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Lidocaine Patch

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221. LaseMD System for the Treatment of Melasma

. Subjects with sensitivity or allergy to pre-treatment medication, EMLA Cream (Lidocaine/Prilocaine). Subjects with sensitivity or allergy to post-treatment cosmeceuticals, Tranexamic Acid and/or coconut. Subjects with photosensitive skin. Concurrent therapy that, in the investigator's opinion, would interfere with the evaluation of the safety or efficacy of the study device. Subjects who are pregnant or lactating or anticipate becoming pregnant during the study. Subjects who anticipate the need (...) for inpatient surgery or overnight hospitalization during the study. Subjects who, in the investigator's opinion, have a history of poor cooperation, noncompliance with medical treatment, or unreliability. Concurrent enrollment in any study involving the use of investigational devices or drugs. Current smoker or history of smoking in the last five years. Current user of any nicotine-containing products, e.g., e-cigarettes, Nicorette gum, nicotine patches, etc. Excessively tanned in areas to be treated

2018 Clinical Trials

222. Effectiveness of Sphenopalatine Ganglion Block for Post-Dural Puncture Headache

: February 12, 2019 See Sponsor: Milton S. Hershey Medical Center Information provided by (Responsible Party): Verghese T Cherian, MD, Milton S. Hershey Medical Center Study Details Study Description Go to Brief Summary: The objective of the study is to determine the effectiveness of Spheno-Palatine (SP) ganglion block to alleviate the pain of post-dural puncture headache (PDPH). Condition or disease Intervention/treatment Phase Post-Dural Puncture Headache Sphenopalatine Ganglion Block Drug: Lidocaine (...) Completion Date : March 2020 Estimated Study Completion Date : March 2020 Resource links provided by the National Library of Medicine related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: Sphenopalatine ganglion block Sphenopalatine ganglion block: this block will be performed by inserting swabs, with lidocaine squirted on them, into each nostril and reaching the nasopharyngeal wall. Drug: Lidocaine Lidocaine 2% viscous (0.5ml) will be squirted on two cotton

2018 Clinical Trials

223. Sodium Channel Nav1.3 Is Expressed by Polymorphonuclear Neutrophils during Mouse Heart and Kidney Ischemia In Vivo and Regulates Adhesion, Transmigration, and Chemotaxis of Human and Mouse Neutrophils In Vitro. (PubMed)

-gated sodium channels was analyzed by polymerase chain reaction. Distribution of Nav1.3 was determined by immunofluorescence and flow cytometry in mouse models of ischemic heart and kidney injury. Adhesion, transmigration, and chemotaxis of neutrophils to endothelial cells and collagen were investigated with voltage-gated sodium channel inhibitors and lidocaine in vitro. Sodium currents were examined with a whole cell patch clamp.Mouse and human neutrophils express multiple voltage-gated sodium (...) prevented chemotactic migration (n = 60, 3 × 20 cells). Lidocaine reduced neutrophil adhesion to 60 ± 9% (n = 10) and transmigration to 54 ± 8% (n = 9). The effect of lidocaine was not increased by ICA121431 or Pterinotoxin-2.Nav1.3 is expressed in neutrophils in vivo; regulates attachment, transmigration, and chemotaxis in vitro; and may serve as a relevant target for antiinflammatory effects of lidocaine.

2018 Anesthesiology

224. Study to Evaluate the Pharmacokinetics of Guaifenesin in Adults and Adolescents

(Day 1 of Period 2) Stable hormonal contraceptive (oral, depo injection, transdermal patch, or vaginal ring) for at least 3 months prior to Day 1 of Period 1 through 30 days beyond completion of study (Day 1 of Period 2). Note: Abstinence (sexually inactive) was not an acceptable form of contraception; however, abstinent female subjects could have been admitted to the study if they agreed, and had signed a statement to the effect, that upon becoming sexually active, would use a condom (...) to guaifenesin or to EMLA® cream (eutectic mixture of local anesthetic) or its components (lidocaine + prilocaine as local anesthetic). Receipt of an investigational drug within 30 days prior to Day 1 of Period 1. Abnormal diet (for whatever reason) during the 30 days prior to Day 1 of Period 1. Donation of blood or significant loss of blood within 56 days prior to Day 1 of Period 1. Donation of plasma within 14 days prior to Day 1 of Period 1. Known or suspected use of illicit drugs (i.e., opiates

2018 Clinical Trials

225. RCT of SPG Blocks for Post-dural Headache

. Patient will also be informed that they can request an EBP at any time. The SPG blockade will be performed twice daily in the hospital and twice daily at home, by the patient. The patient will also be informed, if that at anytime, they would like an EBP, it can be provided. While the study is being conducted, patients will not be offered a SPG block unless enrolled in the study. Outcome Measures Go to Primary Outcome Measures : Epidural Blood Patch [ Time Frame: 7 days after treatment with lidocaine (...) or placebo block ] Proportion of postpartum women with a postdural puncture headache (PDPH) requesting epidural blood patch (EBP) Secondary Outcome Measures : Verbal Numerical Pain [ Time Frame: 30 minutes, 1 hour, 2, hour, 1 day, 2, days, 3 days, 4 days, 5 days, 6 days, and 7 days after treatment with lidocaine or placebo block ] Verbal Numerical Pain score (0-10) Verbal Functionality Score [ Time Frame: 1 day, 2, days, 3 days, 4 days, 5 days, 6 days, and 7 days after treatment with lidocaine or placebo

2018 Clinical Trials

226. HIV-1-Gag Conserved-Element DNA Vaccine as Therapeutic Vaccination in HIV-Infected Persons With Viral Suppression on Antiretroviral Therapy

, or salpingectomy). If participating in sexual activity that could lead to pregnancy, willingness of female participants to use two forms of effective contraception while receiving study medication and for 3 months after stopping study medication is required. NOTE A: Effective forms of contraception include: Barrier methods (condoms [male or female] with or without a spermicidal agent, diaphragm, or cervical cap [with spermicide]) Hormone-based contraception (oral, patch, parenteral, implants, or vaginal ring (...) component, including hypersensitivity to amide-type local anesthetics, such as lidocaine (Xylocaine), mepivacaine (Polocaine/Carbocaine), etidocaine (Duranest), bupivacaine (Marcaine), or prilocaine. Current use of any electronic stimulation device, such as cardiac demand pacemakers, automatic implantable cardiac defibrillator, nerve stimulators, or deep brain stimulators. History of cardiac arrhythmia or palpitations (e.g., supraventricular tachycardia, atrial fibrillation, frequent ectopy, or sinus

2018 Clinical Trials

227. A Comparison of Effectiveness of Oral Sucrolfate, Alginate and Hydrotalcide in Dispeptic Pain Treatment

and the envelope was opened by the study nurse to prepare the study medicine. The study medicines were prepared by an independent person who did not participate in the study or by the responsible work nurse who was at the helpline and was given to the patient by the other nurse. For each group, the drugs prepared in a 10 cc syringe were wrapped around the syringe with a color patch that did not show any similarity. When the medication was given to the patient, the patient's nose was closed and the drug smell (...) -regulated Device Product: No Product Manufactured in and Exported from the U.S.: No Keywords provided by Bulent Erdur, Pamukkale University: Dyspepsia Emergency Department Antacid Viscous Lidocaine Additional relevant MeSH terms: Layout table for MeSH terms Dyspepsia Signs and Symptoms, Digestive Signs and Symptoms Sucralfate Hydrotalcite Aluminum Hydroxide Magnesium Hydroxide Anti-Ulcer Agents Gastrointestinal Agents Antacids Molecular Mechanisms of Pharmacological Action Adjuvants, Immunologic

2018 Clinical Trials

228. AMAZ-02 Effect on Exercise ToLerance in Healthy, Overweight Middle Aged Subjects (ATLAS Trial)

and have a negative urine pregnancy test result. All hormonal birth control must have been in use for a minimum of three months. Acceptable methods of birth control include: Hormonal contraceptives including oral contraceptives, hormone birth control patch (Ortho Evra), vaginal contraceptive ring (NuvaRing), injectable contraceptives (Depo-Provera, Lunelle), or hormone implant (Norplant System) Double-barrier method Intrauterine devices Non-heterosexual lifestyle or agrees to use contraception (...) laboratory results at screening Allergy or sensitivity to test product ingredients (or closely related compounds) Allergy to anesthetic (Xylocaine, lidocaine) Soy allergy Inability to abstain from the consumption of pomegranate juice or walnuts Inability to abstain from frequent consumption of raspberries, strawberries or cloudberries Excessive consumption of beverages containing xanthine bases (>4 cups per day) such as coffee, tea, and cola Use of NHPs for the purposes of muscle building or function

2018 Clinical Trials

229. Oral Pregabalin Effect to the Intravenous Morphine in Multiple Fracture Ribs

be used only in combination with other analgesic modalities such acetaminophen, nonsteroidal anti-inflammatory medication(NSAID), the anticonvulsants gabapentin and pregabalin,and the topical lidocaine patch Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 80 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Triple (Participant, Care Provider, Investigator) Primary Purpose: Treatment Official

2018 Clinical Trials

230. MAST Trial: Multi-modal Analgesic Strategies in Trauma

)/ per oral (PO) q6 hours in the first 48 hours, and Acetaminophen 1g PO q6 hours thereafter; 2. Ketorolac 30mg IV once and Celebrex 200mg PO q12 hours in the first 48 hours, and Naproxen 500mg PO q12 hours thereafter; 3. Tramadol 100mg PO q6 hours in the first 48 hours, and Tramadol 100mg PO q6 hours thereafter; 4. Pregabalin 100mg PO q8 hours in the first 48 hours, and Gabapentin 300mg PO q8 hours thereafter; 5. Lidocaine patch q12 hours in the first 48 hours, and Lidocaine patch q12 hours (...) every 8 hours Drug: Lidocaine Lidocaine patch every 12 hours Drug: Opioids Opioids Drug: Regional anesthesia Regional anesthesia Active Comparator: Treatment Strategy #2 - escalating dose arm Treatment Strategy #2 is the escalating dose arm. Inclusion in this arm will involve one of the following 6 drug combinations, and the treating physician will choose strategy. The 6 strategies are: 1. Acetaminophen 1g PO q6 hours at admission and thereafter; 2. Ketorolac 30mg IV once and Naproxen 500mg PO q12

2018 Clinical Trials

231. Is Sphenopalatine Ganglion Block Treatment Effective on Postspinal Headaches

volume causes decreased brain volume and compensatory mechanisms lead to cerebral venous dilatation. Conservative treatments are iv hydration, analgesic agents, caffeine or theophylline. Epidural blood patch is the gold standard for the treatment . However epidural blood patch is an invasive technic and has some complications such as dural puncture, infection and neurologic trauma. Sphenopalatine ganglion is one of the four parasympathetic thin ganglion in skull. Parasympathetic fibers innervates (...) cerebral and meningeal blood vessels which cause vasodilatation and stimulate nociceptor activation on meninges. Consequently headache is related with sensory cortex. Transnasal SPG block is performed successfully in chronic pain syndromes including migraine, cluster headaches and atypic face pain. Likewise the SPG block is performed in acute treatment of postspinal headache. However gold standard of the treatment is epidural blood patching which is interventional and has many risks. Several studies

2018 Clinical Trials

232. Continuous Non-invasive Blood Pressure Measurement in C-section

. The application of a novel non-invasive, patch-clamp-based continuous blood pressure measurement system (ClearSightTM, Edwards Lifesciences Corporation, Irvine, California, USA) promises to combine the advantages of NIBP, namely non-invasiveness and IBP, the continuous pressure measurement. So far, there have been no randomized, controlled trials for application. Spinal anesthesia is a widespread anaesthetic procedure for performing Caesarean sections. Within the clinical standard, an intermittent blood (...) according to SOP (standard operating procedure) and is continued until the umbilical cord of the fetus is removed. Subsequently, a peripheral venous access is applied and 500 ml of full electrolyte solution are infused. Subsequently, the spinal anesthesia is applied in a seated position. Size-adapted 1.6 - 2.0 ml hyperbaric bupivacaine 0.5%, 0.1 mg morphine and 5 µg sufentanil are used. According to SOP, local skin infiltration with lidocaine 1% is carried out. After application of the spinal

2018 Clinical Trials

233. Comparison Tympanoplasty With Membrane Amniotic and Autologous Fascia

of the eardrum in the absence of its spontaneously healing indicates surgical management. These surgeries are performing using various materials including fascia, cartilage, fats, pericardium and paper patch. It has proven that using different materials results in outcome and postoperative complications. The criteria of the best graft material includes availability, preservability, manageability, and acceptance rate to the hosts. Human amniotic membrane is preservable. Also, there isn't significant (...) with a gas number and a Surgifix. Step4. Patients were discharge from the operating room with an oral administration of Cephalexin capsules. Procedure: Tympanoplasty With Autologous Fascia Autologous Temporalis fascia Tympanoplasty Experimental: Test group Step1. After sedation and conducting local anesthesia with Lidocaine 2% and inserting the edges of the tympanic membrane and inserting the foam gel into the middle ear, amniotic membranes (produced in Iran tissue product) with a thickness of 100

2018 Clinical Trials

234. A Study to Compare Levels of Capsaicin After Intra-Articular Injection and Topical Application in Patients With Painful Knee Osteoarthritis

knee. Drug: CNTX-4975-05 1 mg (2mL) IA injection Other Name: trans-capsaicin Drug: Lidocaine (without epinephrine) 15 mL IA injection of 2% lidocaine (without epinephrine) Active Comparator: Topical 8% Capsaicin Patch Receives Capsaicin Patch on posterior rib cage. Drug: Qutenza 8% topical patch Other Name: cis-capsaicin Outcome Measures Go to Primary Outcome Measures : Capsaicin Pharmacokinetics - AUC0-t [ Time Frame: Day 1 (pre-dose to 12 hours post-dose) and Day 8 (pre-dose to 12 hours post-dose (...) 1 (post-dose), Day 8 (post-dose), and Week 8 (follow-up) ] Number of participants with TEAEs, which includes laboratory test variables IA knee Lidocaine Systemic Pharmacokinetics - Concentration [ Time Frame: Day 1 (pre-dose to 3 hours post-dose) or Day 8 (pre-dose to 3 hours post-dose) [Cross over trial Qutenza® 8% patch or CNTX-4975-05 IA knee injection] ] System exposure to lidocaine measured by plasma concentration Eligibility Criteria Go to Information from the National Library of Medicine

2018 Clinical Trials

235. A Mechanistic Evaluation of the Nociceptive Desensitizing Properties of Topical Capsaicin

). Experimental: Capsaicin + EMLA group All subjects will be pre-treated with lidocain cream before capsaicin application Drug: Capsaicin Topical Capsaicin patches (dosage form: patch 8% Qutenza) will be applied on 4x4 cm squared areas on the volar forearm. The patches will be left in place for 24h and 3 hours after which they will be removed. Other: Histamine 1% To deliver histamine, standard allergy skin prick test (SPT) lancets are applied. The lancets have a 1 mm shouldered tip adapt to introduce a small (...) -desensitization action can still be induced in a skin area pretreated with topical, local anesthetic lidocaine. Condition or disease Intervention/treatment Phase Capsaicin Ultaviolet B Light Burn Neuropathic Pain Lidocaine Drug: Capsaicin Topical Radiation: Ultraviolet-B (UVB) irradiation Other: Histamine 1% Drug: Lidocaine Not Applicable Detailed Description: In this project the Ultraviolet- B pain model, a model using type B ultraviolet rays to induce a first-degree sunburn, will be used to induce a non

2018 Clinical Trials

236. The Effect of Ganglion Sphenopalatine Block (GSP-block) Versus Placebo on Postdural Puncture Headache

Postdural Puncture Headache Sphenopalatine Ganglion Block Procedure: Ganglion sphenopalatine block with local anesthetic Procedure: Ganglion sphenopalatine block with placebo Phase 3 Detailed Description: Adult patients with postdural puncture headache will be enrolled in the study. The patients will be randomised to receive a ganglion sphenopalatine block (GSP-block) with either local anesthetic (lidocaine + ropivacaine) or placebo (isotone NaCl). Primary outcome is hyperactivity in the sphenopalatine (...) ganglion assessed by pain intensity (0-100mm on a visual analogue scale, VAS) of the postdural headache in standing position 30 minutes after block. If the patients in the timeframe of 1 hour to 1 week after block does not achieve remission (VAS <30mm while standing) they will be offered a "rescue GSP-block" defined as a new GSP-block with "open-label" local anesthetic and if continued lack of remission at least 1 hour thereafter then an epidural blood patch will be offered. Study Design Go to Layout

2018 Clinical Trials

237. The Safety and Efficacy of a Novel HSP90 Inhibitor (CUDC-305) in the Treatment of Moderate to Severe Psoriasis.

before baseline (Day 0) until at least 4 weeks after the last study product administration for the duration of the study. Effective contraceptive methods are: systemic hormonal contraceptives (oral contraceptive, patch, vaginal ring, injectables, or implants), intrauterine devices, vasectomy, or barrier methods of contraception in conjunction with spermicide. Hormonal contraceptives must be on a stable dose for at least 4 weeks before baseline (Day 0). Note: Women of nonchildbearing potential (...) sunlight exposure during the study. Use of sunscreen products and protective apparel are recommended for other circumstances when exposure cannot be avoided. Sunscreen must not be applied on the clinic visit days before the visit. Subject has a history of an allergic reaction or significant sensitivity to lidocaine or other local anesthetics. Subject has a history of hypertrophic scarring or keloid formation in scars or suture sites. Subject is taking anticoagulant medication, such as heparin, low

2018 Clinical Trials

238. Bronchoscopy in Determining the Effect of E-Cigarette Smoking on Biomarkers in the Lungs

to use the nicotine-containing SREC for 2 weeks and use both their usual brand of cigarettes and the nicotine-containing SREC starting day 15 for 8 weeks with the intention of smoking reduction to 5 cigarettes or less per day. Participants undergo a second bronchoscopy on day 71. GROUP V: Participants undergo bronchoscopy over 30-60 minutes at baseline. Beginning 2 days before the day 15 quit date, participants stop smoking using NRT comprising either patch, gum, or lozenge for 8 weeks. Participants (...) -Cigarette Electronic Nicotine Delivery System Other: Laboratory Biomarker Analysis Correlative studies Other: Questionnaire Administration Ancillary studies Experimental: Group V (NRT) Participants undergo bronchoscopy over 30-60 minutes at baseline. Beginning 2 days before the day 15 quit date, participants stop smoking using NRT comprising either patch, gum, or lozenge for 8 weeks. Participants undergo a second bronchoscopy on day 71. Procedure: Bronchoscopy with Bronchoalveolar Lavage Undergo

2018 Clinical Trials

239. Transdermal and Topical Drug Administration in the Treatment of Pain (PubMed)

in the structures of the joint and a provision of local anti-inflammatory effects. Topically administered drugs such as lidocaine and capsaicin in patches, capsaicin in cream, EMLA cream, and creams containing antidepressants (i.e., doxepin, amitriptyline) act mainly locally in tissues through receptors and/or ion channels. Transdermal and topical routes offer some advantages over systemic analgesic administration. Analgesics administered topically have a much better profile for adverse effects as they relieve

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2018 Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

240. Study of Efficacy and Safety of Gabapentin to Reduce the Need for Strong Opioid Use in Head and Neck Cancer Patients.

or with prior gabapentin/pregabalin use Patients taking pain medications (e.g. topical analgesics such as lidocaine gel or lidocaine patch) for pre-existing pain of other aetiology. Administration of topical mouthwash is allowed. Patients with pre-existing peripheral neuropathy of another aetiology, B12 deficiency, AIDS, monoclonal gammopathy, diabetes, heavy metal poisoning, syphilis, amyloidosis, hyper- or hypothyroidism, inherited neuropathy Patients taking anti-epileptics for (myoclonic) seizures

2018 Clinical Trials

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