How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

294 results for

Life-Threatening Drug-Induced Rashes

by
...
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

161. Hepatitis B

, it can progress rapidly to life-threatening liver failure with coagulopathy, encephalopathy, and cerebral oedema. The mortality of acute hepatitis B is less than 1%. Chronic hepatitis B infection (persistence of HBsAg in the circulation for more than 6 months) occurs in: Approximately 10% of infants born to hepatitis B–positive mothers in the perinatal period, if they are not immunized from birth. Between 10% and 20% of children infected in later childhood. About 5% of people infected as healthy (...) , alpha 1 antitrypsin deficiency). Drug-induced liver disease. Granulomatous disorders. Hepatitis caused by other viruses such as hepatitis A, C, and D (acute hepatitis B cannot easily be distinguished from other forms of acute hepatitis either by history or examination, or by routine biochemistry tests). Basis for recommendation Basis for recommendation Information about the differential diagnosis of hepatitis B is taken from an Infectious Diseases textbook Mandell, Douglas, and Bennett's Principles

2014 NICE Clinical Knowledge Summaries

162. A Study of the Safety, Tolerability, and Effects of Cobimetinib and GDC-0994 in Patients With Locally Advanced or Metastatic Solid Tumors

included the following: Grade ≥ 1 retinal vein occlusion; Grade ≥ 2 visual disturbances (including events suggestive of serous retinopathy); Grade ≥ 3 rash for > 7 days; Grade ≥ 3 diarrhea for > 3 days; Grade ≥ 2 left ventricular ejection fraction (LVEF) decrease; Grade 3 hepatotoxicity; any dose-limiting toxicity (DLT); cases of potential drug-induced liver injury that include an elevated alanine aminotransferase (ALT) or aspartate aminotransferase (AST) (AST > 3 × baseline value [and above the upper (...) limit of normal, ULN]) in combination with either an elevated bilirubin ( > 2 × ULN) or clinical jaundice; or suspected transmission of an infectious agent by either study drug. Percentage of Participants With at Least One Serious Adverse Event (SAE) [ Time Frame: Up to 15 months ] A SAE is any experience that: results in death, is life-threatening, requires in-patient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity

2015 Clinical Trials

163. Rilutek - riluzole

Outcome Death (1 d ), Hospitalized (12), Life threatening event (2), Other (2) Reporters assessment of drug related ILD (n=15) Probable (12) Likely (2) Unlikely (1) a Interstitial pneumonia: 3 of 8 reported the following specific diagnosis: ‘interstitial pneumonitis, interstitial pneumopathy, or pneumonitis’ b alveolitis: two cases reported specifically: ‘bilateral alveolar infiltrates or drug induced alveolitis’ c One case may be a duplicate, but this could not be reconciled due to a lack of details (...) : This reviewer finds the association of the alleviation of symptoms and the discontinuation of drug most compelling with respect to a causal relationship of the Drug to ILD. The findings of immune- or hypersensitivity findings are suggestive but nonspecific. The value of the Drug Induced Lymphocyte Stimulation Test findings is uncertain give the low sensitivity (and possibly specificity) of the test (1) . 4. Comments This Medical Reviewer agrees with the wording provided by the Sponsor for the CBE

2009 FDA - Drug Approval Package

164. Vaccine safety and adverse events following immunisation

patient, a rational Airway, Breathing, Circulation, Disability, Exposure (ABCDE) approach must be followed and life-threatening problems treated as they are recognised (Resuscitation Council UK, 2008). Confusion arises because some patients have systemic allergic reactions that are less severe. For example, generalised urticaria, angioedema and rhinitis would not be described as an anaphylactic reaction because the life-threatening features – an airway problem, respiratory difficulty (breathing (...) problem) and hypotension (circulation problem) –- are not present. Anaphylaxis is likely when all of the following three criteria are met: ? sudden onset and rapid progression of symptoms ? life-threatening airway and/or breathing and/or circulation problems ? skin and/or mucosal changes (flushing, urticaria, angioedema). The following supports the diagnosis: ? exposure to a known allergen where the patient is already known to be allergic. Remember: ? skin or mucosal changes alone are not a sign

2009 The Green Book

165. Severe skin complications in patients treated with antidepressants: a literature review Full Text available with Trip Pro

Severe skin complications in patients treated with antidepressants: a literature review Clinical manifestations of drug-induced skin reactions include a wide range of symptoms, from mild drug-induced exanthemas to dangerous and life-threatening generalized systematic reactions. Adverse drug reactions of low risk include phenomena such as drug-induced rashes, phototoxic reactions, eczemas and urticarias, which appear most often when the medication is being introduced. Drug-induced skin reactions

2014 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

166. Bioequivalence Study of Fenofibrate Capsules, 130 mg Under Fasting Conditions

pain. History of constipation and/or nausea in one week preceding the study. History and/or any finding of gall bladder disease. History of pancreatitis. History of drug-induced rash and/or pruritis. - Any evidence of organ dysfunction or any clinically significant deviation from the normal, in physical or clinical determinations. Subject had laboratory test parameter(s), which is/are outside acceptable limits and is judged clinically significant. Subject had history of serious medical illnesses (...) including but not limited to gastrointestinal, hepatic, renal, cardiovascular, pulmonary, neurological or haematological disease, diabetes, glaucoma, any serious, potentially life-threatening illness. Inability to communicate well (i.e. language problem, poor mental development, psychiatric illness or poor cerebral function) that might impair the ability to provide, written informed consent. Subject was a regular smoker, who smoked more than 10 cigarettes daily or have difficulty abstaining from smoking

2014 Clinical Trials

167. Valproate Dose Reduction and Its Clinical Evaluation by Introducing Lamotrigine in Japanese Women With Epilepsy

results in death, is life-threatening, requires hospitalisation or prolongation of existing hospitalisation, results in disability/incapacity, is a congenital anomaly/birth defect, based on medical or scientific judgement and all events of possible drug-induced liver injury. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study (...) of the investigational and standard products and all study procedures Exclusion Criteria: Subjects with a history of hypersensitivity to LTG Subjects with a history of rash associated with other AED treatments. Subjects who have received another AED besides VPA during the 12 weeks prior to start of the investigational product Subjects with status epilepticus during the 6 months prior to start of the investigational product Subjects with a history of substance (including alcohol and drug) dependence or substance

2014 Clinical Trials

168. Toxic Epidermal Necrolysis (Diagnosis)

involvement can result in gastrointestinal hemorrhage, respiratory failure, ocular abnormalities, and genitourinary complications. Diffuse maculopapular rash in toxic epidermal necrolysis (TEN). TEN is most commonly drug induced. However, the disorder has other potential etiologies, including infection, malignancy, and vaccinations (see Etiology). TEN is idiosyncratic, and its occurrence is not easily predicted. Some authors believe that (SJS; also known as erythema multiforme major) is a manifestation (...) Necrolysis (TEN) Updated: Dec 20, 2018 Author: Victor Cohen, PharmD; Chief Editor: Michael Stuart Bronze, MD Share Email Print Feedback Close Sections Sections Toxic Epidermal Necrolysis (TEN) Overview Background Toxic epidermal necrolysis (TEN) is a potentially life-threatening dermatologic disorder characterized by widespread erythema, necrosis, and bullous detachment of the epidermis and mucous membranes, resulting in exfoliation and possible sepsis and/or death (see the image below). Mucous membrane

2014 eMedicine.com

169. Benign Vulvar Lesions (Follow-up)

nigricans Acanthosis nigricans is a diffuse pigmentary change typically observed in intertriginous areas and skin folds. It may be hereditary, drug induced, or associated with obesity or endocrine diseases. [ ] It sometimes represents a paraneoplastic syndrome, revealing associated malignant epithelial tumors or lymphoproliferative disorders. Lentigo, lentiginosis, and benign vulvar melanosis Lentigo, lentiginosis, and benign vulvar melanosis are characterized by benign epidermal melanocytic hyperplasia (...) dermatitis consists of a subacute or chronic, symmetric, and ill-defined eczematous rash, usually involving the labia majora and, less frequently, the labia minora and inner thighs. The eruption is characterized by mild erythema, dryness, and fine scaling. Itching and burning are common symptoms. Excoriation secondary to repeated scratching may cause bacterial superinfection with honey-colored crusting and, in chronic forms, lichenification. In some patients, the itch-scratch-itch cycle may gradually

2014 eMedicine.com

170. Uveitis, Evaluation and Treatment (Diagnosis)

spondyloarthropathies HLA-B27, sacroiliac films Aphthous ulcers Behçet disease HLA-B5, HLA-B51 Postsurgical, posttraumatic Infectious endophthalmitis Vitreous tap, vitrectomy Medication induced Rifabutin None None Idiopathic Possibly HLA-B27 Moderate severity of pain and redness Shortness of breath, African descent, subcutaneous nodules Sarcoidosis Serum ACE, lysozyme, chest radiograph or chest CT scan, gallium scan, biopsy Posttraumatic Traumatic iritis ... Increased IOP, sectorial iris atrophy, corneal dendrite (...) Herpetic iritis ... Poor response to steroid, manifestations of 2° or 3° syphilis, HIV Syphilis Rapid plasma reagent (RPR) or VDRL, FTA-ABS Postcataract extraction, white plaque on posterior capsule Endophthalmitis, intraocular lens (IOL)- related iritis Vitrectomy and/or culture, consider anaerobic and fungal cultures Medication induced Etidronate (Didronel), metipranolol (OptiPranolol), latanoprost (Xalatan) History of HIV, alcohol abuse, exposure to infected individuals, residence in endemic regions

2014 eMedicine.com

171. Nonlaser Hair Removal Techniques (Diagnosis)

, abdomen) caused by excess androgens in women [ , , , ] Hypertrichosis: Congenital or drug-induced increase in hair growth in areas that are not androgen dependent; occurs in both men and women Pseudofolliculitis (second image below): Hair growth from grafted donor sites, preoperative hair removal, and sex-change operations performed in men The third image below depicts the anatomy of a hair follicle. Woman with hirsutism. Man with pseudofolliculitis barbae on his neck. Anatomy of a hair follicle. Many (...) not be performed on moles, warts, or irritated, sunburned, or broken skin. Pay special attention to the temperature of wax to avoid burning skin. Adverse effects from waxing include pain, hyperpigmentation, scarring, folliculitis, and ingrown hair pseudofolliculitis. A life-threatening Streptococcus pyogenes and herpes simplexvirus infection of the external genitalia occurred in a 20-year-old diabetic woman following a routine perineal "Brazilian" bikini wax. [ ] Additionally, while the pathogenesis

2014 eMedicine.com

172. Nonneoplastic Epithelial Disorders of the Vulva (Diagnosis)

nigricans Acanthosis nigricans is a diffuse pigmentary change typically observed in intertriginous areas and skin folds. It may be hereditary, drug induced, or associated with obesity or endocrine diseases. [ ] It sometimes represents a paraneoplastic syndrome, revealing associated malignant epithelial tumors or lymphoproliferative disorders. Lentigo, lentiginosis, and benign vulvar melanosis Lentigo, lentiginosis, and benign vulvar melanosis are characterized by benign epidermal melanocytic hyperplasia (...) dermatitis consists of a subacute or chronic, symmetric, and ill-defined eczematous rash, usually involving the labia majora and, less frequently, the labia minora and inner thighs. The eruption is characterized by mild erythema, dryness, and fine scaling. Itching and burning are common symptoms. Excoriation secondary to repeated scratching may cause bacterial superinfection with honey-colored crusting and, in chronic forms, lichenification. In some patients, the itch-scratch-itch cycle may gradually

2014 eMedicine.com

173. Neutropenia (Diagnosis)

, namely neutrophils, eosinophils, and basophils. However, the term granulocytopenia is often used synonymously with neutropenia and, in that sense, is again confined to the neutrophil lineage alone. The risk of serious infection increases as the absolute neutrophil count (ANC) falls to the severely neutropenic range (< 500/µL). The duration and severity of neutropenia directly correlate with the total incidence of all infections and of those infections that are life threatening. Tuberculosis (see (...) if infection has been present Painful aphthous ulcers in the oral cavity Swollen and tender gums See for more detail. Diagnosis Previous to a major workup, rule out infectious and drug-induced causes of neutropenia; then, obtain the following laboratory studies: Complete blood count: Including a manual differential in evaluating cases of agranulocytosis Differential white blood cell count Peripheral smear review by a pathologist The following studies are applicable in some patients with neutropenia

2014 eMedicine.com

174. Liver Disease and Pregnancy (Diagnosis)

-threatening condition often develops in the second half of pregnancy (range: 27-40 weeks' gestation), usually close to term, with a reported mean gestational age of 36 weeks (see the calculator), but AFLP may not be diagnosed until the postpartum period. The differential diagnosis includes fulminant , drug-induced hepatic toxicity, i , adult-onset Reye syndrome, and . Risk factors No clear geographic or racial predisposition for AFLP exists. Risk factors include older maternal age, primiparity, multiple (...) insulin sensitivity and increased baseline cortisol levels in the children of mothers with severe hyperemesis compared to those in the control group. [ ] The lifelong effect of this difference in still unknown, but it may place these children at higher risk for type 2 diabetes and cardiovascular disease. Previous Next: Acute Fatty Liver of Pregnancy The prevalence of , in which microvesicular fatty infiltration of the liver can lead to liver failure, [ ] is 1 per 10,000-15,000 pregnancies. This life

2014 eMedicine.com

175. Migraine Headache: Pediatric Perspective (Diagnosis)

and vegetables. Medications Over-the-counter (OTC) and prescription medications can trigger or exacerbate migraines. Excessive use of OTC pain medications and analgesics can cause occasional migraine attacks to convert to analgesic-abuse headaches or drug-induced refractory headaches. Drugs that can increase migraine frequency include the following: Cimetidine Estrogen Histamine Hydralazine Nifedipine Nitroglycerin Ranitidine Reserpine Advise patients to avoid frequent or long-term use of nonsteroidal anti (...) examination findings should be completely normal. Appropriate follow-up evaluations are necessary for patients with any of the following: Abnormal vital signs Nuchal rigidity Cranial nerve abnormalities Macrocephaly Bruits Papilledema Cutaneous lesions Cognitive changes Asymmetrical signs Previous Next: Associated Diseases and Differentials Headache may be a presenting symptom of a benign condition or a life-threatening disorder. The patient's medical history and physical examination findings often

2014 eMedicine.com

176. Oral Manifestations of Systemic Diseases (Diagnosis)

, purpura, paraneoplastic pemphigus, Sweet syndrome) or therapy-induced lesions (eg, drug reactions, graft vs host disease). [ , ] Oral manifestations are more common in acute leukemias than in chronic leukemias. [ ] Gingival hypertrophy and hyperplasia are most commonly associated with acute myelogenous leukemia and acute promyelocytic leukemia. [ ] The gingiva are friable, edematous, and erythematous. [ , ] Thrombocytopenia commonly manifests as petechiae and ecchymoses on the mucosal surfaces (...) counts. [ , , ] These failures lead to transient recurrent fevers, malaise, and recurrent infections that may be life threatening. [ ] Onset of symptoms occurs in childhood and may improve as the patient approaches adulthood. [ ] Cutaneous manifestations are generally due to poor immune function and include skin infections and abscesses. [ ] Oral manifestations are present in over 90% of patients with cyclic neutropenia. [ ] In one series, investigators found that 94% have recurrent ulcers similar

2014 eMedicine.com

177. Nonlaser Hair Removal Techniques (Overview)

, abdomen) caused by excess androgens in women [ , , , ] Hypertrichosis: Congenital or drug-induced increase in hair growth in areas that are not androgen dependent; occurs in both men and women Pseudofolliculitis (second image below): Hair growth from grafted donor sites, preoperative hair removal, and sex-change operations performed in men The third image below depicts the anatomy of a hair follicle. Woman with hirsutism. Man with pseudofolliculitis barbae on his neck. Anatomy of a hair follicle. Many (...) not be performed on moles, warts, or irritated, sunburned, or broken skin. Pay special attention to the temperature of wax to avoid burning skin. Adverse effects from waxing include pain, hyperpigmentation, scarring, folliculitis, and ingrown hair pseudofolliculitis. A life-threatening Streptococcus pyogenes and herpes simplexvirus infection of the external genitalia occurred in a 20-year-old diabetic woman following a routine perineal "Brazilian" bikini wax. [ ] Additionally, while the pathogenesis

2014 eMedicine.com

178. Nonneoplastic Epithelial Disorders of the Vulva (Overview)

nigricans Acanthosis nigricans is a diffuse pigmentary change typically observed in intertriginous areas and skin folds. It may be hereditary, drug induced, or associated with obesity or endocrine diseases. [ ] It sometimes represents a paraneoplastic syndrome, revealing associated malignant epithelial tumors or lymphoproliferative disorders. Lentigo, lentiginosis, and benign vulvar melanosis Lentigo, lentiginosis, and benign vulvar melanosis are characterized by benign epidermal melanocytic hyperplasia (...) dermatitis consists of a subacute or chronic, symmetric, and ill-defined eczematous rash, usually involving the labia majora and, less frequently, the labia minora and inner thighs. The eruption is characterized by mild erythema, dryness, and fine scaling. Itching and burning are common symptoms. Excoriation secondary to repeated scratching may cause bacterial superinfection with honey-colored crusting and, in chronic forms, lichenification. In some patients, the itch-scratch-itch cycle may gradually

2014 eMedicine.com

179. Migraine Headache: Pediatric Perspective (Overview)

and vegetables. Medications Over-the-counter (OTC) and prescription medications can trigger or exacerbate migraines. Excessive use of OTC pain medications and analgesics can cause occasional migraine attacks to convert to analgesic-abuse headaches or drug-induced refractory headaches. Drugs that can increase migraine frequency include the following: Cimetidine Estrogen Histamine Hydralazine Nifedipine Nitroglycerin Ranitidine Reserpine Advise patients to avoid frequent or long-term use of nonsteroidal anti (...) examination findings should be completely normal. Appropriate follow-up evaluations are necessary for patients with any of the following: Abnormal vital signs Nuchal rigidity Cranial nerve abnormalities Macrocephaly Bruits Papilledema Cutaneous lesions Cognitive changes Asymmetrical signs Previous Next: Associated Diseases and Differentials Headache may be a presenting symptom of a benign condition or a life-threatening disorder. The patient's medical history and physical examination findings often

2014 eMedicine.com

180. Cutaneous T-Cell Lymphoma (Treatment)

therapy, inducing complete remission in four of five patients in one study. [ ] Previous Next: Treatment of Sézary Syndrome The treatment of Sézary syndrome should be predicated on disease burden and rapidity of progression. [ ] Because infection is the major cause of death in patients with mycosis Sézary syndrome, one should attempt to preserve immune response, use immunomodulatory therapy before chemotherapy unless the disease burden or therapeutic failure requires otherwise, and consider (...) combination therapy, particularly systemic immunomodulatory therapy plus skin-directed treatments, as a better option than monotherapy. Because Staphylococcus infection may be associated with a disease flare, systemic antibiotics should be administered when in doubt to prevent life-threatening sepsis. Pruritus treatment is an important quality-of-life consideration and should not be neglected. [ ] It can be so severe that special itch-targeted therapies may need to be devised. Mogamulizumab, a CCR4

2014 eMedicine.com

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>