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1601. A Dose Ranging Study of Different Strengths of Spinosad Topical Creme in Subjects With Pediculosis Capitis

: July 12, 2006 Sponsor: ParaPRO LLC Information provided by: ParaPRO LLC Study Details Study Description Go to Brief Summary: The primary objective of the study is to determine the safety and efficacy of different strengths of Spinosad topical creme, as compared to a vehicle control, in subjects who have been infested with at least a mild case of Pediculosis capitis (head lice). Condition or disease Intervention/treatment Phase Pediculosis Capitis (Head Lice) Drug: Spinosad Creme Rinse Phase 2 (...) Investigators Layout table for investigator information Principal Investigator: Dyal Garg, PhD Hill Top Research Principal Investigator: Robert Lewine, MD Hill Top Research Principal Investigator: Michael Noss, MD Hill Top Research More Information Go to Layout table for additonal information ClinicalTrials.gov Identifier: Other Study ID Numbers: SPN-202-06 First Posted: April 6, 2006 Last Update Posted: July 12, 2006 Last Verified: July 2006 Keywords provided by ParaPRO LLC: Pediculosis capitis Head Lice

2006 Clinical Trials

1602. Albendazole: single or combination therapy with permethrin against pediculosis capitis. (Abstract)

Albendazole: single or combination therapy with permethrin against pediculosis capitis. Pediculosis capitis is a worldwide problem and a growing concern because of resistance to pediculicides. In the present study, we investigated whether albendazole could be used in the treatment of pediculosis capitis in combination with 1% permethrin or alone. A total of 150 children were randomly divided to five groups of 30 each. Group 1 got albendazole in a single dose (400 mg), group 2 got albendazole (...) of this study suggest that albendazole is effective against pediculosis capitis and there is no synergistic effect between albendazole and 1% permethrin.

2006 Pediatric dermatology Controlled trial quality: uncertain

1603. Accuracy of diagnosis of pediculosis capitis: visual inspection vs wet combing. Full Text available with Trip Pro

Accuracy of diagnosis of pediculosis capitis: visual inspection vs wet combing. To determine the diagnostic accuracy of visual inspection and wet combing in pediculosis capitis (head lice infestation). Visual inspection of 5 predilection sites (temples, behind the ears, and neck) was performed first, followed by wet combing of hair moistened with conditioner. Presence of mobile stages was defined as active infestation, presence of nits alone as historic infestation.Observer-blinded comparison (...) of 2 diagnostic methods.Five primary schools in which head lice infestation was epidemic.A total of 304 students aged 6 to 12 years.Presence of nymph, adults, and nits; sensitivity, predictive value, and accuracy of both methods.Visual inspection underestimated the true prevalence of active infestation by a factor of 3.5. The sensitivity of wet combing in diagnosing active infestation was significantly higher than of visual inspection (90.5% vs 28.6%; P < .001). The accuracy of the former method

2009 Archives of Dermatology

1604. Trial of the Ovicidal Activity of Three Head Lice Products (NeutraLice Lotion®, NeutraLice Advance® and Moov Head Lice Solution®) After a Single Application

children (Grades 1 - 7) who have at least 20 live eggs on the hair and who have not used any head lice product in the four weeks prior to the study. Enrollment will continue to achieve 30 subjects in each treatment group (total of 90 subjects). Condition or disease Intervention/treatment Phase Head Lice Drug: NeutraLice Lotion Drug: NeutraLice Advance Solution Drug: Moov Head Lice Solution Phase 4 Detailed Description: Subjects will be examined for the presence of head louse eggs. Those subjects who (...) Trial of the Ovicidal Activity of Three Head Lice Products (NeutraLice Lotion®, NeutraLice Advance® and Moov Head Lice Solution®) After a Single Application Trial of the Ovicidal Activity of Three Head Lice Products (NeutraLice Lotion®, NeutraLice Advance® and Moov Head Lice Solution®) After a Single Application - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record

2009 Clinical Trials

1605. The sex ratio distortion in the human head louse is conserved over time Full Text available with Trip Pro

The sex ratio distortion in the human head louse is conserved over time At the turn of the 19th century the first observations of a female-biased sex ratio in broods and populations of the head louse, Pediculus humanus capitis, had been reported. A study by Buxton in 1940 on the sex ratio of lice on prisoners in Ceylon is still today the subject of reanalyses. This sex ratio distortion had been detected in ten different countries. In the last sixty years no new data have been collected (...) , especially on scalp infestations under economically and socially more developed conditions.Here we report a female bias of head lice in a survey of 480 school children in Argentina. This bias is independent of the intensity of the pediculosis, which makes local mate competition highly unlikely as the source of the aberrant sex ratio; however, other possible adaptive mechanisms cannot be discounted. These lice as well as lice from pupils in Britain were carrying several strains of the endosymbiotic

2004 BMC genetics

1606. Malathion lotion as an insecticide and ovicide in head louse infestation. (Abstract)

Malathion lotion as an insecticide and ovicide in head louse infestation. A lotion containing 0.5% malathion was compared with its vehicle (control) in a double-blind, parallel-group study of 119 patients with head louse infestations confirmed by live ova in the hair. The lotions remained in place for 8 hours. The test preparation was superior to the control lotion by a highly significant margin (p less than 0.001) as determined by the numbers of patients with live lice at 24 hours and 7 days (...) after removal of the respective materials. It also proved superior to the vehicle (p less than 0.001) as an ovicidal agent, judged by comparative differences in hatching rates between nits collected and incubated before treatment and those obtained and incubated after treatment. No adverse reaction occurred.

1986 International journal of dermatology Controlled trial quality: uncertain

1607. The methodology and operation of a pilot randomized control trial of the effectiveness of the Bug Busting method against a single application insecticide product for head louse treatment. (Abstract)

The methodology and operation of a pilot randomized control trial of the effectiveness of the Bug Busting method against a single application insecticide product for head louse treatment. A Department of Health leaflet suggests two treatment methods for head lice: mechanical removal by wet combing; and insecticide lotion/rinses. However, there are no reports in the literature comparing the effectiveness of these two treatment methods and well controlled clinical trials of insecticide treatments (...) are sparse. A pilot randomized control trial of the effectiveness of a specific method of wet combing, 'Bug Busting', against a single application of a proprietary insecticide product is reported. The difficulties of designing a trial are discussed and modifications that would allow a definitive trial to take place are suggested. The pilot study included enzyme analysis of lice for insecticide resistance status assessment.

2000 Public health Controlled trial quality: uncertain

1608. A comparison of a single occasion treatment of head louse infestation with phenothrin liquid shampoo or a carbaryl lotion. (Abstract)

A comparison of a single occasion treatment of head louse infestation with phenothrin liquid shampoo or a carbaryl lotion. Fifty subjects with head louse infestation were recruited into a controlled trial to compare a phenothrin liquid shampoo with a carbaryl lotion. Twenty-seven subjects were treated with phenothrin and 23 with carbaryl, each formulation being applied only on a single occasion. Subjects were inspected for evidence of live lice and eggs at 24 hours and 3 to 4 weeks after (...) in eradicating head lice and eggs.

1991 Current medical research and opinion Controlled trial quality: uncertain

1609. Pseudonits in dreadlocked hair: a louse-y case of nits. (Abstract)

Pseudonits in dreadlocked hair: a louse-y case of nits. We report a case of pseudonits in dreadlocked hair, with prominent hair roots of shed hair closely resembling Pediculosis humanus capitis infestation.

2006 Dermatology

1610. Controlled study of malathion and d-phenothrin lotions for Pediculus humanus var capitis-infested schoolchildren. (Abstract)

then did a randomised controlled trial in which the lotions were administered to 193 P humanus capitis-infested schoolchildren (malathion, 95; d-phenothrin, 98). Success rate was defined as the absence of both live lice and viable nits. Before treatment, live lice were collected and subjected to a pediculicidal test. Pharmacological tests showed 100% killing of the rabbit-grown nits and lice after exposure to both pediculicides. On day 1 of the controlled trial, the success rate was 92 (...) Controlled study of malathion and d-phenothrin lotions for Pediculus humanus var capitis-infested schoolchildren. Anecdotal reports have suggested that reduced efficacy of pediculicides against Pediculus humanus capitis could be related to resistance to treatments. Ovicidal and pediculicidal activities of 0.5% malathion and 0.3% d-phenothrin lotions were tested in an experimental model of P humanus capitis grown on rabbits to ensure that the two treatments were pharmacologically equipotent. We

1995 Lancet Controlled trial quality: uncertain

1611. Insecticides in pediculosis capitis. Full Text available with Trip Pro

Insecticides in pediculosis capitis. 2923477 1989 04 14 2018 11 13 1468-2044 64 1 1989 Jan Archives of disease in childhood Arch. Dis. Child. Insecticides in pediculosis capitis. 69-70 Maunder J W JW Medical Entomology Centre at the University of Cambridge, England. eng Journal Article England Arch Dis Child 0372434 0003-9888 0 Insecticides AIM IM Chemistry, Pharmaceutical Child Drug Administration Schedule Humans Insecticides administration & dosage Lice Infestations drug therapy Scalp 1989 1

1989 Archives of Disease in Childhood

1612. Review of common therapeutic options in the United States for the treatment of pediculosis capitis. Full Text available with Trip Pro

Review of common therapeutic options in the United States for the treatment of pediculosis capitis. Numerous therapies are available in both over-the-counter and prescription formulations for the treatment of head lice infestation. We summarize treatment recommendations from published literature and from a recent meta-analysis from the Cochrane Database of Systematic Reviews that describe the efficacy, safety, and resistance patterns of monotherapies available in the United States. If treatment

2003 Clinical Infectious Diseases

1613. The prevalence of pediculosis capitis in schoolchildren in Mersin, Turkey. (Abstract)

The prevalence of pediculosis capitis in schoolchildren in Mersin, Turkey. Pediculosis capitis is an endemic parasitosis affecting many countries of the world. The aim of this study was to investigate the incidence of head lice infestation in Mersin, Turkey.A total of 5318 elementary schoolchildren, aged 8-16 years, were examined for the presence of Pediculus capitis. If any evidence of head lice was detected, such as live or dead eggs, or nits, the child was considered to be infected (...) , d.f. = 1, P = 0.000). Children aged 8-9 years exhibited a significantly lower prevalence rate than those aged 10-11 years and those aged 12 years and above. The following variables were found to be statistically significantly related to pediculosis capitis: sex, age, father's education level, and pet ownership (cat or dog).Our results show that the prevalence of pediculosis capitis is not very high in Mersin, Turkey, and is observed in all schools regardless of the socio-economic and personal

2003 International Journal of Dermatology

1614. The efficacy of permethrin lotion in pediculosis capitis. (Abstract)

The efficacy of permethrin lotion in pediculosis capitis. A clinical trial of the pyrethroid permethrin in 1% lotion was performed on 20 children. Ten were treated for 10 minutes and 10 for 2 hours. All lice washed off the heads of children treated for 2 hours were dead immediately after treatment. Twenty-four percent of the lice removed from one child treated for 10 minutes were still alive 2 hours later. The ovicidal effect was similar in both groups, with egg mortality 88% and 90% following

1985 International journal of dermatology

1615. 1% permethrin cream rinse vs 1% lindane shampoo in treating pediculosis capitis. (Abstract)

1% permethrin cream rinse vs 1% lindane shampoo in treating pediculosis capitis. The therapeutic efficacy and tolerance of a single application of 1% permethrin cream rinse, applied for ten minutes, and a single application of 1% lindane shampoo applied, as recommended by the manufacturer, for four minutes, against the head louse Pediculus humanus var capitis were compared in a single-blinded, randomized, controlled clinical trial. Of 573 patients enrolled at eight centers, 559 were assessable (...) for tolerance and 508 for efficacy. Of the 257 patients treated with 1% permethrin cream rinse, 99% were lice free at 14 days; of the 251 patients treated with 1% lindane shampoo, 85% were lice free at 14 days. The difference is statistically significant. For both treatments, adverse experiences were infrequent, mild, and usually difficult to distinguish from the symptoms of head lice infestation. A single ten-minute application of 1% permethrin cream rinse was well tolerated, highly effective

1986 American journal of diseases of children (1960) Controlled trial quality: uncertain

1616. Transmission potential of the human head louse, Pediculus capitis (Anoplura: Pediculidae). (Abstract)

Transmission potential of the human head louse, Pediculus capitis (Anoplura: Pediculidae). Millions of people are infested by head lice every year. However, louse transfer between hosts is not well-understood. Our goals were to determine: (1) which stages were most likely to disperse and why, (2) the likelihood of fomites transmission, and (3) if host blood gender affects louse development.Various life stages of lice at differing densities were permitted to cross over a 15-cm hair bridge placed (...) between two artificial blood-feeding arenas. Louse transfer caused by hot air movements, combing, toweling, and passive transfer to fabric was investigated. The ability of lice to oviposit on different foreign substrates and the hatching potential of eggs intermittently incubated for 8 h/night on a host were likewise investigated. Louse in vitro development following feeding on human female or male donor blood was compared.Adult lice were the most likely to disperse. Neither population density nor

2005 International Journal of Dermatology

1617. Clinical efficacy of treatment for head lice. Counting head lice by visual inspection flaws trials' results. Full Text available with Trip Pro

Clinical efficacy of treatment for head lice. Counting head lice by visual inspection flaws trials' results. 7496302 1996 01 18 2018 11 13 0959-8138 311 7016 1995 Nov 18 BMJ (Clinical research ed.) BMJ Clinical efficacy of treatment for head lice. Counting head lice by visual inspection flaws trials' results. 1369; author reply 1369-70 Stallbaumer M M Ibarra J J eng Comment Letter England BMJ 8900488 0959-8138 AIM IM BMJ. 1995 Sep 2;311(7005):604-8 7545045 Clinical Trials as Topic Humans Lice

1995 BMJ : British Medical Journal

1618. Permethrin 1% creme rinse for the treatment of Pediculus humanus var capitis infestation. (Abstract)

Permethrin 1% creme rinse for the treatment of Pediculus humanus var capitis infestation. Permethrin 1% creme rinse (NIX) was tested as a treatment for Pediculus humanus var capitis (head lice) in a placebo-controlled, double-blinded, randomized study. As a positive control, a third arm of the study included nonrandomized, but investigator-blinded, treatment with 1% lindane shampoo (Kwell). At 14 days after treatment, 97% of patients treated with permethrin were free of lice compared to 6 (...) % of placebo-treated patients (P less than 0.001) and 43% of the lindane-treated group. Permethrin was 70% ovicidal compared to 14% for placebo (P less than 0.001) and 45% for lindane. No adverse experiences were noted during this study. Permethrin 1% demonstrated high pediculicidal and ovicidal activities, which in combination with its low mammalian toxicity, residual activity, and cosmetic properties, make it an excellent treatment for pediculosis capitis.

1986 Pediatric dermatology Controlled trial quality: uncertain

1619. Prevalence and treatment of Pediculus humanus capitis with 1% permethrin and 0.4% d-phenothrin in Turkey. (Abstract)

Prevalence and treatment of Pediculus humanus capitis with 1% permethrin and 0.4% d-phenothrin in Turkey. Pediculosis humanus capitis (head lice) is an important public health problem among school children. In our study, 20,612 schoolchildren (10,367 boys, 10,245 girls) were examined for Pediculus humanus capitis in 36 elementary schools between December 1996 and February 1998 in Ankara, Turkey. The prevalence of pediculosis capitis infestation was found to be 3.4% (701/20,612). Of these, 382 (...) students were treated with application of 1% permethrin cream rinse, and 184 students with 0.4% d-phenothrin shampoo. On day 14 of the controlled trial, the success rates were 93.7% in the 1% permethrin cream rinse group and 75.5% in the 0.4% d-phenothrin shampoo group. The 1% permethrin cream rinse was also significantly more active in pediculicidal efficacy when compared to the 0.4% d-phenothrin shampoo (p<0.001). As a result, these findings demonstrate that pediculosis capitis still remains

2003 Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové Controlled trial quality: uncertain

1620. Head lice: scientific assessment of the nit sheath with clinical ramifications and therapeutic options. (Abstract)

Head lice: scientific assessment of the nit sheath with clinical ramifications and therapeutic options. Head lice, like many insects, produce a protective coating for their newly laid eggs that is essential to the survival of the species. Knowledge of the composition of the sheath, which is the glue by which the egg is attached to human hair, and the nit laying process could lead to production of agents that could be used to attack louse infestations by interfering with the normally protected (...) environment of nymph development within the egg. The physical removal of nits has become an important part of treatment of head louse infestations given the "no-nit" policy in schools. Biochemical analysis has revealed that the nit sheath of the head louse is composed of 4 bands of protein, possibly cross-linked to aliphatic components with a tertiary structure of beta sheeting. Nature has protected the louse by making the nit sheath similar in composition to the hair; thereby, agents designed to unravel

2005 Journal of American Academy of Dermatology

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