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Lindane

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201. Is the treatment of scabies hazardous? Full Text available with Trip Pro

Is the treatment of scabies hazardous? Treatment for scabies is usually initiated by general practitioners; most consider lindane (gamma benzene hexachloride) the treatment of choice. Lindane is also widely used as an agricultural and industrial pesticide, and as a result the toxic profile of this insecticide is well understood. Evidence is accumulating that lindane can be toxic to the central nervous system and may be associated with aplastic anaemia. Preparations containing lindane continue

1988 The Journal of the Royal College of General Practitioners

202. Immunochemical detection of different isoenzymes of cytochrome P-450 induced in chick hepatocyte cultures. Full Text available with Trip Pro

spectrophotometrically and characterized by immunoblotting and enzyme assays. From these studies, chemical inducers were classified into three groups: (i) chemicals that induced a P-450 isoenzyme of 50 kDa and increased benzphetamine demethylase activity: glutethimide, phenobarbital, metyrapone, mephenytoin, ethanol, isopentanol, isobutanol, lindane, lysodren; (ii) chemicals that induced a P-450 isoenzyme of 57 kDa and increased ethoxyresorufin de-ethylase activity: 3-methylcholanthrene and 3,3',4,4

1989 Biochemical Journal

203. Aplastic anaemia associated with organochlorine pesticide: case reports and review of evidence. Full Text available with Trip Pro

residues may be a useful confirmation of previous exposure. In the patients studied the presence of Lindane (gamma hexachlorocyclohexane) was shown using gas chromatography/mass spectrometry with selective ion monitoring of fragments obtained from one heavily exposed patient, with concentrations about five times greater than a matched control. The presence of clinically important tissue concentrations of pentachlorophenol was also confirmed in a second patient exposed to this agent. The long term

1990 Journal of Clinical Pathology

204. Agricultural use of DDT and risk of non-Hodgkin's lymphoma: pooled analysis of three case-control studies in the United States. Full Text available with Trip Pro

reduced ORs. Analyses by the number of days of use a year was limited to the Nebraska data. The most notable increase was found among farmers who used DDT for > or = 5 days a year (OR 2.6, 95% CI 1.1 to 5.9); however, additional adjustment for use of organophosphates, phenoxyacetic acids, and the individual pesticides lindane, malathion, and atrazine reduced the ORs to 1.0, 0.9, 1.1, 1.6, and 1.9 respectively.No strong consistent evidence was found for an association between exposure to DDT and risk

1998 Occupational and environmental medicine

205. Demodex folliculorum and topical treatment: acaricidal action evaluated by standardized skin surface biopsy. (Abstract)

Demodex folliculorum and topical treatment: acaricidal action evaluated by standardized skin surface biopsy. A standardized skin surface biopsy was performed in 34 patients suffering from skin diseases with high Demodex folliculorum density (Dd) > 5D/cm2 before, during and after topical treatment. The patients were randomized into six comparable groups to study six topical treatments: metronidazole 2%, permethrin 1%, sublimed sulphur 10%, lindane 1%, crotamiton 10% and benzyl benzoate (BB) 10

1998 The British journal of dermatology Controlled trial quality: uncertain

206. Treatment of public lice infestation: a comparison of two agents. (Abstract)

Treatment of public lice infestation: a comparison of two agents. Bulletins issued by both the United States Public Health Service and the Pan American Health Organization have noted a sharp increase in the incidence of public lice infestation (pediculosis pubis) in this country. At the Haight-Ashbury Free Medical Clinic we conducted a controlled, open study comparing the efficacy and safety of Kwell Shampoo (gamma benzene hexachloride; lindane) with RID, an over-the-counter, pyrethrin-based

1980 Cutis; cutaneous medicine for the practitioner Controlled trial quality: uncertain

207. Comparative trial of treatment with Prioderm lotion and Kwellada shampoo in children with head lice. Full Text available with Trip Pro

Comparative trial of treatment with Prioderm lotion and Kwellada shampoo in children with head lice. The safety and efficacy of treatment with a new pediculicide lotion, Prioderm (0.5% malathion in isopropanol), were compared with those of treatment with Kwellada (1% lindane) shampoo in a randomized trial of children with head lice. The children's scalps were examined for live lice immediately, 7 days and 4 to 6 weeks following treatment. To determine the in-vitro ovicidal effect of treatment

1984 Canadian Medical Association journal Controlled trial quality: uncertain

208. Permethrin 1% creme rinse for the treatment of Pediculus humanus var capitis infestation. (Abstract)

Permethrin 1% creme rinse for the treatment of Pediculus humanus var capitis infestation. Permethrin 1% creme rinse (NIX) was tested as a treatment for Pediculus humanus var capitis (head lice) in a placebo-controlled, double-blinded, randomized study. As a positive control, a third arm of the study included nonrandomized, but investigator-blinded, treatment with 1% lindane shampoo (Kwell). At 14 days after treatment, 97% of patients treated with permethrin were free of lice compared to 6 (...) % of placebo-treated patients (P less than 0.001) and 43% of the lindane-treated group. Permethrin was 70% ovicidal compared to 14% for placebo (P less than 0.001) and 45% for lindane. No adverse experiences were noted during this study. Permethrin 1% demonstrated high pediculicidal and ovicidal activities, which in combination with its low mammalian toxicity, residual activity, and cosmetic properties, make it an excellent treatment for pediculosis capitis.

1986 Pediatric dermatology Controlled trial quality: uncertain

209. Permethrin 5% dermal cream: a new treatment for scabies. (Abstract)

Permethrin 5% dermal cream: a new treatment for scabies. Permethrin 5% dermal cream (Burroughs Wellcome Co.) was compared in an investigator-blinded, randomized study against lindane 1% lotion (Kwell) for the treatment of microscopically confirmed scabies. Eleven of twenty-three patients treated with permethrin cream were cured in 2 weeks (48%). Only two patients had scabies 1 month following a single treatment with this product, giving a cure rate of 91%. One of these two patients (...) was considered to have a reinfestation. Only three of twenty-three (13%) patients treated with 1% lindane lotion (Kwell) were free of scabies 2 weeks after a single treatment and fifteen of twenty-three (65%) were cured at 1 month. The unusually high percentage of treatment failures (35%) following lindane therapy may have been related to extensive use of this agent for head lice and scabies in this village during the preceding 5 years. The higher cure rate at 1 month seen with permethrin cream

1986 Journal of the American Academy of Dermatology Controlled trial quality: uncertain

210. Review: topical permethrin was more effective than topical crotamiton or lindane for scabies

Review: topical permethrin was more effective than topical crotamiton or lindane for scabies Review: topical permethrin was more effective than topical crotamiton or lindane for scabiesCommentary | Evidence-Based Nursing We use cookies to improve our service and to tailor our content and advertising to you. You can manage your cookie settings via your browser at any time. To learn more about how we use cookies, please see our . Log in using your username and password For personal accounts (...) OR managers of institutional accounts Username * Password * your user name or password? Search for this keyword Search for this keyword Main menu Log in using your username and password For personal accounts OR managers of institutional accounts Username * Password * your user name or password? You are here Review: topical permethrin was more effective than topical crotamiton or lindane for scabiesCommentary Article Text Treatment Review: topical permethrin was more effective than topical crotamiton

2008 Evidence-Based Nursing

211. Comparison of the efficacy of topical 1% lindane vs 5% permethrin in scabies: a randomized, double-blind study. (Abstract)

Comparison of the efficacy of topical 1% lindane vs 5% permethrin in scabies: a randomized, double-blind study. Permethrin, a pyrethroid insecticide, is not yet available in Iran and may be a useful substitute for the control of scabies in Iran.To compare the efficacy of topical lindane with topical permethrin in the treatment of scabies in a population in Iran.In a double-blind, randomized study, all consecutive patients with scabies were randomized into two groups. One group and their family (...) contacts received 1% lindane cream, and the other group and their family contacts were treated with topical 5% permethrin cream. Subsequently, patients were followed up at 2- and 4-week post-treatment.Of the 99 patients enrolled in the study, 47 patients received 1% lindane cream, and 52 patients were treated topically with 5% permethrin cream. Permethrin provided an improvement rate of 84.6% after two weeks, whereas lindane was effective only in 48.9% of patients.Permethrin (5%) cream was found

2006 Indian journal of dermatology, venereology and leprology Controlled trial quality: uncertain

212. The hatching of nits as a predictor of treatment failure with lindane and pyrethrin shampoos. (Abstract)

The hatching of nits as a predictor of treatment failure with lindane and pyrethrin shampoos. 1694468 1990 08 06 2018 11 30 0008-4263 81 3 1990 May-Jun Canadian journal of public health = Revue canadienne de sante publique Can J Public Health The hatching of nits as a predictor of treatment failure with lindane and pyrethrin shampoos. 237-9 Mathias R G RG Department of Health Care & Epidemiology, Faculty of Medicine, University of British Columbia, Vancouver. Wallace J F JF eng Clinical Trial

1990 Canadian journal of public health = Revue canadienne de sante publique Controlled trial quality: uncertain

213. The Effect of Lindane Formulations on Tissue Residues in Barrows and on Stillbirths in Sows Full Text available with Trip Pro

The Effect of Lindane Formulations on Tissue Residues in Barrows and on Stillbirths in Sows The potential effect of lindane and its formulations on stillbirths and abortion in pregnant sows was investigated. One of four formulations of lindane were applied at five times the registered dosage to each of ten sows within two weeks of farrowing. Each animal received 5 g of lindane. Formulations included: 1) a wettable powder diluted in water, 2) emulsifiable concentrate (EC) in xylene diluted (...) with water, 3) an emulsifiable concentrate with heavy aromatic naptha diluted with mineral oil and 4) an emulsifiable concentrate ready-to-use mineral oil concentration. Number of stillbirths were not increased in the sows and signs of toxicity were not observed.Three barrows, for each formulation, were sprayed at three times the registered dosage (1.3 g/animal) and slaughtered 24 hours later to determine if increased absorption and residues of lindane were associated with different formulations

1986 The Canadian Veterinary Journal

214. Does lindane (gamma-hexachlorocyclohexane) increase the rapid delayed rectifier outward K+ current (IKr) in frog atrial myocytes? Full Text available with Trip Pro

Does lindane (gamma-hexachlorocyclohexane) increase the rapid delayed rectifier outward K+ current (IKr) in frog atrial myocytes? The effects of lindane, a gamma-isomer of hexachlorocyclohexane, were studied on transmembrane potentials and currents of frog atrial heart muscle using intracellular microelectrodes and the whole cell voltage-clamp technique.Lindane (0.34 microM to 6.8 microM) dose-dependently shortened the action potential duration (APD). Under voltage-clamp conditions, lindane (...) (1.7 microM) increased the amplitude of the outward current (Iout) which developed in Ringer solution containing TTX (0.6 microM), Cd2+ (1 mM) and TEA (10 mM). The lindane-increased Iout was not sensitive to Sr2+ (5 mM). It was blocked by subsequent addition of quinidine (0.5 mM) or E-4031 (1 microM). E-4031 lengthened the APD; it prevented or blocked the lindane-induced APD shortening.In conclusion, our data revealed that lindane increased the quinidine and E-4031-sensitive rapid delayed outward K

2002 BMC pharmacology

215. Partition of the organochlorine insecticide lindane into the human sperm surface induces membrane depolarization and Ca2+ influx. Full Text available with Trip Pro

Partition of the organochlorine insecticide lindane into the human sperm surface induces membrane depolarization and Ca2+ influx. The effects of the insecticide lindane (the gamma-isomer of 1,2,3,4,5,6-hexachlorocyclohexane) on membrane potential, cytosolic free Ca2+ concentration ([Ca2+]i) and surface biophysical properties were studied in human spermatozoa. The insecticide induces rapid, transient and reproducible membrane depolarization and opening of voltage-dependent Ca2+ channels leading (...) to an increase in [Ca2+]i. In contrast with the effect in somatic cells, lindane did not affect gamma-aminobutyric acid receptor-linked Cl- currents. Ca2+ and K+ currents were found to drive lindane-induced membrane depolarization and repolarization respectively, whereas Na+ and Cl- fluxes appear not to have a role in the phenomenon. The insecticide was still able to produce membrane depolarization both in the combined absence of extracellular Ca2+ and Na+ and in high-K+ buffer, suggesting that lindane

1997 Biochemical Journal

216. Concerns over lindane treatment for scabies and lice Full Text available with Trip Pro

Concerns over lindane treatment for scabies and lice 12771080 2003 06 20 2018 11 30 0820-3946 168 11 2003 May 27 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Concerns over lindane treatment for scabies and lice. 1447-8 Wooltorton Eric E eng Journal Article Canada CMAJ 9711805 0820-3946 0 Insecticides 59NEE7PCAB Hexachlorocyclohexane AIM IM CMAJ. 2003 Sep 2;169(5):389 12952791 CMAJ. 2003 Sep 2;169(5):389 12952794 Canada Drug Labeling Drug

2003 CMAJ: Canadian Medical Association Journal

217. Alternatives to lindane Full Text available with Trip Pro

Alternatives to lindane 12952794 2003 10 02 2018 11 30 0820-3946 169 5 2003 Sep 02 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Alternatives to lindane. 389 Nugent Zoann J ZJ eng Letter Comment Canada CMAJ 9711805 0820-3946 0 Insecticides 0 Plant Preparations 59NEE7PCAB Hexachlorocyclohexane AIM IM CMAJ. 2003 May 27;168(11):1447-8 12771080 Hexachlorocyclohexane adverse effects Humans Insecticides adverse effects Lice Infestations drug therapy

2003 CMAJ: Canadian Medical Association Journal

218. Alternatives to lindane Full Text available with Trip Pro

Alternatives to lindane 12952791 2003 10 02 2018 11 30 0820-3946 169 5 2003 Sep 02 CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne CMAJ Alternatives to lindane. 389 Bear Soaring S eng Letter Comment Canada CMAJ 9711805 0820-3946 0 Insecticides 59NEE7PCAB Hexachlorocyclohexane 6M3C89ZY6R Nicotine AIM IM CMAJ. 2003 May 27;168(11):1447-8 12771080 Animals Hexachlorocyclohexane adverse effects Humans Insecticides adverse effects Lice Infestations drug

2003 CMAJ: Canadian Medical Association Journal

219. Plasma gamma-hexachlorocyclohexane concentrations in forestry workers exposed to lindane. Full Text available with Trip Pro

Plasma gamma-hexachlorocyclohexane concentrations in forestry workers exposed to lindane. Plasma gamma-hexachlorocyclohexane (gamma-HCH) and three urinary trichlorophenols were measured in forestry workers who were engaged in planting seedlings treated with gamma-HCH. These two procedures were assessed as potential biological monitoring methods and the data were compared with reported clinical symptoms. The measurement of plasma gamma-HCH was considered to be a feasible and valid monitoring

1988 British Journal of Industrial Medicine

220. Alberta. Lindane toxicity in beef cattle Full Text available with Trip Pro

Alberta. Lindane toxicity in beef cattle 17423448 2010 06 28 2018 11 13 0008-5286 30 10 1989 Oct The Canadian veterinary journal = La revue veterinaire canadienne Can. Vet. J. Alberta. Lindane toxicity in beef cattle. 833 Wood J J Chalmers G G Fenton R R Pritchard J J Schoonderwoerd M M eng Journal Article Canada Can Vet J 0004653 0008-5286 1989 10 1 0 0 1989 10 1 0 1 1989 10 1 0 0 ppublish 17423448 PMC1681291 Can Vet J. 1988 May;29(5):458-9 17423050 Vet Hum Toxicol. 1988 Apr;30(2):118-20

1989 The Canadian Veterinary Journal

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