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Life-Threatening Drug-Induced Rashes

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1. Life-Threatening Drug-Induced Rashes

Life-Threatening Drug-Induced Rashes Life-Threatening Drug-Induced Rashes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Life (...) -Threatening Drug-Induced Rashes Life-Threatening Drug-Induced Rashes Aka: Life-Threatening Drug-Induced Rashes , Acute Life-threatening Hypersensitivity Skin Reaction From Related Chapters II. Causes: ABCDS Mnemonic See ( ) Non-follicular s at the flexor surfaces Within 4 days of beta lactam, or exposure Associated fever, and e insidious onset with s, beta-lactam antibiotics, s, , or ACE-Inhibitor induced ( ) Presentation similar to ( form rash) presentation, but >2 weeks after exposure Anticonvulsants

2018 FP Notebook

2. Drug-Induced Hypersensitivity Syndrome: A Clinical, Radiologic, and Histologic Mimic of Lymphoma Full Text available with Trip Pro

Drug-Induced Hypersensitivity Syndrome: A Clinical, Radiologic, and Histologic Mimic of Lymphoma Drug-induced hypersensitivity syndrome (DIHS; also known as drug reaction with eosinophilia and systemic symptoms, or DRESS) is a rare, potentially life-threatening condition that typically presents 2-8 weeks after drug exposure with fever, rash, organ dysfunction, and lymphadenopathy. Here, we describe the case of an 18-year-old African American female who presented with cervical lymphadenopathy (...) , fevers, and a macular rash. A PET scan showed diffuse hypermetabolic lymphadenopathy suggestive of lymphoma, with involvement of the spleen and kidneys. The clinical history, imaging, and biopsy findings initially raised concern for a malignant process, with a differential diagnosis including classic Hodgkin's lymphoma and T-cell lymphoma. However, the morphologic and immunophenotypic features were not entirely typical for those diagnoses. The patient was ultimately diagnosed with DIHS after

2018 Case reports in hematology

3. Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies Full Text available with Trip Pro

Anticancer Drugs Induced Severe Adverse Cutaneous Drug Reactions: An Updated Review on the Risks Associated with Anticancer Targeted Therapy or Immunotherapies Cutaneous adverse drug reactions are commonly seen in patients with anticancer drug treatment. Anticancer drugs, including chemotherapy, target therapy, and recent immunotherapy causing skin reactions ranging from mild skin rash to life-threatening severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome (SJS

2018 Journal of immunology research

4. HLA Screening in Reducing the Risk of Antiepileptic Drug-induced Cutaneous Adverse Reactions

of Guangzhou Medical University Study Details Study Description Go to Brief Summary: Cutaneous adverse drug reactions (cADRs) include mild maculopapular exanthema (MPE) and severe cutaneous reactions such as hypersensitivity syndrome, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). cADRs are considered as a major public health issue because of their potentially life-threatening morbidity, especially severe cutaneous reactions. The incidence of SJS/TEN is estimated to vary from 1 (...) HLA Screening in Reducing the Risk of Antiepileptic Drug-induced Cutaneous Adverse Reactions HLA Screening in Reducing the Risk of Antiepileptic Drug-induced Cutaneous Adverse Reactions - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more

2017 Clinical Trials

5. Drug-induced Lupus

titer in Drug Induced Lupus: 95% in Drug Induced Lupus: >90% V. Prognosis Symptoms often recede with stopping causative agent Rarely life threatening VI. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Drug-induced Lupus." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Drug-induced lupus erythematosus (C0263591) Definition (NCI (...) -induced Lupus , Drug Induced Lupus , Systemic Lupus Secondary to Medication , Medication Causes of Systemic Lupus Erythematosus II. Causes More than 80 drugs associated (first described in 1945 related to sulfadiazine) (most common cause) ( ) Ethosuximide s s III. Symptoms (following causative medication use) See s Rash Serositis Hematologic abnormalities IV. Labs Screening indicated for causative medication use and symptoms suggestive of SLE (see above) ANA Titer Confirmatory testing if positive ANA

2018 FP Notebook

6. Life-Threatening Drug-Induced Rashes

Life-Threatening Drug-Induced Rashes Life-Threatening Drug-Induced Rashes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Life (...) -Threatening Drug-Induced Rashes Life-Threatening Drug-Induced Rashes Aka: Life-Threatening Drug-Induced Rashes , Acute Life-threatening Hypersensitivity Skin Reaction From Related Chapters II. Causes: ABCDS Mnemonic See ( ) Non-follicular s at the flexor surfaces Within 4 days of beta lactam, or exposure Associated fever, and e insidious onset with s, beta-lactam antibiotics, s, , or ACE-Inhibitor induced ( ) Presentation similar to ( form rash) presentation, but >2 weeks after exposure Anticonvulsants

2015 FP Notebook

7. Drug-Induced Pulmonary Toxicity (Overview)

Drug-Induced Pulmonary Toxicity (Overview) Drug-Induced Pulmonary Toxicity: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTM0MzQ1MS1vdmVydmlldw== processing (...) > Drug-Induced Pulmonary Toxicity Updated: Apr 09, 2019 Author: Klaus-Dieter Lessnau, MD, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP Share Email Print Feedback Close Sections Sections Drug-Induced Pulmonary Toxicity Overview Practice Essentials More than 600 drugs are known to cause pulmonary toxicity, and illicit drugs are well-known to result in pulmonary toxicities. To minimize the potential morbidity and mortality from drug-induced respiratory diseases, healthcare providers should

2014 eMedicine.com

8. Drug-Induced Hepatotoxicity (Overview)

Drug-Induced Hepatotoxicity (Overview) Drug-Induced Hepatotoxicity: Overview, Metabolism of Drugs, Clinical and Pathological Manifestations of Drug-Induced Liver Disease Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTY5ODE0LW92ZXJ2aWV3 processing > Drug-Induced Hepatotoxicity Updated: Dec 08, 2016 Author: Nilesh Mehta, MD; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, MCCM Share Email Print Feedback Close Sections Sections Drug-Induced Hepatotoxicity Overview Overview Background Drugs are an important cause of liver injury. More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. Approximately 75% of the idiosyncratic

2014 eMedicine.com

9. Drug-Induced Hepatotoxicity (Follow-up)

Drug-Induced Hepatotoxicity (Follow-up) Drug-Induced Hepatotoxicity: Overview, Metabolism of Drugs, Clinical and Pathological Manifestations of Drug-Induced Liver Disease Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTY5ODE0LW92ZXJ2aWV3 processing > Drug-Induced Hepatotoxicity Updated: Dec 08, 2016 Author: Nilesh Mehta, MD; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, MCCM Share Email Print Feedback Close Sections Sections Drug-Induced Hepatotoxicity Overview Overview Background Drugs are an important cause of liver injury. More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. Approximately 75% of the idiosyncratic

2014 eMedicine.com

10. Drug-Induced Hepatotoxicity (Treatment)

Drug-Induced Hepatotoxicity (Treatment) Drug-Induced Hepatotoxicity: Overview, Metabolism of Drugs, Clinical and Pathological Manifestations of Drug-Induced Liver Disease Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTY5ODE0LW92ZXJ2aWV3 processing > Drug-Induced Hepatotoxicity Updated: Dec 08, 2016 Author: Nilesh Mehta, MD; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, MCCM Share Email Print Feedback Close Sections Sections Drug-Induced Hepatotoxicity Overview Overview Background Drugs are an important cause of liver injury. More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. Approximately 75% of the idiosyncratic

2014 eMedicine.com

11. Drug-Induced Pulmonary Toxicity (Diagnosis)

Drug-Induced Pulmonary Toxicity (Diagnosis) Drug-Induced Pulmonary Toxicity: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTM0MzQ1MS1vdmVydmlldw== processing (...) > Drug-Induced Pulmonary Toxicity Updated: Apr 09, 2019 Author: Klaus-Dieter Lessnau, MD, FCCP; Chief Editor: Zab Mosenifar, MD, FACP, FCCP Share Email Print Feedback Close Sections Sections Drug-Induced Pulmonary Toxicity Overview Practice Essentials More than 600 drugs are known to cause pulmonary toxicity, and illicit drugs are well-known to result in pulmonary toxicities. To minimize the potential morbidity and mortality from drug-induced respiratory diseases, healthcare providers should

2014 eMedicine.com

12. Drug-Induced Hepatotoxicity (Diagnosis)

Drug-Induced Hepatotoxicity (Diagnosis) Drug-Induced Hepatotoxicity: Overview, Metabolism of Drugs, Clinical and Pathological Manifestations of Drug-Induced Liver Disease Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTY5ODE0LW92ZXJ2aWV3 processing > Drug-Induced Hepatotoxicity Updated: Dec 08, 2016 Author: Nilesh Mehta, MD; Chief Editor: Michael R Pinsky, MD, CM, Dr(HC), FCCP, MCCM Share Email Print Feedback Close Sections Sections Drug-Induced Hepatotoxicity Overview Overview Background Drugs are an important cause of liver injury. More than 900 drugs, toxins, and herbs have been reported to cause liver injury, and drugs account for 20-40% of all instances of fulminant hepatic failure. Approximately 75% of the idiosyncratic

2014 eMedicine.com

13. Drug-reaction eosinophilia and systemic symptoms and drug-induced hypersensitivity syndrome. (Abstract)

Drug-reaction eosinophilia and systemic symptoms and drug-induced hypersensitivity syndrome. Drug reaction with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a rare, severe cutaneous adverse reaction characterised by fever, rash, lymphadenopathy, eosinophilia and/or other leukocyte abnormalities, and internal organ involvement and often has a relapsing-remitting course despite withdrawal of the drug. The drugs that are most (...) *5701 has enabled pharmacogenetics screening to be employed successfully to minimise the occurrence of hypersensitivity. A prolonged course of oral corticosteroids is required to treat DRESS/DIHS, given the relapsing-remitting nature of the condition with i.v. immunoglobulin and valgangciclovir reserved for refractory or life-threatening cases. © 2013 The Australasian College of Dermatologists.

2013 Australasian Journal of Dermatology

14. Skin rash in the intensive care unit: Stevens-Johnson syndrome, toxic epidermal necrolysis, or a rare manifestation of a hidden cutaneous malignancy: A case report Full Text available with Trip Pro

of skin biopsy when encountering SJS and TEN in the ICU in order to identify potentially treatable/controllable causes. Although it appeared reasonable to correlate TEN solely to medications, the skin biopsies clearly demonstrated an aggressive T-cell skin lymphoma. In a patient with a better general condition it may have been helpful to treat this malignancy. TEN is a life-threatening condition and skin biopsy is the cornerstone of diagnosis, despite the presence of multiple risk factors (...) and the typical physical findings of a drug-induced reaction.

2015 Molecular and clinical oncology

15. Expression of α-defensin 1-3 in T cells from severe cutaneous drug-induced hypersensitivity reactions. (Abstract)

Expression of α-defensin 1-3 in T cells from severe cutaneous drug-induced hypersensitivity reactions. Cytotoxic T cells seem to be the main effector cells in Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). However, recent data support a role of the innate immune system in the etiopathology of drug-induced cutaneous reactions. In this study, we analyzed the expression of α-defensins 1-3 in mononuclear cells from patients with SJS/TEN, drug-induced maculopapular exanthema (MPE (...) ), and healthy donors.DEFA1A3 gene expression was analyzed by quantitative and end-point RT-PCR. Intracellular flow cytometry, immunofluorescence and immunohistochemistry were carried out to verify α-defensin 1-3 protein expression in mononuclear cells from peripheral blood and skin infiltrates. α-Defensin 1-3 concentration was evaluated in plasma and blister fluid samples by ELISA.We herein describe DEFA1A3 gene expression in peripheral blood mononuclear cells (PBMCs) from patients with drug-induced

2010 Allergy

16. Suspected neurological conditions: recognition and referral

of Suspected neurological conditions: recognition and referral (NG127) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 26 of 73people with suspected sepsis in the NICE guideline on sepsis. 1.19.3 For children with acute confusion who have a non-blanching rash or other signs or symptoms suggestive of meningococcal septicaemia, follow the recommendations on suspected meningococcal disease (meningitis with non- blanching rash

2019 National Institute for Health and Clinical Excellence - Clinical Guidelines

17. Management of Poisoning

should be consulted (pg 55). GPP D Prolonged resuscitation should be attempted in drug-induced cardiac arrest (pg 55). Grade D, Level 3 C Titrated doses of naloxone, together with bag-valve-mask ventilation, should be administered for suspected opioid-induced coma, prior to intubation for respiratory insuf? ciency (pg 56). Grade C, Level 2+ D In bradycardia due to calcium channel or beta-blocker toxicity that is refractory to conventional vasopressor therapy, intravenous calcium, glucagon or insulin (...) should be used (pg 57). Grade D, Level 3 B Patients with actual or potential life threatening cardiac arrhythmia, hyperkalaemia or rapidly progressive toxicity from digoxin poisoning should be treated with digoxin-speci? c antibodies (pg 57). Grade B, Level 2++ B Titrated doses of benzodiazepine should be given in hyperadrenergic- induced tachycardia states resulting from poisoning (pg 57). Grade B, Level 1+ D Non-selective beta-blockers, like propranolol, should be avoided in stimulant toxicity

2020 Ministry of Health, Singapore

19. Refractory extrapulmonary sarcoidosis: infliximab

and the organs involved depending on the ethnicity of the person. Treatment is not recommended for everyone because of the high rate of spontaneous remission and the risk of adverse effects. The treatment decision is usually based on symptoms, the extent of symptomatic disease, whether the sarcoidosis is acute or chronic, and the risk of life-threatening complications. First-line treatment is usually with corticosteroids such as prednisolone. T opical corticosteroid creams and eye drops may be effective (...) experienced no recurrence of symptoms during the follow-up period of 4–42 months. Infliximab was discontinued in 1 patient due to drug- induced lupus, which resolved after treatment was stopped. The other 8 patients experienced no major adverse effects. Van Rijswijk et al. 2013 Retrospective case review in the Netherlands (n=45, main indication extrapulmonary sarcoidosis in 22 patients). After receiving infliximab, 2 patients with cardiac sarcoidosis experienced an improvement in left ventricular ejection

2017 National Institute for Health and Clinical Excellence - Advice

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