How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

801 results for

Lidocaine Patch

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

601. Molluscum Contagiosum

for Skin Disorders Which of the following diagnostic tests is often done to evaluate pigmented lesions? Shaving Deep excision Patch test Scraping NEWS & VIDEOS Melanoma Survival Varies Among U.S. States FRIDAY, Jan. 18, 2019 (HealthDay News) -- U.S. states with more physicians and a larger percentage of non-Hispanic whites have worse melanoma survival, according to a study published online... SOCIAL MEDIA Add to Any Platform Loading Topic Resources Molluscum contagiosum is characterized by clusters (...) , especially in children. Curettage or liquid nitrogen can be used 40 to 60 min after application of a topical anesthetic such as eutectic mixture of local anesthetics (EMLA) or 4% lidocaine cream under an occlusive dressing. EMLA cream must be applied judiciously because it can cause systemic toxicity, especially in children. In adults, curettage is very effective but painful if done without anesthetic. Cantharidin is safe and effective but can cause blistering. Cantharidin is applied in 1 small drop

2013 Merck Manual (19th Edition)

602. Evaluation of the Patient with Nasal and Pharyngeal Disorders

conditions. Anatomy Throat The uvula hangs in the midline at the far end of the soft palate. It varies greatly in length. A long uvula and loose or excess velopharyngeal tissue may cause snoring and occasionally contribute to obstructive sleep apnea. Tonsils and adenoids are patches of lymphoid tissue surrounding the posterior pharynx in an area termed Waldeyer’s ring. Their role is to combat infection. The larynx is discussed in . Nose The nasal cavity is covered with a highly vascular mucosa that warms (...) , discharge, septal deviation, or perforation; whether mucosa is erythematous, boggy, or swollen; and presence of polyps. The skin over the frontal and maxillary sinuses is examined for erythema and tenderness, suggesting sinus inflammation. If necessary, the nasopharynx and hypopharynx can be examined with a flexible nasopharyngoscope. A topical anesthetic (eg, lidocaine 4%) is sprayed in the nose and throat, and the nose is also sprayed with a decongestant (eg, phenylephrine 0.5%). After several minutes

2013 Merck Manual (19th Edition)

603. Systemic Disorders and the Mouth

Violaceous patches , Keratotic lichenoid patches, sometimes with painful mucosal atrophy if in the mouth of an organ transplant recipient Reddish discoloration of the teeth High, arched soft palate Notched incisors, domed or mulberry molars Hairy leukoplakia (white, vertical folds on lateral border of tongue) transforming to AIDS Red or reddish purple collections of oral telangiectases (Osler-Weber-Rendu syndrome) Multiple impacted supernumerary teeth and osteomas Granulomatous gingivitis (...) defects at the site or adjacent to the site of a prosthetic patch or prosthetic device Cardiac transplantation recipients with a valvulopathy The heart is better protected against low-grade bacteremias, which occur in chronic dental conditions, when dental treatment is received (with prophylaxis) than when it is not received. Patients who are to undergo cardiac valve surgery or repair of congenital heart defects should have any necessary dental treatment completed before surgery. Although probably

2013 Merck Manual (19th Edition)

604. Seborrheic Keratoses

for Skin Disorders Which of the following diagnostic tests is often done to evaluate pigmented lesions? Shaving Deep excision Patch test Scraping NEWS & VIDEOS AAD: Isotretinoin Exposure for Acne Not Linked to Depression Risk FRIDAY, March 1, 2019 (HealthDay News) -- For patients with acne, exposure to isotretinoin is not associated with an increased risk for being diagnosed with depression, according to a study... SOCIAL MEDIA Add to Any Platform Loading , MD, Dartmouth-Hitchcock Medical Center Click (...) of lidocaine . Last full review/revision January 2018 by Denise M. Aaron, MD NOTE: This is the Professional Version. CONSUMERS: © 2018 Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA) Was This Page Helpful? 0, html: helpfultext"> Yes No Professionals also read MSD and the MSD Manuals Merck and Co., Inc., Kenilworth, NJ, USA (known as MSD outside the US and Canada) is a global healthcare leader working to help the world be well. From developing new therapies that treat

2013 Merck Manual (19th Edition)

605. Cutaneous Abscess

Disorders Which of the following diagnostic tests is often done to evaluate pigmented lesions? Shaving Deep excision Patch test Scraping NEWS & VIDEOS Melanoma Survival Varies Among U.S. States FRIDAY, Jan. 18, 2019 (HealthDay News) -- U.S. states with more physicians and a larger percentage of non-Hispanic whites have worse melanoma survival, according to a study published online... SOCIAL MEDIA Add to Any Platform Loading , MD, JD, North Atlanta Dermatology Click here for Patient Education NOTE (...) sterile conditions, local anesthesia is given as either a lidocaine injection or a freezing spray. Patients with large, extremely painful abscesses may benefit from IV sedation and analgesia during drainage. A single puncture with the tip of a scalpel is often sufficient to open the abscess. After the pus drains, the cavity should be bluntly probed with a gloved finger or curette to clear loculations. Irrigation with normal saline is optional. Packing the cavity loosely with a gauze wick reduces

2013 Merck Manual (19th Edition)

606. Principles of Topical Dermatologic Therapy

Diagnostic Tests for Skin Disorders Which of the following diagnostic tests is often done to evaluate pigmented lesions? Shaving Deep excision Patch test Scraping NEWS & VIDEOS AAD: Isotretinoin Exposure for Acne Not Linked to Depression Risk FRIDAY, March 1, 2019 (HealthDay News) -- For patients with acne, exposure to isotretinoin is not associated with an increased risk for being diagnosed with depression, according to a study... SOCIAL MEDIA Add to Any Platform Loading Topic Resources Topical (...) dermatologic are grouped according to their therapeutic functions and include Absorbent (eg, hydrocolloid patches or powder) and (drying agents that precipitate protein and shrink and contract the skin) (emollients, skin hydrators, and softeners) (agents that soften, loosen, and facilitate exfoliation of the squamous cells of the epidermis) For certain topical treatments, successful therapy may also depend on The vehicle with which an agent is formulated The type of used Vehicles Topical therapies can

2013 Merck Manual (19th Edition)

607. Insect Stings

include topical lotions, lidocaine patches, eutectic mixture of local anesthetic cream, intradermal injection of 1% lidocaine (with or without 1:100,000 epinephrine ), and mid-potency corticosteroid creams or ointments (eg, triamcinolone 0.1%). Most folk remedies (eg, application of meat tenderizer) are of limited effectiveness. Allergic reactions are treated with IV antihistamines; is treated with parenteral epinephrine and IV fluids and vasopressors if necessary. People with known hypersensitivity

2013 Merck Manual (19th Edition)

608. Inhibition of Voltage-Gated Sodium Channels by Emulsified Isoflurane May Contribute to Its Subarachnoid Anesthetic Effect in Beagle Dogs. (Abstract)

groups (n = 6/group): intrathecally receiving 1% lidocaine 0.1 mL/kg, 30% intralipid 0.1 mL/kg (control), or 8% EI at doses of 0.05, 0.075, or 0.1 mL/kg, respectively. Consciousness state, motor function of limbs, and response to nociceptive stimulus were observed after drug administration. The effect of EI on voltage-gated Na channel was recorded from isolated spinal neurons of rats, using the whole-cell patch-clamp technique. Inhibition of peak sodium currents and effect of EI on Na channel gating (...) were analyzed.Emulsified isoflurane produced subarachnoid anesthesia in a dose-dependent manner, and at the dose of 0.1 mL/kg, the effect of 8% EI was similar to 1% lidocaine. Sodium channel currents were inhibited by EI at clinically relevant concentrations, with the IC50 (median inhibitory concentration) at 0.69 ± 0.08 mM. Voltage activation of Na channels was positive, shifted by isoflurane at the concentration of 0.77 mM, and V½ of activation (voltage for half-maximal activation) shifted from

2011 Regional Anesthesia and Pain Medicine

609. Evaluate Efficacy and Safety of Extended Release (ER) Naproxen Sodium

Criteria: Healthy, ambulatory, male and female volunteers 15 years of age and above Scheduled to undergo surgical removal of up to two impacted third molars, one of which must be mandibular full or partial bony impaction and the other a maxillary impaction Female subjects of childbearing potential must be using a medically acceptable form of birth control for at least 1 month prior to screening (3 months on oral contraceptives), e.g., oral or patch contraceptives, intrauterine device, NuvaRing, Depo (...) and beverages containing xanthines (examples, coffee, tea, chocolate, and colas) after midnight prior to surgery and agree not to consume any of these foods or beverages throughout the evaluation period Use of only short-acting local anesthetic (e.g., mepivacaine or lidocaine) preoperatively, with or without vasoconstrictor and nitrous oxide Have moderate to severe postoperative pain on the Categorical Pain Intensity Scale (a score of at least 2 on a 4 point scale) and a score of ≥ 50 mm on the 100 mm

2011 Clinical Trials

610. Prolonged Cutaneous Analgesia With Transdermal Application of Amitriptyline and Capsaicin. (Abstract)

receptor may allow LAs to enter the nerve through the TRPV1 pore. In previous studies, we demonstrated that transdermal amitriptyline achieves clinical analgesic effects and is more potent than lidocaine. Here we examine whether the combined application of amitriptyline and capsaicin as a transdermal patch will produce prolonged cutaneous analgesia compared with amitriptyline alone.Male Sprague-Dawley rats (weights 250-300 g) were assigned to five treatment groups (n = 6-8 per group). Transdermal (...) patches containing amitriptyline with different concentrations of capsaicin were applied for 3 hrs to rats' shaved backs: 2.5% amitriptyline alone (control group) and in combination with 0.05%, 0.15%, 1%, and 8% capsaicin. Behavioral testing for cutaneous nociception was conducted before drug application and after patch removal using the cutaneous trunci muscle reflex. In addition, skin appearance was assessed to determine irritation by these formulations.The cutaneous analgesic effect

2011 Regional Anesthesia and Pain Medicine

611. Painful Diabetic Polyneuropathy: Approach to Diagnosis and Management. (Abstract)

(gabapentin and pregabalin), opioid analgesics (tramadol and oxycodone), and agents for topical use, such as lidocaine patch and capsaicin cream. With the exception of transcutaneous electrical nerve stimulation, physical treatment is not supported by adequate evidence.As efficacy and tolerability of current therapy for PDPN are not ideal, the need for a better approach in management further exists. Novel compounds should be developed for the treatment of PDPN.

2011 Clinical Journal of Pain

612. A novel mechanism for LQT3 with 2:1 block: a pore-lining mutation in Nav1.5 significantly affects voltage-dependence of activation. (Abstract)

A novel mechanism for LQT3 with 2:1 block: a pore-lining mutation in Nav1.5 significantly affects voltage-dependence of activation. SCN5A mutations that cause a gain of function in the cardiac voltage-gated sodium channel (Nav1.5) lead to long QT syndrome and a higher risk for sudden cardiac death.Here we functionally characterize the biophysical properties of the LQT3 variant, V411M, found in a newborn with a QT interval of 640 ms and 2:1 atrioventricular block.Whole cell patch clamp (...) was performed on wild-type and V411M Nav1.5 channels stably expressed in human embryonic kidney cells.V411M channels showed hyperpolarizing shifts in both the conductance-voltage (V(1/2) = -48.5 ± 2.2 mV vs. -40.4 ± 1.6 mV for wild-type) and inactivation-voltage (-95.6 ± 1.9 mV vs. -87.7 ± 1.7 mV) relationships, and a two-fold increase in late (sustained) sodium current during voltage ramp repolarizations. While neither mexiletine nor lidocaine exhibited potency differences between WT and V411M

2011 Heart Rhythm

613. Immunolabeling Evaluation of Five Selected Markers in Skin Biopsies of Patients With Postherpetic Neuralgia and Healthy Controls

History of slow-healing diabetic foot ulcers HgA1c >11% within the last three months Active cancer within the previous two years, except treated basal cell carcinoma of the skin Co-morbidities that can produce neuropathy Subjects taking sodium channel blockers within one week of study treatment and throughout the study Subjects taking any other experimental drugs within 30 days prior to enrollment Application of lidocaine patch to either foot or to PHN site within two weeks of enrollment Contacts (...) (VAS) >40mm at Baseline) Group 2: 5 Caucasian males >50 years of age, non-diabetic with no nervous system disease (healthy control groups) Exclusion Criteria: History of clinically significant liver disease, serious peripheral vascular disease, a blood clotting disorder, or any other medical condition felt to be exclusionary by the investigator Allergy to lidocaine Unwillingness to sign informed consent or any other reasons for which the investigator feels the subject cannot complete the study

2011 Clinical Trials

614. NEP-TUNE: Neuropathic Pain

] Pharmacological treatments included tricyclic antidepressants (TCA), gabapentin, non-steroidal anti-inflammatory drugs (NSAIDs), weak opioids, strong opioids, serotonin-norepinephrine reuptake inhibitors (SNRIs), lidocaine or capsaicin patch (L/C) and other (parcetamol containing drugs, xylocain gel or kinin). Participants may have used more than one pharmacological pain treatments and may be presented in more than 1 category. Number of Participants Using Other Pharmacological Pain Treatments For Peripheral (...) Neuropathic Pain After Baseline Visit (Concomitant Medication) [ Time Frame: After Baseline, Month 1, 2, 3 visit ] Pharmacological treatments included tricyclic antidepressants (TCA), gabapentin, non-steroidal anti-inflammatory drugs (NSAIDs), weak opioids, strong opioids, serotonin-norepinephrine reuptake inhibitors (SNRIs), lidocaine or capsaicin patch (L/C) and other (parcetamol containing drugs, xylocain gel or kinin). Participants may have used more than one pharmacological pain treatments and may

2011 Clinical Trials

615. Tolerance Study of the Silicone Bands on Medical Compression Stockings

, regardless of brand and model. Subjects presenting skin lesions caused by the contact with silicone-containing grip-top bands of medical compression stockings (all brands combined). Subjects for whom the incriminated stockings provide class 2 compression or higher. Subjects covered by French national health insurance. Subjects who give their written informed consent and who accept the constraints of the study. Exclusion Criteria: Known allergy to local anesthetics (lidocaine, etc.). History (...) of anaphylactic shock. Ongoing antihistamine treatment or having taken during the week before inclusion. Patient on ongoing systemic corticosteroids or having taken corticosteroids in the month before inclusion. Patient having used a topical corticosteroid in the area where the patch tests or prick tests will be performed during the week before inclusion. Phototherapy or sun exposure in the 30 days preceding the skin tests (on the back). Patient having concomitantly used compression stockings and a topical

2011 Clinical Trials

616. Rapydan Topical Anaesthesia for Arterial Cannulation

Party): Kurt Rutzler, Medical University of Vienna Study Details Study Description Go to Brief Summary: Arterial catheterization is painful and is associated with patient stress and anxiety. Analgesia is usually provided by subcutaneous injection of local anesthetic. An alternative is topical anaesthesia, such as Rapydan which is a novel topical anesthetic patch containing 70 mg each of lidocaine and tetracaine. We therefore tested the hypothesis that Rapydan patch analgesia is non-inferior (...) to subcutaneous local anesthetic. Condition or disease Intervention/treatment Phase Arterial Catheterization Drug: Lidocaine/tetracaine patch Drug: Placebo Patch Drug: Subcutaneous injection of 0.5 ml Lidocain 1% Drug: Subcutaneous injection of saline Phase 4 Detailed Description: Many clinical procedures including arterial and venous punctures, percutaneous venous catheter insertion, lumbar puncture, and dermatological procedures are associated with pain and consequent patient discomfort.1-2

2011 Clinical Trials

617. Study to Evaluate the Safety and Analgesic Activity of ATx08-001 in Subjects With Postherpetic Neuralgia

for at least 2 weeks prior to dosing. Has used a short-acting "as needed" opioid less than 12 hours prior to dosing or an "as needed" NSAID dose less than 24 hours prior to dosing Has used extended duration oral analgesics up to 48 hours prior to the Treatment Visit Has applied lidocaine patches or dermal analgesics within 7 days prior to the Treatment Visit Has received an anesthetic block within two weeks of the Screening Visit Has received any prior neurolytic nerve block in the area of the PHN pain

2011 Clinical Trials

618. Polyinosinic-Polycytidylic Acid-poly-L-lysine Carboxymethylcellulose (Poly-ICLC) in Healthy Volunteers

prior to date of screening evaluation through 6 weeks after study drug administration: Be surgically sterile Be abstinent (or willing to be) Use oral contraceptives, or other form of hormonal birth control including hormonal vaginal rings or transdermal patches Use an intra-uterine device (IUD) Use (by ensuring her male partner(s)uses)barrier contraception (condom) with spermicide Any other equivalent (as judged by the investigative team) methods of contraception Healthy adult males and females (...) , as assessed by a medical history, physical exam, and laboratory tests Exclusion Criteria: Allergy to lidocaine Confirmed HIV-1 or HIV-2 infection Any clinically significant abnormality on history or examination including history of immunodeficiency or autoimmune disease; use of systemic corticosteroids, immunosuppressive, anticancer, or other medications considered significant by the trial physician within the last 6 months Any clinically significant acute or chronic medical conditions requiring care

2011 Clinical Trials

619. Efficacy and Safety of SAR292833 Administration for 4 Weeks in Patients With Chronic Peripheral Neuropathic Pain

picolinate that are known to be used in neuropathic pain; Acetyl salicylic acid (ASA) except up to 325 mg/d for myocardial infarction or transient ischemic attack prophylaxis; Benzodiazepines other than indicated at low doses for sleep disorders; Capsaicin patch; Lidocaine patch; Electroconvulsive therapy within 30 days of baseline evaluation; CYP3A4 potent and moderate inhibitors; CYP3A4 potent and moderate inducers; Substrates of CYP3A4 with narrow therapeutic window. The above information

2011 Clinical Trials

620. Evaluate Onset of Action of a Fast Release Aspirin

Healthy Volunteers: Yes Criteria Inclusion Criteria: Healthy, ambulatory, male and female volunteers between 16 to 45 years of age Scheduled to undergo surgical removal of either two partial bony impactions or one full bony alone or in combination with a partial bony impaction, soft tissue impaction or erupted third molar. Maxillary third molars may be removed regardless of impaction level Use of only short-acting local anesthetic (e.g., mepivacaine or lidocaine) preoperatively, with or without (...) must be using a medically acceptable form of birth control for at least 1 month prior to screening (3 months on oral contraceptives), e.g., oral or patch contraceptives, intrauterine device, NuvaRing, Depo-Provera, or double-barrier and have a negative pregnancy test at Screening and prior to surgery. Female subjects of nonchildbearing potential must be amenorrheic for at least 2 years or had a hysterectomy and/or bilateral oophorectomy Provide a personally signed and dated informed consent

2011 Clinical Trials

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>