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21. Acute lindane poisoning with development of muscle necrosis. Full Text available with Trip Pro

Acute lindane poisoning with development of muscle necrosis. A 35-year-old man ingested food contaminated with lindane, an insecticide containing almost pure gamma hexachlorocyclohexane. Grand mal seizures and severe acidemia developed rapidly. The seizures recurred for nearly 2 hours, then ceased. In addition, the patient had muscle weakness and pain, headaches, episodic hypertension, myoglobinuria, acute renal failure and anemia. Pancreatitis developed 13 days after the ingestion of lindane (...) . A muscle biopsy on the 15th day of illness demonstrated widespread necrosis and regeneration of muscle fibres. The patient's condition improved and he was discharged 24 days after the onset of his illness. During the year following the poisoning the patient noted difficulty with recent memory, loss of libido and easy fatigability. One year after lindane ingestion the results of physical examination, including those for muscle power and bulk, were normal.

1977 Canadian Medical Association Journal

22. Gamma-BHC/Cereclor—a new, long-acting lindane formulation for malaria control Full Text available with Trip Pro

Gamma-BHC/Cereclor—a new, long-acting lindane formulation for malaria control Sorption of insecticides by muds and other materials used in the construction of native huts prolongs their duration of action or persistence. The use of gamma-BHC as a residual insecticide has been limited by the fact that its sorption by most materials is of a low order, so that it is comparatively short acting. If gamma-BHC is melted with a resin, the solid solution can be converted into a water-dispersible

1960 Bulletin of the World Health Organization

23. Lindane Full Text available with Trip Pro

Lindane Lindane - Wikipedia Lindane From Wikipedia, the free encyclopedia Lindane Clinical data / C Topical ( ) ( ) ( ) Legal status Production and agricultural use is banned in the 182 countries that are Parties to the , but pharmaceutical use is allowed as a second-line treatment for scabies and lice data 91% Hepatic cytochrome P-450 oxygenase system 18 hours Identifiers (1 r ,2 R ,3 S ,4 r ,5 R ,6 S )-1,2,3,4,5,6-hexachlorocyclohexane Y Y Y Y Y Y Chemical and physical data C 6 H 6 Cl 6 (...) 290.83 g/mol g·mol −1 3D model ( ) Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4+,5+,6+ Y Key:JLYXXMFPNIAWKQ-GNIYUCBRSA-N Y Lindane , also known as gamma -hexachlorocyclohexane ( γ-HCH ), gammaxene , Gammallin and sometimes incorrectly called ( BHC ), is an chemical and an isomer of that has been used both as an agricultural and as a treatment for and . Lindane is a that interferes with function by interacting

2012 Wikipedia

24. Ivermectin for Parasitic Skin Infections of Scabies: A Review of Comparative Clinical Effectiveness, Cost-Effectiveness, and Guidelines

, and lindane according to one systematic review and more effective than sulphur 10% ointment according to one randomized controlled trial of limited quality. Oral ivermectin may be associated with fewer patients with adverse events than sulfur and more patients with adverse events than synthetic pyrethrins.Topical ivermectin may be more effective than or no different from other scabicides. There was no difference found in clinical effectiveness between topical ivermectin and permethrin in the systematic (...) reviews. According to one systematic review, topical ivermectin may be more effective in treating scabies compared with malathion, lindane, crotamiton, and benzyl benzoate, as well as sulfur at one to two weeks after treatment initiation. Topical permethrin was associated with higher percentages of patients with adverse events compared with synthetic pyrethrins and malathion and lower percentages compared with sulfur.While findings of clinical effectiveness of oral and topical ivermectin were largely

2019 Canadian Agency for Drugs and Technologies in Health - Rapid Review

25. What is the most effective treatment for scabies?

answer: Topical permethrin is the most effective treatment for classic scabies (strength of recommendation [SOR]: A, meta-analyses with consistent results). Topical lindane and crotamiton are inferior to permethrin but appear equivalent to each other and benzyl benzoate, sulfur, and natural synergized pyrethrins (SOR: B, limited randomized trials). Although not as effective as topical permethrin, oral ivermectin is an effective treatment compared with placebo (SOR: B,a single small randomized trial

2018 Clinical Inquiries

28. CRACKCast E163 – Pesticides

that refers to all pest-killing agents, and so it includes insecticides, herbicides, rodenticides, and fungicides. Here are some of the classes and examples Refer to Table 157.1 in Rosen’s 9 th edition for a list of pesticide classes and examples Pesticide Class Example(s) Organophosphates Parathion, malathion Carbamates Aldicarb, carbaryl Chlorinated hydrocarbons DDT, lindane Substituted phenols 2,4-dintriphenol (DNP) Chlorophenoxy pesticides 2,4,5-T, 2,4-D Bypyridyl pesticides Paraquat, diquat (...) . If Benzos are ineffective switch to barbituates, for example This storage allows for toxicity from repeated, low-level exposure . Lindane toxicity often occurs from excessive external (dermal) exposure or accidental oral exposure. Chlorinated hydrocarbon insecticides affect neuronal voltage gated sodium channels. They are also gamma-aminobutyric acid (GABA) antagonists. This results in hyperexcitability and irritability of both central and peripheral neurons . Chlorinated hydrocarbons also increase

2018 CandiEM

29. Scabies

; grade A recommendation} [28]. -Sulfur 6-33% as cream, ointment or lotion is the oldest antiscabietic in use [38]. It is effective and requires application on three successive days {level of evidence Ib; grade A recommendation} [1], [38], [39]. -Synergized pyrethrins are available as a foam preparation in some countries and are as effective as permethrin cream 5% {level of evidence IIa; grade B recommendation} [1], [40]. -Lindane is no longer recommended because of its potential to cause (...) Surg], 2013; Vol. 17 (5), 299-300. [28] Chhaiya SB, Patel VJ, Dave JN, Mehta DS, Shah HA. Comparative efficacy and safety of topical permethrin, topical ivermectin, and oral ivermectin in patients of uncomplicated scabies. Indian Journal Of Dermatology, Venereology And Leprology [Indian J Dermatol Venereol Leprol], 2012; Vol. 78 (5), 605-10. [29] Mohebbipour A, Saleh P, Goldust M, Amirnia M, Zadeh YJ, Mohamadi RM, Rezaee E. Treatment of scabies: comparison of ivermectin vs. lindane lotion 1%. Acta

2017 European Dermatology Forum

30. CRACKCast E098 – Sexually Transmitted Infections

– topical permethrin 5% cream applied topically and washed off after 8-14 hours. Alternative agents include topical benzyl benzoate, topical lindane, or oral ivermectin. *Potentially affected clothing and linen should be washed in hot water with detergent. Wisecracks Question 1) What is a Jarisch-Herxheimer reaction? Acute worsening of symptoms that may develop after initiation of antimicrobial therapy for syphilis. Typically increased malaise, myalgias, and fever within 24 hours of treatment. Thought

2017 CandiEM

31. Difficult-to-treat scabies: oral ivermectin

ivermectin with benzyl benzoate, and one of these plus another trial compared oral ivermectin with permethrin. Two trials compared oral ivermectin with lindane but because this was withdrawn from the UK market in 1996, these trials are not discussed further. Macotela-Ruíz and Peña-González (1993) compared a single dose of 200 micrograms/kg body weight oral ivermectin with placebo in 55 participants aged over 5 years. There were fewer treatment failures in clinically diagnosed cases in the ivermectin

2014 National Institute for Health and Clinical Excellence - Advice

32. Pubic lice

and Prevention [ ] state that pediculosis of the eyelashes should be treated by applying occlusive ophthalmic ointment or petroleum jelly to the eyelid margins twice a day for 10 days and should not be treated with permethrin, pyrethrin or lindane. Paraffin eye ointment is effective by suffocating adult lice and nymphs (immature lice) [ ; ]. An inert ophthalmic ointment with a white or yellow soft paraffin base provides a suitable consistency to produce this effect. Inert ophthalmic ointments are preferred

2018 NICE Clinical Knowledge Summaries

33. Efficacy and safety of antiscabietic agents: A systematic review and network meta-analysis of randomized controlled trials. Full Text available with Trip Pro

). Their probability of having highest efficacy and safety was estimated and ranked.Network meta-analysis based on 52 trials in 9917 patients indicated that permethrin (the reference treatment) had significantly higher cure rate than sulfur, malathion, lindane, crotamiton, and benzyl benzoate. Permethrin+oral ivermectin combination had non-significantly higher cure rate than permethrin. Permethrin+oral ivermectin combination, topical ivermectin, and synergized pyrethrins were the treatment ranked highest in terms

2019 Journal of American Academy of Dermatology

34. Preventing Pressure Ulcers: A Multi-site RCT in Nursing Homes

, these findings will likely influence: (1) public policy and regulations regarding the frequency of turning for preventing PrUs; (2) reallocation of staff time spent repositioning every two hours to activities that improve resident quality of life such as increased assistance at mealtime, mobilization, toileting, and social engagement. 11 | P a g e References 1. Kosiak M. Etiology of decubitus ulcers. Archives of Physical Medicine and Rehabilitation. 1961;42:19-29. 2. Lindan O. Etiology of decubitus ulcers

2012 Health Quality Ontario

35. Kinetically-Controlled Growth of Chestnut-Like Au Nanocrystals with High-Density Tips and Their High SERS Performances on Organochlorine Pesticides Full Text available with Trip Pro

and were 30⁻50 nm in length. There were about 120⁻150 tips in each nanocrystal. The formation of chestnut-like Au nanocrystals is ascribed to surfactant-induced preferential growth of seeds along direction [111]. Importantly, the chestnut-like Au configuration displayed powerful surface enhanced Raman scattering (SERS) performance (enhance factor > 10⁷), owing to the high density of tips. Further, such film was used as a SERS substrate for the detection of lindane (γ-666) molecules (the typical

2018 Nanomaterials

36. Autonomic Dysreflexia and Boosting: Non-pharmacological doping in disability sport

Neurology 2015; 30(2): 91-98 Guttmann and Whiteridge. Effects of bladder distension and autonomic mechanisms after spinal cord injuries. Brain 1947; 70(4): 361-404 Krassioukov A. Autonomic dysreflexia: current evidence related to unstable arterial blood pressure control among athletes with spinal cord injury. Clin J Sport Med 2012; 22: 39-45 Legg D, Mason DS. Autonomic dysreflexia in wheelchair sport: a new game in the legal arena? Marquette Sports Law Review 1998; 8: 225-237 Lindan R, Joiner E

2018 British Journal of Sports Medicine Blog

38. Clinical Inquiry: What is the most effective treatment for scabies? (Abstract)

Clinical Inquiry: What is the most effective treatment for scabies? Topical permethrin is the most effective treatment for classic scabies (strength of recommendation [SOR]: A, meta-analyses with consistent results). Topical lindane and crotamiton are inferior to permethrin but appear equivalent to each other and benzyl benzoate, sulfur, and natural synergized pyrethrins (SOR: B, limited randomized trials). Although not as effective as topical permethrin, oral ivermectin is an effective

2017 Journal of Family Practice

39. Residues of organochlorine pesticides in surface soil and raw foods from rural areas of the Republic of Tajikistan Full Text available with Trip Pro

pesticides, including dairy products, meat, edible plant and cotton seed products. The pesticide analytes included DDTs (DDT, DDD, DDE), lindane isomers (α, β, γ, δ BHC), endosulfan isomers (endosulfan I, II, sulfate), other cyclodienes (aldrin, α and γ chlordanes, dieldrin, endrin, endrin aldehyde and ketone, heptachlor, heptachlor epoxide), and methoxychlor. Pesticide analytes were selected based on availability of commercial standards and known or suspected historical pesticide use and burial

2017 Environmental pollution (Barking, Essex : 1987)

40. Organochlorine compounds in the adipose tissue of urban and rural women who gave birth by cesarean delivery in northern Turkey Full Text available with Trip Pro

-hexachlorocyclohexane (HCH), β-HCH (lindane), γ-HCH, hexachlorobenzene (HCB), aldrin, and dichlorodiphenyltrichloroethane (DDT) and its metabolites, 2,4'-dichlorodiphenyldichloroethylene (DDE), 4,4'-DDE, 2,4'-DDT, 4,4'-DDT, and 16 PCBs, PCB-28, -52, -70, -74, -81, -99, -101, -118, -138, -153, -156, -170, -180, -183, -187 and -208, were investigated with a gas chromatograph equipped with an electron capture detector (GC-ECD). β-HCH was detected in nine samples (mean 23.70 ± 4.24 ng g-1 of fat) and γ-HCH was detected

2017 Toxicology research

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