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Lindane

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221. Comparative study of 5% permethrin cream and 1% lindane lotion for the treatment of scabies. (PubMed)

Comparative study of 5% permethrin cream and 1% lindane lotion for the treatment of scabies. A multicenter, randomized, investigator-blind controlled trial was conducted to compare the safety and efficacy of a single, whole-body application of 5% permethrin cream with that of 1% lindane lotion for the treatment of scabies in 467 patients. At 14 +/- 3 days after treatment, the mean active lesion count decreased from pretreatment levels of 85 (range, 4 to 600) in both treatment groups to 14 (...) (range, 0 to 133) in the permethrin group and to 15 lesions (range, 0 to 500) in the lindane group. At 28 +/- 7 days after treatment, complete resolution had occurred in 181 (91%) of 199 patients treated with permethrin and in 176 (86%) of 205 patients given lindane. Pruritus due to scabies persisted at 28 +/- 7 days in 14% of the permethrin group and in 25% of the lindane group. The most frequent adverse effects were new or increased pruritus and mild, transient burning or stinging; the latter

1990 Archives of Dermatology Controlled trial quality: uncertain

222. Equivalent therapeutic efficacy and safety of ivermectin and lindane in the treatment of human scabies. (PubMed)

Equivalent therapeutic efficacy and safety of ivermectin and lindane in the treatment of human scabies. To compare the therapeutic efficacy and safety of ivermectin and lindane for the treatment of human scabies.Randomized, prospective, controlled, double-blind, "double-dummy," and parallel clinical study.A single department of dermatology at a hospital in Buenos Aires, Argentina.Patients were outpatients, hospitalized patients, and those referred to our hospital from nursing homes and asylums (...) . Fifty-three patients had clinical signs and symptoms compatible with scabies.Patients received either a single oral dose of ivermectin (150-200 microg/kg of body weight) or a topical application of 1% lindane solution. Treatment was repeated after 15 days if clinical cure had not occurred.Clinical healing and adverse effects.Of 53 patients, 43 (81%) completed the study, 19 in the group treated with ivermectin and 24 in the group treated with lindane. At day 15, 14 patients (74%; 95% confidence

1999 Archives of Dermatology Controlled trial quality: predicted high

223. Oral ivermectin in scabies patients: a comparison with 1% topical lindane lotion. (PubMed)

Oral ivermectin in scabies patients: a comparison with 1% topical lindane lotion. Scabies. which constitutes a significant proportion of the outpatient attendance in tropical dermatology clinics, has so far been treated with lindane, crotamiton, sulphur, permethrin, etc. Ivermectin, an orally administered drug, was tried in scabies patients and compared with 1% topical lindane lotion to evaluate its effects and toxicity profile. Two hundred scabies patients were randomly allocated to one of two (...) groups. One group received oral invermectin in a single dose of 200 micrograms/kg body weight. The other received 1% lindane lotion for topical application overnight. Patients were assessed after 48 hours, two weeks and four weeks. After a period of four weeks, 82.6% of the patients in the ivermectin group showed marked improvement; only 44.44% of the patients in the lindance group showed a similar response. A side effects in the form of severe headache were noted in one patient in group A. Oral

2001 The Journal of dermatology Controlled trial quality: uncertain

224. Partition of the organochlorine insecticide lindane into the human sperm surface induces membrane depolarization and Ca2+ influx. (PubMed)

Partition of the organochlorine insecticide lindane into the human sperm surface induces membrane depolarization and Ca2+ influx. The effects of the insecticide lindane (the gamma-isomer of 1,2,3,4,5,6-hexachlorocyclohexane) on membrane potential, cytosolic free Ca2+ concentration ([Ca2+]i) and surface biophysical properties were studied in human spermatozoa. The insecticide induces rapid, transient and reproducible membrane depolarization and opening of voltage-dependent Ca2+ channels leading (...) to an increase in [Ca2+]i. In contrast with the effect in somatic cells, lindane did not affect gamma-aminobutyric acid receptor-linked Cl- currents. Ca2+ and K+ currents were found to drive lindane-induced membrane depolarization and repolarization respectively, whereas Na+ and Cl- fluxes appear not to have a role in the phenomenon. The insecticide was still able to produce membrane depolarization both in the combined absence of extracellular Ca2+ and Na+ and in high-K+ buffer, suggesting that lindane

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1997 Biochemical Journal

225. Does lindane (gamma-hexachlorocyclohexane) increase the rapid delayed rectifier outward K+ current (IKr) in frog atrial myocytes? (PubMed)

Does lindane (gamma-hexachlorocyclohexane) increase the rapid delayed rectifier outward K+ current (IKr) in frog atrial myocytes? The effects of lindane, a gamma-isomer of hexachlorocyclohexane, were studied on transmembrane potentials and currents of frog atrial heart muscle using intracellular microelectrodes and the whole cell voltage-clamp technique.Lindane (0.34 microM to 6.8 microM) dose-dependently shortened the action potential duration (APD). Under voltage-clamp conditions, lindane (...) (1.7 microM) increased the amplitude of the outward current (Iout) which developed in Ringer solution containing TTX (0.6 microM), Cd2+ (1 mM) and TEA (10 mM). The lindane-increased Iout was not sensitive to Sr2+ (5 mM). It was blocked by subsequent addition of quinidine (0.5 mM) or E-4031 (1 microM). E-4031 lengthened the APD; it prevented or blocked the lindane-induced APD shortening.In conclusion, our data revealed that lindane increased the quinidine and E-4031-sensitive rapid delayed outward K

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2002 BMC pharmacology

226. Acute intoxication with lindane. (PubMed)

Acute intoxication with lindane. 6179590 1982 10 29 2018 11 30 0008-4409 127 5 1982 Sep 01 Canadian Medical Association journal Can Med Assoc J Acute intoxication with lindane. 360 Bargman H H eng Letter Canada Can Med Assoc J 0414110 0008-4409 59NEE7PCAB Hexachlorocyclohexane AIM IM Absorption Acute Disease Child, Preschool Hexachlorocyclohexane metabolism poisoning Humans Infant 1982 9 1 1982 9 1 0 1 1982 9 1 0 0 ppublish 6179590 PMC1861993 Can Med Assoc J. 1982 Mar 15;126(6):662-3 6175390

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1982 Canadian Medical Association Journal

227. Lindane Toxicity in Pigeons (PubMed)

Lindane Toxicity in Pigeons A flock of Birmingham Rolles pigeons were fed a commercial whole grain pigeon feed contaminated with 2 100 ppm lindane. Soon after ingestion of the feed, symptoms including diarrhea, vomition, anorexia, depression and sudden death, consistent with a feed related organochlorine toxicity were seen. The rapeseed component of the pigeon feed contained seed which had been treated with a lindane seed dressing. Chemical analysis, history and clinical findings support (...) a diagnosis of acute lindane toxicosis which caused sudden death in 47% of the pigeon flock.

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1982 The Canadian Veterinary Journal

228. Acute intoxication with lindane. (PubMed)

Acute intoxication with lindane. 6182969 1983 01 07 2018 11 30 0008-4409 127 9 1982 Nov 01 Canadian Medical Association journal Can Med Assoc J Acute intoxication with lindane. 821 Telch J J Jarvis D A DA eng Letter Canada Can Med Assoc J 0414110 0008-4409 59NEE7PCAB Hexachlorocyclohexane AIM IM Adult Child Female Hexachlorocyclohexane poisoning Humans Infant Pregnancy Scabies drug therapy Skin Absorption Time Factors 1982 11 1 1982 11 1 0 1 1982 11 1 0 0 ppublish 6182969 PMC1862219 J Pediatr

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1982 Canadian Medical Association Journal

229. Acute intoxication with lindane (gamma benzene hexachloride). (PubMed)

Acute intoxication with lindane (gamma benzene hexachloride). 6175390 1982 06 24 2018 11 30 0008-4409 126 6 1982 Mar 15 Canadian Medical Association journal Can Med Assoc J Acute intoxication with lindane (gamma benzene hexachloride). 662-3 Telch J J Jarvis D A DA eng Case Reports Journal Article Canada Can Med Assoc J 0414110 0008-4409 59NEE7PCAB Hexachlorocyclohexane AIM IM Hexachlorocyclohexane poisoning Humans Infant Male Scabies drug therapy Seizures chemically induced 1982 3 15 1982 3 15

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1982 Canadian Medical Association Journal

230. Plasma gamma-hexachlorocyclohexane concentrations in forestry workers exposed to lindane. (PubMed)

Plasma gamma-hexachlorocyclohexane concentrations in forestry workers exposed to lindane. Plasma gamma-hexachlorocyclohexane (gamma-HCH) and three urinary trichlorophenols were measured in forestry workers who were engaged in planting seedlings treated with gamma-HCH. These two procedures were assessed as potential biological monitoring methods and the data were compared with reported clinical symptoms. The measurement of plasma gamma-HCH was considered to be a feasible and valid monitoring

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1988 British Journal of Industrial Medicine

231. Alberta. Lindane toxicity in beef cattle (PubMed)

Alberta. Lindane toxicity in beef cattle 17423448 2010 06 28 2018 11 13 0008-5286 30 10 1989 Oct The Canadian veterinary journal = La revue veterinaire canadienne Can. Vet. J. Alberta. Lindane toxicity in beef cattle. 833 Wood J J Chalmers G G Fenton R R Pritchard J J Schoonderwoerd M M eng Journal Article Canada Can Vet J 0004653 0008-5286 1989 10 1 0 0 1989 10 1 0 1 1989 10 1 0 0 ppublish 17423448 PMC1681291 Can Vet J. 1988 May;29(5):458-9 17423050 Vet Hum Toxicol. 1988 Apr;30(2):118-20

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1989 The Canadian Veterinary Journal

232. The hatching of nits as a predictor of treatment failure with lindane and pyrethrin shampoos. (PubMed)

The hatching of nits as a predictor of treatment failure with lindane and pyrethrin shampoos. 1694468 1990 08 06 2018 11 30 0008-4263 81 3 1990 May-Jun Canadian journal of public health = Revue canadienne de sante publique Can J Public Health The hatching of nits as a predictor of treatment failure with lindane and pyrethrin shampoos. 237-9 Mathias R G RG Department of Health Care & Epidemiology, Faculty of Medicine, University of British Columbia, Vancouver. Wallace J F JF eng Clinical Trial

1990 Canadian journal of public health = Revue canadienne de sante publique Controlled trial quality: uncertain

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