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Lidocaine Patch

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121. Topical Lidocaine After Major Arthroscopic Knee Surgery

surgical treatment. The aim is to determine a possible reduction in pain after knee arthroscopy with topical lidocaine. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 21 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Double (Participant, Investigator) Primary Purpose: Treatment Official Title: Topical Lidocaine Patch Does Not Have an Analgesic Effect After Major Arthroscopic Knee Surgery (...) soft-tissue Active Comparator: Knee arthroscopic surgery Procedure: Knee arthroscopic surgery A randomized group of patients was given small patches with active 5% lidocaine. Other Name: Knee soft-tissue Outcome Measures Go to Primary Outcome Measures : Administration of analgesic drugs [ Time Frame: 24 hours ] Time for the first necessary administration of analgesic drugs. Secondary Outcome Measures : Pain management after surgical treatment [ Time Frame: 24 hours ] The intake of necessary

2011 Clinical Trials

122. Lidocaine reduces the transition to slow inactivation in Nav1.7 voltage-gated sodium channels Full Text available with Trip Pro

syndromes. Understanding the interaction of lidocaine with Na(v)1.7 channels could provide valuable insight into the drug's action in alleviating pain in distinct patient populations. The aim of this study was to determine how lidocaine interacts with multiple inactivated conformations of Na(v)1.7 channels.We investigated the interactions of lidocaine with wild-type Na(v)1.7 channels and a paroxysmal extreme pain disorder mutation (I1461T) that destabilizes fast inactivation. Whole cell patch clamp (...) Lidocaine reduces the transition to slow inactivation in Nav1.7 voltage-gated sodium channels The primary use of local anaesthetics is to prevent or relieve pain by reversibly preventing action potential propagation through the inhibition of voltage-gated sodium channels. The tetrodotoxin-sensitive voltage-gated sodium channel subtype Na(v)1.7, abundantly expressed in pain-sensing neurons, plays a crucial role in perception and transmission of painful stimuli and in inherited chronic pain

2011 British journal of pharmacology

123. Inhibition of Acid Sensing Ion Channel Currents by Lidocaine in Cultured Mouse Cortical Neurons. Full Text available with Trip Pro

processes including learning/memory, nociception, and in acidosis-mediated neuron injury. In this study, we examined the effect of lidocaine on ASICs in cultured mouse cortical neurons.ASIC currents were activated and recorded using a whole-cell patch-clamp technique in cultured mouse cortical neurons. The effects of lidocaine at different concentrations were examined. To determine whether the inhibition of lidocaine on ASIC currents is subunit specific, we examined the effect of lidocaine on homomeric (...) Inhibition of Acid Sensing Ion Channel Currents by Lidocaine in Cultured Mouse Cortical Neurons. Lidocaine is a local anesthetic that has multiple pharmacological effects including antiarrhythmia, antinociception, and neuroprotection. Acid sensing ion channels (ASICs) are proton-gated cation channels that belong to the epithelial sodium channel/degenerin superfamily. Activation of ASICs by protons results in sodium and calcium influx. ASICs have been implicated in various physiological

2011 Anesthesia and Analgesia

124. Method of Pre-treatment for Application of QUTENZA Capsaicin 8% Patch

links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Tramadol Tramadol prior to QUTENZA Drug: QUTENZA topical Other Name: capsaicin 8% patch Drug: Tramadol oral Experimental: Lidocaine Lidocaine prior to QUTENZA Drug: QUTENZA topical Other Name: capsaicin 8% patch Drug: Lidocaine topical Outcome Measures Go to Primary Outcome Measures : The proportion of subjects who tolerate QUTENZA treatment [ Time Frame: 60 minute (...) Method of Pre-treatment for Application of QUTENZA Capsaicin 8% Patch Method of Pre-treatment for Application of QUTENZA Capsaicin 8% Patch - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Method of Pre

2011 Clinical Trials

125. Comparison of cutaneous anesthetic effect of 8% lidocaine spray with lidocaine patch using current perception threshold test. Full Text available with Trip Pro

Comparison of cutaneous anesthetic effect of 8% lidocaine spray with lidocaine patch using current perception threshold test. A lidocaine patch is often used for topical anesthesia prior to venipuncture, but needs to be applied for several hours before the puncture, and the site is fixed. A metered-dose lidocaine pump spray could be used to produce cutaneous topical anesthesia. In this study, we compared the anesthesia between the spray and the patch.Thirteen healthy male volunteers received (...) three treatments of metered-dose 8% lidocaine spray, a lidocaine patch, and no application as control measurement, in a random order separated by at least 2 days. Each treatment was applied topically on the forearm. Sensory nerve fibers (Abeta, Adelta, and C fibers) were evaluated with a series of 5, 250, and 2,000 Hz stimuli using current perception threshold (CPT) before and 30 minutes after each application.Under the control condition, CPTs measured at baseline and at 30 minutes were similar

2010 Pain medicine (Malden, Mass.) Controlled trial quality: uncertain

126. Evaluation of the depth and duration of anesthesia from heated lidocaine/tetracaine (Synera) patches compared with placebo patches applied to healthy adult volunteers. (Abstract)

Evaluation of the depth and duration of anesthesia from heated lidocaine/tetracaine (Synera) patches compared with placebo patches applied to healthy adult volunteers. The heated lidocaine/tetracaine patch (Synera; ZARS Pharma, Inc, Salt Lake City, UT) is among the local topical anesthetic formulations used to prevent procedural pain. This study was conducted to determine the depth and duration of anesthesia provided by the patch and to evaluate safety and tolerability.This randomized, double (...) -blind, placebo-controlled, 2-period crossover study was conducted in healthy subjects. Subjects were randomized to receive either the heated lidocaine/tetracaine patch (active patch) in period 1 and placebo patch in period 2 or vice versa. Patches were applied for 30 mins to the volar aspect of the forearm. Pain and sensory depths were measured at baseline and at 30, 60, 90, and 150 mins after patch application. Duration of anesthesia was measured at 40, 70, 110, and 130 mins after patch application

2010 Regional Anesthesia and Pain Medicine Controlled trial quality: uncertain

127. MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Ankle Sprains

MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Ankle Sprains MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Ankle Sprains - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. MRX (...) -7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Ankle Sprains The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01198834 Recruitment Status : Completed First Posted : September 10, 2010 Last Update Posted : January 17, 2018 Sponsor: MEDRx USA, Inc. Information provided by (Responsible Party

2010 Clinical Trials

128. Study Evaluating Heated Lidocaine/Tetracaine Patch in Patients With Pain Associated With Myofascial Trigger Points

Study Evaluating Heated Lidocaine/Tetracaine Patch in Patients With Pain Associated With Myofascial Trigger Points Study Evaluating Heated Lidocaine/Tetracaine Patch in Patients With Pain Associated With Myofascial Trigger Points - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number (...) of saved studies (100). Please remove one or more studies before adding more. Study Evaluating Heated Lidocaine/Tetracaine Patch in Patients With Pain Associated With Myofascial Trigger Points The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01106989 Recruitment Status : Completed First Posted : April 20

2010 Clinical Trials

129. Study Evaluating a Heated Lidocaine and Tetracaine Topical Patch in the Treatment of Patients With Patellar Tendinopathy

Study Evaluating a Heated Lidocaine and Tetracaine Topical Patch in the Treatment of Patients With Patellar Tendinopathy Study Evaluating a Heated Lidocaine and Tetracaine Topical Patch in the Treatment of Patients With Patellar Tendinopathy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Study Evaluating a Heated Lidocaine and Tetracaine Topical Patch in the Treatment of Patients With Patellar Tendinopathy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01111773 Recruitment Status : Completed First

2010 Clinical Trials

130. MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Tendonitis and Bursitis of the Shoulder

MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Tendonitis and Bursitis of the Shoulder MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Tendonitis and Bursitis of the Shoulder - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Tendonitis and Bursitis of the Shoulder The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01161615 Recruitment Status : Completed First Posted : July 13, 2010 Last Update Posted : January 17

2010 Clinical Trials

131. Study Evaluating Heated Lidocaine/Tetracaine Topical Patch in Treatment of Patients With Shoulder Impingement Syndrome

Study Evaluating Heated Lidocaine/Tetracaine Topical Patch in Treatment of Patients With Shoulder Impingement Syndrome Study Evaluating Heated Lidocaine/Tetracaine Topical Patch in Treatment of Patients With Shoulder Impingement Syndrome - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum (...) number of saved studies (100). Please remove one or more studies before adding more. Study Evaluating Heated Lidocaine/Tetracaine Topical Patch in Treatment of Patients With Shoulder Impingement Syndrome The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01055444 Recruitment Status : Completed First

2010 Clinical Trials

132. Randomized, double-blind, placebo-controlled trial using lidocaine patch 5% in traumatic rib fractures. (Abstract)

Randomized, double-blind, placebo-controlled trial using lidocaine patch 5% in traumatic rib fractures. The lidocaine patch 5% was developed to treat postherpetic neuralgia. Anecdotal experience at our institution suggests the lidocaine patch 5% decreases narcotic usage in patients with traumatic rib fractures. This trial was developed to define the patch's efficacy.Patients with rib fractures admitted to the trauma service at our Level I trauma center were enrolled and randomized in a 1 to 1 (...) double-blind manner to receive a lidocaine patch 5% or placebo patch. Fifty-eight patients who met the inclusion criteria were enrolled from January 2007 to August 2008. Demographic and clinical information were recorded. The primary outcomes variable was total narcotic use, analyzed using the 1-tailed Mann-Whitney test. The secondary outcomes variables included non-narcotic pain medication, average pain score, pulmonary complications, and length of stay. Significance was defined based on a 1-sided

2010 Journal of the American College of Surgeons. Controlled trial quality: predicted high

135. Management of Type 2 Diabetes Mellitus

(SNRIs) are useful in treating patients with co-morbid depression. Selective Serotonin Reuptake Inhibitors (SSRIs) and trazodone are not as effective in treating painful PDN. Lidocaine 5% patches have been proven to relieve PDN pain and improve quality of life ratings. No side effects were found with the regimen of up to 3 patches worn 12 hours overnight and removed. Other agents. Among other agents, including carbamazepine (200 – 600 mg/day) and valproate (500 mg/day) have been shown to decrease PDN

2020 University of Michigan Health System

138. Opioid Treatments for Chronic Pain

) =30% improvement in pain intensity from screening 1: 64.2% (163/254) 2: 30.5% (78/256) Roland Morris Disability Questionnaire 0 to 24 Difference -1.20 (95% CI, - 2.08 to -0.31) (ANCOVA) NR Gordon, 2010 70 Canada Fair 1: 4 weeks 2: 78 3: Low back pain 1: Buprenorphine patch 10 to 30 mcg/hour (mean 30 mcg/hour) 2: Placebo VAS 0 to 100 1: 44.6 (21.4) 2: 52.4 (24.0) Moderately or highly effective 1: 39.7% (31/78) 2: 23.1% (18/78) Quebec Back Disability Scale 0 to 100, higher score=greater disability (...) , mean change (SD) 1: -19.3% (NR) 2: -11.9% (NR) NR Gordon, 2010 71 Canada Fair 1: 4 weeks 2: 79 3: Low back pain 1: Buprenorphine patch 5 to 20 mcg/hour (mean 15.5 mcg/hour) 2: Placebo VAS 0 to 100 1: 39.2 (20.5) 2: 43.9 (21.3) Moderately or highly effective 1: 30.4% (24/79) 2: 20.2% (16/79) Quebec Back Disability Scale 0 to 5, higher score=greater disability 1: 2.3 (0.9) 2: 2.4 (1.0) NR 32 Study, Year Country Quality 1: Duration of Followup 2: Total Patients Randomized 3: Pain Condition 1: Opioid 2

2020 Effective Health Care Program (AHRQ)

139. Nonopioid Pharmacologic Treatments for Chronic Pain

not improve pain severity. Evidence in patients with chronic headache or sickle cell disease was too limited to draw conclusions. Adverse events categorized as “serious” were more often not reported with nonopioid drugs than placebo in patients with chronic pain, the exception being in neuropathic pain with longer duration capsaicin patch (compared with shorter duration, moderate effect). Withdrawal due to adverse events was increased with anticonvulsants, antidepressants (both moderately), NSAIDs ES-8 (...) /no statistically significant effect), small, moderate, or large increased risk SOE: + = low, ++ = moderate, +++ = high ES-11 Table F. Effects of other drugs in placebo-controlled trials Condition Drug Pain Short Term Effect Size SOE Pain Intermediate Term Effect Size SOE Function Short Term Effect Size SOE Function Intermediate Term Effect Size SOE QoL Short Term Effect Size SOE QoL Intermediate Term Effect Size SOE Neuropathic pain Capsaicin patch None ++ No evidence No evidence No evidence No evidence

2020 Effective Health Care Program (AHRQ)

140. Consensus Practice Guidelines on Interventions for Lumbar Facet Joint Pain from a Multispecialty, International Working Group Full Text available with Trip Pro

to identify presumptive clinical features in 176 patients with chronic LBP using double, comparative LA injections or MBBs. In the 15% of patients who achieved concordant pain relief with lidocaine and bupivacaine, none of the 16 physical signs or symptoms evaluated was associated with a positive response. In a smaller prospective study Schwarzer et al conducted in 63 patients, one or more IA injections of LA produced pain relief in more patients than did injection of saline (32% vs 40%). None (...) , pain not worsened by forward flexion or rising from forward flexion and pain not exacerbated by hyperextension or extension-rotation. Patients were divided into positive (n=43) and negative (n=37) groups based on whether they had at least five of the previously identified seven criteria. Patients randomly received one block, an IA injection with 1.5 mL of lidocaine and contrast, or saline and contrast into the lowest two or three joints in double-blind fashion. A positive response was ≥75% pain

2020 American Society of Regional Anesthesia and Pain Medicine

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