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Leukemia

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11. Management of relapsed or refractory chronic lymphocytic leukemia (CLL)

Management of relapsed or refractory chronic lymphocytic leukemia (CLL)

2017 DynaMed Plus

17. Initial Diagnostic Work-Up of Acute Leukemia

Initial Diagnostic Work-Up of Acute Leukemia Initial Diagnostic Work-Up of Acute Leukemia: ASCO Clinical Practice Guideline Endorsement of the College of American Pathologists and American Society of Hematology Guideline | Journal of Clinical Oncology Search in: Menu Article Tools ASCO SPECIAL ARTICLE Article Tools OPTIONS & TOOLS COMPANION ARTICLES February, 05 2019 ARTICLE CITATION DOI: 10.1200/JCO.18.01468 Journal of Clinical Oncology - published online before print December 3, 2018 PMID (...) : Initial Diagnostic Work-Up of Acute Leukemia: ASCO Clinical Practice Guideline Endorsement of the College of American Pathologists and American Society of Hematology Guideline , PhD 1 x Valérie de Haas ; , MD 2 x Nofisat Ismaila ; , MD 3 x Anjali Advani ; , MD 4 x Daniel A. Arber ; , MD 5 x Raetasha S. Dabney ; , MD 6 x Dipti Patel-Donelly ; , LMSW 7 x Elizabeth Kitlas ; , MD, PhD 1 x Rob Pieters ; , MD 8 x Ching-Hon Pui ; , MD 9 x Kendra Sweet ; and , MD 9 x Ling Zhang 1Princess Máxima Center

2019 American Society of Clinical Oncology Guidelines

18. Myeloid leukemia factor 1 stabilizes tumor suppressor C/EBPα to prevent Trib1-driven acute myeloid leukemia (Full text)

Myeloid leukemia factor 1 stabilizes tumor suppressor C/EBPα to prevent Trib1-driven acute myeloid leukemia C/EBPα is a key transcription factor regulating myeloid differentiation and leukemogenesis. The Trib1-COP1 complex is an E3 ubiquitin ligase that targets C/EBPα for degradation, and its overexpression specifically induces acute myeloid leukemia (AML). Here we show that myeloid leukemia factor 1 (MLF1) stabilizes C/EBPα protein levels by inhibiting the ligase activity of the Trib1-COP1 (...) ) in normal hematopoiesis, which is consistent with the distribution of C/EBPα. An MLF1 deficiency conferred a more immature phenotype on Trib1-induced AML development. A higher expression ratio of Trib1 to MLF1 was a key determinant for AML development in mouse models, which was also confirmed in human patient samples with acute leukemia. These results indicate that MLF1 is a positive regulator that is critical for C/EBPα stability in the early phases of hematopoiesis and leukemogenesis.

2017 Blood advances PubMed

19. Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia; Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia; Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia. (Full text)

Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia; Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia; Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia. 26962747 2016 03 15 2018 07 30 1533-4406 374 10 2016 03 10 The New England journal of medicine N. Engl. J. Med. Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia; Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia; Chimeric Antigen Receptor (...) T Cells for Sustained Remissions in Leukemia. 998 10.1056/NEJMx160005 eng Journal Article Published Erratum United States N Engl J Med 0255562 0028-4793 N Engl J Med. 2011 Aug 25;365(8):725-33 21830940 N Engl J Med. 2013 Apr 18;368(16):1509-1518 23527958 N Engl J Med. 2014 Oct 16;371(16):1507-17 25317870 2016 3 11 6 0 2016 3 11 6 0 2016 3 11 6 1 ppublish 26962747 10.1056/NEJMx160005

2016 NEJM PubMed

20. Clinical course of sepsis in children with acute leukemia admitted to the pediatric intensive care unit

Clinical course of sepsis in children with acute leukemia admitted to the pediatric intensive care unit PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2017 PedsCCM Evidence-Based Journal Club

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