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Lidocaine Patch

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101. Comparison of five commonly-available, lidocaine-containing topical anesthetics and their effect on serum levels of lidocaine and its metabolite monoethylglycinexylidide (MEGX). (PubMed)

% lidocaine; Ebsa Laboratories, Jupiter, Florida), 2.5% lidocaine/2.5% prilocaine (generic EMLA preparation; High Tech Pharmaceuticals, Amityville, New York), LET (4% lidocaine, 1:2000 epinephrine, and 0.5% tetracaine), and BLT (20% benzoncaine, 6% lidocaine, and 4% tetracaine). After a patch test for adverse reactions, the topical anesthetic was applied to each patient's face and neck and covered with an occlusive dressing for 60 minutes. Blood was drawn at 90, 120, 150, 240, and 480 minutes to measure (...) Comparison of five commonly-available, lidocaine-containing topical anesthetics and their effect on serum levels of lidocaine and its metabolite monoethylglycinexylidide (MEGX). Topical anesthetics are commonly applied for a variety of indications. Several lidocaine-containing topical anesthetics are available for purchase over the counter (OTC). Recently, the authors' group has shown that there is great interindividual discrepancy in the manner in which lidocaine is absorbed and metabolized

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2012 Aesthetic surgery journal / the American Society for Aesthetic Plastic surgery

102. Mechanisms of Lidocaine's Action on Subtypes of Spinal Dorsal Horn Neurons Subject to the Diverse Roles of Na+ and K+ Channels in Action Potential Generation. (PubMed)

are exposed to different concentrations of the local anesthetic lidocaine. In this study, we explored its effect on the excitability of sensory neurons.Whole-cell patch-clamp recordings from dorsal horn neurons of Wistar rats were used to study the action of lidocaine on firing properties. To estimate the impact of a blockade of voltage-gated potassium channels by lidocaine (100 μM) on the firing properties of different neurons, the sodium and potassium channel inhibition of lidocaine was investigated (...) Mechanisms of Lidocaine's Action on Subtypes of Spinal Dorsal Horn Neurons Subject to the Diverse Roles of Na+ and K+ Channels in Action Potential Generation. Superficial dorsal horn neurons of the spinal cord receive sensory information from Aδ and C fibers. According to their response to sustained depolarization, these cells can be divided into 3 groups: tonic (TFN), adapting (AFN), and single spike firing (SSN) neurons. During spinal and systemic administration of lidocaine, these neurons

2014 Anesthesia and Analgesia

103. Lidocaine Contact Allergy Is Becoming More Prevalent. (PubMed)

of 1,819 patients who underwent patch testing at the University of British Columbia Contact Dermatitis Clinic between January 2009 and June 2013 was completed. The authors also performed a detailed review of Canadian OTC preparations containing lidocaine in 2013.The prevalence of ACD to local anesthetics is significant at 2.4%. The most common allergen is benzocaine (45%) followed by lidocaine (32%) and dibucaine (23%).The proportion of ACD caused by lidocaine is higher than expected. This is likely (...) secondary to an increase in OTC medicaments containing lidocaine. Patients who are patch test-positive to a local anesthetic should be challenged intradermally to confirm clinical relevance. Because ACD is a delayed Type IV hypersensitivity reaction (localized dermatitis), the risk of anaphylaxis is not a concern.

2014 Dermatologic Surgery

104. Allergy to lidocaine injections: comparison of patient history with skin testing in five patients (PubMed)

Allergy to lidocaine injections: comparison of patient history with skin testing in five patients True allergy to local anesthetics, especially lidocaine, is uncommon. Most adverse reactions to this group of medications are classified as psychomotor, autonomic or toxic. In the case of suspected hypersensitivity to local anesthetics, skin testing is considered to be a useful tool - patch tests and intradermal tests for delayed hypersensitivity and skin prick tests and intradermal tests (...) for immediate reactions. There is a particular need for such a diagnostic procedure, as patients suspected of hypersensitivity to local anesthetic drugs are frequently admitted.To highlight the problem of hypersensitivity to local anesthetics on the basis of authors' own experience and literature data.We present cases of 5 patients referred to the clinic by their dentists with a suspicion of allergy to local anesthetics, four to lidocaine and 1 to articaine.Intradermal tests were positive in 1 out of 5

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2014 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

105. Therapeutic Epidural Patch Versus Pain Block in the Midface for Headache

Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: A Comparison of the Efficacy of Sphenopalatine Ganglion (SPG) Block With 5% Lidocaine Versus Epidural Blood Patch (EBP) for the Treatment of Post-Dural Puncture Headache (PDPH) Study Start Date : September 2016 Estimated Primary Completion Date : July 2021 Estimated Study Completion Date : July 2021 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm (...) consent/assent Exclusion Criteria: <13 years of age Pregnancy Subjects with heart failure Subjects already being treated with lidocaine patch or other vehicle for chronic pain Non-english speaking subjects Subjects with platelets <100,000 Subjects that are septic Subjects with an allergy to lidocaine Subjects with known nasal polyps Subjects with recent neurological event Subjects on anticoagulant therapy Subjects that received prior therapy with SPG block or EBP Contacts and Locations Go

2014 Clinical Trials

106. Study of Capsaicin Patch for the Management of Peripheral Neuropathic Pain

inappropriate to participate in the study painful PHN areas located on the face or above the scalp hairline an implanted medical device for the treatment of neuropathic pain use of topically applied agents including capsaicin-containing products, a 5% lidocaine patch or similar products, local anesthetics, or steroids within the past 21 days hypersensitivity known to capsaicin; current use of any class 1 anti-arrhythmic drug; and uncontrolled diabetes mellitus or uncontrolled hypertension If patients have (...) Study of Capsaicin Patch for the Management of Peripheral Neuropathic Pain Study of Capsaicin Patch for the Management of Peripheral Neuropathic Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Study

2014 Clinical Trials

107. [Topical anesthesia before vascular access in children. Comparison of a warmth-producing lidocaine-tetracaine patch with a lidocaine-prilocaine patch]. (PubMed)

[Topical anesthesia before vascular access in children. Comparison of a warmth-producing lidocaine-tetracaine patch with a lidocaine-prilocaine patch]. Venepuncture is one of the most stressful situations for children during induction of general anesthesia. Therefore, many clinicians use a local anesthesia patch (EMLA) containing a mixture of lidocaine and prilocaine in order to reduce the stress for pediatric patients. This study compared the effect of a new heated topical anesthesia delivery (...) system containing lidocaine and tetracaine (Rapydan) with the lidocaine/prilocaine patch EMLA.The study design was prospective, randomized, single-blinded and monocenter. A total of 200 children aged from 3 to 13 years were randomized into group E (EMLA) or group R (Rapydan). The primary endpoint of the study was the overall incidence of pain. Additionally, the intensity of pain during venous puncture was evaluated by means of an investigator-based 4 point pain score: 0 no reaction, 1 gentle movement

2010 Der Anaesthesist

108. Efficacy Of Clodronate 200 Mg/4 Ml I.M. Solution With 1% Lidocaine Every Other Week Vs Clodronate 100 Mg/3,3ml I.M. Solution With 1% Lidocaine Once-Week In A 1-Year Treatment Period Of Women With Postmenopausal Osteoporosis

Efficacy Of Clodronate 200 Mg/4 Ml I.M. Solution With 1% Lidocaine Every Other Week Vs Clodronate 100 Mg/3,3ml I.M. Solution With 1% Lidocaine Once-Week In A 1-Year Treatment Period Of Women With Postmenopausal Osteoporosis Efficacy Of Clodronate 200 Mg/4 Ml I.M. Solution With 1% Lidocaine Every Other Week Vs Clodronate 100 Mg/3,3ml I.M. Solution With 1% Lidocaine Once-Week In A 1-Year Treatment Period Of Women With Postmenopausal Osteoporosis - Full Text View - ClinicalTrials.gov Hide glossary (...) Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy Of Clodronate 200 Mg/4 Ml I.M. Solution With 1% Lidocaine Every Other Week Vs Clodronate 100 Mg/3,3ml I.M. Solution With 1% Lidocaine Once-Week In A 1-Year Treatment Period Of Women With Postmenopausal

2011 Clinical Trials

109. Comparison of cutaneous anesthetic effect of 8% lidocaine spray with lidocaine patch using current perception threshold test. (PubMed)

Comparison of cutaneous anesthetic effect of 8% lidocaine spray with lidocaine patch using current perception threshold test. A lidocaine patch is often used for topical anesthesia prior to venipuncture, but needs to be applied for several hours before the puncture, and the site is fixed. A metered-dose lidocaine pump spray could be used to produce cutaneous topical anesthesia. In this study, we compared the anesthesia between the spray and the patch.Thirteen healthy male volunteers received (...) three treatments of metered-dose 8% lidocaine spray, a lidocaine patch, and no application as control measurement, in a random order separated by at least 2 days. Each treatment was applied topically on the forearm. Sensory nerve fibers (Abeta, Adelta, and C fibers) were evaluated with a series of 5, 250, and 2,000 Hz stimuli using current perception threshold (CPT) before and 30 minutes after each application.Under the control condition, CPTs measured at baseline and at 30 minutes were similar

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2010 Pain medicine (Malden, Mass.)

110. Evaluation of the depth and duration of anesthesia from heated lidocaine/tetracaine (Synera) patches compared with placebo patches applied to healthy adult volunteers. (PubMed)

Evaluation of the depth and duration of anesthesia from heated lidocaine/tetracaine (Synera) patches compared with placebo patches applied to healthy adult volunteers. The heated lidocaine/tetracaine patch (Synera; ZARS Pharma, Inc, Salt Lake City, UT) is among the local topical anesthetic formulations used to prevent procedural pain. This study was conducted to determine the depth and duration of anesthesia provided by the patch and to evaluate safety and tolerability.This randomized, double (...) -blind, placebo-controlled, 2-period crossover study was conducted in healthy subjects. Subjects were randomized to receive either the heated lidocaine/tetracaine patch (active patch) in period 1 and placebo patch in period 2 or vice versa. Patches were applied for 30 mins to the volar aspect of the forearm. Pain and sensory depths were measured at baseline and at 30, 60, 90, and 150 mins after patch application. Duration of anesthesia was measured at 40, 70, 110, and 130 mins after patch application

2010 Regional Anesthesia and Pain Medicine

111. Mechanism- and experience-based strategies to optimize treatment response to the capsaicin 8% cutaneous patch in patients with localized neuropathic pain. (PubMed)

, efficacy was maintained. Response rates in patients with or without lidocaine pretreatment were comparable. Treatment with the capsaicin 8% cutaneous patch was generally safe and well tolerated. The workshop panel recommended further investigation of opportunities to improve the application procedure and to perform studies on the skin penetration and distribution of capsaicin. A modified quantitative sensory testing (QST) should be developed for clinical practice in order to better understand (...) Mechanism- and experience-based strategies to optimize treatment response to the capsaicin 8% cutaneous patch in patients with localized neuropathic pain. The capsaicin 8% cutaneous patch is an emergent new treatment option for patients with peripheral neuropathic pain. In randomized controlled clinical studies relevant pain relief for 12 weeks was achieved in about one third of patients following a single application. The first part of this paper is a review of the pathophysiology

2013 Current medical research and opinion

112. Trends in patch-test results and allergen changes in the standard series: A Mayo Clinic 5-year retrospective review (January 1, 2006, to December 31, 2010). (PubMed)

-nitropropane-1,3-diol, 0.25%; and lidocaine, 5%. Many final patch-test readings for many allergens were categorized as mild reactions (erythema only). Overall allergenicity and irritancy rates declined significantly since our prior report. Results were generally comparable with those in a North American Contact Dermatitis Group report from 2005 to 2006.This was a retrospective study; there is a lack of long-term follow-up.Since our previous report, our standard series composition has changed, and overall (...) Trends in patch-test results and allergen changes in the standard series: A Mayo Clinic 5-year retrospective review (January 1, 2006, to December 31, 2010). Patch testing is essential for identification of culprits causing allergic contact dermatitis.We sought to identify trends and allergen changes in our standard series during 2006 to 2010, compared with our previous report (2001-2005).We conducted a retrospective review of patch-test results.A total of 3115 patients were tested with a mean

2013 Journal of American Academy of Dermatology

113. A new method of topical anesthesia by using anesthetic solution in a patch. (PubMed)

A new method of topical anesthesia by using anesthetic solution in a patch. We investigated the effects of topical anesthesia of the oral mucosa by using an adhesive patch instilled with 2% lidocaine hydrochloride solution.The subjects were 20 healthy adult volunteers who gave written informed consent. Each patient was treated in a randomized crossover fashion with a hemostatic adhesive patch instilled with one of the following agents: 2% lidocaine hydrochloride with 12.5 μg/mL epinephrine, 2 (...) % lidocaine hydrochloride, 20% ethyl aminobenzoate, or physiological saline solution. A cotton ball containing 20% ethyl aminobenzoate was also tested. The adhesive patch or cotton ball was placed on the gingivobuccal fold of the maxillary right canine for 2 or 5 minutes. Then, a 33-gauge or 30-gauge needle was inserted to a depth of 2 mm. Insertion pain was evaluated with a visual analog scale (VAS) and a 4-level verbal rating scale immediately after needle removal. Efficacy of analgesia was calculated

2013 Journal of Endodontics

114. A novel approach to identify responder subgroups and predictors of response to low- and high-dose capsaicin patches in postherpetic neuralgia. (PubMed)

A novel approach to identify responder subgroups and predictors of response to low- and high-dose capsaicin patches in postherpetic neuralgia. Treatment of chronic pain conditions is commonly assessed at specific endpoints at preset times during or after treatment by analysis of the total study population. An alternative approach is the identification of specific patient subgroups characterized by differential response patterns in their analgesic response and to determine the presence (...) detected with different treatment efficacies, including a group of non-responders, a group showing partial analgesic effect and a group showing full analgesic effect. Active control and Qutenza had similar response profiles, but the proportional distribution of patients among the five response groups was in favour of Qutenza, with 40% less non-responders and 25% more patients showing a full analgesic response. For Qutenza, important predictors of efficacy were efficacy of lidocaine pretreatment

2013 European Journal of Pain

115. Study of Use of Synera for Pain During Local Skin Infiltration With Lidocaine Before Epidural Placement

, 2013 Last Update Posted : May 14, 2015 Sponsor: Northwell Health Information provided by (Responsible Party): Northwell Health Study Details Study Description Go to Brief Summary: Local infiltration with lidocaine prior to epidural placement for cesarean section, although brief, can be painful. This pain can lead to increased anxiety and distress, adversely affecting patient's overall experience. This study proposes to examine the application of Synera pain patch prior to lidocaine infiltration (...) to reduce this pain and anxiety. The primary objective of this study is to determine the effect of the Synera on maternal experience during epidural placement. The efficacy of Synera pain patch in reducing subject pain during skin infiltration with lidocaine prior to epidural placement in subjects presenting for scheduled cesarean section will be assessed. Condition or disease Intervention/treatment Phase Pain Anxiety Drug: Synera Phase 4 Study Design Go to Layout table for study information Study Type

2012 Clinical Trials

116. Lidocaine

website in a new browser window. Related Studies (from Trip Database) Cost: Medications lidocaine (on 5/17/2017 at ) LIDOCAINE 2% VISCOUS SOLN Generic $0.07 per ml LIDOCAINE 3% CREAM Generic $1.26 per gram LIDOCAINE 4% CREAM Generic OTC $0.91 per gram LIDOCAINE 5% OINTMENT Generic $1.37 per gram LIDOCAINE 5% PATCH Generic $3.04 each LIDOCAINE ANORECTAL 5% CREAM Generic OTC $1.28 per gram LIDOCAINE HCL 1% VIAL Generic $0.06 per ml LIDOCAINE HCL 2% JELLY Generic $0.82 per ml LIDOCAINE HCL 2% VIAL (...) Lidocaine Lidocaine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Lidocaine Lidocaine Aka: Lidocaine From Related Chapters II

2015 FP Notebook

117. In Children, Does Using a Synera Patch Decrease Pain When Injecting Propofol at Anesthesia Induction?

of Texas Health Science Center, Houston. Recruitment status was: Recruiting First Posted : April 12, 2012 Last Update Posted : April 12, 2012 Sponsor: The University of Texas Health Science Center, Houston Collaborator: ZARS Pharma Inc. Information provided by (Responsible Party): Samia Khalil, The University of Texas Health Science Center, Houston Study Details Study Description Go to Brief Summary: The purpose of this study is to evaluate if the Synera Patch (lidocaine/tetracaine patch), used to numb (...) the skin before IV placement, is effective in reducing pain associated with propofol IV administration when inducing general anesthesia, compared to Gebauer's Ethyl Chloride topical anesthetic skin refrigerant. Condition or disease Intervention/treatment Phase Pain on Propofol IV Injection Device: lidocaine/tetracaine transdermal patch (NDC 43469-864-01) Drug: Gebauer's Ethyl Chloride Phase 4 Detailed Description: Commonly, anesthesiologists inject Propofol, a sleeping medication, intravenously

2012 Clinical Trials

118. Pain Patch Versus Injections in the Treatment of Pain Associated With Shoulder Impingement Syndrome

: Synera® (lidocaine 70 mg and tetracaine 70 mg) topical patch Drug: Triamcinolone Acetonide Phase 2 Detailed Description: Subjects will receive either a subacromial injection at baseline or will be issued Synera patches to use daily for 2 weeks and then PRN for an additional 2 weeks. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 60 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: None (Open (...) Label) Primary Purpose: Treatment Official Title: Heated Lidocaine Patch Compared to Subacromial Injections in the Treatment of Pain Associated With Shoulder Impingement Syndrome, A Pilot Study Start Date : March 2012 Estimated Primary Completion Date : January 2014 Estimated Study Completion Date : March 2014 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Patch Patch will be applied directly

2012 Clinical Trials

119. Study to Evaluate the Efficacy of the Synera Patch Compared to Naproxen Sodium for Epicondylitis of the Elbow

Study to Evaluate the Efficacy of the Synera Patch Compared to Naproxen Sodium for Epicondylitis of the Elbow Study to Evaluate the Efficacy of the Synera Patch Compared to Naproxen Sodium for Epicondylitis of the Elbow - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Study to Evaluate the Efficacy of the Synera Patch Compared to Naproxen Sodium for Epicondylitis of the Elbow The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01525043 Recruitment Status : Completed First Posted : February 2, 2012 Last

2012 Clinical Trials

120. Safety & Efficacy Study of MRX-7EAT Patch in the Treatment of Pain of the Shoulder

by (Responsible Party): MEDRx USA, Inc. Study Details Study Description Go to Brief Summary: A Randomized, Multi-Center, Double-Blind, Placebo-Controlled Phase III Trial to Evaluate the Efficacy, Tolerability and Safety of MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Pain due to Recent Onset Supraspinatous and/or Subacromial Tendonitis/Bursitis and/or Subdeltoid Bursitis of the Shoulder. Condition or disease Intervention/treatment Phase Bursitis Tendonitis Shoulder Pain Drug: MRX-7EAT Phase 3 (...) to a nerve entrapment syndrome or other medical problem that in the investigator's opinion may interfere with pain measurement of the target joint. Subject has active skin lesions or disease at the intended site of study medication application, which may be covered by the patch. Skin lesions include open wounds, rash, papules and vesicles; abrasions, lacerations or any break in skin. Subject has a history of allergy to etodolac, other NSAIDs, lidocaine or adhesives (e.g., adhesive tape). Subject

2012 Clinical Trials

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