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Lidocaine Patch

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221. LaseMD System for the Treatment of Melasma

. Subjects with sensitivity or allergy to pre-treatment medication, EMLA Cream (Lidocaine/Prilocaine). Subjects with sensitivity or allergy to post-treatment cosmeceuticals, Tranexamic Acid and/or coconut. Subjects with photosensitive skin. Concurrent therapy that, in the investigator's opinion, would interfere with the evaluation of the safety or efficacy of the study device. Subjects who are pregnant or lactating or anticipate becoming pregnant during the study. Subjects who anticipate the need (...) for inpatient surgery or overnight hospitalization during the study. Subjects who, in the investigator's opinion, have a history of poor cooperation, noncompliance with medical treatment, or unreliability. Concurrent enrollment in any study involving the use of investigational devices or drugs. Current smoker or history of smoking in the last five years. Current user of any nicotine-containing products, e.g., e-cigarettes, Nicorette gum, nicotine patches, etc. Excessively tanned in areas to be treated

2018 Clinical Trials

222. Is Sphenopalatine Ganglion Block Treatment Effective on Postspinal Headaches

volume causes decreased brain volume and compensatory mechanisms lead to cerebral venous dilatation. Conservative treatments are iv hydration, analgesic agents, caffeine or theophylline. Epidural blood patch is the gold standard for the treatment . However epidural blood patch is an invasive technic and has some complications such as dural puncture, infection and neurologic trauma. Sphenopalatine ganglion is one of the four parasympathetic thin ganglion in skull. Parasympathetic fibers innervates (...) cerebral and meningeal blood vessels which cause vasodilatation and stimulate nociceptor activation on meninges. Consequently headache is related with sensory cortex. Transnasal SPG block is performed successfully in chronic pain syndromes including migraine, cluster headaches and atypic face pain. Likewise the SPG block is performed in acute treatment of postspinal headache. However gold standard of the treatment is epidural blood patching which is interventional and has many risks. Several studies

2018 Clinical Trials

223. Comparison Tympanoplasty With Membrane Amniotic and Autologous Fascia

of the eardrum in the absence of its spontaneously healing indicates surgical management. These surgeries are performing using various materials including fascia, cartilage, fats, pericardium and paper patch. It has proven that using different materials results in outcome and postoperative complications. The criteria of the best graft material includes availability, preservability, manageability, and acceptance rate to the hosts. Human amniotic membrane is preservable. Also, there isn't significant (...) with a gas number and a Surgifix. Step4. Patients were discharge from the operating room with an oral administration of Cephalexin capsules. Procedure: Tympanoplasty With Autologous Fascia Autologous Temporalis fascia Tympanoplasty Experimental: Test group Step1. After sedation and conducting local anesthesia with Lidocaine 2% and inserting the edges of the tympanic membrane and inserting the foam gel into the middle ear, amniotic membranes (produced in Iran tissue product) with a thickness of 100

2018 Clinical Trials

224. A Study to Compare Levels of Capsaicin After Intra-Articular Injection and Topical Application in Patients With Painful Knee Osteoarthritis

knee. Drug: CNTX-4975-05 1 mg (2mL) IA injection Other Name: trans-capsaicin Drug: Lidocaine (without epinephrine) 15 mL IA injection of 2% lidocaine (without epinephrine) Active Comparator: Topical 8% Capsaicin Patch Receives Capsaicin Patch on posterior rib cage. Drug: Qutenza 8% topical patch Other Name: cis-capsaicin Outcome Measures Go to Primary Outcome Measures : Capsaicin Pharmacokinetics - AUC0-t [ Time Frame: Day 1 (pre-dose to 12 hours post-dose) and Day 8 (pre-dose to 12 hours post-dose (...) 1 (post-dose), Day 8 (post-dose), and Week 8 (follow-up) ] Number of participants with TEAEs, which includes laboratory test variables IA knee Lidocaine Systemic Pharmacokinetics - Concentration [ Time Frame: Day 1 (pre-dose to 3 hours post-dose) or Day 8 (pre-dose to 3 hours post-dose) [Cross over trial Qutenza® 8% patch or CNTX-4975-05 IA knee injection] ] System exposure to lidocaine measured by plasma concentration Eligibility Criteria Go to Information from the National Library of Medicine

2018 Clinical Trials

225. RCT of SPG Blocks for Post-dural Headache

. Patient will also be informed that they can request an EBP at any time. The SPG blockade will be performed twice daily in the hospital and twice daily at home, by the patient. The patient will also be informed, if that at anytime, they would like an EBP, it can be provided. While the study is being conducted, patients will not be offered a SPG block unless enrolled in the study. Outcome Measures Go to Primary Outcome Measures : Epidural Blood Patch [ Time Frame: 7 days after treatment with lidocaine (...) or placebo block ] Proportion of postpartum women with a postdural puncture headache (PDPH) requesting epidural blood patch (EBP) Secondary Outcome Measures : Verbal Numerical Pain [ Time Frame: 30 minutes, 1 hour, 2, hour, 1 day, 2, days, 3 days, 4 days, 5 days, 6 days, and 7 days after treatment with lidocaine or placebo block ] Verbal Numerical Pain score (0-10) Verbal Functionality Score [ Time Frame: 1 day, 2, days, 3 days, 4 days, 5 days, 6 days, and 7 days after treatment with lidocaine or placebo

2018 Clinical Trials

226. HIV-1-Gag Conserved-Element DNA Vaccine as Therapeutic Vaccination in HIV-Infected Persons With Viral Suppression on Antiretroviral Therapy

, or salpingectomy). If participating in sexual activity that could lead to pregnancy, willingness of female participants to use two forms of effective contraception while receiving study medication and for 3 months after stopping study medication is required. NOTE A: Effective forms of contraception include: Barrier methods (condoms [male or female] with or without a spermicidal agent, diaphragm, or cervical cap [with spermicide]) Hormone-based contraception (oral, patch, parenteral, implants, or vaginal ring (...) component, including hypersensitivity to amide-type local anesthetics, such as lidocaine (Xylocaine), mepivacaine (Polocaine/Carbocaine), etidocaine (Duranest), bupivacaine (Marcaine), or prilocaine. Current use of any electronic stimulation device, such as cardiac demand pacemakers, automatic implantable cardiac defibrillator, nerve stimulators, or deep brain stimulators. History of cardiac arrhythmia or palpitations (e.g., supraventricular tachycardia, atrial fibrillation, frequent ectopy, or sinus

2018 Clinical Trials

227. A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin

). Experimental: Capsaicin + EMLA group All subjects will be pre-treated with lidocain cream before capsaicin application Drug: Capsaicin Topical Capsaicin patches (dosage form: patch 8% Qutenza) will be applied on 4x4 cm squared areas on the volar forearm. The patches will be left in place for 24h and 3 hours after which they will be removed. Other: Histamine 1% To deliver histamine, standard allergy skin prick test (SPT) lancets are applied. The lancets have a 1 mm shouldered tip adapt to introduce a small (...) -desensitization action can still be induced in a skin area pretreated with topical, local anesthetic lidocaine. Condition or disease Intervention/treatment Phase Capsaicin Ultaviolet B Light Burn Neuropathic Pain Lidocaine Drug: Capsaicin Topical Radiation: Ultraviolet-B (UVB) irradiation Other: Histamine 1% Drug: Lidocaine Not Applicable Detailed Description: In this project the Ultraviolet- B pain model, a model using type B ultraviolet rays to induce a first-degree sunburn, will be used to induce a non

2018 Clinical Trials

228. Study to Evaluate the Pharmacokinetics of Guaifenesin in Adults and Adolescents

(Day 1 of Period 2) Stable hormonal contraceptive (oral, depo injection, transdermal patch, or vaginal ring) for at least 3 months prior to Day 1 of Period 1 through 30 days beyond completion of study (Day 1 of Period 2). Note: Abstinence (sexually inactive) was not an acceptable form of contraception; however, abstinent female subjects could have been admitted to the study if they agreed, and had signed a statement to the effect, that upon becoming sexually active, would use a condom (...) to guaifenesin or to EMLA® cream (eutectic mixture of local anesthetic) or its components (lidocaine + prilocaine as local anesthetic). Receipt of an investigational drug within 30 days prior to Day 1 of Period 1. Abnormal diet (for whatever reason) during the 30 days prior to Day 1 of Period 1. Donation of blood or significant loss of blood within 56 days prior to Day 1 of Period 1. Donation of plasma within 14 days prior to Day 1 of Period 1. Known or suspected use of illicit drugs (i.e., opiates

2018 Clinical Trials

229. A Comparison of Effectiveness of Oral Sucrolfate, Alginate and Hydrotalcide in Dispeptic Pain Treatment

and the envelope was opened by the study nurse to prepare the study medicine. The study medicines were prepared by an independent person who did not participate in the study or by the responsible work nurse who was at the helpline and was given to the patient by the other nurse. For each group, the drugs prepared in a 10 cc syringe were wrapped around the syringe with a color patch that did not show any similarity. When the medication was given to the patient, the patient's nose was closed and the drug smell (...) -regulated Device Product: No Product Manufactured in and Exported from the U.S.: No Keywords provided by Bulent Erdur, Pamukkale University: Dyspepsia Emergency Department Antacid Viscous Lidocaine Additional relevant MeSH terms: Layout table for MeSH terms Dyspepsia Signs and Symptoms, Digestive Signs and Symptoms Sucralfate Hydrotalcite Aluminum Hydroxide Magnesium Hydroxide Anti-Ulcer Agents Gastrointestinal Agents Antacids Molecular Mechanisms of Pharmacological Action Adjuvants, Immunologic

2018 Clinical Trials

230. Transdermal and Topical Drug Administration in the Treatment of Pain Full Text available with Trip Pro

in the structures of the joint and a provision of local anti-inflammatory effects. Topically administered drugs such as lidocaine and capsaicin in patches, capsaicin in cream, EMLA cream, and creams containing antidepressants (i.e., doxepin, amitriptyline) act mainly locally in tissues through receptors and/or ion channels. Transdermal and topical routes offer some advantages over systemic analgesic administration. Analgesics administered topically have a much better profile for adverse effects as they relieve

2018 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

231. 3VM1001 Cream for the Treatment of Pain Associated With Post Herpetic Neuralgia (PHN)

and frequently interferes with daily activities and with sleep. First line management of PHN pain currently is tricyclic anti-depressants and anti-convulsants such as gabapentin and pregabalin, and use of a 5% lidocaine patch. second line therapies include opioid analgesia and topical capsaicin: combinations of topical and systemic therapies may be used as well. These therapies have common side effects of dry mouth, constipation, sedation, urinary retention, nausea, somnolence, dizziness, weight gain (...) the target area such as eczema or psoriasis; Mild pain in the target area, characterized by VAS score of < 40 mm Pain in any other part of the body that could interfere with the patient's assessment of pain in the target area Subject who has taken concomitant medications for the treatment of PHN (except acetaminophen or gabapentin) in the last four weeks. If taking gabapentin the dose must have been stable for at least four weeks; Treatment with local anesthetic or steroids (including lidocaine patch

2018 Clinical Trials

232. Effectiveness of Sphenopalatine Ganglion Block for Post-Dural Puncture Headache

: February 12, 2019 See Sponsor: Milton S. Hershey Medical Center Information provided by (Responsible Party): Verghese T Cherian, MD, Milton S. Hershey Medical Center Study Details Study Description Go to Brief Summary: The objective of the study is to determine the effectiveness of Spheno-Palatine (SP) ganglion block to alleviate the pain of post-dural puncture headache (PDPH). Condition or disease Intervention/treatment Phase Post-Dural Puncture Headache Sphenopalatine Ganglion Block Drug: Lidocaine (...) Completion Date : March 2020 Estimated Study Completion Date : March 2020 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Sphenopalatine ganglion block Sphenopalatine ganglion block: this block will be performed by inserting swabs, with lidocaine squirted on them, into each nostril and reaching the nasopharyngeal wall. Drug: Lidocaine Lidocaine 2% viscous (0.5ml) will be squirted on two cotton

2018 Clinical Trials

236. 2014 AHA/ACC Guideline for the Management of Patients With Non-ST-Elevation Acute Coronary Syndromes Full Text available with Trip Pro

is not predictive of ACS. One study reported that sublingual nitroglycerin relieved symptoms in 35% of patients with documented ACS compared with 41% of patients without ACS. The relief of chest pain by “gastrointestinal cocktails” (eg, mixtures of liquid antacids, and/or viscous lidocaine, and/or anticholinergic agents) does not predict the absence of ACS. Demographics and History in Diagnosis and Risk Stratification A prior history of MI is associated with a high risk of obstructive and multivessel

2014 American Heart Association

238. Management of vulval conditions

. T4 and TSH) as it is often asymptomatic and has been found be associated (IV,C) 5 ? Skin swab: only useful to exclude co-existing infection if there are symptoms or signs suggestive of this ? Patch testing: rarely required and only if secondary medicament allergy suspected. The advice of a dermatologist should be sought. Treatment General Advice ? Patients should be informed about the condition and given written information. Patients should be made aware of the small risk of neoplastic change (...) % are classic on biopsy and clinicopathological discussion is important ? Investigation for autoimmune disease especially of the thyroid (i.e T4 and TSH if there is any suspicion of abnormality) (IV C) 5 ? Skin swab: to exclude secondary infection especially of excoriated lesions ? Patch testing: if secondary medicament allergy suspected ? Whilst a link with hepatitis C and sometimes B has been noted in some countries there is no evidence of increased incidence in the UK and routine screening is not thought

2014 British Association for Sexual Health and HIV

239. Briefs: Tongue lacerations – sew or let go

Journal, 2008. You can generally tell parents that the wound will approximate itself over several days, usually less than a week. It will then look like a whitish raised patch on the tongue, before receding into a more normal appearance over days to weeks. Initially the wound will be sensitive, especially to salty, acidic, or spicy foods. A bland, soft diet can help. Acetaminophen or ibuprofen will be sufficient for pain control, and popsicles will help with the pain and swelling too. Sending patients (...) need to get everything together beforehand, and consider providing sedation. Local anesthesia can be provided with 4% lidocaine gel on gauze applied for 5 minutes, 1% lidocaine injected into the tongue, or an inferior alveolar nerve block which will block the lingual nerve and the anterior 2/3 of the tongue. You also need to control the tongue and keep it protruded. This can be accomplished by grabbing the tip with forceps, or by placing a large (3-0, 2-0) suture thorough the tip

2020 PEM Blog

240. Osteoarthritis of the Knee

for or against the use of acetaminophen, opioids, or pain patches for patients with symptomatic osteoarthritis of the knee. Strength of Recommendation: Inconclusive Description: Evidence from a single low quality study or conflicting findings that do not allow a recommendation for or against the intervention. An Inconclusive recommendation means that there is a lack of compelling evidence that has resulted in an unclear balance between benefits and potential harm. Implications: Practitioners should feel

2013 American Academy of Orthopaedic Surgeons

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