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Lichen Sclerosus

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1. Insights into the pathophysiology of urethral stricture disease due to lichen sclerosus: comparison of pathologic markers in lichen sclerosus induced strictures versus non-lichen sclerosus induced strictures. (PubMed)

Insights into the pathophysiology of urethral stricture disease due to lichen sclerosus: comparison of pathologic markers in lichen sclerosus induced strictures versus non-lichen sclerosus induced strictures. We evaluated the pathophysiology of lichen sclerosus and nonlichen sclerosus urethral stricture disease by comparing protein expression related to inflammation, cell cycle disruption, oxidative stress, hormone receptor status and infection.Tissue samples were collected from the urethral (...) strictures of 81 patients undergoing urethroplasty. Clinical and demographic data were obtained by chart review. After identifying areas pathognomonic for lichen sclerosus a tissue microarray was created with cores from each sample and immunohistochemistry was performed.Patients had similar baseline demographics and comorbidities. Of the 81 strictures 58 were and 23 were not due to lichen sclerosus. Lichen sclerosus strictures were significantly longer and showed higher levels of inflammation

2019 Journal of Urology

3. Lichen Sclerosus

Lichen Sclerosus EDF Guidelines Secretariat to Prof. Dr. Alexander Nast: Bettina Schulze, Klinik für Dermatologie, Venerologie und Allergologie, Campus Charité Mitte, Charité – Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany phone: ++49 30 450 518 062, fax: ++49 30 450 518 911, e-mail: bettina.schulze@charité.de Guideline on Lichen sclerosus Developed by the Guideline Subcommittee of the European Dermatology Forum Subcommittee Members: Dr. med. habil. Gudula Kirtschig (...) influenced, or that give the appearance of potentially influencing, what you wrote in the submitted work? no no no no Evidence-based (S3) Guideline on (anogenital) Lichen sclerosus Dr. med. habl. Gudula Kirtschig, Nottingham (United Kingdom); Tübingen (Germany) Dr. Silke Riechardt, Hamburg (Germany) Dr. Karl Becker, Bonn (Germany) Dr. Francesco Casabona, Genova (Italy) Prof. Dr. Andreas Günthert, Lucerne (Switzerland) Dr. Jenny Powell, Hampshire (United Kingdom) Associate Professor Daiva Jasaitienè

2018 European Dermatology Forum

4. British Association of Dermatologists' guidelines for the management of lichen sclerosus

British Association of Dermatologists' guidelines for the management of lichen sclerosus GUIDELINE BJD British Journal of Dermatology British Association of Dermatologists guidelines for the management of lichen sclerosus, 2018* F.M. Lewis iD, 1,2 F.M. Tatnall, 3 S.S. Velangi, 4 C.B. Bunker, 5,6 A. Kumar, 7 F. Brackenbury, 8 M.F. Mohd Mustapa 9 and L.S. Exton 9 1 Frimley Health NHS Foundation Trust, Slough SL2 4HL, U.K. 2 St John’s Institute of Dermatology, Guy’s & St Thomas’ NHS Foundation (...) Trust, London SE1 9RT, U.K. 3 West Hertfordshire NHS Trust, Watford WD18 0HB, U.K. 4 University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, U.K. 5 University College London Hospitals NHS Foundation Trust, University College Hospital, London NW1 2BU, U.K. 6 Chelsea & Westminster NHS Foundation Trust, London SW10 9NH, U.K. 7 King’s College London, London SE1 3ER, U.K. 8 Association for Lichen Sclerosus and Vulval Health, Brighton, U.K. 9 British Association of Dermatologists, Willan

2018 British Association of Dermatologists

5. Determining if Platelet-rich Plasma is an Effective Treatment of Lichen Sclerosus in Adult Women

Determining if Platelet-rich Plasma is an Effective Treatment of Lichen Sclerosus in Adult Women "Determining if Platelet-rich Plasma is an Effective Treatment of Liche" by Grace McInnes < > > > > > Title Author Date of Graduation Summer 8-10-2019 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies Rights . Abstract Background: Lichen sclerosus (LS) is a chronic, inflammatory tissue disease that most commonly affects adult women. The current treatment (...) is long-term topical steroids. Platelet-rich plasma (PRP) has gained much attention as a treatment for multiple tissue disorders due to its rejuvenating qualities. The purpose of this review is to investigate PRP’s effectiveness on treating lichen sclerosus in adult women. Methods: An Exhaustive literature search was performed using MEDLINE, TRIP, and Google Scholar and the following search terms were used “vaginal atrophy,” "lichen sclerosus," "vulvovaginal atrophy," "lichen simplex chronicus

2019 Pacific University EBM Capstone Project

6. Carcinome épidermoïde sur lichen scléro-atrophique vulvaire: Epidermoid carcinoma associated with atrophic vulvar lichen sclerosus (PubMed)

Carcinome épidermoïde sur lichen scléro-atrophique vulvaire: Epidermoid carcinoma associated with atrophic vulvar lichen sclerosus We here report the case of a 58-year old female patient with no particular past medical history, presenting with a 5-year history of vulvar pruritis, drought and vulvodynia at the Department of Dermatology. Clinical examination showed diffuse porcelaine lesions at the level of the vulva, with a yellowish hemispheric nodular lesion measuring 1 cm in diameter (...) on the whitish plates and some excoriated lesions due to scratching. A skin biopsy was performed at the level of the whitish lesions and at the level of the nodular lesion. Histological examination suggested epidermoid carcinoma for the budding lesion and atrophic vulvar lichen sclerosus for the porcelaine lesions. Surgical treatment was recommended associated with radiation therapy. This study aims to highlight the risk for atrophic vulvar lichen sclerosu degeneration.

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2018 The Pan African medical journal

7. What is the role of one-stage oral mucosa urethroplasty in the management of strictures due to male Lichen Sclerosus?

What is the role of one-stage oral mucosa urethroplasty in the management of strictures due to male Lichen Sclerosus? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated

2019 PROSPERO

8. Treatment alternatives for vulvar lichen sclerosus: a systematic review and armed based network meta-analysis

Treatment alternatives for vulvar lichen sclerosus: a systematic review and armed based network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

9. What is the current understanding of the pathophysiology of lichen sclerosus?

What is the current understanding of the pathophysiology of lichen sclerosus? Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites. Email

2019 PROSPERO

10. Laser therapy for lichen sclerosus: a systematic review of the current evidence base

Laser therapy for lichen sclerosus: a systematic review of the current evidence base Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites

2019 PROSPERO

11. Under expression of the Sonic Hedgehog receptor, Patched1 (PTCH1), is associated with an increased risk of local recurrence in squamous cell carcinoma of the vulva arising on a background of Lichen Sclerosus. (PubMed)

Under expression of the Sonic Hedgehog receptor, Patched1 (PTCH1), is associated with an increased risk of local recurrence in squamous cell carcinoma of the vulva arising on a background of Lichen Sclerosus. Dysregulation of the Hedgehog (Hh) pathway has been described in a variety of cancers, including cervical cancer, a disease which shares a common aetiology with vulval squamous cell carcinoma (VSCC). Here, we investigate a large number of primary VSCC cases for evidence of Hedgehog pathway (...) of key Hh pathway components on clinical outcomes.We show that 92% of primary VSCC cases over-expressed one or more components of the Hh signalling pathway when compared to the adjacent normal epithelium. While expression of SHH and GLI1 did not correlate with any clinicopathological criteria, over- or under-expression of PTCH1 was associated with a reduced or increased risk of developing a local disease recurrence, respectively. In VSCC arising on a background of Lichen Sclerosus, the risk of local

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2018 PLoS ONE

12. Male genital lichen sclerosus and filaggrin. (PubMed)

Male genital lichen sclerosus and filaggrin. 31206209 2019 07 05 1365-2230 2019 Jun 17 Clinical and experimental dermatology Clin. Exp. Dermatol. Male genital lichen sclerosus and filaggrin. 10.1111/ced.14023 Shim T N TN https://orcid.org/0000-0001-8967-9811 University College London Hospitals NHS Foundation Trust, London, UK. Brown S J SJ Department of Dermatology and Genetic Medicine, University of Dundee, Dundee, UK. Francis N D ND Department of Histopathology, Imperial College Healthcare

2019 Clinical & Experimental Dermatology

13. Living with vulval lichen sclerosus: a systematic review. (PubMed)

Living with vulval lichen sclerosus: a systematic review. Lichen sclerosus (LS) is an under-researched disorder, particularly from the perspective of individuals who have the condition. A recent James Lind Alliance Priority Setting Partnership identified uncertainties in many aspects of the condition, including its impact on quality of life which was ranked within the 'Top 10' future research priorities.1,2 We set out to systematically review the qualitative literature exploring the lived

2019 British Journal of Dermatology

14. A randomized double-blind placebo-controlled trial of autologous platelet-rich plasma intradermal injections for the treatment of vulvar lichen sclerosus. (PubMed)

A randomized double-blind placebo-controlled trial of autologous platelet-rich plasma intradermal injections for the treatment of vulvar lichen sclerosus. 30639885 2019 02 09 1097-6787 2019 Jan 11 Journal of the American Academy of Dermatology J. Am. Acad. Dermatol. A randomized double-blind placebo-controlled trial of autologous platelet-rich plasma intradermal injections for the treatment of vulvar lichen sclerosus. S0190-9622(19)30066-0 10.1016/j.jaad.2018.12.060 Goldstein Andrew T AT Center

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2019 Journal of the American Academy of Dermatology Controlled trial quality: predicted high

15. Efficacy of Non-ablative Laser Therapy for Lichen Sclerosus: A Randomized Controlled Trial. (PubMed)

Efficacy of Non-ablative Laser Therapy for Lichen Sclerosus: A Randomized Controlled Trial. The aim of this randomized controlled trial was to evaluate the safety and efficacy of neodymium: yttrium aluminum garnet laser treatment of lichen sclerosus (LS) by comparing it with topical corticosteroid treatment.A total of 40 female patients with vulvar LS were randomized 1:1 into a study (laser) group and a control (topical corticosteroids) group. The laser group received three laser treatments

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2019 Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC Controlled trial quality: uncertain

16. Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation. (PubMed)

Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation. Lichen sclerosus (LS) is a disease of the skin of unclear etiology that can occur in the foreskin. Topical therapy with corticosteroids is recommended, but they can have side effects.We aimed to compare the effects of ozonides with vitamin E acetate (OZOILE) versus topical corticosteroid in children undergoing circumcision.Twenty children

2019 Urologia internationalis Controlled trial quality: uncertain

17. Ultrasound evidence of bladder outlet obstruction secondary to lichen sclerosus et atrophicus in boys (balanitis xerotica obliterans). (PubMed)

Ultrasound evidence of bladder outlet obstruction secondary to lichen sclerosus et atrophicus in boys (balanitis xerotica obliterans). Lichen sclerosus (LS), (balanitis xerotica obliterans), causes pathological phimosis. Many boys present with obstructive symptoms, the cause is usually obvious on examination so ultrasound scans (USS) of the urinary tract are not routinely indicated. We review a series of abnormal USS in boys with LS.Retrospective note review for boys undergoing surgical

2019 Journal of Pediatric Surgery

18. The long-term clinical consequences of Juvenile Vulvar Lichen Sclerosus, a systematic review. (PubMed)

The long-term clinical consequences of Juvenile Vulvar Lichen Sclerosus, a systematic review. Vulvar lichen sclerosus (VLS) occurring in juveniles (children and adolescents) may have repercussions throughout life.We sought to assess the evidence available on the long-term consequences of juvenile vulvar lichen sclerosus (JVLS).Multiple databases were searched for studies containing long-term follow-up information on children or adolescents up to age 18 with VLS. Articles were classified

2019 Journal of American Academy of Dermatology

19. Paediatric vulval lichen sclerosus: a retrospective study. (PubMed)

Paediatric vulval lichen sclerosus: a retrospective study. Lichen sclerosus (LS) is a chronic inflammatory dermatosis with a predilection for the anogenital region, which mainly affects prepubertal girls and postmenopausal women. The cause is unknown, but a number of potential aetiological factors have been identified.To examine a cohort of patients with prepubertal-onset vulval LS (VLS) and assess baseline characteristics, clinical presentation, potential precipitating and predisposing factors

2019 Clinical & Experimental Dermatology

20. Pediatric lichen sclerosus: A systematic review of 4516 cases. (PubMed)

Pediatric lichen sclerosus: A systematic review of 4516 cases. Lichen sclerosus (LS) represents a chronic autoinflammatory disease of unknown etiology and is not rarely encountered in pediatric dermatology centers. Recent surveys have highlighted the lack of confidence of physicians in addressing LS in the pediatric age group. We performed a systematic analysis of the PubMed and Embase databases using the terms 'lichen sclerosus', 'lichen sclerosis', 'kraurosis vulvae', and 'balanitis xerotica

2019 British Journal of Dermatology

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