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Lidocaine Patch

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261. Efficacy of Intralesional Triamcinolone Injection in the Treatment of Vitiligo

to Arm Intervention/treatment Experimental: Experimental group All lesions will treated with NBUVB or excimer laser weekly and application of topical tacrolimus ointment twice daily for a total of 12-week period. Intervention: Intralesional injection of triamcinolone acetonide (0.4mg/cc) will be performed weekly. Drug: Triamcinolone acetonide 0.4mg/cc Intralesional injection of dilute triamcinolone acetonide with 2% lidocaine (400mg/20 mL) would be performed to reduce pain when injecting the drug (...) Application of topical tacrolimus ointment twice a day Outcome Measures Go to Primary Outcome Measures : The repigmentation rate (change from baseline) of the vitiliginous patch [ Time Frame: Baseline and 12 weeks ] The degree of repigmentation will be assessed as % from baseline by using a computer program. Secondary Outcome Measures : The adverse effects [ Time Frame: every weeks up to 13 weeks ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate

2017 Clinical Trials

262. Sphenopalatine Ganglion Nerve Block for Postdural Puncture Headache in Obstetrics

: Washington University School of Medicine Information provided by (Responsible Party): Washington University School of Medicine Study Details Study Description Go to Brief Summary: During labor and delivery, pregnant women may choose to receive pain relief called epidural analgesia, which is the delivery of a numbing agent through the back and into a body space around the spinal column. This numbs the area of the stomach and the pelvis. Typically the numbing agent is lidocaine, which is a local anesthetic (...) standard care for their headache if they do not have relief from the study procedures. Standard care would be decided by their treating physician and may include oral pain medications and/or medications like ibuprofen [Motrin] or they could have a procedure called an epidural blood patch. This is performed by injecting a small amount of the patient's own blood into the areas of the spinal column where the original epidural anesthesia was injected in order to "patch" the leaks in the dura. Condition

2017 Clinical Trials

263. Evaluation of Pathway Modulation by Raf, MEK, & Kinase Inhibitors

Simulator Model 600 (Solar Light Co., Inc., Philadelphia, PA) will be used to administer Solar Simulated Light (SSL) exposures to formerly unexposed buttock skin.The device is equipped with six 8mm liquid light guides (LLG), allowing for 6 simultaneously conducted exposures.A large 3x2 endplate places the LLGs several centimeters apart and is specifically designed for Sun Protection Factor (SPF) and photo patch testing. The dose of emission from each LLG can be precisely regulated and the spectrum (...) ) and photo patch testing. The dose of emission from each LLG can be precisely regulated and the spectrum of emission can be limited to UVA (320-390 nm) or UVB+UVA (290-390 nm). The operator can select between UVA only and a combined Ultraviolet-A (UVA)/ Ultraviolet-B (UVB) spectrum by placement of an optical filter. The spectral output (indicated below) follows the distribution of sunlight from 290 to 390 nm. Other Name: Multiport UV Solar Simulator Model 60 No Intervention: ArmC: Without Solar Simulated

2017 Clinical Trials

264. Topical phenytoin for the treatment of neuropathic pain (PubMed)

Topical phenytoin for the treatment of neuropathic pain We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin in patients suffering from treatment refractory neuropathic pain. The use of commercial topical analgesics is not widespread due to the facts that capsaicin creams or patches can give rise to side effects, such as burning, and analgesic patches (e.g., lidocaine 5% patches) have complex handling, especially for geriatric patients. Only in a few

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2017 Journal of pain research

265. Sweet 16 (papers of the year for NYGH EMU 2017)

Sweet 16 (papers of the year for NYGH EMU 2017) Sweet 16 (papers of the year for NYGH EMU 2017) - First10EM Search Sweet 16 (papers of the year for NYGH EMU 2017) by | Published - Updated At this year’s , I was asked to review the most important emergency medicine papers of the year. These are the 10 papers I decided to talk about. If you have questions or comments, please join the discussion at the bottom of the post. Placebo is as good as (or maybe better than) amiodarone or lidocaine for out (...) of hospital cardiac arrest (the ALPS trial) Kudenchuk PJ et al. Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. NEJM 2016. PMID: Methods: Large multicenter, randomized, double blind trial. Included a total of 3026 patients (4653 in the intention to treat analysis) 18 years of age or older with nontraumatic out of hospital cardiac arrest and shock-refractory ventricular fibrillation or pulseless ventricular tachycardia (defined as persistent or recurrent VF or pulseless VT after one

2017 First10EM

266. Delayed hemorrhage effect of local anesthesia with epinephrine in the loop electrosurgical excisional procedure (PubMed)

of the population (103, 27.9%) underwent LEEP in the operating room under general anesthesia without injection of local anesthesia. The remaining patients (266, 72.1%) underwent LEEP with local anesthesia (lidocaine HCl 2% with epinephrine 1:100,000) in the office procedure room. Patients given local anesthesia including epinephrine had significantly lower delayed hemorrhage compared to patients with general anesthesia without injection of local anesthesia (P=0.001). Hemostats, such as fibrin glue or patch

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2017 Obstetrics & gynecology science

267. Magnesium sulfate diminishes the effects of amide local anesthetics in rat sciatic-nerve block. (PubMed)

block model. Further, the mechanism of possible synergy between LAs and MgSO(4) was investigated in whole-cell mode patch-clamp experiments.Sciatic nerves were exposed to 2%/73.9 mM lidocaine, 0.25%/7.7 mM bupivacaine, and 0.5%/15.4 mM ropivacaine, with or without addition of 1.25%, 2.5%, or 5% MgSO(4)/50.7 mM, and nerve block characteristics were assessed. To elucidate the LA-MgSO(4) interaction, voltage-dependent inactivation curves were determined in cultured rat GH(3) cells that expressed (...) neuronal Na(+) channels.Unexpectedly, the addition of MgSO(4) overall significantly shortened the duration of block by lidocaine, bupivacaine, and ropivacaine. The steady-state inactivation of Na(+) channels in the presence of 300 muM lidocaine was almost unchanged by the addition of 10 mM MgSO(4), indicating that MgSO(4) does not affect the potency of lidocaine toward the inactivated Na(+) channel.MgSO(4) coadministered with amide-type LAs shortened the duration of sciatic-nerve block in rats

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2017 Regional Anesthesia and Pain Medicine

268. Topical anesthesia for staple removal from surgical wounds on the knee: a prospective, double-blind, randomized trial. (PubMed)

underwent primary total knee replacement were assigned to an experimental group or control group. One lidocaine patch was applied around the surgical wound for each patient in the experimental group. Alternatively, the adhesive sides of the lidocaine patches were shielded with waterproof films in the control group. A resident peeled off the patch before a single nursing practitioner removed the staples. Pain was assessed with the 10-cm visual analog scale, and a face pain scale-revised was performed (...) with moderate-to-severe pain. The lidocaine patch applied topically around the surgical wound could effectively reduce the pain during the procedure, without remarkable complications such as systemic adverse effects or wound contamination.Copyright © 2017 Elsevier Inc. All rights reserved.

2017 The Journal of surgical research Controlled trial quality: uncertain

269. Ipsilateral and contralateral sensory changes in healthy subjects after experimentally induced concomitant sensitization and hypoesthesia. (PubMed)

by quantitative sensory testing (QST) using the protocol of the German Research Network on Neuropathic Pain.Twenty eight healthy subjects were firstly randomized in 2 groups to receive either topical capsaicin (0.6%, 12 cm2, application duration: 15 min.) or a lidocaine/prilocaine patch (25/25 mg, 10 cm2, application duration: 60 min.) on the right volar forearm. Secondly, 7-14 days later in the same area either at first capsaicin (for 15 min.) and immediately afterwards local anesthetics (for 60 min (...) .) was applied (Cap/LA), or in inversed order with the same application duration (LA/Cap). Before, after each application and 7-14 days later a QST was performed bilaterally.Wilcoxon-test, ANOVA, p < 0.05.Single application of 0,6% capsaicin induced thermal hypoesthesia, cold hypoalgesia, heat hyperalgesia and tactile allodynia. Lidocaine/prilocaine alone induced thermal and tactile hypoesthesia as well as mechanical and cold hypoalgesia, and a heat hyperalgesia (to a smaller extent). Ipsilaterally both co

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2017 BMC Neurology Controlled trial quality: uncertain

270. CIRSE Guidelines on Below the Knee Interventions

or resolve vasospasm (Table 4)[21]. The majority of BTK interventions can be performed under local anesthesia. Local analgesics such as lidocaine 1 % may be administered under US guidance to facilitate precise deposition [18]. Mild con- scious sedation (usually up to 50–100 lg of fentanyl and 5 mg of midazolam are suf?cient) may be required in anxious patients or for painful procedures. Data regarding the anti- platelet regime after BTK angioplasty and/or stenting are limited, and most protocols reported (...) can be treated in the same endovascular session via a contralateral retrograde CFA approach. It is also possible to gain ipsilateral retrograde access and invert the sheath, or to use popliteal or pedal access in the same session, depending on the local anatomical situation. The in?ow needs to be corrected before the BTK intervention. When concomitant ipsilateral CFA occlusive disease is present, surgical patch atherectomy and BTK angioplasty can be performed during the same session if an adequate

2013 Cardiovascular and Interventional Radiological Society of Europe

272. Treatment of Osteoarthritis of the Knee

for or against the use of acetaminophen, opioids, or pain patches for patients with symptomatic osteoarthritis of the knee. Strength of Recommendation: Inconclusive Description: Evidence from a single low quality study or conflicting findings that do not allow a recommendation for or against the intervention. An Inconclusive recommendation means that there is a lack of compelling evidence that has resulted in an unclear balance between benefits and potential harm. Implications: Practitioners should feel

2013 American Academy of Orthopaedic Surgeons

273. Pulmonary Contusion and Flail Chest, Management of

are beyond the scope of this study, and the reader is referred to the EAST guideline on Analgesia in Blunt Thoracic Trauma. [130] However, mention should be made of the increased use of local anesthetic administered by transcutaneous patch (lidocaine 5%, Lidoderm, Endo Pharmaceuticals) since that guideline was published. At this writing, the patch is Food and Drug Administration approved for postherpetic neuralgia, but it has been used “off-label” for other analgesic indications including chronic lower (...) back pain, [131] postlaparoscopic surgical pain, [132] and headache. Ingalls et al. [133] performed an eloquent prospective, randomized controlled trial of lidocaine 5% patch versus placebo for patients with rib fractures. The study was well powered, and the lidocaine patch failed to show sparing of narcotics versus the placebo group. Yet, other work in progress may indicate a narcotic-sparing effect of the patch (unpublished data, work in progress). Vasopressin for PC Arginine vasopressin versus

2012 Eastern Association for the Surgery of Trauma

275. Supporting smoking cessation - a guide for health professionals

and substantial changes in the approved use of nicotine replacement therapy (NRT). Another important development for smoking cessation in Australia has been the listing of nicotine patches on the Pharmaceutical Benefits Scheme (PBS), initially for Aboriginal and Torres Strait Islander people in 2008, and for the general community since February 2011. In recognition of the emerging evidence and the need to keep this guide current, updates were done in June 2012 and 2014. Supporting smoking cessation: a guide (...) ) non-smokers; children under 12 years; hypersensitivity to nicotine or any component of the patch; diseases of the skin that may complicate patch therapy 8 Gum First cigarette >30 minutes after waking 2 mg 8–12 per day >8 (Unscheduled) non-tobacco users; known hypersensitivity to nicotine or any component of the gum; children ( 8 Inhaler >10 cigarettes per day 6–12 cartridges per day >8 (S2) Non-tobacco users; hypersensitivity to nicotine or menthol; children ( 8 (S2) Non-tobacco users

2012 Clinical Practice Guidelines Portal

278. Treatment of painful diabetic neuropathy

effect (20%–30% reduction in pain scores from baseline and 70% of patients experienced more than a 30% decrease in pain). e16,e17 Conclusions. Based on Class I and Class II evidence, capsaicin cream is probably effective in lessening the pain of PDN. Based on Class III studies, there is insufficient evidence to determine if IV lidocaine is effective in lessening the pain of PDN. Based on Class III evidence, the Lidoderm patch is possibly effective in lessening the pain of PDN. Based on Class I (...) reviewed include anticonvulsants, antidepressants, opioids, anti-arrhythmics, cannabinoids, aldose reductase inhibitors, protein kinase C beta inhibitors, antioxidants (α-lipoic acid), transketolase activators (thiamines and allithiamines), topical medications (analgesic patches, anesthetic patches, capsaicin cream, clonidine), and others. The nonpharmacologic modalities include infrared therapy, shoe magnets, exercise, acupuncture, external stimulation (transcutaneous electrical nerve stimulation

2011 American Academy of Neurology

279. Supportive care in multiple myeloma

(buccal, sublingual, nasal), TD, IV, Sp 12 μg/h TD patch over 72 h Reduced sedation, emesis, constipation cf morphine; Convenience of 3 d patch TM applications very short‐acting (1–2 h) – best reserved for incident (movement‐related) pains and dressing changes, etc.; Probably immunoneutral Safe in renal failure (Alternative for parenteral use is alfentanil) Safe Use rapid acting TM formulations with caution in patients with addictive tendencies; Affected by CYP3A4‐acting drugs Buprenorphine Partial (...) MOR, ORL1 agonist; KOR, DOR antagonist TM (sublingual), TD, IV 20 μg/h TD patch over 7 d Reduced respiratory depression; Convenience of patches (5–20 μg dose TD patches can last 7 d Nausea with initiation of higher dose TD patch; TM tablet causes nausea Safe Safe Ceiling dose for respiratory depression makes it safer for COPD patients; Does not reverse other MOR opioids at therapeutic doses Diamorphine MOR agonist IV, SC 10 mg SC, IV Familiarity; High water solubility As for morphine Do not use

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2011 British Committee for Standards in Haematology

280. General Palliative Care Guidelines for the Management of Pain at the End of Life in Adult Patients

he Cochrane library Issue 2, Chichester; john w iley. nb this review has been withdrawn!! 65 s iddall P, Cousins M, o tte a, g reising t, Chambers r , Murphy t (2006) “Pregabalin in central neuropathic pain associated with spinal cord injury: a placebo-controlles trial” Neurology, 67,10,1792-800 66 Meier t, w asner g , Faust M, kuntzer t, o chsner F, h ueppe M et al (2003) “efficacy of lidocaine patch 5% in the treatment of focal peripheral neuropathic pain syndromes: a randomised, double-blind (...) should be titrated to the need of the individual patient. • Review regularly • Ensure regular laxatives are prescribed with strong opioids. • All patients should have access to antiemetics when opioids are prescribed. • Do not prescribe two paracetamol – containing products at the same time. • Transdermal opioid patches should only be used for stable pain. • Patients receiving a NSAID who are at risk of gastrointestinal side effects should be prescribed appropriate gastric protection. STEP 2: Pain

2011 Regulation and Quality Improvement Authority

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