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Lemierre Syndrome

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181. Cefepime for Injection USP and Dextrose Injection USP in the Duplex® Container

therapy and anticonvulsant treatment. A fatal outcome was reported in four cases. According to the articles, the causes of deaths were related to patient’s underlying medical illness. One patient died of multi-organ failure with refractory status epilepticus (SE) and coma. The case report describes a 15 year old girl on hemodialysis since the age of 4 years for end stage renal disease secondary to polycystic kidney. She was admitted to the hospital with a history of fever for 3 days. Blood culture (...) encephalopathy are two different clinical conditions that can cause a confusional state. It is very important to be able to distinguish these entities because treatment varies based on the diagnosis. According to Maganti et al, from the practical standpoint, NCSE can be defined as a condition with prolonged state of impaired consciousness or altered sensorium associated with continuous paroxysmal activity or EEG discharges. Etiology varies and includes metabolic/medical disorders; medications (e.g

2009 FDA - Drug Approval Package

182. Septic pulmonary embolism: presenting features and clinical course of 14 patients. Full Text available with Trip Pro

) and included five women. Presenting symptoms included fever (93%), dyspnea (36%), pleuritic chest pain (29%), cough (14%), and hemoptysis (7%). The median duration of symptoms before diagnosis was 18 days (range, 5 to 180 days). A potential source or underlying condition that predisposed to SPE was identified in all 14 patients and included Lemierre syndrome (4 patients), central venous catheter infection (3 patients), prosthetic cardiac valve (2 patients), and pacemaker infection (2 patients). Two (...) Septic pulmonary embolism: presenting features and clinical course of 14 patients. Septic pulmonary embolism (SPE) is an uncommon disorder with an insidious onset and is difficult to diagnose.To characterize the presenting features and clinical course of patients with SPE.Retrospective study.Tertiary care, referral medical center.Fourteen subjects with SPE diagnosed during a 6-year period between 1996 and 2002.None.The median age of these patients was 37.5 years (range, 14 to 81 years

2005 Chest

183. The changing pattern of Fusobacterium infections in humans: recent experience with Fusobacterium bacteraemia. Full Text available with Trip Pro

The changing pattern of Fusobacterium infections in humans: recent experience with Fusobacterium bacteraemia. A retrospective study was conducted of 26 adult cases of fusobacterium bacteraemia that occurred between 1998 and 2003 at Center Hospitalier Universitaire de Grenoble, France. Most patients presented with pre-existing adverse medical conditions, including evolving malignant diseases (eight patients), recent surgery (four patients), and chronic organ failure (six patients). Only one (...) patient presented with a classic Lemierre's syndrome. These results suggest an opportunistic pattern of modern fusobacterium infections.

2006 Clinical Microbiology and Infection

184. Fusobacteriosis presenting as community acquired pneumonia. (Abstract)

Fusobacteriosis presenting as community acquired pneumonia. Fusobacterium species are anaerobic Gram-negative bacilli, which colonise the mucus membranes of man and animals and can cause a number of clinical manifestations including Lemierre's disease (postanginal septicaemia), abdominal infection and deep-seated abscesses. The incidence of fusobacterium infections appears to be increasing, and we present three cases of fusobacteriosis who presented with features of community acquired pneumonia

2005 Journal of Infection

185. Prevotella bivia necrobacillosis following infectious mononucleosis. (Abstract)

Prevotella bivia necrobacillosis following infectious mononucleosis. A case of Lemierre's syndrome is reported. Although Fusobacterium species are commonly associated with this presentation, Prevotella bivia was the causative micro-organism identified in this case. The finding that disseminated anaerobic sepsis followed primary EBV infection led to the construction of a hypothetical model of infection.

2006 Journal of Infection

186. "My back is killing me". Full Text available with Trip Pro

"My back is killing me". This is a case of a rare cause of back pain that presented to several clinicians before the diagnosis became obvious and the correct management was initiated. Lemierre's syndrome was confirmed at post mortem examination. We conclude that thoracic back pain should not be assumed to have a simple mechanical cause and that efforts should be made to discover the underlying aetiology.

2005 Emergency Medicine Journal

187. Real-time PCR investigation into the importance of Fusobacterium necrophorum as a cause of acute pharyngitis in general practice. Full Text available with Trip Pro

Real-time PCR investigation into the importance of Fusobacterium necrophorum as a cause of acute pharyngitis in general practice. Fusobacterium necrophorum is recognized as the cause of a severe life-threatening illness characterized by bacteraemia with metastatic abscesses following an acute sore throat (Lemierre's disease). However, the importance of F. necrophorum as a cause of simple sore throat in the community is unknown. Using quantitative real-time PCR with primers targeting the rpoB

2004 Journal of Medical Microbiology

188. Fusobacterium necrophorum Middle Ear Infections in Children and Related Complications: Report of 25 Cases and Literature Review. (Abstract)

Fusobacterium necrophorum Middle Ear Infections in Children and Related Complications: Report of 25 Cases and Literature Review. Fusobacterium necrophorum is associated with Lemierre syndrome (pharyngitis with septic thrombosis of the internal jugular veins) but it can also be involved in other head and neck infections, including sinusitis, parotitis, dental infections, and otitis media.This retrospective study analyzes a series of 25 pediatric cases of acute otitis media caused by F (...) . necrophorum and treated in our institution between 1995 and 2006.We observed 3 clinical presentations: (1) uncomplicated otitis media (44%; n = 11); (2) acute mastoiditis (40%; n = 10); and (3) otogenic variant of Lemierre syndrome (16%; n = 4) associating acute mastoiditis, suppurative thrombophlebitis of the lateral and/or cavernous sinuses, meningitis syndrome, and sometimes distant septic metastasis or extensive osteolysis of the temporal bone. Sixty percent of these cases were diagnosed during

2008 Pediatric Infectious Dsease Journal

189. Closed traumatic head injury: dural sinus and internal jugular vein thrombosis. (Abstract)

causes (eg, Lemierre's syndrome). A case of thrombosis of the transverse sinus, sigmoid sinus and internal jugular vein associated with a closed head injury as the result of a motorcycle accident is presented. (...) Closed traumatic head injury: dural sinus and internal jugular vein thrombosis. Dural sinus thrombosis (DST) has an annual incidence of 3-4 per million and can result from many aetiologies. Presentation of the disease can vary considerably, as can the aetiology and delay of symptoms to clinical detection. Symptoms on presentation include headache, seizures, focal neural deficits and altered mental status. There are many aetiological risk factors associated with DST, which include

2008 Emergency Medicine Journal

190. Unusual otolaryngological manifestations of certain systemic bacterial and fungal infections in children. (Abstract)

searching for specific issues was performed in order to achieve more information as possible with regards to ENT manifestation of systemic bacterial and fungal infections. Limits for pediatric age were used. Two separate sections for bacterial and fungal disease are included. The section on systemic bacterial infections considers cat-scratch disease, Lyme borreliosis, actinomycosis, Lemierre's syndrome and congenital syphilis, and the section on systemic fungal infections includes candidiasis (...) Unusual otolaryngological manifestations of certain systemic bacterial and fungal infections in children. Systemic bacterial and fungal infections may sometimes present local manifestations within otolaryngological district whose early detection may be useful in establishing a correct diagnosis and more appropriate treatment. This paper reviews certain systemic bacterial and fungal diseases presenting ENT manifestations in the pediatric population from an otolaryngological perspective.A medline

2009 International Journal of Pediatric Otorhinolaryngology

191. Direct 16S rRNA gene sequencing of polymicrobial culture-negative samples with analysis of mixed chromatograms. Full Text available with Trip Pro

Direct 16S rRNA gene sequencing of polymicrobial culture-negative samples with analysis of mixed chromatograms. Two cases involving polymicrobial culture-negative samples were investigated by 16S rRNA gene sequencing, with analysis of mixed chromatograms. Fusobacterium necrophorum, Prevotella intermedia and Streptococcus constellatus were identified from pleural fluid in a patient with Lemierre's syndrome and Neisseria meningitidis and Escherichia coli were identified from a petechia (...) in a patient with meningococcal disease.

2009 Journal of Medical Microbiology

192. Tonsillitis (Acute and Chronic)

dehydration. Peritonsillar abscess or cellulitis, parapharyngeal abscess, retropharyngeal abscess, or Lemierre's syndrome (as there is a risk of airway compromise or rupture of the abscess). Signs of marked systemic illness or sepsis. A suspected rare cause such as Kawasaki disease, diphtheria, or yersinial pharyngitis. Use clinical judgement to determine whether hospital admission is necessary in vulnerable people (eg, infants, very old people, and those who are immunosuppressed or immunocompromised (...) Guidelines. You may find the article more useful, or one of our other . In this article In This Article Tonsillitis In this article Tonsillitis is inflammation due to infection of the tonsils. Pharyngitis is inflammation of the oropharynx but not the tonsils. The tonsils tend to atrophy in early adulthood. In laryngitis there are few visible signs of infection but with soreness lower down the throat often associated with a hoarse voice. Epidemiology It is a very common condition, most frequent

2008 Mentor

193. Sore Throat

[ ] . Immediate prescription of antibiotics . This option should be offered to people who: Are systemically very unwell. Have signs of serious illness and/or complications such as peritonsillar abscess or cellulitis. Are immunosuppressed. Have valvular heart disease. Have a significant comorbidity (eg, heart, lung, renal, liver or neuromuscular disease, cystic fibrosis). A discussion with patients/parents/carers should take place as to which strategy is best for individual patients. This decision should (...) . Respiratory difficulty. Dehydration. Severe suppurative complications (local abscess or cellulitis, which may compromise the airway). Severe systemic illness. Suspected Kawasaki disease or epiglottitis. Assess urgently and/or seek specialist advice in those who are immunocompromised. Urgent FBC should be done and medication such as carbimazole or disease-modifying antirheumatic agents should be withheld pending FBC results and specialist advice. Consider routine referral for consideration of tonsillectomy

2008 Mentor

194. Rigors

a fit or convulsion. There is a wide range of conditions that can be associated with rigors, such as: Cardiac . . Lemierre's syndrome. . Pulmonary . . Genitourinary . . . . Obstetric Over half of women in labour experience shaking rigors. Epidurals and fever seem to be associated with the rigors. Rheumatological . . Infectious diseases . . . . (miliary). . Louse-borne relapsing fever (endemic in Ethiopia). GI . . . Medication reactions (usually intravenous) . Gentamicin. Vancomycin. Interleukin II (...) infections, biliary disease, and gastrointestinal (GI) infections. Recent surgical procedures. Any relevant past medical history such as rheumatic heart disease. Recent foreign travel [ ] . Medication and allergies. Examination This should be performed according to the history. Care should be taken in children where even an otitis media or upper respiratory infection may have triggered a rigor. It should be remembered that rigors can be an early symptom in septicaemia, particularly meningococcal

2008 Mentor

195. A vanishing disease can still happen. (Abstract)

A vanishing disease can still happen. Lemierre's syndrome is a rare disease in the antibiotic era which is characterised by oropharyngitis, thrombophlebitis and septic metastases, but it can still occur and early recognition of its characteristic features and commencement of appropriate treatment can be life saving. The case history is described of a middle-aged man with Lemierre's syndrome who made an uneventful recovery following treatment with co-amoxiclav and metronidazole for 6 weeks.

2009 Emergency Medicine Journal

196. Lemierre's--the sinister sore throat. (Abstract)

Lemierre's--the sinister sore throat. Lemierre's syndrome is a rare and sometimes life threatening condition that requires prompt management. A case is reported of a previously healthy young male with Lemierre's syndrome. He developed internal jugular vein and cavernous sinus thrombosis, metastatic abscesses in the temporal lobe and lungs, temporal lobe venous infarction and severe thrombocytopaenia. Discussed are aspects of clinical presentation, diagnosis and management issues.

2007 Journal of Laryngology & Otology

197. Lemierre syndrome: two cases and a review. (Abstract)

of the syndrome, subsequent re-emergence of this "forgotten disease" is becoming more common in clinical settings. Lemierre syndrome has significant morbidity. Cranial nerve complications associated with the condition have been increasingly diagnosed in the last few years. Looking back at literature on Lemierre syndrome, there have been review articles in medical and microbiology journals but rarely in otolaryngology journals. By presenting our cases we demonstrate the diverse presentations and severity (...) Lemierre syndrome: two cases and a review. Lemierre syndrome is usually caused by an acute oropharyngeal infection in previously healthy young adults, resulting in thrombophlebitis of the internal jugular vein, leading to metastatic septic embolization and bacteraemia. The usual organism is Fusobacterium necrophorum. Lemierre syndrome, not so long ago labeled as the "forgotten disease," is on the rise. Today with increasing antibiotic-resistant organisms, and decreasing awareness

2007 Laryngoscope

198. Was Systemic Venous Thrombosis Really Due to the Administration of Recombinant Factor VIIa? Or Was It Possibly a Manifestation of Lemierre Syndrome? Full Text available with Trip Pro

Was Systemic Venous Thrombosis Really Due to the Administration of Recombinant Factor VIIa? Or Was It Possibly a Manifestation of Lemierre Syndrome? 18941643 2009 01 09 2018 11 13 0730-2347 35 3 2008 Texas Heart Institute journal Tex Heart Inst J Was systemic venous thrombosis really due to the administration of recombinant factor VIIa? or was it possibly a manifestation of Lemierre syndrome? 373-4; author reply 374-6 Saeed Giovanni G Ganster George G Friedel Norbert N eng Comment Letter United (...) States Tex Heart Inst J 8214622 0730-2347 0 Recombinant Proteins EC 3.4.21.21 Factor VIIa IM Tex Heart Inst J. 2007;34(4):485-8 18172537 Bacterial Infections diagnosis Diagnosis, Differential Factor VIIa administration & dosage adverse effects Humans Jugular Veins Postoperative Hemorrhage drug therapy Recombinant Proteins administration & dosage adverse effects Syndrome Thrombophlebitis diagnosis Venous Thrombosis diagnosis etiology 2008 10 23 9 0 2009 1 10 9 0 2008 10 23 9 0 ppublish 18941643

2008 Texas Heart Institute Journal

199. A case of Lemierre syndrome Full Text available with Trip Pro

A case of Lemierre syndrome 19139613 2009 04 07 2018 11 13 0256-4947 29 1 2009 Jan-Feb Annals of Saudi medicine Ann Saudi Med A case of Lemierre syndrome. 58-60 Alherabi Ameen A Department of Otolaryngology/Head & Neck Surgery, Umm Al-Qura University, Al-Noor Specialist Hospital, Makkah, Saudi Arabia. herabi@hotmail.com eng Case Reports Journal Article Saudi Arabia Ann Saudi Med 8507355 0256-4947 IM Adult Empyema, Pleural etiology microbiology Fusobacterium Infections diagnosis microbiology (...) physiopathology Fusobacterium necrophorum isolation & purification Humans Jugular Veins microbiology pathology Male Syndrome Tomography, X-Ray Computed 2009 1 14 9 0 2009 1 14 9 0 2009 4 8 9 0 ppublish 19139613 08-001 PMC2813609 N Engl J Med. 2004 Apr 15;350(16):e14 15084710 Arch Pediatr. 2003 Dec;10(12):1071-4 14643536 Ann Vasc Surg. 2004 Mar;18(2):243-5 15253264 Acta Otorhinolaryngol Ital. 1998 Oct;18(5):332-7 10361747 J Chin Med Assoc. 2004 Aug;67(8):419-21 15553803 Acta Anaesthesiol Scand. 2005 Apr;49(4

2009 Annals of Saudi Medicine

200. Bilateral intraocular involvement in Lemierre's syndrome Full Text available with Trip Pro

Bilateral intraocular involvement in Lemierre's syndrome 16424550 2006 02 23 2018 11 13 0007-1161 90 2 2006 Feb The British journal of ophthalmology Br J Ophthalmol Bilateral intraocular involvement in Lemierre's syndrome. 249-50 Olson J L JL Mandava N N eng Case Reports Letter England Br J Ophthalmol 0421041 0007-1161 IM Adolescent Female Fusobacterium Infections diagnosis Fusobacterium necrophorum isolation & purification Humans Pharyngeal Diseases diagnosis microbiology Syndrome Visual

2006 The British journal of ophthalmology

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