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1581. Synergized pyrethrin mousse, a new approach to head lice eradication: efficacy in field and laboratory studies. (Abstract)

Synergized pyrethrin mousse, a new approach to head lice eradication: efficacy in field and laboratory studies. The purpose of this study was to evaluate the pediculicidal and ovicidal efficacy of a new, single-application formulation of synergized natural pyrethrins (presented in an aerosol mousse form) compared with an established, effective formulation based on permethrin (in a creme rinse form). The trial was a single-blind, comparative, randomized, parallel-group study. Children between (...) the ages 7 and 15 years and adults with active head lice infections, identified by the presence of live lice, were enrolled from a school and a children's home in Dhaka, Bangladesh. Prevalence of infection ranged from 75% to 100% in the two study centers. The field study confirmed laboratory findings showing pyrethrin mousse to be effective at killing both lice and their eggs with a single 10-minute application. Of 52 patients identified with lice, 42 were treated with pyrethrin mousse and 10

1994 Clinical therapeutics Controlled trial quality: uncertain

1582. Head lice infestation: single drug versus combination therapy with one percent permethrin and trimethoprim/sulfamethoxazole. (Abstract)

Head lice infestation: single drug versus combination therapy with one percent permethrin and trimethoprim/sulfamethoxazole. Head lice infestation (HLI) is a vexing problem for pediatricians and families because lice are becoming resistant to approved antipediculosis agents.This study compared the efficacy of 3 different treatments for HLI and determined whether combination therapy reduced treatment failures.A randomized, clinical trial performed in 3 private practices.The population (...) was retreated per their protocol. We defined successful treatment as the absence of adult lice and nymphal stage or eggs (nits). The presence of nits alone was not considered a treatment failure.At the 2-week follow-up visit, successful treatment for groups 1, 2, and 3 was 79.5%, 83%, and 95%, respectively. At the 4-week follow-up, successful treatment was 72%, 78%, and 92.5% for groups 1, 2, and 3, respectively. The absolute risk reduction for recurrence comparing group 1 versus group 2 was 6%, group 2

2001 Pediatrics Controlled trial quality: uncertain

1583. Comparative trial of treatment with Prioderm lotion and Kwellada shampoo in children with head lice. Full Text available with Trip Pro

Comparative trial of treatment with Prioderm lotion and Kwellada shampoo in children with head lice. The safety and efficacy of treatment with a new pediculicide lotion, Prioderm (0.5% malathion in isopropanol), were compared with those of treatment with Kwellada (1% lindane) shampoo in a randomized trial of children with head lice. The children's scalps were examined for live lice immediately, 7 days and 4 to 6 weeks following treatment. To determine the in-vitro ovicidal effect of treatment (...) , samples of hair with nits were removed before and immediately following treatment; the subsequent rates of hatching were compared. No live lice were present immediately following either treatment. At 7 days after treatment 2 of the 29 children treated with Prioderm lotion and 4 of the 33 children treated with Kwellada shampoo were infested with live lice, whereas at 4 to 6 weeks after treatment 5 and 3 children respectively were infested. The initial effectiveness of treatment was 93% in the children

1984 Canadian Medical Association journal Controlled trial quality: uncertain

1584. Efficacy of a reduced application time of Ovide lotion (0.5% malathion) compared to Nix creme rinse (1% permethrin) for the treatment of head lice. (Abstract)

Efficacy of a reduced application time of Ovide lotion (0.5% malathion) compared to Nix creme rinse (1% permethrin) for the treatment of head lice. Our objective was to conduct a randomized, investigator-blinded evaluation of the pediculicidal and ovicidal activity of a reduced application time (20 minutes) of Ovide (0.5% malathion) compared to Nix (1% permethrin) in a south Florida population infested with Pediculus humanus capitis. Either Ovide or Nix was applied according to the label (...) was significantly more pediculicidal and ovicidal (98%) compared to Nix (55%) at day 15 (p < 0.0001). The percentage of Ovide subjects who required treatment at day 8 was half that of the Nix group. The reinfestation rate was 0% with Ovide and 33% with Nix. In conclusion, a 20-minute treatment with Ovide, instead of the approved 8- to 12-hour application, cured 40 of 41 subjects (98%), demonstrating superior efficacy to Nix. The poor efficacy of Nix confirms the resistance of head lice to permethrin in south

2004 Pediatric dermatology Controlled trial quality: uncertain

1585. Head lice infestation: bug busting vs. traditional treatment. (Abstract)

Head lice infestation: bug busting vs. traditional treatment. The two main methods of managing head lice infestation in the UK are head lice lotions and bug busting; there is no conclusive evidence as to which of these methods is most effective. The aim of this study was to compare the effectiveness of the bug busting method with lotion. A pilot study in the form of a randomized controlled trial involving two semi-rural general practices was used. Thirty children aged 4-16 years were randomly (...) assigned to two intervention groups. After initial dry combing to detect the presence of head lice, one group was treated with phenothrin lotion. The bug busting group received combing using special combs provided in the bug busting pack and hair conditioner. The main outcome measure was the number of adult live lice and nymphs at day 14. On day 14 in the bug busting group, total eradication of head lice had occurred in eight children; in the lotion group, total eradication had occurred in two children

2001 Journal of clinical nursing Controlled trial quality: uncertain

1586. An observer-blinded study of 1% permethrin creme rinse with and without adjunctive combing in patients with head lice. (Abstract)

An observer-blinded study of 1% permethrin creme rinse with and without adjunctive combing in patients with head lice. To determine if NIX (Warner Lambert Healthcare, Morris Plains, NJ) 1% Permethrin Creme Rinse Lice Treatment (1% PLT) without combing will effectively treat >/=95% of patients on day 2 or on day 15; to determine whether combing influences efficacy.A randomized, observer-blinded study enrolled 95 infested adults and children. All patients were treated with 1% PLT on day 1 (...) and, if still infested, on day 8. One third of households were randomized to the combing group and two thirds to the no-combing group. Efficacy was assessed by: (1) visual inspection on days 1, 2, 8, 9, and 15 and, (2) shampooing/straining on days 2, 9, and 15. The target efficacy was 95%.In the no-combing group, the lice-free rate was 83.1% on day 2 (95% CI, 71.0-91.6), 45.8% on day 8 (before second treatment) (95% CI, 32.7-59.2), 77.6% on day 9 (95% CI, 64.7-87.5), and 78.3% on day 15 (95% CI, 65.8-87.9

2002 The Journal of pediatrics Controlled trial quality: uncertain

1587. Repellency of citronella for head lice: double-blind randomized trial of efficacy and safety. (Abstract)

Repellency of citronella for head lice: double-blind randomized trial of efficacy and safety. Head lice move easily from head to head. The lack of safe, effective repellents leads to reinfestation.To test the efficacy of a slow-release citronella formulation as a repellent against the head louse.During 4 months in 2003 a randomized, placebo-controlled double-blind clinical study was conducted in four elementary schools; 103 children were treated with the test formulation and 95 with a placebo.A (...) with the placebo (15.4% and 55.1% respectively, P < 0.0001). Side effects were observed in 4.4% of children who disliked the odor of the formulation, and an additional 1.0% who complained of a slight itching and burning sensation.Use of an effective repellent could significantly lower the incidence of reinfestations, which would lower expenditure on lice control, including pediculicides, combs and products for nit removal, and the time spent on treatment and removal of the nits.

2004 The Israel Medical Association journal : IMAJ Controlled trial quality: uncertain

1588. Relationship of treatment-resistant head lice to the safety and efficacy of pediculicides. (Abstract)

Relationship of treatment-resistant head lice to the safety and efficacy of pediculicides. Head lice infestation is a common and growing problem that primarily affects school-aged children. Most cases of head lice are diagnosed and treated by nonphysicians. Misdiagnosis may lead to treatment when no lice are present. Treatment failure may lead to repeated use of and improperly applied pediculicides, potentially resulting in overexposure to pesticides. These treatment failures are primarily due (...) , along with the safety and efficacy of other treatments, such as ivermectin, that are not indicated for the treatment of head lice but are being used increasingly.

2004 Mayo Clinic Proceedings

1589. Head lice. (Abstract)

Head lice. Head lice infestation is associated with little morbidity but causes a high level of anxiety among parents of school-aged children. This statement attempts to clarify issues of diagnosis and treatment of head lice and makes recommendations for dealing with head lice in the school setting.

2002 Pediatrics

1590. A simple treatment for head lice: dry-on, suffocation-based pediculicide. Full Text available with Trip Pro

A simple treatment for head lice: dry-on, suffocation-based pediculicide. The emergence of drug-resistant lice has created the need for new therapies. This study assesses a new method without neurotoxins, extensive household cleaning, or nit removal.One hundred thirty-three subjects participated in 2 open clinical trials. In the first trial, 93 subjects completed treatment using a nontoxic, dry-on, suffocation-based, pediculicide lotion, minimal household cleaning measures, and physical removal (...) of the nits. In the second trial, 40 subjects completed treatment using an identical protocol except that the nits were not removed. Head lice infestation was defined as a wet combing test showing lice. Cure was defined as a wet combing test showing no lice, with an absence of symptoms. Subjects were contacted 6 months later, for assessment of their disease status.Cure was achieved for 97% of the patients in the first trial and 95% in the second trial. Remission at the follow-up assessment was reported

2004 Pediatrics

1591. Human pathogens in body and head lice. Full Text available with Trip Pro

Human pathogens in body and head lice. Using polymerase chain reaction and sequencing, we investigated the prevalence of Rickettsia prowazekii, Bartonella quintana, and Borrelia recurrentis in 841 body lice collected from various countries. We detected R. prowazekii in body lice from Burundi in 1997 and in lice from Burundi and Rwanda in 2001; B. quintana infections of body lice were widespread. We did not detect B. recurrentis in any lice.

2002 Emerging Infectious Diseases

1592. Head lice on pillows, and strategies to make a small risk even less. (Abstract)

Head lice on pillows, and strategies to make a small risk even less. Due to a lack of evidence, controversy exists about the role of bedding in the transmission of head lice.To determine the proportion of the head lice population found on pillowcases of people with head lice, and to test strategies available to householders to kill head lice on pillowcases.To assess the incidence of head lice on pillowcases, people with active pediculosis had their head lice collected and counted (...) and median intensity of infection of 38.4 and 21 lice, respectively. Two of the 48 pillowcases contained live lice, one nymph on each, 2 h and 9 h after the pillowcases had been removed from the bed. Another pillowcase contained a dehydrated nymph. The incidence of live lice on pillowcases was 4.2% per night and the proportion of the head louse population on the pillowcases was 0.11%. Heat (hot wash and hot clothes dryer) killed head lice experimentally placed in pillowcases. Cold wash and hanging

2003 International Journal of Dermatology

1593. Permethrin-resistant human head lice, Pediculus capitis, and their treatment. Full Text available with Trip Pro

Permethrin-resistant human head lice, Pediculus capitis, and their treatment. To compare the pediculicidal activity of Ovide lotion and its active ingredient, 0.5% malathion, with Nix and its active ingredient, 1% permethrin, in permethrin-resistant head lice.In vitro pediculicidal product and active ingredient comparison. The presence of knockdown resistance-type mutations (T929I and L932F) was validated by DNA sequencing.University of Massachusetts-Amherst; University of Miami School (...) sequencing in lice collected from children in south Florida that were resistant to the pediculicidal effects of permethrin and the leading permethrin-based head lice product, Nix. Malathion resistance was not observed in this study. The data also show that Ovide killed these same permethrin-resistant head lice approximately 10 times faster than permethrin or Nix.

2003 Archives of Dermatology

1594. A Study Evaluating the Safety and Efficacy of BGC20-0582 Lice Treatment Gel for Head Lice Infestation

28, 2010 Last Update Posted : December 28, 2010 Sponsor: BTG International Inc. Information provided by: BTG International Inc. Study Details Study Description Go to Brief Summary: The main purpose of this study is to investigate the safety and efficacy of an investigational treatment for head lice infestation against a placebo. Condition or disease Intervention/treatment Phase Pediculus Humanus Capitis Head Lice Drug: Placebo Drug: BGC20-0582 Phase 2 Detailed Description: The main purpose (...) : Medical Monitor BTG International Inc. More Information Go to Layout table for additonal information Responsible Party: Tom Logan, BTG ClinicalTrials.gov Identifier: Other Study ID Numbers: BCG20-0582-001 First Posted: September 11, 2007 Results First Posted: December 28, 2010 Last Update Posted: December 28, 2010 Last Verified: November 2010 Keywords provided by BTG International Inc.: Head Lice Lice Infestation Pediculosis Pediculosis Capitis Additional relevant MeSH terms: Layout table for MeSH

2007 Clinical Trials

1595. Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice

. For general information, Layout table for eligibility information Ages Eligible for Study: 6 Months and older (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Males and females 6 months of age or older. Have an active infestation with Pediculus capitis, the human head louse, with at least three live lice at baseline. Agree not to use any other pediculicides or medicated hair-grooming products during the duration of the study. Be healthy (...) Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2007 Clinical Trials

1596. Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice

Months and older (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Males and females 6 months of age or older. Have an active infestation with Pediculus capitis, the human head louse, with at least three live lice at baseline, or treatment failure with any live lice from Protocol SU-01-2005 or Protocol SU-02-2005. Agree not to use any other pediculicides or medicated hair grooming products during the duration of the study. Be healthy (...) Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove

2006 Clinical Trials

1597. Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice.

information, Layout table for eligibility information Ages Eligible for Study: 6 Months and older (Child, Adult, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Males and females 6 months of age or older. Have an active infestation with pediculus capitis, the human head louse, with at least three live lice at baseline. Agree not to use any other pediculicides or medicated hair-grooming products during the duration of the study. Be healthy, non-febrile (...) Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice. Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2006 Clinical Trials

1598. Bartonella quintana in body lice and head lice from homeless persons, San Francisco, California, USA. Full Text available with Trip Pro

the homeless and their caregivers on prevention and control of louse-borne disease. During 2007-2008, 33.3% of body lice-infested persons and 25% of head lice-infested persons had lice pools infected with B. quintana strain Fuller. Further work is needed to examine how homeless persons acquire lice and determine the risk for illness to persons infested with B. quintana-infected lice. (...) Bartonella quintana in body lice and head lice from homeless persons, San Francisco, California, USA. Bartonella quintana is a bacterium that causes trench fever in humans. Past reports have shown Bartonella spp. infections in homeless populations in San Francisco, California, USA. The California Department of Public Health in collaboration with San Francisco Project Homeless Connect initiated a program in 2007 to collect lice from the homeless to test for B. quintana and to educate

2009 Emerging Infectious Diseases

1599. Is wet combing effective in children with pediculosis capitis infestation? Full Text available with Trip Pro

Is wet combing effective in children with pediculosis capitis infestation? 17715448 2007 09 18 2018 11 13 1468-2044 92 9 2007 Sep Archives of disease in childhood Arch. Dis. Child. Is wet combing effective in children with pediculosis capitis infestation? 818-20 Tebruegge Marc M Department of Paediatric Infectious Diseases, St Mary's Hospital London, UK. marctebruegge@nhs.net Runnacles Jane J eng Journal Article Review England Arch Dis Child 0372434 0003-9888 AIM IM Animals Child Humans Lice (...) Infestations therapy Male Pediculus Scalp Dermatoses parasitology therapy 19 2007 8 24 9 0 2007 9 19 9 0 2007 8 24 9 0 ppublish 17715448 92/9/818 10.1136/adc.2007.121368 PMC2084044 Lancet. 2000 Aug 12;356(9229):540-4 10950230 Arch Dis Child. 2006 Sep;91(9):777-8 16774979 Int J Dermatol. 2001 Apr;40(4):292-4 11454092 Cochrane Database Syst Rev. 2001;(3):CD001165 11686980 J Clin Nurs. 2001 Nov;10(6):775-83 11822849 J R Soc Med. 2002 Jul;95(7):348-52 12091509 Int J Dermatol. 2003 Dec;42(12):973-6 14636196

2007 Archives of Disease in Childhood

1600. A Dose Ranging Study of Different Strengths of Spinosad Topical Creme in Subjects With Pediculosis Capitis

: July 12, 2006 Sponsor: ParaPRO LLC Information provided by: ParaPRO LLC Study Details Study Description Go to Brief Summary: The primary objective of the study is to determine the safety and efficacy of different strengths of Spinosad topical creme, as compared to a vehicle control, in subjects who have been infested with at least a mild case of Pediculosis capitis (head lice). Condition or disease Intervention/treatment Phase Pediculosis Capitis (Head Lice) Drug: Spinosad Creme Rinse Phase 2 (...) Investigators Layout table for investigator information Principal Investigator: Dyal Garg, PhD Hill Top Research Principal Investigator: Robert Lewine, MD Hill Top Research Principal Investigator: Michael Noss, MD Hill Top Research More Information Go to Layout table for additonal information ClinicalTrials.gov Identifier: Other Study ID Numbers: SPN-202-06 First Posted: April 6, 2006 Last Update Posted: July 12, 2006 Last Verified: July 2006 Keywords provided by ParaPRO LLC: Pediculosis capitis Head Lice

2006 Clinical Trials

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