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Lichen Sclerosus

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1. Insights into the pathophysiology of urethral stricture disease due to lichen sclerosus: comparison of pathologic markers in lichen sclerosus induced strictures versus non-lichen sclerosus induced strictures. (PubMed)

Insights into the pathophysiology of urethral stricture disease due to lichen sclerosus: comparison of pathologic markers in lichen sclerosus induced strictures versus non-lichen sclerosus induced strictures. We evaluated the pathophysiology of lichen sclerosus and nonlichen sclerosus urethral stricture disease by comparing protein expression related to inflammation, cell cycle disruption, oxidative stress, hormone receptor status and infection.Tissue samples were collected from the urethral (...) strictures of 81 patients undergoing urethroplasty. Clinical and demographic data were obtained by chart review. After identifying areas pathognomonic for lichen sclerosus a tissue microarray was created with cores from each sample and immunohistochemistry was performed.Patients had similar baseline demographics and comorbidities. Of the 81 strictures 58 were and 23 were not due to lichen sclerosus. Lichen sclerosus strictures were significantly longer and showed higher levels of inflammation

2019 Journal of Urology

3. British Association of Dermatologists' guidelines for the management of lichen sclerosus

British Association of Dermatologists' guidelines for the management of lichen sclerosus GUIDELINE BJD British Journal of Dermatology British Association of Dermatologists guidelines for the management of lichen sclerosus, 2018* F.M. Lewis iD, 1,2 F.M. Tatnall, 3 S.S. Velangi, 4 C.B. Bunker, 5,6 A. Kumar, 7 F. Brackenbury, 8 M.F. Mohd Mustapa 9 and L.S. Exton 9 1 Frimley Health NHS Foundation Trust, Slough SL2 4HL, U.K. 2 St John’s Institute of Dermatology, Guy’s & St Thomas’ NHS Foundation (...) Trust, London SE1 9RT, U.K. 3 West Hertfordshire NHS Trust, Watford WD18 0HB, U.K. 4 University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2TH, U.K. 5 University College London Hospitals NHS Foundation Trust, University College Hospital, London NW1 2BU, U.K. 6 Chelsea & Westminster NHS Foundation Trust, London SW10 9NH, U.K. 7 King’s College London, London SE1 3ER, U.K. 8 Association for Lichen Sclerosus and Vulval Health, Brighton, U.K. 9 British Association of Dermatologists, Willan

2018 British Association of Dermatologists

4. Carcinome épidermoïde sur lichen scléro-atrophique vulvaire: Epidermoid carcinoma associated with atrophic vulvar lichen sclerosus (PubMed)

Carcinome épidermoïde sur lichen scléro-atrophique vulvaire: Epidermoid carcinoma associated with atrophic vulvar lichen sclerosus We here report the case of a 58-year old female patient with no particular past medical history, presenting with a 5-year history of vulvar pruritis, drought and vulvodynia at the Department of Dermatology. Clinical examination showed diffuse porcelaine lesions at the level of the vulva, with a yellowish hemispheric nodular lesion measuring 1 cm in diameter (...) on the whitish plates and some excoriated lesions due to scratching. A skin biopsy was performed at the level of the whitish lesions and at the level of the nodular lesion. Histological examination suggested epidermoid carcinoma for the budding lesion and atrophic vulvar lichen sclerosus for the porcelaine lesions. Surgical treatment was recommended associated with radiation therapy. This study aims to highlight the risk for atrophic vulvar lichen sclerosu degeneration.

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2018 The Pan African medical journal

5. Treatment alternatives for vulvar lichen sclerosus: a systematic review and armed based network meta-analysis

Treatment alternatives for vulvar lichen sclerosus: a systematic review and armed based network meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

6. Paediatric vulval lichen sclerosus: a retrospective study. (PubMed)

Paediatric vulval lichen sclerosus: a retrospective study. Lichen sclerosus (LS) is a chronic inflammatory dermatosis with a predilection for the anogenital region, which mainly affects prepubertal girls and postmenopausal women. The cause is unknown, but a number of potential aetiological factors have been identified.To examine a cohort of patients with prepubertal-onset vulval LS (VLS) and assess baseline characteristics, clinical presentation, potential precipitating and predisposing factors

2019 Clinical & Experimental Dermatology

7. Living with vulval lichen sclerosus: a systematic review. (PubMed)

Living with vulval lichen sclerosus: a systematic review. Lichen sclerosus (LS) is an under-researched disorder, particularly from the perspective of individuals who have the condition. A recent James Lind Alliance Priority Setting Partnership identified uncertainties in many aspects of the condition, including its impact on quality of life which was ranked within the 'Top 10' future research priorities.1,2 We set out to systematically review the qualitative literature exploring the lived

2019 British Journal of Dermatology

8. A randomized double-blind placebo-controlled trial of autologous platelet-rich plasma intradermal injections for the treatment of vulvar lichen sclerosus. (PubMed)

A randomized double-blind placebo-controlled trial of autologous platelet-rich plasma intradermal injections for the treatment of vulvar lichen sclerosus. 30639885 2019 02 09 1097-6787 2019 Jan 11 Journal of the American Academy of Dermatology J. Am. Acad. Dermatol. A randomized double-blind placebo-controlled trial of autologous platelet-rich plasma intradermal injections for the treatment of vulvar lichen sclerosus. S0190-9622(19)30066-0 10.1016/j.jaad.2018.12.060 Goldstein Andrew T AT Center

2019 Journal of the American Academy of Dermatology

9. Tacrolimus 0.03% ointment for treatment of paediatric lichen sclerosus: a case series and literature review (PubMed)

Tacrolimus 0.03% ointment for treatment of paediatric lichen sclerosus: a case series and literature review Objectives This study aimed to investigate the usefulness and tolerability of topical tacrolimus in paediatric vulvar lichen sclerosus (LS). We examined whether there was improvement of the most problematic symptoms, such as itching, pain, and vulvar constipation. Methods Ten girls, aged from 4 to 9 years old who were affected by vulvar LS, were enrolled in an open clinical study

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2018 The Journal of international medical research

10. Male and female genital lichen sclerosus. Clinical and functional classification criteria (PubMed)

Male and female genital lichen sclerosus. Clinical and functional classification criteria Lichen sclerosus (LS) is a chronic inflammatory disease affecting mainly the genital mucous membranes in both sexes. In the past, different terms were used to describe the disease, rendering a unique and specific clinical classification impossible.New therapeutic approaches are being defined, which may contribute to a proper clinical management, however, a stage classification is essential to better define (...) alterations and structural modifications of the genital mucosa were also taken into consideration in order to assign every patient to a specific stage.Lichen sclerosus is clinically described differently in females and in males and every form of LS is put into one of two stages according to the degree of severity: early and late stages. Within the clinical practice, it is useful to screen patients for groups of early or late forms of the disease in order to obtain a uniform subdivision of patients: those

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2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

11. Vulvar Neoplasms in 275 Women With Genital Lichen Sclerosus and Impact of Treatment: A Retrospective Chart Review. (PubMed)

Vulvar Neoplasms in 275 Women With Genital Lichen Sclerosus and Impact of Treatment: A Retrospective Chart Review. 29524285 2018 08 23 1468-3083 32 9 2018 Sep Journal of the European Academy of Dermatology and Venereology : JEADV J Eur Acad Dermatol Venereol Vulvar neoplasms in 275 women with genital lichen sclerosus and impact of treatment: a retrospective chart review. e363-e365 10.1111/jdv.14938 Dell E A EA Department of Dermatology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA

2018 Journal of the European Academy of Dermatology and Venereology

12. Lichen Sclerosus

Lichen Sclerosus Lichen Sclerosus - the Influence on Quality of Life - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Lichen Sclerosus - the Influence on Quality of Life The safety and scientific validity (...) , Vendsyssel Hospital Study Details Study Description Go to Brief Summary: A randomised controlled trial of Lichen Sclerosus in a period of six months measuring Quality of Life and sexuality among women with Lichen Sclerosus. Condition or disease Intervention/treatment Phase Lichen Sclerosus Other: Standard care and sexological counseling Not Applicable Detailed Description: The patients are randomized to an intervention Group and a control Group. The intervention gets 6-8 visits with clinical sexologist

2018 Clinical Trials

13. The Comfort and Adherence of Rivelin® Plain Patches in Vulva Lichen Sclerosus Patients

The Comfort and Adherence of Rivelin® Plain Patches in Vulva Lichen Sclerosus Patients The Comfort and Adherence of Rivelin® Plain Patches in Vulva Lichen Sclerosus Patients - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. The Comfort and Adherence of Rivelin® Plain Patches in Vulva Lichen Sclerosus Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03686800 Recruitment Status : Completed First Posted : September 27, 2018 Last Update Posted : March 19, 2019 Sponsor: Dermtreat Collaborator

2018 Clinical Trials

14. Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists. (PubMed)

Diagnosis and Treatment of Vulvar Lichen Sclerosus: An Update for Dermatologists. Vulvar lichen sclerosus is an important skin disease that is common in women in their 50 s and beyond; however, it can also affect females of any age, including children. If not treated, it has the potential to cause significant and permanent scarring and deformity of the vulvar structure. In addition, if untreated, it is associated with a 2-6% lifetime risk of malignant squamous neoplasia of the vulva. Lichen (...) sclerosus has been considered a difficult to manage condition; however, both serious complications can potentially be prevented with early intervention with topical corticosteroid, suggesting that the course of the disease can be treatment modified.

2018 American journal of clinical dermatology

15. Prospective evaluation of frequency of genital lichen sclerosus in 79 patients with systemic sclerosis. (PubMed)

Prospective evaluation of frequency of genital lichen sclerosus in 79 patients with systemic sclerosis. 29928761 2018 10 15 1365-2133 179 4 2018 Oct The British journal of dermatology Br. J. Dermatol. Prospective evaluation of the frequency of genital lichen sclerosus in 79 patients with systemic sclerosis. 999-1000 10.1111/bjd.16898 Goussot R R http://orcid.org/0000-0001-5102-983X Clinique Dermatologique des Hôpitaux Universitaires, 1 Place de l'Hôpital, 67091, Strasbourg CEDEX, France

2018 British Journal of Dermatology

16. Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell Carcinoma. (PubMed)

Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell Carcinoma. Molecular alterations in lichen sclerosus-associated vulvar squamous cell carcinoma (LS-VSCC) are largely unknown.To determine whether the retinoic acid receptor β (RARβ) tumor-suppressor gene is involved in the onset and/or progression of LS-VSCC.The case-control study, conducted at University-Hospital of Ferrara, Italy, included 20 LS-VSCC (mean [SD] age, 75

2018 JAMA dermatology (Chicago, Ill.)

17. Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva. (PubMed)

Differentiated Vulvar Intraepithelial Neoplasia-like and Lichen Sclerosus-like Lesions in HPV-associated Squamous Cell Carcinomas of the Vulva. Most human papillomavirus (HPV)-associated vulvar squamous cell carcinomas (VSCCs) originate from high-grade squamous intraepithelial lesions, also named usual type vulvar intraepithelial neoplasia. However, growing evidence suggests that morphologic studies have limitations in predicting HPV status in vulvar lesions. We aimed to evaluate adjacent (...) intraepithelial lesions in a series of DNA HPV-positive VSCCs, focusing on unusual histologic patterns mimicking differentiated vulvar intraepithelial neoplasia (dVIN) or lichen sclerosus (LS). We identified 326 DNA HPV-positive VSCC with at least 1 cm of skin adjacent to the invasive tumor and analyzed HPV typing, HPV E6*I mRNA, and p16 immunohistochemistry in all cases. A careful histologic evaluation was conducted. A conclusive association with HPV was based on a positive p16 or HPV E6*I mRNA result

2018 American Journal of Surgical Pathology

18. Oral lichen sclerosus: a systematic review of reported cases and two new cases. (PubMed)

Oral lichen sclerosus: a systematic review of reported cases and two new cases. Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease with uncertain etiology. It occurs as white plaque-like lesions mostly in the anogenital skin. Oral mucosal involvement is extremely rare. This study aims to summarize the features of published oral lichen sclerosus (OLS) and two new cases. A systematic search of the English literature from 1955 to 2016 was performed in MEDLINE, Scopus, and Web (...) of Science, and cross-references were searched manually. Search phrases included "lichen sclerosus," "mouth," "oral," "lip," "palate," "floor of mouth," "tongue," "gingiva," "buccal mucosa," and "mouth diseases." Cases with clinical and histopathological confirmation of diagnosis of OLS were included. A total of 41 (39 published and 2 new) histologically confirmed OLS cases were available. The median age of OLS patients was 31 years, and 66% of the patients were female. Most of the OLS lesions were

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2018 International Journal of Dermatology

19. British Association of Dermatologists guidelines for the management of lichen sclerosus 2018. (PubMed)

British Association of Dermatologists guidelines for the management of lichen sclerosus 2018. 29313888 2018 04 18 1365-2133 178 4 2018 Apr The British journal of dermatology Br. J. Dermatol. British Association of Dermatologists guidelines for the management of lichen sclerosus, 2018. 839-853 10.1111/bjd.16241 Lewis F M FM http://orcid.org/0000-0003-4267-1518 Frimley Health NHS Foundation Trust, Slough, SL2 4HL, U.K. St John's Institute of Dermatology, Guy's & St Thomas' NHS Foundation Trust (...) , London, SE1 9RT, U.K. Tatnall F M FM West Hertfordshire NHS Trust, Watford, WD18 0HB, U.K. Velangi S S SS University Hospitals Birmingham NHS Foundation Trust, Birmingham, B15 2TH, U.K. Bunker C B CB University College London Hospitals NHS Foundation Trust, University College Hospital, London, NW1 2BU, U.K. Chelsea & Westminster NHS Foundation Trust, London, SW10 9NH, U.K. Kumar A A King's College London, London, SE1 3ER, U.K. Brackenbury F F Association for Lichen Sclerosus and Vulval Health

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2018 British Journal of Dermatology

20. Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. (PubMed)

Does application of topical steroids for lichen sclerosus (balanitis xerotica obliterans) affect the rate of circumcision? A systematic review. To determine whether treatment of lichen sclerosus et atrophicus (LS), with topical steroids reduces the rate of circumcision.Two independent reviewers performed a literature search of studies reporting treatment of LS with topical steroids using EMBASE and MEDLINE database(s).boys aged 0-18 years, clinical diagnosis of LS, treatment with topical

2018 Journal of Pediatric Surgery

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