluorescence. Patient sera reacted with the dermal side of 1 mol/L NaCl-split skin and with the recombinant noncollagenous (i.e., NC1) domain of type VII collagen by both immunoblot and ELISA in the presence of VCM. The investigation of an additional 13 patients with VCM-induced LAD showed that 10 out of the 14 sera (71.4%) reacted with the NC1 domain of type

2018 Journal of Investigative Dermatology

2. Drug-induced Linear IgA Bullous Dermatosis: a Case Report and Review of the Literature. (PubMed)

Drug-induced Linear IgA Bullous Dermatosis: a Case Report and Review of the Literature. Linear IgA bullous dermatosis (LABD) is a rare subepidermal autoimmune blistering disease characterized by linear deposition of IgA along the basement membrane zone. Although most reported cases are idiopathic, there is a subset of patients with drug-induced LABD. Various drugs have been associated with the drug-induced form of the disease. This paper reviews the literature on drugs reported to elicit linear (...) IgA dermatosis and its specific clinical presentation. In addition, a case report of a 77-year-old male patient with linear IgA dermatosis induced by vancomycin is described. The aim of this paper is to emphasize the need to include this differential diagnosis in cases of suspected adverse drug reactions, as well as to highlight the role of drugs in LABD.

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2019 Acta Dermato-Venereologica

3. IgA tracheobronchial deposits underlie respiratory compromise in neonatal linear IgA bullous dermatosis. (PubMed)

IgA tracheobronchial deposits underlie respiratory compromise in neonatal linear IgA bullous dermatosis. 28079922 2017 07 21 1468-3083 31 7 2017 Jul Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol IgA tracheobronchial deposits underlie respiratory compromise in neonatal linear IgA bullous dermatosis. e333-e335 10.1111/jdv.14120 Diociaiuti A A Dermatology Division, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. Zambruno G G Dermatology

2017 Journal of the European Academy of Dermatology and Venereology

4. Intraepidermal neutrophilic dermatosis type of IgA pemphigus with circulating linear IgA disease antibodies associated with ulcerative colitis. (PubMed)

Intraepidermal neutrophilic dermatosis type of IgA pemphigus with circulating linear IgA disease antibodies associated with ulcerative colitis. 28653439 2018 01 18 1468-3083 32 1 2018 Jan Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Intraepidermal neutrophilic dermatosis type of IgA pemphigus with circulating linear IgA disease antibodies associated with ulcerative colitis. e10-e11 10.1111/jdv.14436 Papakonstantinou E E Department

2017 Journal of the European Academy of Dermatology and Venereology

5. A clinical and serological study of linear IgA bullous dermatosis without linear immunoglobulin deposition other than IgA at the basement membrane zone in direct immunofluorescence. (PubMed)

A clinical and serological study of linear IgA bullous dermatosis without linear immunoglobulin deposition other than IgA at the basement membrane zone in direct immunofluorescence. Linear IgA bullous dermatosis (LABD) is a heterogeneous disease. Different diagnostic criteria have been used in different reports.To reappraise the characteristic features of LABD with only IgA deposition at the basement membrane zone (BMZ) with direct immunofluorescence (DIF).We retrospectively collected data from (...) 101 patients from our archival records from 1 January 1996 to 31 December 2014 who had: (i) blisters on the skin and/or mucous membranes; (ii) subepidermal blisters in a biopsy specimen; and (iii) linear IgA deposition along the BMZ with/without linear C3 deposition at the BMZ with DIF. Most patients were referred for serological evaluation. Patients who showed concurrent linear IgG and/or IgM deposition at the BMZ under DIF were excluded. Clinical manifestations and serological findings were

2016 British Journal of Dermatology

6. C-terminal processing of collagen XVII induces neoepitopes for linear IgA dermatosis autoantibodies. (PubMed)

C-terminal processing of collagen XVII induces neoepitopes for linear IgA dermatosis autoantibodies. Transmembrane collagen XVII (COL17) is a hemidesmosomal component of basal keratinocytes that can be targeted by autoantibodies in autoimmune blistering disorders, including linear IgA dermatosis (LAD). COL17 can be physiologically cleaved within the juxtamembranous extracellular NC16A domain, and LAD autoantibodies preferentially react with the processed ectodomains, indicating

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2017 Journal of Investigative Dermatology

7. Piperacillin-tazobactam-induced linear IgA bullous dermatosis presenting clinically as Stevens-Johnson syndrome/toxic epidermal necrolysis overlap. (PubMed)

Piperacillin-tazobactam-induced linear IgA bullous dermatosis presenting clinically as Stevens-Johnson syndrome/toxic epidermal necrolysis overlap. Linear IgA bullous dermatosis (LABD) is a subepidermal autoimmune bullous disease characterized by linear IgA deposition at the basement membrane zone, which is visualized by direct immunofluorescence. Patients with LABD typically present with widespread vesicles and bullae; however, this is not necessarily the case, as the clinical presentation

2017 Clinical & Experimental Dermatology

8. Linear IgA bullous dermatosis mimicking oral lichen planus (PubMed)

Linear IgA bullous dermatosis mimicking oral lichen planus Linear IgA bullous dermatosis (LABD) is an autoimmune disease characterized by blisters on the skin and mucous membranes. Polycyclic, grouped bullae on cutaneous skin are the most characteristic clinical feature of LABD. Lesions are often indistinguishable from bullous pemphigoid or may resemble dermatitis herpetiformis. Oral lesions may be seen in 5% to 70% of patients with LABD, and in some cases, the oral mucosa may be the only area

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2017 Proceedings (Baylor University. Medical Center)

9. A Case of Linear IgA Bullous Dermatosis Associated with Systemic Lupus Erythematosus (PubMed)

A Case of Linear IgA Bullous Dermatosis Associated with Systemic Lupus Erythematosus 27746656 2018 11 13 1013-9087 28 5 2016 Oct Annals of dermatology Ann Dermatol A Case of Linear IgA Bullous Dermatosis Associated with Systemic Lupus Erythematosus. 660-662 Lee Ho-June HJ Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea. Yun Sook Jung SJ Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea. Lee Seung-Chul SC Department

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2016 Annals of dermatology

10. Idiopathic linear IgA bullous dermatosis: prognostic factors based on a case-series of 72 adults. (PubMed)

Idiopathic linear IgA bullous dermatosis: prognostic factors based on a case-series of 72 adults. Linear IgA bullous dermatosis (LABD) is a clinically and immunologically heterogeneous, subepidermal, autoimmune bullous disease (AIBD), for which the long-term evolution is poorly described.To investigate the clinical and immunological characteristics, follow-up and prognostic factors of adult idiopathic LABD.This retrospective study, conducted in our AIBD referral centre, included adults (...) , diagnosed between 1995 and 2012, with idiopathic LABD, defined as pure or predominant IgA deposits by direct immunofluorescence. Clinical, histological and immunological findings were collected from charts. Standard histology was systematically reviewed, and indirect immunofluorescence (IIF) on salt-split skin (SSS) and immunoblots (IBs) on amniotic membrane extracts using anti-IgA secondary antibodies were performed, when biopsies and sera obtained at diagnosis were available. Prognostic factors

2016 British Journal of Dermatology

11. Linear IgA Dermatosis

Linear IgA Dermatosis Linear IgA Dermatosis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Linear IgA Dermatosis Linear IgA (...) Dermatosis Aka: Linear IgA Dermatosis , Linear IgA Bullous Dermatosis From Related Chapters II. Epidemiology Onset over age 30 years III. Pathophysiology Autoimmune bullous disorder Variant of IV. Symptoms V. Signs s s (may be excoriated and crusted) s e Distribution Symmetric involvement on extensor surfaces s, knees, and buttocks affected Mucusa involvement may occur ( , oral) VI. Labs Histology s Inflammatory infiltrates at basement membrane zone Immunofluorescence IgA deposition along basement

2018 FP Notebook

12. Linear IgA dermatosis after infliximab infusion for ulcerative colitis (PubMed)

Linear IgA dermatosis after infliximab infusion for ulcerative colitis 27981215 2019 02 26 2352-5126 2 6 2016 Nov JAAD case reports JAAD Case Rep Linear IgA dermatosis after infliximab infusion for ulcerative colitis. 448-450 Bryant Kelli D KD Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, Florida. DeNunzio Matthew J MJ Department of Internal Medicine, Florida State University, Tallahassee, Florida. Ford Michael J MJ Florida State University College of Medicine (...) , Tallahassee, Florida. eng Case Reports 2016 12 05 United States JAAD Case Rep 101665210 2352-5126 IBD, inflammatory bowel disease LAD, linear IgA dermatosis TNF, tumor necrosis factor UC, ulcerative colitis autoimmune infliximab linear IgA dermatosis ulcerative colitis 2016 12 17 6 0 2016 12 17 6 0 2016 12 17 6 1 epublish 27981215 10.1016/j.jdcr.2016.09.002 S2352-5126(16)30102-3 PMC5148767 Dermatology. 2015;231(2):112-5 26088700 Dermatology. 2010;221(3):201-5 20720390 RMD Open. 2016 Jul 15;2(2):e000239

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2016 JAAD Case Reports

13. Linear IgA Bullous Dermatosis Associated with Immunoglobulin Light-chain Amyloidosis. (PubMed)

Linear IgA Bullous Dermatosis Associated with Immunoglobulin Light-chain Amyloidosis. 27882389 2017 11 07 2017 11 07 1651-2057 97 4 2017 04 06 Acta dermato-venereologica Acta Derm. Venereol. Linear IgA Bullous Dermatosis Associated with Immunoglobulin Light-chain Amyloidosis. 528-529 10.2340/00015555-2590 Yamaguchi Yasuyuki Y Department of Dermatology, Hokkaido University Graduate School of Medicine, , Japan. Ujiie Hideyuki H Ohigashi Hiroyuki H Iwata Hiroyuki H Muramatsu Ken K Endou Tomoyuki T (...) Teshima Takanori T Shimizu Hiroshi H eng Case Reports Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 0 Autoantibodies 0 Glucocorticoids 0 Immunoglobulin A 0 Immunoglobulin Light Chains 0 Proteasome Inhibitors IM Aged Amyloidosis diagnosis drug therapy immunology Autoantibodies immunology Biopsy Drug Therapy, Combination Fluorescent Antibody Technique Glucocorticoids therapeutic use Humans Immunoglobulin A immunology Immunoglobulin Light Chains immunology Linear IgA Bullous Dermatosis

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2016 Acta Dermato-Venereologica

14. Linear Immunoglobulin A dermatosis mimicking Toxic Epidermal Necrolysis: a case report of etanercept treatment. (PubMed)

literature of successful use of etanercept in these cases, she was treated with a single dose of this antitumour necrosis factor (anti-TNF) agent. Subsequently, the exanthema progression stopped and resolution of the lesions happened in a few days. Later on, histopathology revealed a subepidermal blister with dense neutrophilic infiltrate and linear deposits of immunoglobulin A (IgA) on the dermoepidermal junction, allowing us to establish the diagnosis of drug-induced linear IgA dermatosis mimicking TEN (...) . Linear IgA dermatosis can have severe clinical manifestations, even mimicking TEN, and can have high mortality, especially in drug-induced cases. We have not found any other report of linear IgA dermatosis treated with etanercept in the English literature. Anti-TNF medications could represent useful therapeutic alternatives in this dermatosis.© 2017 British Association of Dermatologists.

2017 British Journal of Dermatology

15. A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis (PubMed)

A Rare Case of Vancomycin-Induced Linear Immunoglobulin A Bullous Dermatosis Linear IgA bullous dermatosis (LABD) is an autoimmune vesiculobullous disease, which is typically idiopathic but can also rarely be caused by medications or infections. Vancomycin is the most common drug associated with LABD. Lesions typically appear 24 hours to 15 days after the first dose of vancomycin. It is best characterized pathologically by subepidermal bulla (blister) formation with linear IgA deposition (...) completely when intravenous vancomycin was discontinued and colchicine treatment was begun. Curiously, complete resolution occurred despite the presence of the vancomycin containing joint spacer. The diagnosis of vancomycin-induced linear IgA bullous dermatosis was made based on characteristic clinical and histopathologic presentations.

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2017 Case reports in dermatological medicine

16. Causative drug detection by drug-induced lymphocyte stimulation test in drug-induced linear IgA bullous dermatosis. (PubMed)

Causative drug detection by drug-induced lymphocyte stimulation test in drug-induced linear IgA bullous dermatosis. 26265104 2017 09 11 2018 12 02 1365-2133 175 5 2016 Nov The British journal of dermatology Br. J. Dermatol. Causative drug detection by drug-induced lymphocyte stimulation test in drug-induced linear IgA bullous dermatosis. 1106-1108 10.1111/bjd.14069 Tomida E E Division of Dermatology, Okazaki City Hospital, Okazaki, Japan. Kato Y Y Division of Dermatology, Okazaki City Hospital (...) -u.ac.jp. eng Case Reports Letter 2016 08 23 England Br J Dermatol 0004041 0007-0963 0 Anti-Bacterial Agents 0 Drug Combinations 7C782967RD Ampicillin 87-53-6 Penicillanic Acid S4TF6I2330 Sulbactam SE10G96M8W Tazobactam X00B0D5O0E Piperacillin IM Aged Ampicillin adverse effects Anti-Bacterial Agents adverse effects Drug Combinations Drug Eruptions diagnosis etiology Female Humans Linear IgA Bullous Dermatosis chemically induced diagnosis Lymphocyte Activation drug effects Penicillanic Acid adverse

2015 British Journal of Dermatology

17. Urticarial linear IgA bullous dermatosis (LABD) as a presenting sign of chronic lymphocytic leukemia (CLL) (PubMed)

Urticarial linear IgA bullous dermatosis (LABD) as a presenting sign of chronic lymphocytic leukemia (CLL) 27051795 2016 04 07 2019 02 26 2352-5126 1 6 2015 Nov JAAD case reports JAAD Case Rep Urticarial linear IgA bullous dermatosis (LABD) as a presenting sign of chronic lymphocytic leukemia (CLL). 412-4 10.1016/j.jdcr.2015.10.001 Tiger Jeffrey B JB Lahey Hospital and Medical Center, Burlington, Massachusetts. Rush Jessica T JT Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire. Barton (...) Dorothea T DT Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire. Danilov Alexey V AV Oregon Health and Science University, Portland, Oregon. Chapman M Shane MS Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire. eng Case Reports 2015 11 24 United States JAAD Case Rep 101665210 2352-5126 atypical presentation chronic lymphocytic leukemia linear IgA bullous dermatosis paraneoplastic dermatosis presenting sign rash skin manifestation of internal disease skin manifestation of internal

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2015 JAAD Case Reports

18. A Case of Neonatal Linear IgA Bullous Dermatosis with Severe Eye Involvement. (PubMed)

A Case of Neonatal Linear IgA Bullous Dermatosis with Severe Eye Involvement. 25708647 2016 08 12 2015 11 04 1651-2057 95 8 2015 Nov Acta dermato-venereologica Acta Derm. Venereol. A case of neonatal linear IgA bullous dermatosis with severe eye involvement. 1015-7 10.2340/00015555-2074 Romani Lorenza L Diociaiuti Andrea A D'Argenio Patrizia P El Hachem May M Gargiullo Livia L Boldrini Renata R De Pità Ornella O Petroni Sergio S Zambruno Giovanna G eng Case Reports Journal Article Research (...) Support, Non-U.S. Gov't Sweden Acta Derm Venereol 0370310 0001-5555 IM Conjunctivitis etiology Corneal Ulcer etiology Humans Infant, Newborn Linear IgA Bullous Dermatosis complications pathology Male Respiratory Sounds etiology 2015 2 25 6 0 2015 2 25 6 0 2016 8 16 6 0 ppublish 25708647 10.2340/00015555-2074

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2015 Acta Dermato-Venereologica

19. Linear IgA dermatosis adult variant with oral manifestation: A rare case report (PubMed)

Linear IgA dermatosis adult variant with oral manifestation: A rare case report Linear immunoglobulin A (IgA) dermatosis (LAD) is a rare autoimmune disorder that presents as a vesiculo-bullous lesion with cutaneous manifestations, but rare oral mucosal involvement. Here we discuss a case of a vesiculobullous lesion with severe oral and ocular mucosal involvement mimicking pemphigoid with histopathological evidence of subepithelial blisters. Direct immunofluorescence (DIF) confirmed the lesion

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2015 Journal of oral and maxillofacial pathology : JOMFP

20. UV-induced linear IgA bullous dermatosis: a case report and literature survey. (PubMed)

UV-induced linear IgA bullous dermatosis: a case report and literature survey. 24888577 2015 08 18 2014 12 19 1365-2133 171 6 2014 Dec The British journal of dermatology Br. J. Dermatol. Ultraviolet-induced linear IgA bullous dermatosis: a case report and literature survey. 1578-81 10.1111/bjd.13154 Wozniak K K Department of Dermatology and Immunodermatology, Medical University of Warsaw, Koszykowa 82a, 02-008, Warsaw, Warszawa, Poland. kwozniak@wum.edu.pl. Kalinska-Bienias A A Hashimoto T T (...) Kowalewski C C eng Case Reports Letter Research Support, Non-U.S. Gov't Review 2014 10 30 England Br J Dermatol 0004041 0007-0963 IM Adult Diagnosis, Differential Female Humans Linear IgA Bullous Dermatosis diagnosis etiology Photosensitivity Disorders diagnosis Sunlight adverse effects Ultraviolet Rays adverse effects 2014 6 4 6 0 2014 6 4 6 0 2015 8 19 6 0 ppublish 24888577 10.1111/bjd.13154

2014 British Journal of Dermatology

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