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41. Pesticide Exposure and Head and Neck Cancers: A Case-Control Study in an Agricultural Region Full Text available with Trip Pro

controlling for age, sex, and smoking. Pesticide exposure was associated with total HNC cases (OR, 7.45; 95% CI, 1.78-3.07) and larynx cancer (OR, 9.33; 95% CI, 1.65-52.68). A dose-response pattern was observed for HNC cases (P=0.06) and larynx cancer (P=0.01). In tracing the pesticide residue, five chlorinated pesticides, namely dichlorodiphenyltrichloroethane (DDT), dichlorodipheny-ldichloroethane (DDD), dichlorodiphenyldichloroethylene (DDE), dieldrin, and lindane, were identified in the adipose tissue

2017 Iranian journal of otorhinolaryngology

42. A prospective study of cancer risk among Agricultural Health Study farm spouses associated with personal use of organochlorine insecticides Full Text available with Trip Pro

and cancer among the female spouses of pesticide applicators in the Agricultural Health Study.At enrollment (1993-1997), spouses of private applicators in the cohort provided information about their own use of pesticides, including seven OCs (aldrin, chlordane, dieldrin, DDT, heptachlor, lindane, and toxaphene), and information on potential confounders. We used Poisson regression to estimate relative risks (RRs) and 95% confidence intervals (CIs) for cancers (n ≥ 3 exposed cases) reported to state cancer (...) registries from enrollment through 2012 (North Carolina) and 2013 (Iowa), and use of the individual OCs, as well as use of any of the specific OCs.Among 28,909 female spouses, 2191 (7.58%) reported ever use of at least one OC, of whom 287 were diagnosed with cancer. Most cancers were not associated with OC use. Risk of glioma was increased among users of at least one OC (Nexposed = 11, RR = 3.52, 95% CI 1.72-7.21) and specifically among lindane users (Nexposed = 3, RR = 4.45, 95% CI 1.36-14.55). Multiple

2017 Environmental Health

43. Presence of pesticide residues on produce cultivated in Suriname Full Text available with Trip Pro

exceeding MRLs in this study regarded cypermethrin (0.32 μg/g) in tomatoes (USA MRL 0.20 μg/g), lambda-cyhalothrin (1.08 μg/g) in Chinese cabbage (USA MRL 0.40 μg/g), endosulfan (0.07 μg/g) in tannia (EU MRL 0.05 μg/g), and lindane (0.02 and 0.03 μg/g, respectively) in tannia (EU MRL 0.01 μg/g). While only a few pesticide residues were detected in this small pilot study, these residues included two widely banned pesticides (endosulfan and lindane). There is a need to address environmental policy gaps

2017 Environmental Monitoring and Assessment

44. Worldwide Regulations of Standard Values of Pesticides for Human Health Risk Control: A Review Full Text available with Trip Pro

pesticide could vary over seven (DDT drinking water MCLs), eight (Lindane soil RGVs), or even nine (Dieldrin soil RGVs) orders of magnitude. Human health risk uncertainty bounds and the implied total exposure mass burden model were applied to analyze the most commonly regulated and used pesticides for human health risk control. For the top 27 commonly regulated pesticides in soil, there are at least 300 RGVs (8% of the total) that are above all of the computed upper bounds for human health risk

2017 International journal of environmental research and public health

45. Scabies

, podpaží aj. Nález u osob s dobrou hygienou však nemusí být takto typický. K léčbě se používají skabicidní přípravky (např. lindan), ev. magistraliter přípravky obsahující mj. síru. (cit. Velký lékařský slovník online, 2013 ) Definition (NCI) A contagious skin infection that is caused by the burrowing parasitic mite, sarcoptes scabiei, and is characterized by intense itching and small, raised red spots in the area of the mite burrows. Definition (MSH) A contagious cutaneous

2018 FP Notebook

46. Ivermectin Lotion 0.5% (Sklice)

accessories. 1 Head lice are uncommon in African-Americans because anatomic differences in American lice do not allow for proper positioning of the female in order to lay eggs on coarse, curly hair. 2,3 Genetic resistance to pyrethroids and to lindane is common in the United States. 4 Available treatments without resistance documented in the United States include malathion 0.5% lotion, benzyl alcohol 5% lotion and Spinosad 0.9% suspension. Malathion is limited to use in children 6 years and older (...) in US but common in United Kingdom Repeat if needed in 7- days > 6 yrs B No teratogenic effects in animal studies Lindane 1% 1% lotion Rx common Do not re- treat Caution 4 yrs B No teratogenic effects in animal studies Reference ID: 3067484Clinical Review {Insert Reviewer Name} {Insert Application Type and Number} {Insert Product Trade and Generic Name} 11 reactions (> 1% and more common than with placebo) are: ocular irritation, applicant site irritation, and application site anesthesia

2011 FDA - Drug Approval Package

47. Briefs: Scabies

is not technically FDA approved – 200 to 250 μ g/kg PO as single dose and repeated in 1 week Crotamiton (Eurax) 10% creams applied from the neck down for 24 hours, rinsed off, then reapplied for an additional 24 hours, and finally washed off. Lindane 1% lotion – Apply to all skin surfaces from the neck down and wash off 6 to 8 hours later. Two applications 1 week apart are sufficient, any more frequently runs the risk of neurotoxicity in patients with a seizure disorder. Following treatment lesions regress in 1

2018 PEM Blog

48. Prioritizing Chemicals for Risk Assessment Using Chemoinformatics: Examples from the IARC Monographs on Pesticides Full Text available with Trip Pro

, and publicly available information concerning cancer epidemiology, cancer bioassays, and carcinogenic mechanisms. For the IARC Monograph meetings that took place in March and June 2015, this approach supported high-priority evaluation of glyphosate, malathion, parathion, tetrachlorvinphos, diazinon, p,p'-dichlorodiphenyltrichloroethane (DDT), lindane, and 2,4-dichlorophenoxyacetic acid (2,4-D).This systematic approach, accounting for chemical similarity and overlaying multiple data sources, can be used

2016 Environmental health perspectives

49. A Recombinant Human Pluripotent Stem Cell Line Stably Expressing Halide-Sensitive YFP-I152L for GABAAR and GlyR-Targeted High-Throughput Drug Screening and Toxicity Testing Full Text available with Trip Pro

maturation. We applied the cell line in concentration-response experiments with the neurotransmitters GABA and glycine as well as with the drugs strychnine, picrotoxin, fipronil, lindane, bicuculline, and zinc and demonstrate that the established in vitro model is applicable to GABAAR and GlyR-targeted pharmacological and toxicological profiling. We quantified the proportion of GABAAR and GlyR-sensitive cells, respectively, and identified percentages of approximately 20% each within the overall

2016 Frontiers in molecular neuroscience

50. Assessment of organochlorine pesticide residues in soils and drinking water sources from cocoa farms in Ghana Full Text available with Trip Pro

Assessment of organochlorine pesticide residues in soils and drinking water sources from cocoa farms in Ghana Residues of organochlorine pesticides were determined in soils and drinking water sources in cocoa growing areas in Ghana. Soil samples analysed showed the presence of four organochlorine pesticide residues namely lindane (0.005-0.05 mg/kg), beta-HCH (<0.01-0.05 mg/kg), dieldrin (0.005-0.02 mg/kg), and p,p'-DDT (0.005-0.04 mg/kg), with dieldrin occurring most frequently. Similarly (...) , organochlorine pesticide residues detected in the water samples were lindane (0.01-0.03 µg/l), alpha-endosulfan (0.01-0.03 µg/l), endosulfan-sulphate (0.01-0.04 µg/l), dieldrin (0.01-0.03 µg/l) and p,p'-DDT (0.01-0.04 µg/l), with heptachlor occurring most frequently. The concentrations of the detected organochlorine residues in the soil samples were below their respective US maximum residues limits (MRLs) for agricultural soils, except for lindane recorded at Kwakuanya (S4) and beta-HCH recorded at Krakrom

2016 SpringerPlus

51. Chemopreventive agents attenuate rapid inhibition of gap junctional intercellular communication induced by environmental toxicants Full Text available with Trip Pro

could be effectively evaluated using in vitro methods. Rat liver epithelial cells WB-F344 were pretreated with a CPA for either 30 min or 24 h, and then exposed to GJIC-inhibiting concentration of a selected tumor promoter or environmental toxicant [12-O-tetradecanoylphorbol-13-acetate (TPA), lindane, fluoranthene, 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT), perfluorooctanoic acid (PFOA), or pentachlorophenol]. Out of nine CPAs tested, quercetin and silibinin elicited the most pronounced

2016 Nutrition and cancer

52. Spontaneous honeybee behaviour is altered by persistent organic pollutants Full Text available with Trip Pro

to either a sublethal concentration of the polychlorinated biphenyl (PCB) mixture Aroclor 1254 (100 ng/ml), the organochlorine insecticide lindane (2.91 ng/ml) or vehicle (0.01% DMSO, 0.00015% ethanol in 1M sucrose) for 1-4 days. The frequency of single event behaviours and the time engaged in one of four behavioural states (walking, flying, upside down and stationary) were monitored for 15 min after 1, 2, 3 and 4 days exposure. Exposure to Aroclor 1254 but not lindane increased the frequency and time (...) engaged in honeybee motor activity behaviours in comparison to vehicle. The Aroclor 1254-induced hyperactivity was evident after 1 day of exposure and persisted with repeated daily exposure. In contrast, 1 day of exposure to lindane elicited abdominal spasms and increased the frequency of grooming behaviours in comparison to vehicle exposure. After 4 days of exposure, abdominal spasms and increased grooming behaviours were also evident in honeybees exposed to Aroclor 1254. These data demonstrate

2016 Ecotoxicology (London, England)

53. Silicone wristbands detect individuals' pesticide exposures in West Africa Full Text available with Trip Pro

of a broad range of agricultural, domestic, legacy and current-use pesticides, including esfenvalerate, cypermethrin, lindane, DDT and chlorpyrifos. Participants reported the use of 13 pesticide active ingredients while wearing wristbands. All six of the pesticides that were both reportedly used and included in the analytical method were detected in at least one wristband. An additional 19 pesticide compounds were detected beyond those that were reported to be in use, highlighting the importance

2016 Royal Society Open Science

54. Hair analysis for the biomonitoring of pesticide exposure: comparison with blood and urine in a rat model Full Text available with Trip Pro

that is averaged over several months; therefore, this method has been proposed as an alternative to solely relying on these fluids. Although the possibility of detecting pesticides in hair has been demonstrated over the past few years, the unknown linkage between exposure and pesticides concentration in hair has limited the recognition of this matrix as a relevant tool for assessing human exposure. Based on a rat model in which there was controlled exposure to a mixture of pesticides composed of lindane, β

2016 Archives of toxicology

55. Bio-equivalence Study Comparing Permethrin Cream, 5% With Elimite in Patients With Active Scabies.

, including permethrin, benzyl alcohol, lindane, crotamiton, malathion, and ivermectin. Use of prohibited medications: Topical or oral scabicidal/antiparasitic treatment including: permethrin, benzyl alcohol, benzyl benzoate, lindane, crotamiton, malathion, ivermectin, precipitated sulfur, albendazole, keratolytic cream, tea tree oil, or oil of the leaves of Lippia multiflora Moldenke within 28 days of visit 2. Systemic corticosteroids (including inhaled steroids) taken within 14 days of visit 2. Topical

2016 Clinical Trials

56. Organochlorine pesticides (OCPs) in wetland soils under different land uses along a 100-year chronosequence of reclamation in a Chinese estuary Full Text available with Trip Pro

reflected the recent use of lindane and aldrin. The presence of dominant DDT isomers (p,p'-DDE and p,p'-DDD) indicated the historical input of DDT and significant aerobic degradation of the compound. Generally, DW soils had a higher ecotoxicological risk of OCPs than RiW and ReW soils, and the top 30 cm soils had higher ecotoxicological risks of HCHs than of DDTs.

2015 Scientific reports

57. Organochlorine pesticides and prostate cancer, Is there an association? A meta-analysis of epidemiological evidence. (Abstract)

exposure 1.30 (0.94-1.67), I (2) = 13.4 %, p = 0.315. A positive but also insignificant association was obtained for pooling results for high exposure to lindane among farmers and pesticide applicators, 1.56 (0.82-2.29), I (2) = 41.7 %, p = 0.180.The existing epidemiological data do not support the hypothesis that exposure to specific OCPs is associated with an increased incidence of PC in the general population.

2015 Cancer causes & control : CCC

58. Comparing the efficacy of oral ivermectin vs malathion 0.5% lotion for the treatment of scabies. (Abstract)

, and the second was treated with two applications of topical lindane lotion 1%, with a 1-week interval between applications. Treatment was evaluated at intervals of 2 and 4 weeks, and if there was treatment failure at the 2-week follow-up, treatment was repeated. A single dose of ivermectin provided a cure rate of 60.8% at the 2-week follow-up, which increased to 89.1% at the 4-week follow-up after repeating the treatment. Treatment with two applications oflindane lotion 1%, with a 1-week interval between (...) them, was effective in 47.2% of patients at the 2-week follow-up, which increased to 72.9% at the 4-week follow-up after this treatment was repeated. A single dose of ivermectin was as effective as two applications of lindane lotion 1% at the 2-week follow-up. After repeat treatment, ivermectin was superior to lindane lotion 1% at the 4-week follow-up. The delay in clinical response with ivermectin suggests that it may not be effective against the parasite at all stages in the life cycle.

2015 Skinmed Controlled trial quality: uncertain

59. Treatment of Pediculosis Capitis Full Text available with Trip Pro

Treatment of Pediculosis Capitis An endeavour to delineate the salient details of the treatment of head lice infestation has been made in the present article. Treatment modalities including over the counter permethrin and pyrethrin, and prescription medicines, including malathion, lindane, benzyl alcohol, spinosad are discussed. Salient features of alternative medicine and physical treatment modalities are outlined. The problem of resistance to treatment has also been taken cognizance of.

2015 Indian journal of dermatology

60. Phosphatidylcholine Specific PLC-Induced Dysregulation of Gap Junctions, a Robust Cellular Response to Environmental Toxicants, and Prevention by Resveratrol in a Rat Liver Cell Model Full Text available with Trip Pro

signaling pathways, using a pluripotent rat liver epithelial oval-cell line, WB-F344. Epidermal growth factor, 12-O-tetradecanoylphorbol-13-acetate, thrombin receptor activating peptide-6 and lindane regulated GJIC through a MEK1/2-dependent mechanism that was independent of PC-PLC; whereas PAHs, DDT, PCB 153, dicumylperoxide and perfluorodecanoic acid inhibited GJIC through PC-PLC independent of Mek. Dysregulation of GJIC by perfluorooctanoic acid and R59022 required both MEK1/2 and PC-PLC; while

2015 PloS one

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