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Lidocaine Patch

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741. Local anaesthetics block hyperpolarization-activated inward current in rat small dorsal root ganglion neurones Full Text available with Trip Pro

Local anaesthetics block hyperpolarization-activated inward current in rat small dorsal root ganglion neurones (1) Hyperpolarizing voltage steps evoke slowly activating inward currents in a variety of neurones and in cardiac cells. This hyperpolarization-activated inward current (I(h)) is thought to play a significant role in cell excitability, firing frequency, or in setting of the resting membrane potential in these cells. We studied the effects of lidocaine, mepivacaine, QX-314 (...) and bupivacaine as well as its enantiomers on I(h) in the membrane of dorsal root ganglion neurones (DRG). (2) The patch-clamp technique was applied to small dorsal root ganglion neurones identified in 200 micro M thin slices of young rat DRGs. Under voltage-clamp conditions, the whole-cell I(h) current was recorded in the presence of different concentrations of the local anaesthetics. In current-clamp mode the resting membrane potential and the voltage response of DRG neurones to injected current pulses were

2003 British journal of pharmacology

742. Is there any evidence to suggest which analgesic patch would be the most appropriate to use for a patient with uncontrolled chronic pain who also suffers from Fibrosing Alveolitis?.

are receiving Durogesic DTrans and CYP3A4 inhibitors should be monitored for signs of respiratory depression and dosage adjustments should be made if warranted.” [1] In addition, we located one study evaluating the use of lidocaine 5% patch (a 2-week pilot study) and one assessing a topical diclofenac patch in patients with OA. In brief, the authors report: Gammaitoni AR, Galer BS and Onawola R et al. Lidocaine patch 5% and its positive impact on pain qualities in osteoarthritis: results of a pilot 2-week (...) , open-label study using the Neuropathic Pain Scale. Curr Med Res Opin. 2004;20 Suppl 2:S13-9. ( ) “ CONCLUSIONS: In patients with moderate-to-severe OA of the knee, 2 weeks of treatment with the lidocaine patch 5% significantly reduces the intensity of pain qualities as measured by all 4 NPS composite measures. Our results coincide with previously reported improvements in pain and physical function in the same patient population, as measured by the Western Ontario and McMaster Universities OA Index

2008 TRIP Answers

743. Changes in properties of substantia gelatinosa neurons after surgical incision in the rat: in vivo patch-clamp analysis. (Abstract)

Changes in properties of substantia gelatinosa neurons after surgical incision in the rat: in vivo patch-clamp analysis. Noxious information through A delta and C afferent fibers is transmitted to substantia gelatinosa, a process that plays an important role in plastic changes of nociceptive processing in pathophysiological conditions. In this study, changes in properties of substantia gelatinosa neurons and their sensitivity to systemic administration of lidocaine after surgical incision were (...) investigated using the in vivo patch-clamp technique.Under urethane anesthesia, in the current clamp mode, spontaneous activities and responses of substantia gelatinosa neurons to nonnoxious air-puff stimuli and noxious pinch stimuli were recorded before and after 1-cm-long incisions had been made in hairy skin of the hindquarters of rats. Systemic administration of lidocaine (2 mg/kg) was applied at 30 min after the incision.Stable recordings for 30 min or more after the incision were obtained from 18

2006 Anesthesiology

744. Management of complex regional pain syndrome type II using lidoderm 5% patches. Full Text available with Trip Pro

Management of complex regional pain syndrome type II using lidoderm 5% patches. We report a case of a patient developing complex regional pain syndrome of the upper limb after a laceration injury with glass. The pain in his hand was resistant to all conventional modes of treatment. The pain reduced dramatically after a diagnostic lidocaine infusion and the reduction in pain lasted for 3 days. Following this the patient responded well to lidoderm 5% patches and achieved 80% pain relief

2007 British Journal of Anaesthesia

745. The Efficacy of EMLA Cream vs. Synera Patch for Pain Reduction During Venipuncture in Children

: Venipunctures are common and necessary components of pediatric health care. Unfortunately, many children have "needle phobia" and even a simple procedure, such as a venipuncture, can cause significant stress and anxiety to the patient and the parents involved. Studies have shown that needles are the worst part of hospital/healthcare related visits for children. The Synera patch uses a controlled heating system to transcutaneously deliver a lidocaine/tetracaine mixture for analgesic effect. No published (...) to the venipuncture site 1 hour before the procedure. Dosage based on age and weight: 4-6 years old and heavier than 10kg will receive 10g of EMLA; 7-12 years old and more than 20kg will receive 20g of EMLA. Drug: EMLA Cream 60 minutes x1 Other Name: Lidocaine/prilocaine cream Active Comparator: Synera Patch Participants will have a Synera Patch applied to the venipuncture site 20 minutes prior to the procedure. Combination Product: Synera Patch 20 minutes x1 Other Name: Lidocaine/tetracaine patch Outcome

2007 Clinical Trials

746. Efficacy and Safety of the Lidoderm Patch Applied to Patients With Osteoarthritis of the Knee

/treatment Phase Osteoarthritis of the Knee Drug: Lidoderm (Lidocaine 5% Patch) Drug: Placebo Patch Phase 2 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 169 participants Allocation: Randomized Intervention Model: Crossover Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Treatment Official Title: Efficacy and Safety of the Lidocaine 5% Patch When Used as Adjunct Treatment in Patients (...) With Osteoarthritis of the Knee Receiving Sub-Optimal Pain Relief From Their Current Analgesic Regimen Study Start Date : March 2007 Actual Primary Completion Date : June 2008 Actual Study Completion Date : October 2008 Resource links provided by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Lidoderm (Lidocaine 5% Patch) Lidoderm (lidocaine 5% patch) 10cm X 14cm patches each on the front and back of the index

2007 Clinical Trials

747. Use of the Synera patch for local anesthesia before vascular access procedures: a randomized, double-blind, placebo-controlled study. Full Text available with Trip Pro

Use of the Synera patch for local anesthesia before vascular access procedures: a randomized, double-blind, placebo-controlled study. This randomized, double-blind, placebo-controlled, paired study compared the Synera patch, a drug delivery device comprised of an eutectic mixture of lidocaine (70 mg) and tetracaine (70 mg) whose onset is accelerated by a controlled heating device, with placebo. The objective of the study was to evaluate the efficacy of Synera in inducing local anesthesia before

2007 Pain medicine (Malden, Mass.) Controlled trial quality: uncertain

748. A randomized controlled trial to evaluate S-Caine patch for reducing pain associated with vascular access in children. (Abstract)

A randomized controlled trial to evaluate S-Caine patch for reducing pain associated with vascular access in children. A randomized, double-blinded trial was performed to evaluate the efficacy and safety of the S-Caine Patch (ZARS, Inc., Salt Lake City, UT), a eutectic mixture of lidocaine and tetracaine, for pain relief during venipuncture in children.With institutional review board approval, parental consent, and patient assent, 64 children who were scheduled for medically indicated vascular (...) access at two centers were randomly assigned (2:1) to receive either an S-Caine Patch or a placebo patch for 20 min before venipuncture procedures. The primary outcome measure was the child's rating of pain during venipuncture using the Oucher pain scale. Additional measures of efficacy included the blinded investigator's and an independent observer's four-point categorical scores. Variables were compared between treatments using Mantel-Haenszel summary chi-square tests or Pearson chi-square

2005 Anesthesiology Controlled trial quality: predicted high

749. Lidocaine increases intracellular sodium concentration through voltage-dependent sodium channels in an identified lymnaea neuron. (Abstract)

to determine whether lidocaine changes [Na]i and membrane potential and whether INa is related to these changes.Intracellular recording and sodium imaging were used simultaneously to measure membrane potentials and [Na]i, respectively. Measurements for [Na]i were made in normal, high-Na, and Na-free salines, with membrane hyperpolarization, and with tetrodotoxin pretreatment trials. Furthermore, changes of INa were measured by whole cell patch clamp configuration.Lidocaine increased [Na]i in a dose (...) -dependent manner concurrent with a depolarization of the membrane potential. In the presence of high-Na saline, [Na]i increased and the membrane potential was depolarized; the addition of lidocaine further increased [Na]i, and the membrane potential was further depolarized. In Na-free saline or in the presence of tetrodotoxin, lidocaine did not change [Na]i. Similarly, hyperpolarization of the membrane by current injections also prevented the lidocaine-induced increase of [Na]i. In the patch clamp

2004 Anesthesiology

750. JMF2-1, a lidocaine derivative acting on airways spasm and lung allergic inflammation in rats. (Abstract)

JMF2-1, a lidocaine derivative acting on airways spasm and lung allergic inflammation in rats. Prior reports show that nebulized lidocaine might be an effective treatment for asthma.We sought to determine the anti-inflammatory and spasmolytic effects of lidocaine and its analogue, JMF2-1, which we have synthesized for reduced local anesthetic activity.Blockade of Na(+) currents was assayed in cultured GH(3) cells by using the patch-clamp technique, whereas anesthesia was assessed in a cutaneous (...) pinching test in rats. Lidocaine and its analogue were nebulized into sensitized rats for evaluation of their effectiveness on airways spasm and inflammation induced by methacholine and allergen, respectively. Tissue histamine release and tracheal spasm triggered by allergen challenge in the absence and presence of these treatments were also examined in vitro.The 50% inhibitory concentration values for blockade of Na(+) currents after treatment with JMF2-1 (25.4 mM) was remarkably higher than

2007 Journal of Allergy and Clinical Immunology

751. Trial of Analgesia With Lidocaine or Extended-release Oxycodone for Neuropathic Pain Treatment in Multiple Sclerosis

with multiple sclerosis (MS). If treatment with topical lidocaine is efficacious, it will have important implications for understanding this chronic pain syndrome, which is widely assumed to be caused by central nervous system pathology. Condition or disease Intervention/treatment Phase Neuropathic Pain Chronic Pain Multiple Sclerosis Drug: Lidocaine patch 5% Drug: Extended-release oxycodone Drug: Placebo extended-release oxycodone pills Drug: Placebo lidocaine patches Phase 4 Detailed Description (...) : This study is a single-center, double-blind, 15-week, 3-period crossover clinical trial. Subjects will complete each of the following 5-week long periods (unless they withdraw from the trial): 1) placebo pills and topical lidocaine patches, 2)extended-release oxycodone pills and placebo(vehicle) patches, and 3)placebo pills and placebo patches. Sixty subjects will be randomized to one of 6 treatment sequences. It is expected that this trial will take approximately 2 years to complete. Study Design Go

2006 Clinical Trials

752. Topical lidocaine for the treatment of postherpetic neuralgia. (Abstract)

of all identified trials.Randomised or quasi-randomised trials comparing all topical applications of lidocaine, including gels and patches in patients of all ages with postherpetic neuralgia (pain persisting at the site of shingles at least one month after the onset of the acute rash).Two review authors extracted data, and a third checked them. We obtained some missing data from the US Food and Drugs Administration.Three trials involving 182 topical lidocaine treated participants and 132 control (...) participants were included. Two trials gave data on pain relief, and the remaining study provided data on secondary outcome measures. The largest trial published as an abstract compared topical lidocaine patch to a placebo patch and accounted for 150 of the 314 patients (48%).A meta-analysis combining two of the three studies identified a significant difference between the topical lidocaine and control groups for the primary outcome measure: a mean improvement in pain relief according to a pain relief

2007 Cochrane database of systematic reviews (Online)

753. A comparison of mepivacaine versus lidocaine for episcleral (sub-tenon's) block for cataract surgery in an ambulatory setting. (Abstract)

A comparison of mepivacaine versus lidocaine for episcleral (sub-tenon's) block for cataract surgery in an ambulatory setting. For eye surgery, motor block is still often requested by the surgeon. For cataract surgery, rapid block resolution allows eyelids to move and allows eye-patch removal. Therefore, short-duration block is useful in early rehabilitation for ambulatory surgery. Lidocaine is classically assumed to have shorter duration than mepivacaine. Therefore, lidocaine alone might (...) be considered as an alternative to mepivacaine.In this randomized, double-blind study, we compared mepivacaine 2% (n = 22) and lidocaine 2% (n = 25) in 47 patients who received episcleral (sub-Tenon's) block for cataract surgery. Akinesia score was measured 1, 5, 10, and 15 minutes and 1, 2, 4, and 6 hours after the end of injection. Primary outcome was block duration (time from injection to full recovery). Secondary outcomes were time to block onset and best akinesia score for each patient. Complications

2006 Regional Anesthesia and Pain Medicine Controlled trial quality: predicted high

754. Lidocaine-Induced Brugada Syndrome Phenotype Linked to a Novel Double Mutation in the Cardiac Sodium Channel. Full Text available with Trip Pro

characterized a novel double mutation of SCN5A (V232I in DI-S4+L1308F in DIII-S4) identified in a rare case of lidocaine (1 mg/kg)-induced Brugada syndrome. We studied lidocaine blockade of I(Na) generated by wild-type and V232I+L1308F mutant cardiac sodium channels expressed in mammalian TSA201 cells using patch clamp techniques. Despite no significant difference in steady-state gating parameters between V232I+L1308F and wild-type sodium currents at baseline, use-dependent inhibition of I(Na) by lidocaine (...) Lidocaine-Induced Brugada Syndrome Phenotype Linked to a Novel Double Mutation in the Cardiac Sodium Channel. Brugada syndrome has been linked to mutations in SCN5A. Agents that dissociate slowly from the sodium channel such as flecainide and ajmaline unmask the Brugada syndrome electrocardiogram and precipitate ventricular tachycardia/fibrillation. Lidocaine, an agent with rapid dissociation kinetics, has previously been shown to exert no effect in patients with Brugada syndrome. We

2008 Circulation Research

755. Insufficient evidence to recommend topical lidocaine as first-line treatment for postherpetic neuralgia. Full Text available with Trip Pro

and previous systematic reviews. Authors of all identified trials were contacted.Studies of interest were randomised controlled trials (RCT) or quasi-RCT comparing all topical applications of lidocaine, including gels and patches in people of all ages suffering from postherpetic neuralgia (PHN; pain persisting at the site of shingles at least 1 month after the onset of the acute rash).Data were extracted independently by two authors with disputes resolved by a third reviewer. A meta-analysis was conducted (...) using a fixed-effect approach.Three trials were included, giving a total of 182 individuals who used topical lidocaine and 132 controls. Two trials provided data on pain relief, and the remaining study provided data on secondary outcome measures. The largest trial published as an abstract compared a topical lidocaine patch to a placebo patch and accounted for 150 of the 314 patients (48%). A meta-analysis combining two of the three studies identified a significant difference between the topical

2007 Evidence Based Dentistry

756. Brief report: a randomized controlled trial of Synera versus lidocaine for epidural needle insertion in labouring parturients. Full Text available with Trip Pro

Brief report: a randomized controlled trial of Synera versus lidocaine for epidural needle insertion in labouring parturients. Skin infiltration with lidocaine, although brief, can be very stressful, painful, and may perpetuate anxiety. Synerat, a local anesthetic patch, which contains an oxygen-activated heating component to enhance the delivery of a eutectic mixture of lidocaine (70 mg) and tetracaine (70 mg), has provided analgesia for minor, dermatological procedures. We hypothesized (...) that the analgesic effect of Synera, for pain in labouring parturients, would be superior to the traditional infiltration of lidocaine prior to epidural needle insertion.With Institutional Review Board approval, we recruited women, who consented to epidural labour analgesia and who met the following criteria: older than 18 yr; body mass index less than 45 kg x m(-2); and with no history of hypersensitivity to any study medications. We randomized the labouring parturients into Synera (SS) or placebo (PL) groups

2008 Canadian journal of anaesthesia = Journal canadien d'anesthesie Controlled trial quality: uncertain

757. Postherpetic neuralgia: topical lidocaine is effective in nociceptor-deprived skin. (Abstract)

prospectively in 18 PHN patients. A controlled study using cutaneous lidocaine (lidocaine 5% patch, IBSA) followed.Six patients (group I, sensitised nociceptors) had no sensory loss. Heat pain thresholds were equal or lower than on the contralateral side. Histamine-induced flare and axon reflex vasodilatation were not different on both sides. Histamine evoked pain increased. In 12 patients (group II, nociceptor impairment) heat pain thresholds were higher than contralateral. Histamine-induced flare (...) Postherpetic neuralgia: topical lidocaine is effective in nociceptor-deprived skin. Topical lidocaine is effective in postherpetic neuralgia (PHN). The aim of the present investigation was to classify patients according to their predominant peripheral nociceptor function and to compare these data with the results of a controlled study using dermal lidocaine patch.Within the skin area of maximal pain QST (thermotest) and QCART (histamine iontophoresis and laser Doppler flowmetry) were performed

2005 Journal of neurology Controlled trial quality: uncertain

758. Effectiveness of a transmucosal lidocaine delivery system for local anaesthesia during scaling and root planing. (Abstract)

Effectiveness of a transmucosal lidocaine delivery system for local anaesthesia during scaling and root planing. This study compared the efficacy of transmucosal anaesthetic patches containing lidocaine (46.1 mg/2 cm(2)) to placebo for local anaesthesia during quadrant scaling and root planing using periodontal clinical indices and patient perception of pain.Forty healthy adults with moderate periodontal disease and moderate subgingival calculus were scaled at weekly intervals, two quadrants (...) analogue scales demonstrated significantly greater pain relief with the treatment patches after 15 min. (p=0.0003) and at the end of treatment (p=0.0149). Efficacy of periodontal therapy was equivalent for treatment and control groups. No adverse events were observed; localized minimal gingival irritation was noted in three subjects.Transmucosal lidocaine patches provided sufficient anaesthesia for therapeutic quadrant scaling and root planing procedures.

2005 Journal of clinical periodontology Controlled trial quality: uncertain

759. A randomized double-blind, placebo-controlled trial of the EMLA patch for the reduction of pain associated with intramuscular injection in four to six-year-old children. (Abstract)

A randomized double-blind, placebo-controlled trial of the EMLA patch for the reduction of pain associated with intramuscular injection in four to six-year-old children. The effectiveness of a eutectic mixture lidocaine-prilocaine topical anaesthetic cream (EMLA) patch compared with a placebo patch in the reduction of pain associated with intramuscular immunization was evaluated. As part of the study, 161 children (aged 4-6-y) undergoing routine diphtheria, pertussis, tetanus and polio (DPTP (...) ) immunization in five urban and five rural private office settings were randomly assigned to an EMLA patch (n = 83) or a placebo patch control group (n = 78). Pain measurements included: child's self-report on a Faces Pain Scale; facial action on the Child Facial Coding System; the Children's Hospital of Eastern Ontario Pain Scale and parent and technician ratings on a Visual Analogue Scale. Parents also rated their own and their child's immunization-related anxiety on a Visual Analogue Scale. The EMLA

2001 Acta paediatrica (Oslo, Norway : 1992) Controlled trial quality: predicted high

760. Should a mucoadhesive patch (DentiPatch) be used for gingival anesthesia in children? Full Text available with Trip Pro

Should a mucoadhesive patch (DentiPatch) be used for gingival anesthesia in children? A local anesthetic-impregnated mucosal adhesive patch (DentiPatch) was compared with topical anesthetic (Hurricaine Dry Handle Swab) for gingival anesthesia before rubber dam clamp placement in children. Twenty-eight children needing sealants on their posterior teeth were enrolled in this study. Topical anesthesia was provided using either the mucoadhesive patch (20% lidocaine) or topical anesthetic (20 (...) % benzocaine). Subjects were randomized using a split mouth model. Either the patch or topical anesthetic was applied to the gingiva for 5 minutes or 1 minute, respectively. Subjects used a visual analog scale to describe their pain during the procedure. Linear regression and mixed linear models were used for data analysis. The visual analog scale results (pain scores) showed no significant difference between treatments. The mean per-child patch-sticking fraction was 29.7%. Patch adherence to oral mucosa

2002 Anesthesia progress Controlled trial quality: uncertain

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