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Lemierre Syndrome

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61. Vertebral osteomyelitis as a rare manifestation of Lemierre’s syndrome Full Text available with Trip Pro

Vertebral osteomyelitis as a rare manifestation of Lemierre’s syndrome 28879094 2018 11 13 2214-2509 10 2017 IDCases IDCases Vertebral osteomyelitis as a rare manifestation of Lemierre's syndrome. 46-48 10.1016/j.idcr.2017.08.006 Matsuo Takahiro T Department of Infectious Diseases, St. Luke's International Hospital, 9-1, Akashi-cho, Chuo-ku, 104-8560 Tokyo, Japan. Mori Nobuyoshi N Department of Infectious Diseases, St. Luke's International Hospital, 9-1, Akashi-cho, Chuo-ku, 104-8560 Tokyo (...) Fusobacterium nucleatum Lemierre’s syndrome Vertebral osteomyelitis 2017 07 31 2017 08 08 2017 08 08 2017 9 8 6 0 2017 9 8 6 0 2017 9 8 6 1 epublish 28879094 10.1016/j.idcr.2017.08.006 S2214-2509(17)30129-4 PMC5582373 Laryngoscope. 2009 Aug;119(8):1552-9 19554637 Eur Spine J. 2015 May;24 Suppl 4:S502-7 25245891 Clin Infect Dis. 2015 Sep 15;61(6):e26-46 26229122

2017 IDCases

62. Some neck swellings are serious; a case of Lemierre’s Syndrome Full Text available with Trip Pro

Some neck swellings are serious; a case of Lemierre’s Syndrome Lemierre's syndrome also termed post-anginal septicemia, is a disease characterized by internal jugular septic thrombophlebitis leading to Fusobacterium septicemia with multiple metastatic foci following an oropharyngeal infection. Diagnosis and management is challenging and can result in fatal consequences due to potential multisystem involvement and multiple complications. We describe here a case of Lemierre's syndrome (...) with multifocal pneumonia, acute renal failure and protracted course of illness over forty days with successful recovery. A brief overview of literature is also presented.

2017 Journal of community hospital internal medicine perspectives

63. Lemierre’s syndrome: Case report and brief literature review Full Text available with Trip Pro

Lemierre’s syndrome: Case report and brief literature review Lemierre's syndrome has been shown to be increasing in incidence in the past 20 years with one popular suggesting that said rise occurred from less aggressive antibacterial coverage. We report a case of Lemierre's syndrome and also reviewed the 15 most recent case reports. A previously healthy 25 year old male who initially developed sore throat and flu-like symptoms, was prescribed antibacterials as an outpatient (...) but was hospitalized for worsening symptoms. He was later diagnosed with Lemierre's syndrome and improved clinically with IV antimicrobials alone. From our concise literature review, we determined that a decrease in antibiotic prescriptions may not fully explain why the incidence of Lemierre's has been increasing. Thus, future research should be focused in evaluating possible worsening susceptibilities to antibiotics and improvements on detection. We also advise physicians to be aware of the signs and symptoms

2017 IDCases

64. Lemierre’s syndrome, necrotizing pneumonia and staphylococcal septic shock treated with extracorporeal life support Full Text available with Trip Pro

Lemierre’s syndrome, necrotizing pneumonia and staphylococcal septic shock treated with extracorporeal life support Lemierre's syndrome cause by methicillin-sensitive Staphylococcus aureus is rare, but can lead to necrotizing pneumonia and septicaemia. When treating such patient with extracorporeal life support source control can be both challenging and controversial.In this report we present a 12 year old male who presented with Lemierre's syndrome from which he developed septic shock (...) , and partial pneumectomy was avoided. He was successfully separated from extracorporeal life support and respiratory support and recovered from his illness. Follow-up imaging showed almost complete resolution of the pulmonary abscesses. Osteomyelitis of C1/C2 and severe muscle wasting required a prolonged hospital stay.This case highlights the challenges of supporting patients suffering from disseminated staphylococcal sepsis with extracorporeal life support and the key role of source control

2017 SAGE Open Medical Case Reports

65. The Forgotten One: Lemierre’s Syndrome Due to Gram-Negative Rods Prevotella Bacteremia Full Text available with Trip Pro

The Forgotten One: Lemierre’s Syndrome Due to Gram-Negative Rods Prevotella Bacteremia Lemierre's syndrome (LS) is a rare syndrome caused by an acute oropharyngeal infection with metastatic spreading. It was described in 1939 as jugular vein septic thrombophlebitis associated with retropharyngeal infection. Different organisms can cause LS, such as Fusobacterium species, Peptostreptococcus, group B and C, Streptococcus, Staphylococcus, and Enterococcus species, but the most commonly isolated (...) antibiotics. Subsequent imaging of the chest showed pleural effusion with septic emboli. He underwent thoracentesis and chest tube placement. Final blood cultures were remarkable for gram-negative rods - Prevotella anaerobes - which supported the diagnosis of LS. His condition improved, including the dyspnea, and he was discharged on the proper antibiotics coverage with outpatient follow-up.LS is a rare condition associated with metastatic infection spreading. This syndrome can be associated with further

2016 The American journal of case reports

66. Lemierre’s syndrome: current perspectives on diagnosis and management Full Text available with Trip Pro

Lemierre’s syndrome: current perspectives on diagnosis and management This is a systematic review of cases with Lemierre's syndrome (LS) in the past 5 years. LS is characterized by sepsis often evolving after a sore throat or tonsillitis and then complicated by various septic emboli and thrombosis of the internal jugular vein. Symptoms include sepsis, pain, and/or swelling in the throat or neck, as well as respiratory symptoms. Laboratory findings show elevated infectious parameters (...) and radiological findings show thrombosis of the internal jugular vein and emboli in the lungs or other organs. The syndrome is often associated with an infection with Fusobacterium necrophorum. We found a total of 137 cases of LS, of which 47 were infected with F. necrophorum and others with Staphylococcus and Streptococcus. Complications of this rare but severe disease included osteomyelitis, meningitis, and acute respiratory distress syndrome. Mortality was extremely high in the pre-antibiotic era but has

2016 Infection and drug resistance

67. Clival Syndrome Secondary to Anaerobic Mastoiditis in a 2-Year Old Child. (Abstract)

Clival Syndrome Secondary to Anaerobic Mastoiditis in a 2-Year Old Child. Complications of acute mastoiditis can occur in about 10-20% of cases. Clival syndrome is a rare complication of mastoiditis, involving the 6th and 12th cranial nerves. We describe a case of a child with mastoiditis and presumed Lemierre syndrome complicated by clival syndrome.

2015 Pediatric Infectious Dsease Journal

68. Liver abscessation and multiple septic pulmonary emboli associated with Lemierre’s syndrome: a case report Full Text available with Trip Pro

Liver abscessation and multiple septic pulmonary emboli associated with Lemierre’s syndrome: a case report In Lemierre's syndrome, patients first exhibit pharyngitis and peritonsillar abscessation, followed by the development of anaerobic bacterial (usually Fusobacterium necrophorum) septicemia and metastatic infections throughout the body. However, these infections rarely affect the liver. We describe a case of Lemierre's syndrome, in which the first disease manifestation was liver abscess (...) suspected. The patient was hospitalized and antibiotic treatment was initiated. On hospital day 6, blood culture results confirmed Fusobacterium necrophorum septicemia. The patient was diagnosed with Lemierre's syndrome, as pharyngitis developed into bacteremia associated with hepatic and pulmonary lesions. The patient's condition improved with antibiotics and he was discharged following three weeks of treatment in the hospital.With the widespread use of antibiotics, Lemierre's syndrome is rarely

2015 BMC research notes

69. Lemierre’s Syndrome Full Text available with Trip Pro

Lemierre’s Syndrome 24672595 2015 10 30 2018 11 13 1936-900X 15 2 2014 Mar The western journal of emergency medicine West J Emerg Med Lemierre's Syndrome. 125-6 10.5811/westjem.2013.12.20418 Shook Jayten J Lakeland Regional Medical Center, Department of Emergency Medicine, St Joseph, Michigan. Trigger Christopher C Lakeland Regional Medical Center, Department of Emergency Medicine, St Joseph, Michigan. eng Case Reports Journal Article United States West J Emerg Med 101476450 1936-900X IM (...) Adult Emergency Service, Hospital Female Humans Lemierre Syndrome complications diagnosis diagnostic imaging Neck Pain diagnostic imaging etiology Tomography, X-Ray Computed Original DateCompleted: 20140327 2013 11 19 2013 12 09 2014 3 28 6 0 2014 3 29 6 0 2014 3 29 6 1 ppublish 24672595 10.5811/westjem.2013.12.20418 wjem-15-125 PMC3966442 Laryngoscope. 2009 Aug;119(8):1552-9 19554637 J Thromb Thrombolysis. 2014 Apr;37(3):246-8 23686643 Acta Radiol. 2013 Jul;54(6):622-7 23528567

2014 Western Journal of Emergency Medicine

70. Lemierre's and Lemierre's-like syndromes in association with infectious mononucleosis. (Abstract)

clinical and laboratory findings as well as the outcome of infection in patients aged 21 years or less with a diagnosis of Lemierre's syndrome. An additional case of Lemierre's-like syndrome was also included. The illness severity and duration of in-patient management of those testing positive for heterophile antibody were then compared with the same parameters in patients who tested negative.Of the five patients diagnosed with Lemierre's syndrome, two had concomitant acute infection with Epstein-Barr (...) to admission, and tested positive for heterophile antibody. These patients subsequently underwent more extensive in-patient treatment, including intensive care management and ventilator support. The patients who tested negative for heterophile antibody experienced a milder course of illness, with a shorter duration of in-patient management.Two patients diagnosed with Lemierre's syndrome, and a third with Fusobacterium necrophorum sepsis, had coexisting acute Epstein-Barr virus infection. Patients who

2010 Journal of Laryngology & Otology

71. Lemierre’s Syndrome presenting with neurological and pulmonary symptoms: Case report and review of the literature Full Text available with Trip Pro

Lemierre’s Syndrome presenting with neurological and pulmonary symptoms: Case report and review of the literature Lemierre's Syndrome (LS) is a potentially life-threatening condition, characterized by clinical or radiologic evidence of internal jugular vein thrombosis following an oropharyngeal infection, most commonly by Fusobacterium necrophorum. A high index of suspicion and early recognition is important for successful management and to prevent systemic complications like multiorgan

2013 Annals of Indian Academy of Neurology

72. Sore throat (acute): antimicrobial prescribing

of: alternative diagnoses such as scarlet fever or glandular fever any symptoms or signs suggesting a more serious illness or condition previous antibiotic use, which may lead to resistant organisms. P People who are unlik eople who are unlikely to benefit from an antibiotic ( ely to benefit from an antibiotic (F Fe ev verP erPAIN score AIN score of 0 or 1, or of 0 or 1, or Centor score Centor score of 0, 1 or 2): of 0, 1 or 2): 1.1.6 Do not offer an antibiotic prescription. Sore throat (acute): antimicrobial (...) , as well as the general advice in recommendation 1.1.4, give advice about seeking medical help if symptoms worsen rapidly or significantly or the person becomes systemically very unwell. See the evidence and committee discussion on back-up antibiotics and choice of antibiotic. P People who are systemically v eople who are systemically very un ery unwell, ha well, hav ve symptoms and signs of a more serious e symptoms and signs of a more serious illness or condition, or are at high-risk of complications

2018 National Institute for Health and Clinical Excellence - Clinical Guidelines

73. Lemierre's Syndrome Mimicking Leptospirosis Full Text available with Trip Pro

Lemierre's Syndrome Mimicking Leptospirosis Lemierre's syndrome is a suppurative thrombophlebitis involving the internal jugular vein, most commonly associated with Fusobacterium necrophorum, usually a complication of oropharyngeal infections. This syndrome is rare and is often overlooked. We present a case of sepsis mimicking initially severe leptospirosis (Weil's disease) due to acute febrile illness with multiorgan failure and hyperbilirubinemia. Finally, blood cultures revealed

2010 Hawaii Medical Journal

74. Lemierre syndrome: unusual cause and presentation. (Abstract)

Lemierre syndrome: unusual cause and presentation. Lemierre syndrome is a potentially fatal condition after an oropharyngeal infection. It is characterized by thrombophlebitis of head and neck veins with systemic dissemination of septic emboli. The most frequently isolated pathogen is Fusobacterium necrophorum. We report an unusual case of Lemierre syndrome in a 4-year-old child caused by Staphylococcus aureus, with multivisceral emboli to the brain, orbits, lungs, and heart valves. We also (...) discuss its atypical clinical presentation, the crucial role of imaging in the early diagnosis, and the different treatment modalities of this life-threatening syndrome.

2010 Pediatric Emergency Care

75. Lemierre syndrome: a pediatric case series and review of literature. (Abstract)

Lemierre syndrome: a pediatric case series and review of literature. Lemierre syndrome is a rare disease of the head and neck often affecting adolescents and young adults. Classically, infection begins in the oropharynx with thrombosis of the tonsillar veins followed by involvement of the parapharyngeal space and the internal jugular vein. Septicemia and pulmonary lesions develop as infection spreads via septic emboli. Although a rare entity in modern times, Lemierre syndrome remains a disease (...) was crucial in all cases.Lemierre syndrome is a rare but severe opportunistic infection with poor prognostic outcomes if left untreated. Early diagnosis and treatment is essential. Aggressive antibiotic therapy coupled with surgical intervention, when necessary, provides excellent outcomes.

2010 American Journal of Otolaryngology

76. HTA of C-reactive protein point-of-care testing to guide antibiotic prescribing

and their sequelae include: paediatric ( 70 years) patients, those with a pre-existing lung condition (such as chronic obstructive pulmonary disease [COPD] or asthma), immuno-compromised patients, and patients resident in long-term care (LTC) facilities such as nursing homes. RTIs are seasonal in nature, with incidence peaking in the winter months. Health Technology Assessment (HTA) of CRP POCT Health Information and Quality Authority xiii RTIs may be classified as upper (pharyngitis, tonsillitis, laryngitis (...) device (IVD) market. The test is indicated for the quantitative determination of CRP in human whole blood and in human serum and plasma. The measurement of CRP provides information for the detection and evaluation of infection, tissue injury, inflammatory disorders and associated diseases. These tests are CE marked in accordance with the IVD Directive (98/79/EC) and are classified as general category IVDs. (10) The CE marking process for this class of IVDs involves the manufacturer self-declaring

2019 Health Information and Quality Authority

77. Management of Stroke in Neonates and Children Full Text available with Trip Pro

epilepsy, or with a presumed perinatal stroke. A study from Switzerland corroborated these findings, showing that 2 years after birth, 39% were diagnosed with cerebral palsy and 31% had delayed mental performance. Congenital heart disease and potentially other medical comorbidities can impair brain growth and development even in the absence of stroke; therefore, it can be difficult to ascribe neurological deficits to the stroke per se in individuals with these conditions. Studies specific to children (...) of seizures at the time of presentation does not predict the occurrence of long-term epilepsy. Risk Factors and Causes Conditions that are associated with CSVT in neonates include gestational or delivery complications, dehydration, sepsis, meningitis, cardiac defects, and coagulation disorders. Although these factors are commonly thought of as risk factors, no controlled studies have proved the associations. Management Appropriate supportive measures include the control of epileptic seizures

2019 American Heart Association

78. CRACKCast E075 – Upper Respiratory Tract Infections

albicans [6] What are the potential complications of deep space neck/face infections? List 5. Airway Obstruction Trismus Lemierre’s syndrome Carotid aneurysm Cavernous sinus thrombosis Retropharyngeal abscess Empyema/pneumonia Sepsis/ acute respiratory distress syndrome Necrotizing fasciitis Mediastinitis Peri-myocarditis Osteomyelitis of the mandible, cervicothoracic necrotizing fasciitis [7] When do the sinuses typically develop? Fully develop by age 10. [8] What the pathophysiology of sinusitis (...) CRACKCast E075 – Upper Respiratory Tract Infections CRACKCast E075 - Upper Respiratory Tract Infections - CanadiEM CRACKCast E075 – Upper Respiratory Tract Infections In , by Adam Thomas May 4, 2017 This episode of CRACKCast covers Rosen’s Chapter 75, Upper Respiratory Tract Infections (URTI). This spectrum of disease involves a range of management strategies, all the way from supportive care to life-saving interventions. Shownotes – Rosens in Perspective For these questions, see “CC E023

2017 CandiEM

79. Sore throat - acute

). Fusobacterium necrophorum , which may cause pharyngitis or tonsillitis, and can (very rarely) lead to Lemierre syndrome (septic phlebitis of the internal jugular vein). Rarer infectious causes include [ ; ; ]: Haemophilus influenza type b — can cause epiglottitis. Enteroviruses — can cause herpangina and hand, foot, and mouth disease. Measles virus. Candida albicans — causes candidal pharyngitis. Neisseria gonorrhoeae — can cause gonococcal pharyngitis. Corynebacterium diphtheria, C. ulcerans — cause (...) rheumatic fever and acute glomerulonephritis, although these are rare in developed countries. Pharyngitis/tonsillitis as a result of Fusobacterium necrophorum infection can (very rarely) lead to Lemierre disease (sepsis and jugular vein thrombosis). [ ; ; ; ] Prognosis What is the prognosis? Sore throat due to a viral or bacterial cause is a self-limiting condition which generally resolves within two weeks [ ; ; ] : A sore throat will spontaneously resolve by 3 days in about 40% of people. By 1 week

2018 NICE Clinical Knowledge Summaries

80. Analysis of the tonsillar microbiome in young adults with sore throat reveals a high relative abundance of Fusobacterium necrophorum with low diversity. Full Text available with Trip Pro

Analysis of the tonsillar microbiome in young adults with sore throat reveals a high relative abundance of Fusobacterium necrophorum with low diversity. Fusobacterium necrophorum (Fn), a gram-negative anaerobe, is increasingly implicated as an etiologic agent in older adolescents and young adults with sore throat. Inadequately treated Fn pharyngitis may result in suppurative complications such as peritonsillar abscess and Lemierre's syndrome. Data from the literature suggest that the incidence (...) of life-threating complications in these age groups from Fn pharyngitis (Lemierre's syndrome) in the United States exceeds those associated with group A beta-hemolytic streptococcal (GAS) pharyngitis (acute rheumatic fever). Using real-time PCR, we previously reported about a 10% prevalence of Fn in asymptomatic medical students and about 20% in students complaining of sore throat at a university student health clinic (p = 0.009). In this study, a comprehensive microbiome analysis of the same study

2018 PLoS ONE

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