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Life-Threatening Drug-Induced Rashes

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141. Use of iProâ„¢2 in Real Life Diabetes Management of Type 2 Patients in India

Use of iProâ„¢2 in Real Life Diabetes Management of Type 2 Patients in India Use of iPro™2 in Real Life Diabetes Management of Type 2 Patients in India - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Use (...) of iPro™2 in Real Life Diabetes Management of Type 2 Patients in India The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01995539 Recruitment Status : Completed First Posted : November 26, 2013 Results First Posted : October 18, 2018 Last Update Posted : December 4, 2018 Sponsor: Medtronic Diabetes

2013 Clinical Trials

142. Insights into the poor prognosis of allopurinol-induced severe cutaneous adverse reactions: the impact of renal insufficiency, high plasma levels of oxypurinol and granulysin. (PubMed)

Insights into the poor prognosis of allopurinol-induced severe cutaneous adverse reactions: the impact of renal insufficiency, high plasma levels of oxypurinol and granulysin. Allopurinol, an antihyperuricaemic agent, is one of the common causes of life-threatening severe cutaneous adverse reactions (SCAR), including drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN). The prognostic factors for allopurinol-related SCAR

2014 Annals of the Rheumatic Diseases

143. Evaluation of the Efficacy of Low-dose Acetylsalicylic Acid on Diarrhea Induced by Anti-cancer Targeted Therapies.

of thromboxane B2 and P-selectin leaves suggest a role of platelet activation in the occurrence of side effects associated with targeted therapies. Kanazawa's study was conducted in 39 Japanese patients, trying to assess the value of low-dose acetylsalicylic acid or 100mg per day, that is to say, anti-aggrégantes doses, the occurrence rash and diarrhea induced by gefitinib. In this study, the group of patients treated with acetylsalicylic acid presented a lower rate of side effects significantly, 58.3 (...) Evaluation of the Efficacy of Low-dose Acetylsalicylic Acid on Diarrhea Induced by Anti-cancer Targeted Therapies. Evaluation of the Efficacy of Low-dose Acetylsalicylic Acid on Diarrhea Induced by Anti-cancer Targeted Therapies. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number

2014 Clinical Trials

144. Non-steroidal anti-inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults. (PubMed)

Non-steroidal anti-inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults. Lateral elbow pain, or tennis elbow, is a common condition that causes pain in the elbow and forearm. Although self-limiting, it can be associated with significant disability and often results in work absence. It is often treated with topical and oral non-steroidal anti-inflammatory drugs (NSAIDs). This is an update of a review first published in 2002 (search date October 11, 2012).To assess the benefits (...) , function, quality of life, pain-free grip strength, overall treatment success, work loss and adverse effects.Two review authors independently selected the studies for inclusion, extracted the data, and performed a risk of bias assessment.Fifteen trials, involving 759 participants and reporting 17 comparisons, were included in the review. Four new trials identified from the updated search were included, along with 11 of 14 trials included in the original review (three trials included in the previous

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2013 Cochrane database of systematic reviews (Online)

145. A review of cutaneous drug eruptions. (PubMed)

A review of cutaneous drug eruptions. Cutaneous drug eruptions can range from an asymptomatic rash to a life-threatening emergency. Because of the high frequency, morbidity, and potential mortality associated with drug eruptions, patients with possible drug reactions should promptly be recognized, worked up, and treated. Drug reactions are common in the elderly population due to age-related alterations in metabolism, excretion of medications, and polypharmacy. This review discusses (...) the epidemiology, pathogenesis, clinical presentation, diagnosis, and management of drug eruptions that providers commonly encounter in the care of the geriatric population. An algorithm for an approach to patients with a suspected drug eruption is presented.Copyright © 2013 Elsevier Inc. All rights reserved.

2013 Clinics in Geriatric Medicine

146. Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Year of Life

) visits. Number of Subjects Reporting Any Serious Adverse Events (SAEs) [ Time Frame: From Day 0 through the end of the study (Day 222) ] SAEs assessed include any untoward medical occurrences that resulted in death, were life-threatening, required hospitalization or prolongation of existing hospitalization or resulted in disability/incapacity. Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk (...) Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Year of Life Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Year of Life - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record

2012 Clinical Trials

147. Adverse Drug Reactions to Antiretroviral Therapy: Prospective Study in Children in Sikasso (Mali) (PubMed)

with rash. We observed one case of grade 3 side effects during our study. The treatment regimen was changed in 15.2% of cases, including one case because of side effects.ADRs are not rare in Mali, particularly in children. These ADRs have an impact on quality of life for patients. We recommend a pharmacovigilance system for sustainable management of side effects in patients infected with human immunodeficiency virus in Mali. (...) Adverse Drug Reactions to Antiretroviral Therapy: Prospective Study in Children in Sikasso (Mali) Adverse events during antiretroviral treatment are frequent and various. Their diagnosis incurs some various difficulties according to the geographic context. Our aim was to describe the frequency, nature, and preventability of adverse drug reactions (ADRs) due to antiretroviral treatment in Malian outpatient children.The study was a 6-month (June 1 to November 30, 2010) prospective, observational

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2012 The Journal of Pediatric Pharmacology and Therapeutics : JPPT

148. Adverse Drug Reaction

the actions of one or both drugs. The drugs might not work, or you could get side effects. Side effects are unwanted effects caused by the drugs. Most are mild, such as a stomach aches or drowsiness, and go away after you stop taking the drug. Others can be more serious. Drug allergies are another type of reaction. They can be mild or life-threatening. Skin reactions, such as hives and rashes, are the most common type. When you start a new prescription or over-the-counter medication, make sure you (...) Reaction Aka: Adverse Drug Reaction , Medication Hypersensitivity , Drug Reaction From Related Chapters II. Types: Medication-induced Hypersensitivity Reaction See III. Differential Diagnosis: Non-immune mediated Drug Reaction (examples) Medication intolerance Significant gastrointestinal upset with Sensitization See Idiosyncratic reaction (examples) Pseudoallergic reaction (direct mast cell activation) anaphylactoid reaction s See Example: (examples) Medication toxicity (examples) s s Medication

2015 FP Notebook

149. Vitamin D Status, Disease Specific and Quality of Life Outcomes in Patients With Cutaneous Lupus

of the body and often affects the skin, with immune cells attacking autoantigens in the skin and causing a rash. This rash is often visible to the public because it tends to occur on sun-exposed areas, for example a patient's face, chest, and arms. For this reason, among others, skin lupus can be a source of disability and poor health related quality of life in many patients with this disease. It is not completely understood why or how someone might develop lupus, however there are likely many reasons (...) Vitamin D Status, Disease Specific and Quality of Life Outcomes in Patients With Cutaneous Lupus Vitamin D Status, Disease Specific and Quality of Life Outcomes in Patients With Cutaneous Lupus - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2011 Clinical Trials

150. Endocrine Side Effects Induced by Immune Checkpoint Inhibitors. (PubMed)

Endocrine Side Effects Induced by Immune Checkpoint Inhibitors. In recent years, progress has been made in cancer immunotherapy by the development of drugs acting as modulators of immune checkpoint proteins, such as the cytotoxic T-lymphocyte antigen-4 (CTLA4) and programmed death-1 (PD-1), two co-inhibitory receptors that are expressed on T cells upon activation. These molecules play crucial roles in maintaining immune homeostasis by down-regulating T-cell signaling, thereby preventing (...) with ipilimumab includes most commonly hypophysitis, more rarely thyroid disease or abnormalities in thyroid function tests, and occasionally primary adrenal insufficiency. Hypophysitis has emerged as a distinctive side effect of CTLA4-blocking antibodies, establishing a new form of autoimmune pituitary disease. This condition, if not promptly recognized, may be life-threatening (due to secondary hypoadrenalism). Hypopituitarism caused by these agents is rarely reversible, and prolonged or lifelong

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2013 Journal of Clinical Endocrinology and Metabolism

151. Safety Study of Cord Blood-derived Cytokine-induced Killer Cells in Patients With Solid Tumor After Radical Resection

Safety Study of Cord Blood-derived Cytokine-induced Killer Cells in Patients With Solid Tumor After Radical Resection Safety Study of Cord Blood-derived Cytokine-induced Killer Cells in Patients With Solid Tumor After Radical Resection - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Safety Study of Cord Blood-derived Cytokine-induced Killer Cells in Patients With Solid Tumor After Radical Resection The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01914263 Recruitment Status : Unknown Verified July 2014

2013 Clinical Trials

152. Is drug allergy less prevalent than previously assumed? A 5-year analysis. (PubMed)

Is drug allergy less prevalent than previously assumed? A 5-year analysis. Rashes are a frequent conundrum in clinical practice as they may be reactive, drug induced or disease specific. Identification of the culprit drug is important as re-exposure may be harmful or even life-threatening and unnecessary avoidance of 'innocent' drugs leads to limitations of treatment options.To objectify the cause of suspected cutaneous drug reactions in a large patient population.Over 5years (2006-10), 612 (...) (24%) were reactive rashes or had other causes. Mostly, cutaneous drug reactions were maculopapular rashes, urticaria/angio-oedema; less frequently, acute generalized exanthematous pustulosis, drug reaction with eosinophilia and systemic symptoms, systemic drug-related intertriginous and flexural exanthema, toxic epidermal necrolysis and fixed drug eruptions were present. Of all the cutaneous drug reactions investigated, 39·8% were caused by antibiotics, 21·2% by anti-inflammatories, 7·6

2011 British Journal of Dermatology

153. Extended Open Challenge in Patients With a History of Drug Eruption Following Beta-lactam Treatment

antibiotic Patients with a diagnosis of penicillin allergy who have no data on the nature of the symptoms that have eventually resulted in establishing this diagnosis Exclusion Criteria: Patients in whom the rash appeared within 1 hour after the last dose of the drug Patients who also developed other anaphylactic symptoms Patients who had a life-threatening rash such as Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis or DRESS. Pregnancy Contacts and Locations Go to Information from the National (...) , 2015 Sponsor: Meir Medical Center Information provided by (Responsible Party): Arnon Goldberg, Meir Medical Center Study Details Study Description Go to Brief Summary: Beta-lactam allergy is the most prevalent drug allergy. Drug eruption is the most common symptom whereas life-threatening anaphylaxis is rather rare. A recently published study (Journal of Allergy and Clinical Immunology, January 2011, Vol. 127, p. 218-222) described the safety of a 2-day oral beta-lactam challenge in penicillin

2011 Clinical Trials

154. Antiretroviral Drug Interaction Study in Volunteers With HIV

ability to absorb drugs. Drug or alcohol use that may impair safety or adherence. History of intolerance or allergic reaction (rash; hives; swollen lips; difficulty breathing) to atovaquone. Bleeding disorders (hemophilia, G.I., or intracranial bleeding). Organ transplant recipient. Documented ongoing problems with medication adherence. High likelihood of switching ARV regimen within 12 weeks of the start of the study. Contacts and Locations Go to Information from the National Library of Medicine (...) Antiretroviral Drug Interaction Study in Volunteers With HIV Antiretroviral Drug Interaction Study in Volunteers With HIV - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Antiretroviral Drug Interaction

2011 Clinical Trials

155. Multiple Dose Study to Evaluate Security, Tolerance and Pharmacokinetic of Fexinidazole (Drug Candidate for Human African Trypanosomiasis) Administered With a Loading Dose and With Food

forfeit their freedom by administrative or legal award or who were under guardianship, Unwilling to give their informed consent, Who have a positive laboratory test for Hepatitis B surface antigen (HbsAg), or anti-HIV 1/2 or anti-HCV antibodies Who have a history of allergy, intolerance or photosensitivity to any drug, Who have a history of serious allergy, asthma, allergic skin rash or sensitivity to any drug, Who are known or suspected alcohol or drug abusers (more than 14 units of alcohol per week (...) to this study by its ClinicalTrials.gov identifier (NCT number): NCT01483170 Locations Layout table for location information France SGS Life Sciences Paris, France, 75015 Sponsors and Collaborators Drugs for Neglected Diseases Investigators Layout table for investigator information Principal Investigator: Lionel Hovsepian, MD SGS Aster More Information Go to Additional Information: Layout table for additonal information Responsible Party: Drugs for Neglected Diseases ClinicalTrials.gov Identifier: Other

2011 Clinical Trials

156. Phase II Study of SyB D-0701 for Radiotherapy-Induced Nausea and Vomiting (RINV)

(CTCAE) version 4.0. Grade 1: Mild, Grade 2: Moderate, Grade 3: Severe or medically significant but not immediately life-threatening, Grade 4: Life-threatening consequences, Grade 5: Death related to AE Skin Manifestations at Study Drug Application Site [ Time Frame: Up to 192 hours ] The investigator or sub-investigator recorded skin manifestations observed after removal of the study drug. Skin manifestations were counted for each type of patches (placebo patch, SyB D-0701 15 cm2 patch, SyB D-0701 (...) (RINV) Drug: SyB D-0701 Drug: Placebo Phase 2 Detailed Description: Exploratory study of dose response of SyB D-0701 to preventing effects for nausea and emesis associated with radiotherapy (fractionated/localized irradiation) Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 189 participants Intervention Model: Parallel Assignment Masking: Double Official Title: Phase II Clinical Study of SyB D-0701 for Radiotherapy Induced Nausea

2012 Clinical Trials

157. Erlotinib-induced Hepatotoxicity—Clinical Presentation and Successful Management: A Case Report (PubMed)

Erlotinib-induced Hepatotoxicity—Clinical Presentation and Successful Management: A Case Report Drug-induced liver injury (DILI) is a common occurrence in clinical practice in the present era because of frequent use of drugs and increase in patients who have increased susceptibility to DILI (because of underlying non-alcoholic steatohepatitis [NASH], chronic hepatitis C, chronic hepatitis B and alcoholic liver disease). DILI is the most common reason for withdrawal of an approved drug from (...) × upper limit of normal [ULN]) LFT abnormalities are observed in around 4% of patients while Grade 3 (ALT < 5-20× ULN) are not reported. We report a case of acute hepatitis due to administration of erlotinib in 81-year-old gentleman diagnosed as having non-small cell lung cancer with metastasis to mediastinal lymph nodes and started on erlotinib 150 mg/day. This type of deep jaundice is very rare, and timely diagnosis and withdrawal of the drug saved the life of the patient. It is recommended

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2011 Journal of clinical and experimental hepatology

158. The prevalence and natural course of food protein-induced enterocolitis syndrome to cow's milk: A large-scale, prospective population-based study. (PubMed)

with probable adverse reactions to cow's milk protein (CMP) were clinically examined, skin prick tested, and challenged orally. Diagnostic criteria for CMP-induced FPIES included age less than 9 months, delayed recurrent vomiting (usually with nausea), and lethargy after exposure to CMP in the absence of other IgE-mediated symptoms, such as rash, urticaria, and respiratory symptoms. In addition, a positive challenge response to milk resulted in the above-mentioned gastrointestinal symptoms, removal of milk (...) The prevalence and natural course of food protein-induced enterocolitis syndrome to cow's milk: A large-scale, prospective population-based study. The prevalence and natural history for food protein-induced enterocolitis syndrome (FPIES) have not been determined.We sought to determine the prevalence, clinical manifestations, and rate of recovery for FPIES in a large-scale, population-based prospective study.In a prospective study the feeding history of 13,019 infants was obtained. Infants

2011 Journal of Allergy and Clinical Immunology

159. Pre-emptive Cycline Treatment on Cetuximab Induced Skin Toxicity in Colorectal Cancer

Description: Cetuximab, an Epidermal Growth Factor Receptor (EGFR) inhibitor, has shown to improve FOLFIRI efficacy up to 59.3% OR, in wild KRAS patients with advanced colorectal cancer. Skin toxicity occurs in 81.6% of patients as an acne-like skin rash developed on the face and the trunk inducing pain, decreasing quality of life and drug compliance. Over 104 patients enrolled in a phase II clinical trial sponsored by Center Paul Papin (NCT 00 559741), a grade > or = 2 cetuximab-acneiform rash occured (...) Last Update Posted : February 29, 2012 Sponsor: ICO Paul Papin Information provided by (Responsible Party): ICO Paul Papin Study Details Study Description Go to Brief Summary: The aim of this study is to test the role of cycline in the prevention of acne-like skin rash in metastatic colorectal patients treated with Cetuximab and intensified FOLFIRI. Condition or disease Intervention/treatment Phase Colorectal Cancer Metastatic Skin Toxicity Drug: Doxycycline Drug: Cetuximab Phase 3 Detailed

2011 Clinical Trials

160. Cough (acute): antimicrobial prescribing

are viral infections. It can also be caused by acute bronchitis, a lower respiratory tract infection, which is usually a viral infection but can be bacterial. Other infective causes of cough include pneumonia, acute exacerbations of asthma, chronic obstructive pulmonary disease or bronchiectasis (which may also be non-infective exacerbations), and viral-induced wheeze, bronchiolitis, croup or whooping cough. Non-infective causes may include lung cancer, a foreign body, interstitial lung disease (...) difference in the number of people with adverse events which led to withdrawal (0.5% versus 1.0%; very low quality evidence). Based on 2 systematic reviews and meta-analyses, Wagner et al. (2015) and Timmer et al. (2013), in adults, young people or children with an acute cough or acute bronchitis. Non-ster Non-steroidal anti-inflammatory drugs (NSAIDs) oidal anti-inflammatory drugs (NSAIDs) NSAIDs (naproxen or ibuprofen) were not significantly different to placebo for a cumulative cough score at follow

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

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