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Does lindane (gamma-hexachlorocyclohexane) increase the rapid delayed rectifier outward K+ current (IKr) in frog atrial myocytes? The effects of lindane, a gamma-isomer of hexachlorocyclohexane, were studied on transmembrane potentials and currents of frog atrial heart muscle using intracellular microelectrodes and the whole cell voltage-clamp technique.Lindane (0.34 microM to 6.8 microM) dose-dependently shortened the action potential duration (APD). Under voltage-clamp conditions, lindane (...) (1.7 microM) increased the amplitude of the outward current (Iout) which developed in Ringer solution containing TTX (0.6 microM), Cd2+ (1 mM) and TEA (10 mM). The lindane-increased Iout was not sensitive to Sr2+ (5 mM). It was blocked by subsequent addition of quinidine (0.5 mM) or E-4031 (1 microM). E-4031 lengthened the APD; it prevented or blocked the lindane-induced APD shortening.In conclusion, our data revealed that lindane increased the quinidine and E-4031-sensitive rapid delayed outward K
Equivalent therapeutic efficacy and safety of ivermectin and lindane in the treatment of human scabies. To compare the therapeutic efficacy and safety of ivermectin and lindane for the treatment of human scabies.Randomized, prospective, controlled, double-blind, "double-dummy," and parallel clinical study.A single department of dermatology at a hospital in Buenos Aires, Argentina.Patients were outpatients, hospitalized patients, and those referred to our hospital from nursing homes and asylums (...) . Fifty-three patients had clinical signs and symptoms compatible with scabies.Patients received either a single oral dose of ivermectin (150-200 microg/kg of body weight) or a topical application of 1% lindane solution. Treatment was repeated after 15 days if clinical cure had not occurred.Clinical healing and adverse effects.Of 53 patients, 43 (81%) completed the study, 19 in the group treated with ivermectin and 24 in the group treated with lindane. At day 15, 14 patients (74%; 95% confidence
Oral ivermectin in scabies patients: a comparison with 1% topical lindane lotion. Scabies. which constitutes a significant proportion of the outpatient attendance in tropical dermatology clinics, has so far been treated with lindane, crotamiton, sulphur, permethrin, etc. Ivermectin, an orally administered drug, was tried in scabies patients and compared with 1% topical lindane lotion to evaluate its effects and toxicity profile. Two hundred scabies patients were randomly allocated to one of two (...) groups. One group received oral invermectin in a single dose of 200 micrograms/kg body weight. The other received 1% lindane lotion for topical application overnight. Patients were assessed after 48 hours, two weeks and four weeks. After a period of four weeks, 82.6% of the patients in the ivermectin group showed marked improvement; only 44.44% of the patients in the lindance group showed a similar response. A side effects in the form of severe headache were noted in one patient in group A. Oral
Comparative study of 5% permethrin cream and 1% lindane lotion for the treatment of scabies. A multicenter, randomized, investigator-blind controlled trial was conducted to compare the safety and efficacy of a single, whole-body application of 5% permethrin cream with that of 1% lindane lotion for the treatment of scabies in 467 patients. At 14 +/- 3 days after treatment, the mean active lesion count decreased from pretreatment levels of 85 (range, 4 to 600) in both treatment groups to 14 (...) (range, 0 to 133) in the permethrin group and to 15 lesions (range, 0 to 500) in the lindane group. At 28 +/- 7 days after treatment, complete resolution had occurred in 181 (91%) of 199 patients treated with permethrin and in 176 (86%) of 205 patients given lindane. Pruritus due to scabies persisted at 28 +/- 7 days in 14% of the permethrin group and in 25% of the lindane group. The most frequent adverse effects were new or increased pruritus and mild, transient burning or stinging; the latter
1% permethrin cream rinse vs 1% lindane shampoo in treating pediculosis capitis. The therapeutic efficacy and tolerance of a single application of 1% permethrin cream rinse, applied for ten minutes, and a single application of 1% lindane shampoo applied, as recommended by the manufacturer, for four minutes, against the head louse Pediculus humanus var capitis were compared in a single-blinded, randomized, controlled clinical trial. Of 573 patients enrolled at eight centers, 559 were assessable (...) for tolerance and 508 for efficacy. Of the 257 patients treated with 1% permethrin cream rinse, 99% were lice free at 14 days; of the 251 patients treated with 1% lindane shampoo, 85% were lice free at 14 days. The difference is statistically significant. For both treatments, adverse experiences were infrequent, mild, and usually difficult to distinguish from the symptoms of head lice infestation. A single ten-minute application of 1% permethrin cream rinse was well tolerated, highly effective
Comparative study of permethrin 1% creme rinse and lindane shampoo for the treatment of head lice. The efficacy and safety of permethrin 1% creme rinse and lindane shampoo were compared for the treatment of head lice (Pediculus humanus var. capitis). A total of 1040 patients in the Nezahualcoyotl community of Mexico City representing 296 family groups were enrolled and randomized to treatment, with one patient in each family designated as the index patient. Among index patients 98% treated (...) with permethrin and 76% treated with lindane were louse-free 2 weeks after treatment (P less than 0.001). Comparable results were found with nonindex patients as well. Mild dermal reactions, such as pruritus or erythema, occurred in 1.2% of permethrin-treated patients and 2.6% of lindane-treated patients. There were no reports of central nervous system adverse effects or conjunctivitis.
Treatment of pediculosis pubis. Clinical comparison of efficacy and tolerance of 1% lindane shampoo vs 1% permethrin creme rinse. Pediculosis pubis (PP) is a common sexually transmitted disease. Current therapy with 1% lindane or various synergized pyrethrins as a single dose has been accepted as adequate by the medical community. We treated 53 men with the diagnosis of PP with either 1% lindane (Kwell) shampoo for four minutes or 1% permethrin (Nix) creme rinse for ten minutes, according (...) to random assignment. All patients combed with fine-toothed combs immediately after therapy. They were examined for tolerance and efficacy at 24 to 48 hours and again at ten days (eight- to 12-day range). In the lindane group, ten (40%) of 25 subjects were infested at the final assessment. In the permethrin group, 12 (43%) of 28 subjects were infested at the final assessment. The difference was not statistically significant. Both treatments were well tolerated, with one mild adverse reaction in each
Partition of the organochlorine insecticide lindane into the human sperm surface induces membrane depolarization and Ca2+ influx. The effects of the insecticide lindane (the gamma-isomer of 1,2,3,4,5,6-hexachlorocyclohexane) on membrane potential, cytosolic free Ca2+ concentration ([Ca2+]i) and surface biophysical properties were studied in human spermatozoa. The insecticide induces rapid, transient and reproducible membrane depolarization and opening of voltage-dependent Ca2+ channels leading (...) to an increase in [Ca2+]i. In contrast with the effect in somatic cells, lindane did not affect gamma-aminobutyric acid receptor-linked Cl- currents. Ca2+ and K+ currents were found to drive lindane-induced membrane depolarization and repolarization respectively, whereas Na+ and Cl- fluxes appear not to have a role in the phenomenon. The insecticide was still able to produce membrane depolarization both in the combined absence of extracellular Ca2+ and Na+ and in high-K+ buffer, suggesting that lindane
Lindane Toxicity in Pigeons A flock of Birmingham Rolles pigeons were fed a commercial whole grain pigeon feed contaminated with 2 100 ppm lindane. Soon after ingestion of the feed, symptoms including diarrhea, vomition, anorexia, depression and sudden death, consistent with a feed related organochlorine toxicity were seen. The rapeseed component of the pigeon feed contained seed which had been treated with a lindane seed dressing. Chemical analysis, history and clinical findings support (...) a diagnosis of acute lindane toxicosis which caused sudden death in 47% of the pigeon flock.
Acute intoxication with lindane. 6179590 1982 10 29 2018 11 30 0008-4409 127 5 1982 Sep 01 Canadian Medical Association journal Can Med Assoc J Acute intoxication with lindane. 360 Bargman H H eng Letter Canada Can Med Assoc J 0414110 0008-4409 59NEE7PCAB Hexachlorocyclohexane AIM IM Absorption Acute Disease Child, Preschool Hexachlorocyclohexane metabolism poisoning Humans Infant 1982 9 1 1982 9 1 0 1 1982 9 1 0 0 ppublish 6179590 PMC1861993 Can Med Assoc J. 1982 Mar 15;126(6):662-3 6175390
Acute intoxication with lindane. 6182969 1983 01 07 2018 11 30 0008-4409 127 9 1982 Nov 01 Canadian Medical Association journal Can Med Assoc J Acute intoxication with lindane. 821 Telch J J Jarvis D A DA eng Letter Canada Can Med Assoc J 0414110 0008-4409 59NEE7PCAB Hexachlorocyclohexane AIM IM Adult Child Female Hexachlorocyclohexane poisoning Humans Infant Pregnancy Scabies drug therapy Skin Absorption Time Factors 1982 11 1 1982 11 1 0 1 1982 11 1 0 0 ppublish 6182969 PMC1862219 J Pediatr
Acute intoxication with lindane (gamma benzene hexachloride). 6175390 1982 06 24 2018 11 30 0008-4409 126 6 1982 Mar 15 Canadian Medical Association journal Can Med Assoc J Acute intoxication with lindane (gamma benzene hexachloride). 662-3 Telch J J Jarvis D A DA eng Case Reports Journal Article Canada Can Med Assoc J 0414110 0008-4409 59NEE7PCAB Hexachlorocyclohexane AIM IM Hexachlorocyclohexane poisoning Humans Infant Male Scabies drug therapy Seizures chemically induced 1982 3 15 1982 3 15
Plasma gamma-hexachlorocyclohexane concentrations in forestry workers exposed to lindane. Plasma gamma-hexachlorocyclohexane (gamma-HCH) and three urinary trichlorophenols were measured in forestry workers who were engaged in planting seedlings treated with gamma-HCH. These two procedures were assessed as potential biological monitoring methods and the data were compared with reported clinical symptoms. The measurement of plasma gamma-HCH was considered to be a feasible and valid monitoring
Alberta. Lindane toxicity in beef cattle 17423448 2010 06 28 2018 11 13 0008-5286 30 10 1989 Oct The Canadian veterinary journal = La revue veterinaire canadienne Can. Vet. J. Alberta. Lindane toxicity in beef cattle. 833 Wood J J Chalmers G G Fenton R R Pritchard J J Schoonderwoerd M M eng Journal Article Canada Can Vet J 0004653 0008-5286 1989 10 1 0 0 1989 10 1 0 1 1989 10 1 0 0 ppublish 17423448 PMC1681291 Can Vet J. 1988 May;29(5):458-9 17423050 Vet Hum Toxicol. 1988 Apr;30(2):118-20