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Lidocaine Patch

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661. Lidocaine patch for postoperative analgesia after radical retropubic prostatectomy. (Abstract)

Lidocaine patch for postoperative analgesia after radical retropubic prostatectomy. In a prospective, double-blind, placebo-controlled study, patients undergoing radical retropubic prostatectomy under general anesthesia were randomly assigned to receive a lidocaine patch or placebo applied on each side of the wound at the end of surgery. Data were collected for 24 h after surgery. Seventy patients completed the study (36 lidocaine group, 34 placebo group). Demographics and postoperative (...) morphine consumption were not different between the groups. However, the lidocaine patch group reported significantly less pain on coughing (19%-33% reduction) over all time periods (treatment vs placebo P < 0.0001, time x treatment P = 0.3056) and at rest (17%-32% reduction) for up to 6 h (treatment vs placebo P = 0.0003, time x treatment P = 0.0130).

2009 Anesthesia and analgesia Controlled trial quality: uncertain

662. Contact allergies in haemodialysis patients: a prospective study of 75 patients. (Abstract)

) and latex skin prick test.Seventy-five patients (41 men, 34 women, mean age of 65 years old), with a mean 3.8 years under dialysis, were included. Nineteen patients (25%) had at least one positive skin test and 13 (17%) a positive patch test to at least one allergen relative to dialysis process including eight tests to lidocaine-prilocaine cream and three to povidone-iodine. Tests results seemed clinically relevant since nine patients had localized pruritus at the fistula site and six patients active (...) eczema around it.Contact sensitizations are frequent in haemodialysis patients and are linked to vascular access conditioning especially the use of lidocaine-prilocaine cream. Designing a specific test battery could help to diagnose the potential allergens and subsequently to give advice to avoid contact with sensitizing agents.

2009 Allergy

663. Sources of sensitization, cross-reactions, and occupational sensitization to topical anaesthetics among general dermatology patients. (Abstract)

patients. Possible sources of sensitization and the clinical histories of the patients are analysed.Positive patch test reactions to one or more topical anaesthetics were seen in 25/620 patients. Dibucaine reactions were most common (20/25), and lidocaine sensitization was seen in two patients. Six patients had reactions to ester-type and/or amide-type anaesthetics concurrently. Local preparations for perianal conditions were the most common sensitizers. One patient had developed occupational (...) sensitization to procaine with multiple cross-reactions and with concurrent penicillin sensitization from procaine penicillin.Dibucaine-containing perianal medicaments are the major source of contact sensitization to topical anaesthetics. Although sensitization to multiple anaesthetics can be seen, cross-reactions are possible. Contact sensitization to lidocaine is not common, and possible cross-reactions should be determined when reactions to lidocaine are seen. Occupational procaine sensitization from

2009 Contact Dermatitis

664. Clove

of the penis improves premature (early) ejaculation. Insufficient evidence to rate effectiveness for... Anal tears . Early research shows that applying a clove oil cream to anal tears for 6 weeks improves healing compared to using stool softeners and applying lidocaine cream. Mosquito repellent . Early research shows that applying clove oil or clove oil gel directly to the skin can repel mosquitos for up to 5 hours. Pain . Early research shows that applying a gel containing ground cloves for 5 minutes

2009 National Centre for Complementary and Alternative Medicine

665. Cardiac arrhythmias in coronary heart disease

benefits of reperfusion, including reduction in sudden death. 4 Studies of intravenous beta blockers showed reduction in the incidence of early VF, but evidence from the thrombolytic era has indicated no additional total mortality benefit of intravenous compared to oral administration. 36,38,43,55,57 Anti-arrhythmic drugs Anti-arrhythmic drugs (lidocaine, amiodarone) reduce arrhythmic death but with no, or minor, overall benefit on total mortality. Class 1C drugs have been shown to be associated (...) for ICD implantation who have prolonged QRS duration (>120ms) and Ny Ha class III-Iv symptoms should be considered for CRT-D therapy. Table 1 Entry criteria and results of trials examining ICD effectiveness in primary prevention of life threatening arrhythmias Trial entry criteria maDIT I 100 CaBG- paTCH 102 mUSTT 101 maDIT II 98 COmpaNION 103 *** DINamIT 52 SCD-HEfT 99 Non-sustained VT/inducible VT at epS yes* No yes No No No No lV ejection fraction =0.35 =0.35 =0.40 =0.30 =0.35 =0.35 =0.35 NyHA

2007 SIGN

666. Sequential medication strategies for postherpetic neuralgia: a cost-effectiveness analysis

of 6 drugs (Finnerup et al. 2005, see ‘Other Publications of Related Interest’ below for bibliographic details). Interventions Twenty-five sequential management strategies were considered. These comprised the following six drugs: gabapentin, topical lidocaine patches, tricyclic antidepressants (TCAs), opioid analgesics, pregabalin, and tramadol. Other (recommended) sequential medication strategies were used as a comparator. Location/setting USA. The setting was not reported. Methods Analytical

2007 NHS Economic Evaluation Database.

667. Dexamethasone in Benign Headaches

. Unfortunately, this desire to help our patients has often led us to wide-scale adoption of treatments that were used in thousands of patients before ultimately being proven unsound. Allow me to point to some historical treatments, such as steroids in septic shock, aminophylline in status asthmaticus, prophylactic lidocaine in acute MI, eye patching for corneal abrasion, the pneumatic anti-shock garment in hemorrhagic shock, forced IV fluids for ureteral stones, magnesium in acute MI, antibiotics for acute

2007 Sinai EM Journal Club

671. Treatment of postherpetic neuralgia: a systematic review of the literature

trials (RCTs) were eligible. Both parallel-group and crossover trials were included. Trials scoring one point on the validity scale were generally excluded. The exceptions were two RCTs that could not be adequately blinded. Specific interventions included in the review The inclusion criteria for the interventions were not specified and any treatments were eligible. The following treatments were included: topical therapies compared with placebo (lidocaine patch, capsaicin 0.075% cream and benzydamine (...) baseline differences between the groups; small sample sizes; and short study durations. Topical therapies. Lidocaine patch versus placebo (2 RCTs ranging in duration from 2 days to 4 weeks): the results were inconsistent. One RCT reported no statistically-significant difference in the pain scores between lidocaine and placebo. The other RCT enrolled patients who had obtained at least moderate relief after using a lidocaine patch for at least a month, and had reported significant benefit from lidocaine

2002 DARE.

672. Cost-effectiveness analysis of anesthetic agents during peripheral intravenous cannulation in the pediatric emergency department Full Text available with Trip Pro

iontophoresis; nitrous oxide inhalation analgesia; a heated lidocaine and tetracaine patch; sonophoresis with lidocaine cream, 4%; lidocaine cream alone, 4%; and use of a eutectic mixture of lidocaine and prilocaine cream.Currently, the needle-free jet injection of lidocaine device and injection of buffered lidocaine appear to provide the most cost-effective alternatives to pediatric ED physicians. (...) , 1966) through June 2007.The main outcome measure was the incremental cost-effectiveness ratio, which represented the additional cost that must be incurred by the hospital to obtain a reduction of 1 additional unit (10 mm or 1 cm) in the VAS score compared with a baseline option of no anesthetic.Our results suggest that the needle-free jet injection of lidocaine device had the lowest incremental cost-effectiveness ratio, followed by intradermal injection of buffered lidocaine; lidocaine

2008 EvidenceUpdates Controlled trial quality: uncertain

673. Contact urticaria from Emla cream. (Abstract)

Contact urticaria from Emla cream. We report the first case of immediate-type hypersensitivity caused by Emla cream. A 55-year-old woman, after using Emla cream, went on to develop urticaria. An open test was positive to Emla cream. Patch tests and prick tests were performed with Emla cream, the components of Emla cream (lidocaine, prilocaine and castor oil) and other local anaesthetics. The patch test with lidocaine and the prick test with Emla cream were both positive. An intradermal test (...) and subcutaneous administration of 3 anaesthetics that had negative patch tests and prick tests were performed and well tolerated, allowing their use. In the literature, anaphylactic reactions to lidocaine injections, delayed-type hypersensitivity after lidocaine subcutaneous injections and contact dermatitis from Emla cream have all been described. This first case of contact urticaria from Emla cream was due to lidocaine and did not show any cross-reaction with other local anaesthetics.

2004 Contact Dermatitis

674. Transdermal treatment options for neurological disorders: impact on the elderly. (Abstract)

an important role in the management of neuropathic pain. The transdermal lidocaine (lignocaine) patch is recommended as first-line therapy for the treatment of postherpetic neuralgia. Furthermore, in patients with severe persistent pain, transdermal delivery systems using the opioids fentanyl and buprenorphine are able to achieve satisfactory analgesia with good tolerability, comparable to the benefits seen with oral formulations. Transdermal administration is the ideal therapeutic approach for chronic

2006 Drugs & Aging

675. Bulleyaconitine A isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo. Full Text available with Trip Pro

Bulleyaconitine A isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo. Bulleyaconitine A (BLA) is an active ingredient of Aconitum bulleyanum plants. BLA has been approved for the treatment of chronic pain and rheumatoid arthritis in China, but its underlying mechanism remains unclear.The authors examined (1) the effects of BLA on neuronal voltage-gated Na channels in vitro under the whole cell patch clamp configuration and (2) the sensory (...) of the sciatic nerve but also induced hyperexcitability, followed by sedation, arrhythmia, and respiratory distress. When BLA at 0.375 mm was coinjected with 2% lidocaine (approximately 80 mm) or epinephrine (1:100,000) to reduce drug absorption by the bloodstream, the sensory and motor functions of the sciatic nerve remained fully blocked for approximately 4 h and regressed completely after approximately 7 h, with minimal systemic effects.BLA reduces neuronal Na currents strongly at +50 mV in a use

2007 Anesthesiology

676. A role for peripheral afferents in the pathophysiology and treatment of at-level neuropathic pain in spinal cord injury? A case report. (Abstract)

thermosensory deficits in the neuropathic pain area. However, topical application of capsaicin in the neuropathic pain area induced a burning pain sensation, a marked decrease in heat pain threshold and an increase in mechanical allodynia. Treatment with topical lidocaine patches (5%) led to considerable pain relief. These results indicate a functional connection between peripheral, spinal and supraspinal nociceptive pathways and that peripheral afferents may contribute to at-level neuropathic pain after

2007 Pain

677. In vitro effects of local anaesthetics on the thromboelastographic profile of parturients. Full Text available with Trip Pro

In vitro effects of local anaesthetics on the thromboelastographic profile of parturients. Post-dural puncture headache can be an incapacitating complication of obstetric epidural analgesia/anaesthesia and early or prophylactic epidural blood patch (EBP) is one of the treatment options. Although local anaesthetic (LA) agents have been shown to have anticoagulation effects in vitro, peri-partum women are known to be hypercoagulable. We postulated that the presence of residual LA might not result (...) in impaired haemostasis of the EBP in parturients.Blood samples from 10 healthy term parturients were subjected to thromboelastography after the addition of four different LA (lidocaine, bupivacaine, levobupivacaine, and ropivacaine) preparations.There was a significant reduction in reaction (R) and coagulation (K) time (P<0.001, P<0.05) and an increase in alpha degrees angle (P<0.01) when comparing undiluted blood with the saline control group. Maximum amplitude (MA) and clot lysis (Ly30) did not change

2005 British Journal of Anaesthesia

678. The effects of class Ic antiarrhythmics on tetrodotoxin-resistant Na+ currents in rat sensory neurons. (Abstract)

drug) on TTX-R Na(+) currents in rat dorsal root ganglion neurons using the whole-cell patch-clamp method. Flecainide, pilsicainide, and lidocaine reversibly blocked the peak amplitude of TTX-R Na(+) currents in a concentration-dependent manner with half-maximum inhibitory concentration values of 8.5 +/- 6.6 microM (n = 7), 78 +/- 6.9 microM (n = 7), and 73 +/- 6.8 microM (n = 7), respectively. Each drug shifted the inactivation curve for the TTX-R Na(+) currents in the hyperpolarizing direction (...) The effects of class Ic antiarrhythmics on tetrodotoxin-resistant Na+ currents in rat sensory neurons. IV or oral administration of antiarrhythmics has been reported to be effective for relieving neuropathic pain. Recent reports have indicated that tetrodotoxin-resistant (TTX-R) Na(+) channels play important roles in the nerve conduction of nociceptive sensation. In the present study, we investigated the effects of flecainide, pilsicainide (class Ic antiarrhythmics), and lidocaine (a class Ib

2004 Anesthesia and Analgesia

679. Practice parameter: treatment of postherpetic neuralgia: an evidence-based report of the Quality Standards Subcommittee of the American Academy of Neurology. (Abstract)

therapies of postherpetic neuralgia. Tricyclic antidepressants, gabapentin, pregabalin, opioids, and lidocaine patch were found to be effective in reducing the pain of postherpetic neuralgia.

2004 Neurology

680. Influence of Rapydan on Clinical Chemistry and Hematology Measurements

Actual Primary Completion Date : May 2010 Actual Study Completion Date : May 2010 Resource links provided by the National Library of Medicine available for: Arms and Interventions Go to Arm Intervention/treatment Rapydan Internal control. Blood from both arms will be drawn. Only one arm of the subject is treated with Rapydan. Drug: Rapydan lidocaine / tetracaine 70/70 mg patch Other Name: Lidocaine Tetracaine Patch Outcome Measures Go to Primary Outcome Measures : Routine Clinical Chemistry (...) to Brief Summary: There is an increasing awareness of the importance of treating procedure-related pain. Patients undergoing vascular access procedures are often afraid of needles and the discomfort associated with injections. This type of pain and/or fear can be stressful to patients. [1] For prevention of the pain associated with these procedures, the hospital is using Rapydan plasters. Rapydan consists out of two local anesthetics: lidocaine and tetracaïne. Rapydan produces topical anesthesia after

2008 Clinical Trials

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