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41. Lidocaine

, the plaster may need to be stopped. Resources Twyross R et al. Palliative Care Formulary (Fourth Edition). Palliativedrugs.com. Nottingham, 2011 Electronic Medicines Compendium, Grunenthal Ltd. Lidocaine patches 5% (Versatis ® ). Summary of product characteristics. Updated January 2012. www.medicines.org.uk. References Copyright © 2014 NHSScotland Last Updated: 08 Apr 2015 Created: 14 Nov 2013 Indicates this use is off licence Indicates this medication is associated with QT prolongation Colour codes: Red (...) Lidocaine Scottish Palliative Care Guidelines - Lidocaine Scottish Palliative Care Guidelines search / / / Lidocaine Lidocaine Introduction Lidocaine Plaster in Palliative Care Description Lidocaine is a local anaesthetic effective in some types of such as post-herpetic neuralgia. It is available in a topical plaster formulation, with approximately 3% systemic absorption, reducing the risk of systemic adverse reactions and drug interactions. The use of lidocaine plasters in palliative care has

2015 Scottish Palliative Care Guidelines

42. Treatment of neuropathic pain with the capsaicin 8% patch: is pretreatment with lidocaine necessary? (PubMed)

Treatment of neuropathic pain with the capsaicin 8% patch: is pretreatment with lidocaine necessary? The capsaicin 8% patch can effectively treat neuropathic pain, but application can cause discomfort or a burning sensation. Until March 2013, it was recommended that patients be pretreated with a topical anesthetic, for example lidocaine, before capsaicin patch application. However, speculation existed over the need for pretreatment and its effectiveness in alleviating treatment-associated (...) discomfort. This article compares tolerability to and efficacy of the capsaicin patch in pretreated and non-pretreated patients. All patients received a single capsaicin patch application. Pretreated patients received a lidocaine plaster before and intravenous lidocaine and metamizole infusions during capsaicin patch application. Pain levels, assessed using a Numeric Rating Scale (NRS), were used to determine tolerability and efficacy. All patients (pretreated n = 32; non-pretreated n = 26) completed 100

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2014 Pain Practice

43. Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection

Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (...) (100). Please remove one or more studies before adding more. Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02240628 Recruitment Status : Completed First Posted : September 15, 2014 Results

2014 Clinical Trials

44. Commercial Lidocaine Patch as a Treatment for Ear-ringing

Commercial Lidocaine Patch as a Treatment for Ear-ringing Commercial Lidocaine Patch as a Treatment for Ear-ringing - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Commercial Lidocaine Patch as a Treatment (...) Study Description Go to Brief Summary: The purpose of this investigation is to evaluate if topically applied lidocaine, in the form of lidocaine patches, reduces the burden of chronic subjective tinnitus in a consistent and measurable way. Condition or disease Intervention/treatment Phase Tinnitus Drug: Transdermal Lidocaine Early Phase 1 Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 30 participants Intervention Model: Single

2014 Clinical Trials

45. Lidocaine Patches for Attenuating the Pain of Venipuncture Intravenous Cannulation

Lidocaine Patches for Attenuating the Pain of Venipuncture Intravenous Cannulation Lidocaine Patches for Attenuating the Pain of Venipuncture Intravenous Cannulation - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. Lidocaine Patches for Attenuating the Pain of Venipuncture Intravenous Cannulation The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02061475 Recruitment Status : Unknown Verified June 2014 by RenJi Hospital. Recruitment status was: Recruiting First Posted : February 12, 2014 Last Update

2014 Clinical Trials

46. A randomized clinical study of the heated lidocaine/tetracaine patch versus subacromial corticosteroid injection for the treatment of pain associated with shoulder impingement syndrome. (PubMed)

A randomized clinical study of the heated lidocaine/tetracaine patch versus subacromial corticosteroid injection for the treatment of pain associated with shoulder impingement syndrome. Treatment for pain due to shoulder impingement syndrome (SIS) typically begins conservatively with nonsteroidal anti-inflammatory drugs and physical therapy and can include subacromial injection of corticosteroids, particularly in patients unresponsive to conservative measures. The heated lidocaine/tetracaine (...) (HLT) patch has been reported to reduce SIS pain in a small case series.This was a prospective, randomized, open-label clinical trial in which adult patients with SIS pain lasting at least 14 days, with an average intensity of ≥4 on a 0-10 scale (0= no pain, 10= worst pain) were randomized to treatment with the HLT patch or a single subacromial injection of triamcinolone acetonide (10 mg). Patients in the HLT patch group applied a single HLT patch to the shoulder for 4 hours twice daily, with a 12

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2014 Journal of pain research

47. The Pain Quality Response Profile of a Corticosteroid Injections and Heated Lidocaine/Tetracaine Patch in the Treatment of Shoulder Impingement Syndrome. (PubMed)

The Pain Quality Response Profile of a Corticosteroid Injections and Heated Lidocaine/Tetracaine Patch in the Treatment of Shoulder Impingement Syndrome. To describe the effects of 2 pain treatments for shoulder impingement syndrome (SIS), and illustrate how investigators can use pain quality information to understand treatment response differences.This study presents pain quality data from a randomized open-label study comparing the effects of an injection of triamcinolone and up to twice (...) daily application of a heated lidocaine/tetracaine (Trilexis) patch in individuals with SIS. Study participants completed a measure of pain quality at baseline and again on study days 14, 28, and 42 following initiation of 2 treatments for SIS. Baseline and posttreatment pain quality scores were graphed to provide a visual representation of treatment-associated changes. Analyses of variance were used to examine the differences between treatment conditions in changes in pain quality

2014 Clinical Journal of Pain

48. Tolerability of the capsaicin 8% patch following pretreatment with lidocaine or tramadol in patients with peripheral neuropathic pain: A multicentre, randomized, assessor-blinded study. (PubMed)

Tolerability of the capsaicin 8% patch following pretreatment with lidocaine or tramadol in patients with peripheral neuropathic pain: A multicentre, randomized, assessor-blinded study. Application of the capsaicin 8% patch is associated with treatment-related discomfort. Consequently, pretreatment for 60 min with anaesthetic cream is recommended; however, this may be uncomfortable and time consuming.We conducted a multicentre, randomized (1:1), assessor-blinded study in patients (...) with peripheral neuropathic pain to assess tolerability of the capsaicin patch following topical lidocaine (4%) or oral tramadol (50 mg) pretreatment. The primary endpoint was the proportion of patients tolerating capsaicin patch application (ability to receive ≥90% of a 60-min application). Numeric Pain Rating Scale (NPRS) scores were assessed before, during and after treatment.Overall, 122 patients were included (61 per arm). The capsaicin patch was tolerated by 121 patients. Tolerability of the capsaicin

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2014 European Journal of Pain

49. Effectiveness and safety of 5% lidocaine-medicated plaster on localized neuropathic pain after knee surgery: a randomized, double-blind controlled trial. (PubMed)

Effectiveness and safety of 5% lidocaine-medicated plaster on localized neuropathic pain after knee surgery: a randomized, double-blind controlled trial. Localized neuropathic pain symptoms are reported after knee surgery in 30% to 50% of patients. 5% lidocaine plaster (LP5) is recommended for localized neuropathic pain, but evidence in postsurgery neuropathic pain is missing. This study focuses on the effectiveness of LP5 on allodynia, hyperalgesia, and thermal stimuli in postsurgery knee (...) in knee localized neuropathic pain. Beyond the inhibition of sodium channels by LP5, these findings suggest the involvement of cold and mechanical receptors that participate to pain chronicisation and also of the non-negligible placebo effect of the patch, items that need to be explored further and challenged in other etiologies of localized neuropathic pain.

2019 Pain

50. Transdermal lidocaine as treatment for chronic subjective tinnitus: A pilot study. (PubMed)

was 56.2. After 1 month the average TFI decreased to 41 (p < 0.05). The scores dropped to 34 and 35 after 2 and 3 months of treatment respectively. Despite improvement in symptoms of tinnitus, most patients did not continue the study after the first month, dropping out due to the size, discomfort, and appearance of the lidocaine patch, failure to follow-up and lack of perceived benefit from treatment.In this preliminary study, 5% transdermal lidocaine appears to be a potential treatment for chronic (...) Transdermal lidocaine as treatment for chronic subjective tinnitus: A pilot study. To assess the efficacy of transdermal lidocaine as a treatment for chronic subjective tinnitus as measured by the Tinnitus Functional Index (TFI).Pilot, prospective efficacy trial.Tertiary care hospital.Men and women, over the age of 18 with chronic subjective tinnitus for >6 months.Daily application of commercially available transdermal lidocaine patch.Change in the TFI.The average pre-treatment TFI score

2019 American Journal of Otolaryngology

51. Injectable Lidocaine Versus Lidocaine/Tetracaine Patch for the Incision and Drainage of Skin Abscesses

Injectable Lidocaine Versus Lidocaine/Tetracaine Patch for the Incision and Drainage of Skin Abscesses Injectable Lidocaine Versus Lidocaine/Tetracaine Patch for the Incision and Drainage of Skin Abscesses - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please (...) remove one or more studies before adding more. Injectable Lidocaine Versus Lidocaine/Tetracaine Patch for the Incision and Drainage of Skin Abscesses The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT02066818 Recruitment Status : Completed First Posted : February 20, 2014 Last Update Posted : February

2013 Clinical Trials

52. TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons. (PubMed)

TRPA1 and TRPV1 for lidocaine-induced Ca2+-influx, neuropeptide release and neurotoxicity in mouse sensory neurons.Cultured dorsal root ganglion (DRG) neurons from wildtype and mutant mice lacking TRPV1, TRPA1 or both channels were explored by means of calcium imaging, whole-cell patch clamp recordings and trypan blue staining for cell death. Release of calcitonin gene-related peptide (CGRP) from isolated mouse peripheral nerves was determined with ELISA.Lidocaine up to 10 mM induced a concentration (...) TRPA1 and TRPV1 are required for lidocaine-evoked calcium influx and neuropeptide release but not cytotoxicity in mouse sensory neurons. Local anaesthetics (LA) reduce neuronal excitability by inhibiting voltage-gated Na+ channels. When applied at high concentrations in the direct vicinity of nerves, LAs can also induce relevant irritation and neurotoxicity via mechanisms involving an increase of intracellular Ca2+. In the present study we explored the role of the Ca2+-permeable ion channels

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2017 PLoS ONE

53. Topical Lignocaine Patches in Traumatic Rib Fractures

: (exp lidocaine OR lignocaine patch OR lidocaine patch AND rib fractures. Embase via NHS evidence 1980 to November 26 3013: (exp lidocaine OR lidocaine patch OR lignocaine patch AND rib fracture) Cochrane Database of Systematic Reviews (exp lidocaine OR lignocaine patch OR lidocaine patch AND rib fractures) Search Outcome 10 papers identified using medline search 38 papers identified using Embase search No reviews identified using Cochrane Database of Systematic Reviews 2 papers were relevant (...) to the clinical question Relevant Paper(s) Author, date and country Patient group Study type (level of evidence) Outcomes Key results Study Weaknesses Zink et al, 2011 USA 58 patients presenting to the hospital’s trauma system, emergency room, or clinics with rib fractures receiving lignocaine patches (29) identified through pharmacy records, or matched control subjects not recieving lidocaine patches (29). Observational study. Prospective cohort of patients were retrospectively analysed for use of lignocaine

2015 BestBETS

54. The use of 5% lidocaine medicated plaster for acute postoperative pain after gynecological surgery: A pilot randomized controlled feasibility trial. (PubMed)

The use of 5% lidocaine medicated plaster for acute postoperative pain after gynecological surgery: A pilot randomized controlled feasibility trial. To examine the feasibility and potential efficacy of 5% lidocaine medicated plaster for acute postoperative pain in a parallel, blinded, randomized controlled pilot trial.Twenty-eight women undergoing elective gynecological surgery with midline incisions were randomly allocated 5% lidocaine medicated patch (Lignopad) or placebo plasters (...) . Postoperative pain at rest and on movement at 24 hours were the primary study endpoints, with secondary endpoints of postoperative pain within the first 48 hours, cumulative morphine consumption (mg), predicted peak flow rate (PFR) (%) and adverse effects. We assessed pain scores at rest and on movement using the visual analogue scale (0-100).The lidocaine patch group had lower postoperative pain scores at rest at 24 hours (mean difference [MD] -15.1, 95% confidence interval [95% CI] -28.3 to -2.0; P = .024

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2018 Medicine

55. A Study With Lidocaine 5% Medicated Plaster in Patients Suffering From Postherpetic Neuralgia

: Grünenthal GmbH Information provided by (Responsible Party): Grünenthal GmbH Study Details Study Description Go to Brief Summary: This study was performed to evaluate the local and systemic safety profile and the analgesic efficacy of long-term treatment with lidocaine 5% medicated plaster (Lido-Patch). The study was an open-label, multi-center, multiple-dose, Phase III study and comprised a main and an extension period. 161 participants who completed treatment in KF10004/01 (NCT03745404) and 98 newly (...) A Study With Lidocaine 5% Medicated Plaster in Patients Suffering From Postherpetic Neuralgia A Study With Lidocaine 5% Medicated Plaster in Patients Suffering From Postherpetic Neuralgia - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one

2018 Clinical Trials

56. Does the Use of Nitroglycerin Patch Improve Local Anaesthetic Effects in Bier's Block? A Double-Blind Placebo Controlled Study (PubMed)

Does the Use of Nitroglycerin Patch Improve Local Anaesthetic Effects in Bier's Block? A Double-Blind Placebo Controlled Study The aim of the study was to assess the nitroglycerin patch as a new additive to Bier's block and its impact on the effects and dose of lidocaine.Forty patients of each sex belonging to ASA I or II underwent elective tendon repair surgeries of the forearm and hand. The patients were divided into two equal groups as follows: Group C received only lidocaine (1.5 mg/kg (...) , 0.25%) and Group N received lidocaine (1.5 mg/kg, 0.25%) + 5 mg transcutaneous nitroglycerin patch. Onset and recovery times for sensory and motor block, visual analogue scale (VAS) scores for bandage pain, postoperative VAS score, analgesic requirements, patients' satisfaction, and surgeons' opinion were recorded.Sensory block onset time was shorter in Group N (3.80 ± 1.0) than that in Group C (5.72 ± 1.46), and motor block onset time was shorter in Group N (10.72 ± 1.93) than that in Group C

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2018 Anesthesiology research and practice

57. A Study With Lido-Patch and Placebo Plaster in Patients Suffering From Postherpetic Neuralgia (PHN)

, 2018 Sponsor: Grünenthal GmbH Information provided by (Responsible Party): Grünenthal GmbH Study Details Study Description Go to Brief Summary: This study investigated the efficacy of the Lido-Patch (lidocaine 5% medicated plaster) in treatment of pain caused by PHN which is a neuropathic pain syndrome (nerve-related pain conditions) following an acute attack of herpes zoster (shingles). Condition or disease Intervention/treatment Phase Post Herpetic Neuralgia Drug: Lidocaine 5% medicated Plaster (...) : available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Lido-Patch (Open-label Run-in Phase) All participants applied up to 3 Lido-Patches (lidocaine 5% medicated plaster) per day (depending on the size of PHN area). Patches were applied topically for up to 12 hours per day (patch free interval: at least 12 hours) at the site of skin affected by painful PHN. Drug: Lidocaine 5% medicated Plaster Other Names: Versatis (Trade Mark) Lidoderm (Trade Mark) Neurodol Tissugel (Trade

2018 Clinical Trials

58. Cost-effectiveness analysis of a new 8% capsaicin patch compared to existing therapies for postherpetic neuralgia

for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary The objective was to evaluate the cost-effectiveness of a new 8% capsaicin patch, compared with existing treatments, for postherpetic neuralgia. The authors concluded that the 8% capsaicin and the topical lidocaine patches were the most effective treatments. They had similar acceptable (...) was compared with the usual treatments for PHN. These included tricyclic antidepressants, a topical lidocaine patch, duloxetine, gabapentin, and pregabalin. Location/setting USA/primary care. Methods Analytical approach: The study used a state-transition Markov model to assess the costs and effects of the capsaicin patch, compared with the other treatments. The time horizon was one year and the authors stated that the study was conducted from the perspective of the payer. Effectiveness data: : The clinical

2012 NHS Economic Evaluation Database.

59. Efficacy of piroxicam patch compared to lidocaine patch for the treatment of postherpetic neuralgia. (PubMed)

Efficacy of piroxicam patch compared to lidocaine patch for the treatment of postherpetic neuralgia. The lidocaine patch has been effectively used as a first-line therapy to treat neuropathic pain such as postherpetic neuralgia (PHN).To evaluate the safety and efficacy of the topical piroxicam patch as a treatment option for the treatment of PHN.Eighteen patients completed a 3-session study, applying three different patches (lidocaine, piroxicam and control) in random order. A maximum of three (...) patches were applied to the most painful area for three consecutive days (12 hours on followed by 12 hours off). Each session was conducted at least seven days apart. The changes in visual analog scale (VAS) scores based pain intensity, quality of sleep and adverse effects were recorded.When compared to the control, both the lidocaine and piroxicam patches significantly reduced the mean VAS scores of pain intensity of all different types. However, the lidocaine patch was better at reducing allodynia

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2011 Annals of dermatology

60. Pharmacodynamics and Pharmacokinetics of Lidocaine in a Rodent Model of Diabetic Neuropathy. (PubMed)

diabetes.We performed a series of sciatic nerve block experiments in 25 Zucker Diabetic Fatty rats aged 20 weeks with a neuropathy component confirmed by neurophysiology and control rats. We determined in vivo the minimum local anesthetic dose of lidocaine for sciatic nerve block. To investigate the pharmacokinetic hypothesis, we determined concentrations of radiolabeled (C) lidocaine up to 90 min after administration. Last, dorsal root ganglia were excised for patch clamp measurements of sodium channel (...) Pharmacodynamics and Pharmacokinetics of Lidocaine in a Rodent Model of Diabetic Neuropathy. Clinical and experimental data show that peripheral nerve blocks last longer in the presence of diabetic neuropathy. This may occur because diabetic nerve fibers are more sensitive to local anesthetics or because the local anesthetic concentration decreases more slowly in the diabetic nerve. The aim of this study was to investigate both hypotheses in a rodent model of neuropathy secondary to type 2

2017 Anesthesiology

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